BR112017000135A2 - processo para a preparação de ácidos 4-alcóxi-3-hidroxipicolínico - Google Patents

processo para a preparação de ácidos 4-alcóxi-3-hidroxipicolínico

Info

Publication number
BR112017000135A2
BR112017000135A2 BR112017000135A BR112017000135A BR112017000135A2 BR 112017000135 A2 BR112017000135 A2 BR 112017000135A2 BR 112017000135 A BR112017000135 A BR 112017000135A BR 112017000135 A BR112017000135 A BR 112017000135A BR 112017000135 A2 BR112017000135 A2 BR 112017000135A2
Authority
BR
Brazil
Prior art keywords
alkoxy
preparation
hydroxypicolinic acids
hydroxypicolinic
acids
Prior art date
Application number
BR112017000135A
Other languages
English (en)
Other versions
BR112017000135B1 (pt
BR112017000135B8 (pt
Inventor
T Whiteker Gregory
M Renga James
Choy Nakyen
Zhu Yuanming
Original Assignee
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Agrosciences Llc filed Critical Dow Agrosciences Llc
Publication of BR112017000135A2 publication Critical patent/BR112017000135A2/pt
Publication of BR112017000135B1 publication Critical patent/BR112017000135B1/pt
Publication of BR112017000135B8 publication Critical patent/BR112017000135B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

a presente invenção refere-se a 4,6-dibromo-3-hidroxipicolinonitrila que pode ser preparado a partir de furfural em uma série de etapas químicas selecionadas de ciano-aminação, formação de sal de amina e rearranjo de bromação.
BR112017000135A 2014-07-08 2015-07-08 Processo para a preparação de ácidos 4-alcóxi-3-hidroxipicolínico BR112017000135B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462021877P 2014-07-08 2014-07-08
US201462021876P 2014-07-08 2014-07-08
US201462021881P 2014-07-08 2014-07-08
US62/021,876 2014-07-08
US62/021,877 2014-07-08
US62/021,881 2014-07-08
PCT/US2015/039568 WO2016007637A1 (en) 2014-07-08 2015-07-08 Process for the preparation of 4-alkoxy-3-hydroxypicolinic acids

Publications (3)

Publication Number Publication Date
BR112017000135A2 true BR112017000135A2 (pt) 2017-11-07
BR112017000135B1 BR112017000135B1 (pt) 2022-08-09
BR112017000135B8 BR112017000135B8 (pt) 2023-05-16

Family

ID=55064837

Family Applications (3)

Application Number Title Priority Date Filing Date
BR112017000061A BR112017000061B8 (pt) 2014-07-08 2015-07-08 Processo para a preparação de ácidos 4-alcóxi-3-hidroxipicolínicos
BR112017000135A BR112017000135B8 (pt) 2014-07-08 2015-07-08 Processo para a preparação de ácidos 4-alcóxi-3-hidroxipicolínico
BR112016031007A BR112016031007B8 (pt) 2014-07-08 2015-07-08 Intermediários para preparação de ácidos 4-alcóxi-3- hidroxipicolínicos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR112017000061A BR112017000061B8 (pt) 2014-07-08 2015-07-08 Processo para a preparação de ácidos 4-alcóxi-3-hidroxipicolínicos

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112016031007A BR112016031007B8 (pt) 2014-07-08 2015-07-08 Intermediários para preparação de ácidos 4-alcóxi-3- hidroxipicolínicos

Country Status (16)

Country Link
US (4) US9522887B2 (pt)
EP (3) EP3166927B1 (pt)
JP (4) JP6625115B2 (pt)
KR (3) KR102436286B1 (pt)
CN (3) CN106573005B (pt)
BR (3) BR112017000061B8 (pt)
CA (3) CA2954167C (pt)
CO (3) CO2017000049A2 (pt)
DK (3) DK3166927T3 (pt)
ES (3) ES2738401T3 (pt)
IL (3) IL249891B (pt)
MX (3) MX2016017127A (pt)
PL (3) PL3166927T3 (pt)
TW (5) TW201943703A (pt)
WO (3) WO2016007634A1 (pt)
ZA (1) ZA201700254B (pt)

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BR112018014763B8 (pt) * 2016-01-22 2023-05-16 Dow Agrosciences Llc Processo para preparação de ácidos 4-alcóxi-3-hidroxipicolínicos
TW201733985A (zh) * 2016-02-29 2017-10-01 陶氏農業科學公司 用於製備4-烷氧基-3-羥基吡啶甲酸之方法
TWI733749B (zh) * 2017-01-25 2021-07-21 美商陶氏農業科學公司 用於製備4-烷氧基-3-羥基吡啶甲酸之方法
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AR123502A1 (es) 2020-09-15 2022-12-07 Pi Industries Ltd Nuevos compuestos de picolinamida para combatir hongos fitopatógenos
AR123501A1 (es) 2020-09-15 2022-12-07 Pi Industries Ltd Nuevos compuestos de picolinamida para combatir hongos fitopatógenos
WO2024018354A1 (en) 2022-07-18 2024-01-25 Pi Industries Ltd. A process for the synthesis of 4-alkoxy-3-hydroxypicolinic acids and intermediates thereof

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Also Published As

Publication number Publication date
US9475771B2 (en) 2016-10-25
US20160009649A1 (en) 2016-01-14
CA2954167A1 (en) 2016-01-14
CN106660957A (zh) 2017-05-10
CO2017000430A2 (es) 2017-04-28
KR102436286B1 (ko) 2022-08-26
WO2016007634A1 (en) 2016-01-14
CN106573005B (zh) 2020-05-29
CA2954284A1 (en) 2016-01-14
KR20170023942A (ko) 2017-03-06
EP3166612A4 (en) 2017-12-20
TW201625541A (zh) 2016-07-16
JP2017523962A (ja) 2017-08-24
DK3166612T3 (da) 2019-09-23
EP3166612B1 (en) 2019-06-12
BR112016031007B8 (pt) 2022-08-23
JP6625115B2 (ja) 2019-12-25
US20160009676A1 (en) 2016-01-14
EP3166927B1 (en) 2020-04-22
CN106659724B (zh) 2020-04-28
CA2954276A1 (en) 2016-01-14
JP2020073575A (ja) 2020-05-14
TWI682923B (zh) 2020-01-21
BR112017000061B1 (pt) 2022-10-25
ES2836201T3 (es) 2021-06-24
TW201625542A (zh) 2016-07-16
PL3166612T3 (pl) 2019-12-31
PL3166927T3 (pl) 2020-10-19
US9522887B2 (en) 2016-12-20
WO2016007638A1 (en) 2016-01-14
TWI720647B (zh) 2021-03-01
IL249911A0 (en) 2017-03-30
MX369327B (es) 2019-11-05
MX2016017106A (es) 2017-05-10
TWI684587B (zh) 2020-02-11
IL249893B (en) 2020-02-27
WO2016007637A1 (en) 2016-01-14
CO2017000446A2 (es) 2017-05-10
TW201625571A (zh) 2016-07-16
TW202003481A (zh) 2020-01-16
DK3166927T3 (da) 2020-07-27
JP6688278B2 (ja) 2020-04-28
US9481651B2 (en) 2016-11-01
CN106573005A (zh) 2017-04-19
BR112017000135B1 (pt) 2022-08-09
CN106660957B (zh) 2019-11-29
MX2016017127A (es) 2017-05-10
KR102450085B1 (ko) 2022-10-04
ES2738401T3 (es) 2020-01-22
JP2017521429A (ja) 2017-08-03
US20160009650A1 (en) 2016-01-14
MX2016017120A (es) 2017-05-10
CN106659724A (zh) 2017-05-10
BR112016031007B1 (pt) 2021-04-27
BR112017000061A2 (pt) 2017-11-07
KR20170029501A (ko) 2017-03-15
EP3166611A1 (en) 2017-05-17
DK3166611T3 (da) 2020-12-07
EP3166611A4 (en) 2018-02-21
BR112017000061B8 (pt) 2023-05-16
EP3166927A4 (en) 2017-12-20
EP3166611B1 (en) 2020-09-16
TW201943703A (zh) 2019-11-16
JP6513178B2 (ja) 2019-05-15
ES2807622T3 (es) 2021-02-23
IL249891A0 (en) 2017-03-30
IL249891B (en) 2020-07-30
KR20170029506A (ko) 2017-03-15
JP2017523960A (ja) 2017-08-24
CA2954276C (en) 2022-12-13
ZA201700254B (en) 2018-12-19
TWI689498B (zh) 2020-04-01
US9718783B2 (en) 2017-08-01
EP3166612A1 (en) 2017-05-17
CO2017000049A2 (es) 2017-05-10
CA2954167C (en) 2023-01-03
BR112017000135B8 (pt) 2023-05-16
IL249911B (en) 2020-02-27
US20170044105A1 (en) 2017-02-16
PL3166611T3 (pl) 2021-04-06
IL249893A0 (en) 2017-03-30
EP3166927A1 (en) 2017-05-17
CA2954284C (en) 2022-12-13
KR102441177B1 (ko) 2022-09-07

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