BR112017014160A2 - produção de partículas semelhantes a rotavírus nas plantas - Google Patents
produção de partículas semelhantes a rotavírus nas plantasInfo
- Publication number
- BR112017014160A2 BR112017014160A2 BR112017014160-4A BR112017014160A BR112017014160A2 BR 112017014160 A2 BR112017014160 A2 BR 112017014160A2 BR 112017014160 A BR112017014160 A BR 112017014160A BR 112017014160 A2 BR112017014160 A2 BR 112017014160A2
- Authority
- BR
- Brazil
- Prior art keywords
- rotavirus
- rlp
- host
- nucleotide sequence
- plant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12323—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12351—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562106941P | 2015-01-23 | 2015-01-23 | |
| US62/106,941 | 2015-01-23 | ||
| PCT/CA2016/050043 WO2016115630A1 (en) | 2015-01-23 | 2016-01-21 | Rotavirus-like particle production in plants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017014160A2 true BR112017014160A2 (pt) | 2018-01-02 |
Family
ID=56416224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017014160-4A BR112017014160A2 (pt) | 2015-01-23 | 2016-01-21 | produção de partículas semelhantes a rotavírus nas plantas |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10287555B2 (https=) |
| EP (1) | EP3256575B1 (https=) |
| JP (1) | JP6841762B2 (https=) |
| KR (1) | KR20170104595A (https=) |
| CN (1) | CN107208072A (https=) |
| AU (1) | AU2016208999A1 (https=) |
| BR (1) | BR112017014160A2 (https=) |
| CA (1) | CA2974438A1 (https=) |
| EA (1) | EA201791683A1 (https=) |
| ES (1) | ES2826402T3 (https=) |
| HK (1) | HK1245333A1 (https=) |
| IL (1) | IL253040A0 (https=) |
| MX (1) | MX2017009568A (https=) |
| PH (1) | PH12017501330A1 (https=) |
| SG (1) | SG11201705991XA (https=) |
| WO (1) | WO2016115630A1 (https=) |
| ZA (1) | ZA201705555B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019018768A1 (en) | 2017-07-20 | 2019-01-24 | Spogen Biotech Inc. | BIOACTIVE POLYPEPTIDES FOR PLANT PROTECTION, GROWTH AND PRODUCTIVITY ENHANCEMENTS |
| JP2022521217A (ja) * | 2019-02-19 | 2022-04-06 | メディカゴ インコーポレイテッド | ロタウイルスｖｐ７融合タンパク質およびそれらを含むロタウイルス様粒子 |
| KR102647829B1 (ko) * | 2020-04-22 | 2024-03-14 | 포항공과대학교 산학협력단 | 삼량체를 형성하는 코로나-19 바이러스 (COVID-19, Coronavirus Disease 2019)의 재조합 스파이크 단백질 및 식물에서의 상기 재조합 스파이크 단백질의 대량 생산 방법과 이를 기반으로하는 백신조성물 제조 방법 |
| CN112251461B (zh) * | 2020-10-22 | 2022-08-23 | 植链(上海)生物科技有限公司 | 一种采用本氏烟作为生物反应器制备的轮状病毒疫苗及其制备方法和应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5428147A (en) | 1983-04-15 | 1995-06-27 | Mycogen Plant Science, Inc. | Octopine T-DNA promoters |
| EP0152295B1 (en) | 1984-02-09 | 1991-03-20 | Royal Children's Hospital Research Foundation | Live attenuated human rotavirus vaccine and preparation thereof |
| US4636385A (en) | 1985-02-15 | 1987-01-13 | The Wistar Institute Of Anatomy & Biology | Vaccine, method for its preparation, and use thereof in vaccinating humans against rotavirus infection |
| US4751080A (en) | 1985-08-26 | 1988-06-14 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine against rotavirus diseases |
| US4704275A (en) | 1985-08-26 | 1987-11-03 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine against rotavirus diseases |
| US4927628A (en) | 1987-09-21 | 1990-05-22 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine against rotavirus diseases and method of preparing same |
| KR0171434B1 (ko) | 1990-11-16 | 1999-02-01 | 윌리엄 케이. 슈버트 | 인체 로타바이러스, 백신 및 방법 |
| WO1997000088A2 (en) * | 1995-06-14 | 1997-01-03 | Baylor College Of Medicine | Rotavirus enterotoxin nsp4 and methods of using same |
| US7422747B2 (en) * | 1997-10-07 | 2008-09-09 | Loma Linda University | Transgenic plant-based vaccines |
| US20050186219A1 (en) | 1997-10-07 | 2005-08-25 | Langridge William H. | Transgenic plant-based vaccines |
| US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| US6867353B2 (en) | 2000-02-12 | 2005-03-15 | Exploregen Inc. | Production method of recombinant rotavirus structural proteins and vaccine composition |
| FR2806087B1 (fr) | 2000-03-07 | 2002-10-18 | Agronomique Inst Nat Rech | Particules pseudovirales de rotavirus et leur utilisation pour vectoriser des proteines ou des acides nucleiques |
| CA2427809A1 (en) * | 2000-11-03 | 2002-05-10 | Baylor College Of Medicine | Rotavirus enterotoxin nsp4 and methods of using same |
| ES2514316T3 (es) | 2005-11-22 | 2014-10-28 | Novartis Vaccines And Diagnostics, Inc. | Partículas similares a virus (VLPs) de Norovirus y Sapovirus |
| CA2651907C (en) | 2006-05-22 | 2016-12-20 | Plant Bioscience Limited | Bipartite system, method and composition for the constitutive and inducible expression of high levels of foreign proteins in plants |
| WO2009076778A1 (en) | 2007-11-27 | 2009-06-25 | Medicago Inc. | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| GB0800272D0 (en) | 2008-01-08 | 2008-02-13 | Plant Bioscience Ltd | Protein expression systems |
| EP2297186B1 (en) | 2008-05-29 | 2018-08-29 | The Government of The United States of America, as represented by the Secretary, Department of Health and Human Services, | Expression and assembly of human group c rotavirus-like particles and uses thereof |
| WO2012058762A1 (en) | 2010-11-04 | 2012-05-10 | Medicago Inc. | Plant expression system |
| KR101963792B1 (ko) * | 2011-06-13 | 2019-07-31 | 메디카고 인코포레이티드 | 식물에서 광견병 바이러스 유사 입자 생성 |
| EA032089B1 (ru) * | 2012-05-11 | 2019-04-30 | Медикаго Инк. | Получение ротавирус-подобных частиц в растениях |
-
2016
- 2016-01-21 AU AU2016208999A patent/AU2016208999A1/en not_active Abandoned
- 2016-01-21 HK HK18104978.8A patent/HK1245333A1/zh unknown
- 2016-01-21 CN CN201680006015.6A patent/CN107208072A/zh active Pending
- 2016-01-21 EP EP16739705.8A patent/EP3256575B1/en not_active Not-in-force
- 2016-01-21 CA CA2974438A patent/CA2974438A1/en not_active Abandoned
- 2016-01-21 US US15/545,362 patent/US10287555B2/en active Active
- 2016-01-21 ES ES16739705T patent/ES2826402T3/es active Active
- 2016-01-21 SG SG11201705991XA patent/SG11201705991XA/en unknown
- 2016-01-21 BR BR112017014160-4A patent/BR112017014160A2/pt not_active Application Discontinuation
- 2016-01-21 WO PCT/CA2016/050043 patent/WO2016115630A1/en not_active Ceased
- 2016-01-21 EA EA201791683A patent/EA201791683A1/ru unknown
- 2016-01-21 JP JP2017538629A patent/JP6841762B2/ja not_active Expired - Fee Related
- 2016-01-21 MX MX2017009568A patent/MX2017009568A/es unknown
- 2016-01-21 KR KR1020177023021A patent/KR20170104595A/ko not_active Withdrawn
-
2017
- 2017-06-20 IL IL253040A patent/IL253040A0/en unknown
- 2017-07-21 PH PH12017501330A patent/PH12017501330A1/en unknown
- 2017-08-16 ZA ZA2017/05555A patent/ZA201705555B/en unknown
-
2019
- 2019-03-29 US US16/369,703 patent/US20190345454A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PH12017501330A1 (en) | 2017-12-18 |
| KR20170104595A (ko) | 2017-09-15 |
| JP2018504119A (ja) | 2018-02-15 |
| US20190345454A1 (en) | 2019-11-14 |
| US10287555B2 (en) | 2019-05-14 |
| AU2016208999A1 (en) | 2017-07-13 |
| EP3256575A4 (en) | 2018-10-31 |
| JP6841762B2 (ja) | 2021-03-10 |
| EP3256575B1 (en) | 2020-07-29 |
| HK1245333A1 (zh) | 2018-08-24 |
| WO2016115630A1 (en) | 2016-07-28 |
| EA201791683A1 (ru) | 2017-12-29 |
| CA2974438A1 (en) | 2016-07-28 |
| ES2826402T3 (es) | 2021-05-18 |
| CN107208072A (zh) | 2017-09-26 |
| US20180016561A1 (en) | 2018-01-18 |
| SG11201705991XA (en) | 2017-08-30 |
| IL253040A0 (en) | 2017-08-31 |
| MX2017009568A (es) | 2018-03-01 |
| EP3256575A1 (en) | 2017-12-20 |
| ZA201705555B (en) | 2020-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
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