EA201791683A1 - Получение ротавирусоподобных частиц в растениях - Google Patents
Получение ротавирусоподобных частиц в растенияхInfo
- Publication number
- EA201791683A1 EA201791683A1 EA201791683A EA201791683A EA201791683A1 EA 201791683 A1 EA201791683 A1 EA 201791683A1 EA 201791683 A EA201791683 A EA 201791683A EA 201791683 A EA201791683 A EA 201791683A EA 201791683 A1 EA201791683 A1 EA 201791683A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- host
- nucleotide sequence
- rlp
- plant
- rotavirus
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 4
- 125000003729 nucleotide group Chemical group 0.000 abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 108700010850 rotavirus proteins Proteins 0.000 abstract 3
- 101710138767 Non-structural glycoprotein 4 Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000001105 regulatory effect Effects 0.000 abstract 2
- 102100031056 Serine protease 57 Human genes 0.000 abstract 1
- 101710197596 Serine protease 57 Proteins 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12323—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12351—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562106941P | 2015-01-23 | 2015-01-23 | |
| PCT/CA2016/050043 WO2016115630A1 (en) | 2015-01-23 | 2016-01-21 | Rotavirus-like particle production in plants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201791683A1 true EA201791683A1 (ru) | 2017-12-29 |
Family
ID=56416224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201791683A EA201791683A1 (ru) | 2015-01-23 | 2016-01-21 | Получение ротавирусоподобных частиц в растениях |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10287555B2 (https=) |
| EP (1) | EP3256575B1 (https=) |
| JP (1) | JP6841762B2 (https=) |
| KR (1) | KR20170104595A (https=) |
| CN (1) | CN107208072A (https=) |
| AU (1) | AU2016208999A1 (https=) |
| BR (1) | BR112017014160A2 (https=) |
| CA (1) | CA2974438A1 (https=) |
| EA (1) | EA201791683A1 (https=) |
| ES (1) | ES2826402T3 (https=) |
| HK (1) | HK1245333A1 (https=) |
| IL (1) | IL253040A0 (https=) |
| MX (1) | MX2017009568A (https=) |
| PH (1) | PH12017501330A1 (https=) |
| SG (1) | SG11201705991XA (https=) |
| WO (1) | WO2016115630A1 (https=) |
| ZA (1) | ZA201705555B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019018768A1 (en) | 2017-07-20 | 2019-01-24 | Spogen Biotech Inc. | BIOACTIVE POLYPEPTIDES FOR PLANT PROTECTION, GROWTH AND PRODUCTIVITY ENHANCEMENTS |
| JP2022521217A (ja) * | 2019-02-19 | 2022-04-06 | メディカゴ インコーポレイテッド | ロタウイルスｖｐ７融合タンパク質およびそれらを含むロタウイルス様粒子 |
| KR102647829B1 (ko) * | 2020-04-22 | 2024-03-14 | 포항공과대학교 산학협력단 | 삼량체를 형성하는 코로나-19 바이러스 (COVID-19, Coronavirus Disease 2019)의 재조합 스파이크 단백질 및 식물에서의 상기 재조합 스파이크 단백질의 대량 생산 방법과 이를 기반으로하는 백신조성물 제조 방법 |
| CN112251461B (zh) * | 2020-10-22 | 2022-08-23 | 植链(上海)生物科技有限公司 | 一种采用本氏烟作为生物反应器制备的轮状病毒疫苗及其制备方法和应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5428147A (en) | 1983-04-15 | 1995-06-27 | Mycogen Plant Science, Inc. | Octopine T-DNA promoters |
| EP0152295B1 (en) | 1984-02-09 | 1991-03-20 | Royal Children's Hospital Research Foundation | Live attenuated human rotavirus vaccine and preparation thereof |
| US4636385A (en) | 1985-02-15 | 1987-01-13 | The Wistar Institute Of Anatomy & Biology | Vaccine, method for its preparation, and use thereof in vaccinating humans against rotavirus infection |
| US4751080A (en) | 1985-08-26 | 1988-06-14 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine against rotavirus diseases |
| US4704275A (en) | 1985-08-26 | 1987-11-03 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine against rotavirus diseases |
| US4927628A (en) | 1987-09-21 | 1990-05-22 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine against rotavirus diseases and method of preparing same |
| KR0171434B1 (ko) | 1990-11-16 | 1999-02-01 | 윌리엄 케이. 슈버트 | 인체 로타바이러스, 백신 및 방법 |
| WO1997000088A2 (en) * | 1995-06-14 | 1997-01-03 | Baylor College Of Medicine | Rotavirus enterotoxin nsp4 and methods of using same |
| US7422747B2 (en) * | 1997-10-07 | 2008-09-09 | Loma Linda University | Transgenic plant-based vaccines |
| US20050186219A1 (en) | 1997-10-07 | 2005-08-25 | Langridge William H. | Transgenic plant-based vaccines |
| US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| US6867353B2 (en) | 2000-02-12 | 2005-03-15 | Exploregen Inc. | Production method of recombinant rotavirus structural proteins and vaccine composition |
| FR2806087B1 (fr) | 2000-03-07 | 2002-10-18 | Agronomique Inst Nat Rech | Particules pseudovirales de rotavirus et leur utilisation pour vectoriser des proteines ou des acides nucleiques |
| CA2427809A1 (en) * | 2000-11-03 | 2002-05-10 | Baylor College Of Medicine | Rotavirus enterotoxin nsp4 and methods of using same |
| ES2514316T3 (es) | 2005-11-22 | 2014-10-28 | Novartis Vaccines And Diagnostics, Inc. | Partículas similares a virus (VLPs) de Norovirus y Sapovirus |
| CA2651907C (en) | 2006-05-22 | 2016-12-20 | Plant Bioscience Limited | Bipartite system, method and composition for the constitutive and inducible expression of high levels of foreign proteins in plants |
| WO2009076778A1 (en) | 2007-11-27 | 2009-06-25 | Medicago Inc. | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| GB0800272D0 (en) | 2008-01-08 | 2008-02-13 | Plant Bioscience Ltd | Protein expression systems |
| EP2297186B1 (en) | 2008-05-29 | 2018-08-29 | The Government of The United States of America, as represented by the Secretary, Department of Health and Human Services, | Expression and assembly of human group c rotavirus-like particles and uses thereof |
| WO2012058762A1 (en) | 2010-11-04 | 2012-05-10 | Medicago Inc. | Plant expression system |
| KR101963792B1 (ko) * | 2011-06-13 | 2019-07-31 | 메디카고 인코포레이티드 | 식물에서 광견병 바이러스 유사 입자 생성 |
| EA032089B1 (ru) * | 2012-05-11 | 2019-04-30 | Медикаго Инк. | Получение ротавирус-подобных частиц в растениях |
-
2016
- 2016-01-21 AU AU2016208999A patent/AU2016208999A1/en not_active Abandoned
- 2016-01-21 HK HK18104978.8A patent/HK1245333A1/zh unknown
- 2016-01-21 CN CN201680006015.6A patent/CN107208072A/zh active Pending
- 2016-01-21 EP EP16739705.8A patent/EP3256575B1/en not_active Not-in-force
- 2016-01-21 CA CA2974438A patent/CA2974438A1/en not_active Abandoned
- 2016-01-21 US US15/545,362 patent/US10287555B2/en active Active
- 2016-01-21 ES ES16739705T patent/ES2826402T3/es active Active
- 2016-01-21 SG SG11201705991XA patent/SG11201705991XA/en unknown
- 2016-01-21 BR BR112017014160-4A patent/BR112017014160A2/pt not_active Application Discontinuation
- 2016-01-21 WO PCT/CA2016/050043 patent/WO2016115630A1/en not_active Ceased
- 2016-01-21 EA EA201791683A patent/EA201791683A1/ru unknown
- 2016-01-21 JP JP2017538629A patent/JP6841762B2/ja not_active Expired - Fee Related
- 2016-01-21 MX MX2017009568A patent/MX2017009568A/es unknown
- 2016-01-21 KR KR1020177023021A patent/KR20170104595A/ko not_active Withdrawn
-
2017
- 2017-06-20 IL IL253040A patent/IL253040A0/en unknown
- 2017-07-21 PH PH12017501330A patent/PH12017501330A1/en unknown
- 2017-08-16 ZA ZA2017/05555A patent/ZA201705555B/en unknown
-
2019
- 2019-03-29 US US16/369,703 patent/US20190345454A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PH12017501330A1 (en) | 2017-12-18 |
| KR20170104595A (ko) | 2017-09-15 |
| JP2018504119A (ja) | 2018-02-15 |
| US20190345454A1 (en) | 2019-11-14 |
| US10287555B2 (en) | 2019-05-14 |
| AU2016208999A1 (en) | 2017-07-13 |
| EP3256575A4 (en) | 2018-10-31 |
| BR112017014160A2 (pt) | 2018-01-02 |
| JP6841762B2 (ja) | 2021-03-10 |
| EP3256575B1 (en) | 2020-07-29 |
| HK1245333A1 (zh) | 2018-08-24 |
| WO2016115630A1 (en) | 2016-07-28 |
| CA2974438A1 (en) | 2016-07-28 |
| ES2826402T3 (es) | 2021-05-18 |
| CN107208072A (zh) | 2017-09-26 |
| US20180016561A1 (en) | 2018-01-18 |
| SG11201705991XA (en) | 2017-08-30 |
| IL253040A0 (en) | 2017-08-31 |
| MX2017009568A (es) | 2018-03-01 |
| EP3256575A1 (en) | 2017-12-20 |
| ZA201705555B (en) | 2020-01-29 |
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