CN107208072A - 在植物中产生轮状病毒样颗粒 - Google Patents

在植物中产生轮状病毒样颗粒 Download PDF

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Publication number
CN107208072A
CN107208072A CN201680006015.6A CN201680006015A CN107208072A CN 107208072 A CN107208072 A CN 107208072A CN 201680006015 A CN201680006015 A CN 201680006015A CN 107208072 A CN107208072 A CN 107208072A
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CN
China
Prior art keywords
nucleotide sequence
rotavirus
nucleic acid
protein
sequence
Prior art date
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Pending
Application number
CN201680006015.6A
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English (en)
Chinese (zh)
Inventor
皮埃尔-奥利维耶·拉瓦伊
马克-安德烈·蒂奥斯特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medicago Inc
Tanabe Pharma Corp
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Medicago Inc
Mitsubishi Tanabe Pharma Corp
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Application filed by Medicago Inc, Mitsubishi Tanabe Pharma Corp filed Critical Medicago Inc
Publication of CN107208072A publication Critical patent/CN107208072A/zh
Pending legal-status Critical Current

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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12323—Virus like particles [VLP]
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    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12351—Methods of production or purification of viral material

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  • Health & Medical Sciences (AREA)
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  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201680006015.6A 2015-01-23 2016-01-21 在植物中产生轮状病毒样颗粒 Pending CN107208072A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562106941P 2015-01-23 2015-01-23
US62/106,941 2015-01-23
PCT/CA2016/050043 WO2016115630A1 (en) 2015-01-23 2016-01-21 Rotavirus-like particle production in plants

Publications (1)

Publication Number Publication Date
CN107208072A true CN107208072A (zh) 2017-09-26

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CN201680006015.6A Pending CN107208072A (zh) 2015-01-23 2016-01-21 在植物中产生轮状病毒样颗粒

Country Status (17)

Country Link
US (2) US10287555B2 (https=)
EP (1) EP3256575B1 (https=)
JP (1) JP6841762B2 (https=)
KR (1) KR20170104595A (https=)
CN (1) CN107208072A (https=)
AU (1) AU2016208999A1 (https=)
BR (1) BR112017014160A2 (https=)
CA (1) CA2974438A1 (https=)
EA (1) EA201791683A1 (https=)
ES (1) ES2826402T3 (https=)
HK (1) HK1245333A1 (https=)
IL (1) IL253040A0 (https=)
MX (1) MX2017009568A (https=)
PH (1) PH12017501330A1 (https=)
SG (1) SG11201705991XA (https=)
WO (1) WO2016115630A1 (https=)
ZA (1) ZA201705555B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112251461A (zh) * 2020-10-22 2021-01-22 植链(上海)生物科技有限公司 一种采用本氏烟作为生物反应器制备的轮状病毒疫苗及其制备方法和应用
US12268727B2 (en) 2017-07-20 2025-04-08 Spogen Biotech Inc. Bioactive polypeptides for improvements in plant protection, growth and productivity

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JP2022521217A (ja) * 2019-02-19 2022-04-06 メディカゴ インコーポレイテッド ロタウイルスｖｐ７融合タンパク質およびそれらを含むロタウイルス様粒子
KR102647829B1 (ko) * 2020-04-22 2024-03-14 포항공과대학교 산학협력단 삼량체를 형성하는 코로나-19 바이러스 (COVID-19, Coronavirus Disease 2019)의 재조합 스파이크 단백질 및 식물에서의 상기 재조합 스파이크 단백질의 대량 생산 방법과 이를 기반으로하는 백신조성물 제조 방법

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CN104284978A (zh) * 2012-05-11 2015-01-14 麦迪卡格公司 植物中类轮状病毒颗粒的产生

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CN103998601A (zh) * 2011-06-13 2014-08-20 麦迪卡格公司 在植物中产生狂犬病病毒样颗粒
CN104284978A (zh) * 2012-05-11 2015-01-14 麦迪卡格公司 植物中类轮状病毒颗粒的产生

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12268727B2 (en) 2017-07-20 2025-04-08 Spogen Biotech Inc. Bioactive polypeptides for improvements in plant protection, growth and productivity
US12599649B2 (en) 2017-07-20 2026-04-14 Spogen Biotech Inc. Bioactive polypeptides for improvements in plant protection, growth and productivity
CN112251461A (zh) * 2020-10-22 2021-01-22 植链(上海)生物科技有限公司 一种采用本氏烟作为生物反应器制备的轮状病毒疫苗及其制备方法和应用

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Publication number Publication date
PH12017501330A1 (en) 2017-12-18
KR20170104595A (ko) 2017-09-15
JP2018504119A (ja) 2018-02-15
US20190345454A1 (en) 2019-11-14
US10287555B2 (en) 2019-05-14
AU2016208999A1 (en) 2017-07-13
EP3256575A4 (en) 2018-10-31
BR112017014160A2 (pt) 2018-01-02
JP6841762B2 (ja) 2021-03-10
EP3256575B1 (en) 2020-07-29
HK1245333A1 (zh) 2018-08-24
WO2016115630A1 (en) 2016-07-28
EA201791683A1 (ru) 2017-12-29
CA2974438A1 (en) 2016-07-28
ES2826402T3 (es) 2021-05-18
US20180016561A1 (en) 2018-01-18
SG11201705991XA (en) 2017-08-30
IL253040A0 (en) 2017-08-31
MX2017009568A (es) 2018-03-01
EP3256575A1 (en) 2017-12-20
ZA201705555B (en) 2020-01-29

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