BR112017000058A2 - dispositivos e métodos para esclero espumas vasculares injetáveis utilizando uma matriz carreadora e seus usos - Google Patents

dispositivos e métodos para esclero espumas vasculares injetáveis utilizando uma matriz carreadora e seus usos

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Publication number
BR112017000058A2
BR112017000058A2 BR112017000058A BR112017000058A BR112017000058A2 BR 112017000058 A2 BR112017000058 A2 BR 112017000058A2 BR 112017000058 A BR112017000058 A BR 112017000058A BR 112017000058 A BR112017000058 A BR 112017000058A BR 112017000058 A2 BR112017000058 A2 BR 112017000058A2
Authority
BR
Brazil
Prior art keywords
scleral
foams
methods
devices
matrix
Prior art date
Application number
BR112017000058A
Other languages
English (en)
Inventor
Christof Ragg Johann
Original Assignee
Swiss Vx Venentherapie Und Forschung Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Swiss Vx Venentherapie Und Forschung Gmbh filed Critical Swiss Vx Venentherapie Und Forschung Gmbh
Publication of BR112017000058A2 publication Critical patent/BR112017000058A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/122—Foams; Dry foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M2005/1401—Functional features
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring

Abstract

a presente invenção relaciona-se particularmente a uma espuma de fármaco esclerosante injetável compreendendo: (i) uma matriz; (ii) pelo menos um fluido;(iii) pelo menos um fármaco esclerosante; (iv) uma mistura de gás medicinal ou gás medicinal aceitável para uso intravenoso,(v) na qual a referida matriz possui propriedades físicas, que são comparáveis ao sangue desnaturado, em que o sangue desnaturado é obtido a partir de uma amostra de sangue venoso integral de carne humana de 1 ml de volume, que foi aquecida em um container de polietileno de 3 mm de diâmetro interno e 3,4 mm de diâmetro externo por aproximadamente 0,5 a 10 min numa temperatura de cerca de 70°c a 100°c e/ou (vi) o referido nível de desnaturação é definido pela mudança na coloração vermelha da hemoglobina para marrom como indicador, em que o fe2+ é reduzido para fe3+ no complexo de hemoglobina em um grau de pelo menos 80%, preferivelmente 90% e ainda mais preferivelmente 95%.
BR112017000058A 2014-07-03 2015-07-02 dispositivos e métodos para esclero espumas vasculares injetáveis utilizando uma matriz carreadora e seus usos BR112017000058A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14175609.8A EP2962681A1 (en) 2014-07-03 2014-07-03 Devices and methods for injectable vascular sclerofoams using a carrier made of human blood and uses thereof
PCT/EP2015/065142 WO2016001378A1 (en) 2014-07-03 2015-07-02 Devices and methods for injectable vascular sclerofoams using a carrier matrix and uses thereof

Publications (1)

Publication Number Publication Date
BR112017000058A2 true BR112017000058A2 (pt) 2017-11-07

Family

ID=51063316

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017000058A BR112017000058A2 (pt) 2014-07-03 2015-07-02 dispositivos e métodos para esclero espumas vasculares injetáveis utilizando uma matriz carreadora e seus usos

Country Status (12)

Country Link
US (2) US10441539B2 (pt)
EP (2) EP2962681A1 (pt)
JP (1) JP6704356B2 (pt)
KR (2) KR102503994B1 (pt)
CN (1) CN106572973B (pt)
AU (1) AU2015282889B2 (pt)
BR (1) BR112017000058A2 (pt)
CA (1) CA2954023C (pt)
IL (1) IL249915B (pt)
RU (1) RU2683033C2 (pt)
SG (2) SG10202103272QA (pt)
WO (1) WO2016001378A1 (pt)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2962681A1 (en) 2014-07-03 2016-01-06 Swiss VX Venentherapie und Forschung GmbH Devices and methods for injectable vascular sclerofoams using a carrier made of human blood and uses thereof
US11103590B2 (en) * 2016-09-06 2021-08-31 Cell-Medicine, Inc. Immunostimulant
KR20190135021A (ko) * 2017-03-27 2019-12-05 융화 둥 기차형(train-like) 약학적 구성(pharmaceutical configuration) 및 이의 제조 장치 및 저장 장치
CN107837439B (zh) * 2017-12-15 2023-10-17 广东省人民医院(广东省医学科学院) 一体式可更换注射筒造影设备
CN110123757B (zh) * 2019-05-28 2020-09-01 山东大学齐鲁医院 一种应用于治疗脉管异常的乙醇泡沫硬化剂及制备方法
CN110736789B (zh) * 2019-11-28 2022-01-25 山东大学齐鲁医院 一种泡沫硬化剂制备终点的判断方法及应用
CN111495222B (zh) * 2020-04-28 2022-05-03 山东大学齐鲁医院 一种用于增强硬化剂泡沫稳定性的装置
CN113143864B (zh) * 2021-01-29 2022-10-18 山东大学 一种泡沫疗法用泡沫硬化剂及其制备方法与应用
CN114903877B (zh) * 2021-02-10 2024-04-19 上海交通大学医学院附属第九人民医院 脉管畸形栓塞硬化治疗用药物组合物及其制备方法与应用

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US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
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GB2369996B (en) * 2000-12-18 2004-06-23 S T D Pharmaceutical Products Method and apparatus for producing an injectable foam
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EP2962681A1 (en) 2014-07-03 2016-01-06 Swiss VX Venentherapie und Forschung GmbH Devices and methods for injectable vascular sclerofoams using a carrier made of human blood and uses thereof

Also Published As

Publication number Publication date
US10441539B2 (en) 2019-10-15
RU2017103172A3 (pt) 2018-09-06
EP3164109A1 (en) 2017-05-10
US20170157047A1 (en) 2017-06-08
AU2015282889B2 (en) 2020-09-24
EP2962681A1 (en) 2016-01-06
AU2015282889A1 (en) 2017-02-16
US11229601B2 (en) 2022-01-25
RU2683033C2 (ru) 2019-03-26
KR20170039661A (ko) 2017-04-11
CA2954023A1 (en) 2016-01-07
KR102503994B1 (ko) 2023-02-28
SG11201700018UA (en) 2017-01-27
WO2016001378A1 (en) 2016-01-07
CA2954023C (en) 2024-01-09
JP6704356B2 (ja) 2020-06-03
IL249915A0 (en) 2017-03-30
RU2017103172A (ru) 2018-08-06
SG10202103272QA (en) 2021-05-28
KR20220163501A (ko) 2022-12-09
US20190336445A1 (en) 2019-11-07
IL249915B (en) 2020-07-30
CN106572973B (zh) 2020-11-24
CN106572973A (zh) 2017-04-19
JP2017524683A (ja) 2017-08-31

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B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]