BR112016031007B8 - Intermediários para preparação de ácidos 4-alcóxi-3- hidroxipicolínicos - Google Patents
Intermediários para preparação de ácidos 4-alcóxi-3- hidroxipicolínicosInfo
- Publication number
- BR112016031007B8 BR112016031007B8 BR112016031007A BR112016031007A BR112016031007B8 BR 112016031007 B8 BR112016031007 B8 BR 112016031007B8 BR 112016031007 A BR112016031007 A BR 112016031007A BR 112016031007 A BR112016031007 A BR 112016031007A BR 112016031007 B8 BR112016031007 B8 BR 112016031007B8
- Authority
- BR
- Brazil
- Prior art keywords
- alkoxy
- preparation
- acids
- intermediaries
- hydroxypicolinonitrile
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCESSO PARA A PREPARAÇÃO DE ÁCIDOS 4-ALCÓXI-3-HIDROXIPICOLÍNICOS. A presente invenção refere-se a 4,6-dibromo-3-hidroxipicoli-nonitrila que pode ser preparada a partir de furfural em uma série de etapas químicas selecionadas dentre aminação de ciano, formação de sal de amina e rearranjo de bromação. Os ácidos 4-alcóxi-3-hidroxipi-colínicos podem ser convenientemente preparados a partir de 4,6-dibromo-3-hidroxipicolinonitrila em uma série de etapas químicas selecionadas dentre substituição de bromo, hidrólise de nitrila e redução de halogênio.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462021877P | 2014-07-08 | 2014-07-08 | |
| US201462021876P | 2014-07-08 | 2014-07-08 | |
| US201462021881P | 2014-07-08 | 2014-07-08 | |
| US62/021,876 | 2014-07-08 | ||
| US62/021,877 | 2014-07-08 | ||
| US62/021,881 | 2014-07-08 | ||
| PCT/US2015/039569 WO2016007638A1 (en) | 2014-07-08 | 2015-07-08 | Process for the preparation of 4-alkoxy-3-hydroxypicolinic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112016031007B1 BR112016031007B1 (pt) | 2021-04-27 |
| BR112016031007B8 true BR112016031007B8 (pt) | 2022-08-23 |
Family
ID=55064837
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017000061A BR112017000061B8 (pt) | 2014-07-08 | 2015-07-08 | Processo para a preparação de ácidos 4-alcóxi-3-hidroxipicolínicos |
| BR112017000135A BR112017000135B8 (pt) | 2014-07-08 | 2015-07-08 | Processo para a preparação de ácidos 4-alcóxi-3-hidroxipicolínico |
| BR112016031007A BR112016031007B8 (pt) | 2014-07-08 | 2015-07-08 | Intermediários para preparação de ácidos 4-alcóxi-3- hidroxipicolínicos |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017000061A BR112017000061B8 (pt) | 2014-07-08 | 2015-07-08 | Processo para a preparação de ácidos 4-alcóxi-3-hidroxipicolínicos |
| BR112017000135A BR112017000135B8 (pt) | 2014-07-08 | 2015-07-08 | Processo para a preparação de ácidos 4-alcóxi-3-hidroxipicolínico |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US9522887B2 (pt) |
| EP (3) | EP3166927B1 (pt) |
| JP (4) | JP6625115B2 (pt) |
| KR (3) | KR102436286B1 (pt) |
| CN (3) | CN106573005B (pt) |
| BR (3) | BR112017000061B8 (pt) |
| CA (3) | CA2954167C (pt) |
| CO (3) | CO2017000049A2 (pt) |
| DK (3) | DK3166927T3 (pt) |
| ES (3) | ES2738401T3 (pt) |
| IL (3) | IL249891B (pt) |
| MX (3) | MX2016017127A (pt) |
| PL (3) | PL3166927T3 (pt) |
| TW (5) | TW201943703A (pt) |
| WO (3) | WO2016007634A1 (pt) |
| ZA (1) | ZA201700254B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10476159B2 (en) * | 2015-11-30 | 2019-11-12 | Electronics And Telecommunications Research Institute | Coaxial resonance coil having toroidal shape for wireless power transmission |
| US10259789B2 (en) * | 2016-01-22 | 2019-04-16 | Dow Agrosciences Llc | Process for the preparation of 4-alkoxy-3-acetoxypicolinic acids |
| BR112018014763B8 (pt) * | 2016-01-22 | 2023-05-16 | Dow Agrosciences Llc | Processo para preparação de ácidos 4-alcóxi-3-hidroxipicolínicos |
| TW201733985A (zh) * | 2016-02-29 | 2017-10-01 | 陶氏農業科學公司 | 用於製備4-烷氧基-3-羥基吡啶甲酸之方法 |
| TWI733749B (zh) * | 2017-01-25 | 2021-07-21 | 美商陶氏農業科學公司 | 用於製備4-烷氧基-3-羥基吡啶甲酸之方法 |
| US10382579B2 (en) * | 2017-02-28 | 2019-08-13 | International Business Machines Corporation | Personalized location-based services for users |
| AR123502A1 (es) | 2020-09-15 | 2022-12-07 | Pi Industries Ltd | Nuevos compuestos de picolinamida para combatir hongos fitopatógenos |
| AR123501A1 (es) | 2020-09-15 | 2022-12-07 | Pi Industries Ltd | Nuevos compuestos de picolinamida para combatir hongos fitopatógenos |
| WO2024018354A1 (en) | 2022-07-18 | 2024-01-25 | Pi Industries Ltd. | A process for the synthesis of 4-alkoxy-3-hydroxypicolinic acids and intermediates thereof |
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| ZA815129B (en) * | 1980-07-28 | 1982-07-28 | Ciba Geigy Ag | Thiazoline derivatives and processes for their manufacture |
| DE3170401D1 (en) * | 1980-07-28 | 1985-06-13 | Ciba Geigy Ag | Triazoline derivatives and processes for their preparation |
| ATE24504T1 (de) * | 1981-03-19 | 1987-01-15 | Ici Plc | Amidderivate, verfahren zu ihrer herstellung, ihre verwendung als fungizide und pestizide, die sie enthalten. |
| US7250389B1 (en) | 1998-02-06 | 2007-07-31 | Meiji Seika Kaisha, Ltd. | Antifungal compound and process for producing the same |
| CA2353627C (en) * | 1998-11-04 | 2010-10-26 | Keiichi Imamura | Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component |
| EP1155011A1 (en) | 1999-02-20 | 2001-11-21 | AstraZeneca AB | Di- and tripeptide nitrile derivatives as inhibitors of cathepsin l and cathepsin s |
| WO2001005769A2 (en) | 1999-07-20 | 2001-01-25 | Dow Agrosciences Llc | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation |
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| US6355660B1 (en) | 1999-07-20 | 2002-03-12 | Dow Agrosciences Llc | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation |
| US20050239873A1 (en) | 1999-08-20 | 2005-10-27 | Fred Hutchinson Cancer Research Center | 2 Methoxy antimycin a derivatives and methods of use |
| EP1204643B1 (en) * | 1999-08-20 | 2008-06-04 | Dow AgroSciences LLC | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation |
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| AU2002341989A1 (en) | 2001-10-05 | 2003-04-22 | Dow Agrosciences Llc | Process to produce derivatives from uk-2a derivatives |
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| EA022245B1 (ru) | 2009-12-08 | 2015-11-30 | Басф Се | Пестицидные смеси |
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| RU2014149194A (ru) | 2012-05-07 | 2016-06-27 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Макроциклические пиколинамиды в качестве фунгицидов |
| JP6129300B2 (ja) | 2012-05-07 | 2017-05-17 | ダウ アグロサイエンシィズ エルエルシー | 殺真菌剤としての大環状ピコリンアミド |
| WO2013169662A2 (en) | 2012-05-07 | 2013-11-14 | Dow Agrosciences Llc | Macrocyclic picolinamides as fungicides |
| ES2666144T3 (es) | 2012-12-28 | 2018-05-03 | Dow Agrosciences Llc | Mezclas fungicidas sinérgicas para control fúngico en cereales |
| WO2014105817A1 (en) | 2012-12-31 | 2014-07-03 | Dow Agrosciences Llc | Macrocyclic picolinamides as fungicides |
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2015
- 2015-07-08 CA CA2954167A patent/CA2954167C/en active Active
- 2015-07-08 JP JP2017500905A patent/JP6625115B2/ja active Active
- 2015-07-08 TW TW108129670A patent/TW201943703A/zh unknown
- 2015-07-08 PL PL15818435T patent/PL3166927T3/pl unknown
- 2015-07-08 CN CN201580036750.7A patent/CN106573005B/zh active Active
- 2015-07-08 BR BR112017000061A patent/BR112017000061B8/pt active IP Right Grant
- 2015-07-08 CA CA2954284A patent/CA2954284C/en active Active
- 2015-07-08 JP JP2017500029A patent/JP6688278B2/ja active Active
- 2015-07-08 KR KR1020177000726A patent/KR102436286B1/ko active IP Right Grant
- 2015-07-08 MX MX2016017127A patent/MX2016017127A/es active IP Right Grant
- 2015-07-08 BR BR112017000135A patent/BR112017000135B8/pt active IP Right Grant
- 2015-07-08 WO PCT/US2015/039565 patent/WO2016007634A1/en active Application Filing
- 2015-07-08 WO PCT/US2015/039568 patent/WO2016007637A1/en active Application Filing
- 2015-07-08 US US14/794,430 patent/US9522887B2/en active Active
- 2015-07-08 TW TW104122162A patent/TWI682923B/zh active
- 2015-07-08 ES ES15819075T patent/ES2738401T3/es active Active
- 2015-07-08 PL PL15818752T patent/PL3166611T3/pl unknown
- 2015-07-08 DK DK15818435.8T patent/DK3166927T3/da active
- 2015-07-08 CN CN201580036749.4A patent/CN106660957B/zh active Active
- 2015-07-08 ES ES15818435T patent/ES2807622T3/es active Active
- 2015-07-08 ES ES15818752T patent/ES2836201T3/es active Active
- 2015-07-08 EP EP15818435.8A patent/EP3166927B1/en active Active
- 2015-07-08 BR BR112016031007A patent/BR112016031007B8/pt active IP Right Grant
- 2015-07-08 PL PL15819075T patent/PL3166612T3/pl unknown
- 2015-07-08 US US14/794,450 patent/US9481651B2/en active Active
- 2015-07-08 TW TW104122166A patent/TWI684587B/zh active
- 2015-07-08 WO PCT/US2015/039569 patent/WO2016007638A1/en active Application Filing
- 2015-07-08 US US14/794,471 patent/US9475771B2/en active Active
- 2015-07-08 EP EP15818752.6A patent/EP3166611B1/en active Active
- 2015-07-08 TW TW108136698A patent/TWI720647B/zh active
- 2015-07-08 MX MX2016017106A patent/MX369327B/es active IP Right Grant
- 2015-07-08 MX MX2016017120A patent/MX2016017120A/es unknown
- 2015-07-08 EP EP15819075.1A patent/EP3166612B1/en active Active
- 2015-07-08 TW TW104122167A patent/TWI689498B/zh active
- 2015-07-08 CN CN201580036748.XA patent/CN106659724B/zh active Active
- 2015-07-08 CA CA2954276A patent/CA2954276C/en active Active
- 2015-07-08 KR KR1020177000806A patent/KR102441177B1/ko active IP Right Grant
- 2015-07-08 DK DK15819075.1T patent/DK3166612T3/da active
- 2015-07-08 JP JP2017500360A patent/JP6513178B2/ja active Active
- 2015-07-08 DK DK15818752.6T patent/DK3166611T3/da active
- 2015-07-08 KR KR1020177000805A patent/KR102450085B1/ko active IP Right Grant
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2016
- 2016-10-31 US US15/339,190 patent/US9718783B2/en active Active
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2017
- 2017-01-02 IL IL249891A patent/IL249891B/en active IP Right Grant
- 2017-01-02 IL IL249893A patent/IL249893B/en active IP Right Grant
- 2017-01-03 IL IL249911A patent/IL249911B/en active IP Right Grant
- 2017-01-04 CO CONC2017/0000049A patent/CO2017000049A2/es unknown
- 2017-01-11 ZA ZA2017/00254A patent/ZA201700254B/en unknown
- 2017-01-19 CO CONC2017/0000446A patent/CO2017000446A2/es unknown
- 2017-01-19 CO CONC2017/0000430A patent/CO2017000430A2/es unknown
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2020
- 2020-01-20 JP JP2020006857A patent/JP2020073575A/ja not_active Withdrawn
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