BR112016003381A8 - sistema para administrar uma formulação de cantaridina a um indivíduo; dispositivo aplicador para administrar uma formulação de cantaridina a um indivíduo; usos de uma formulação de cantaridina; kit para administrar uma formulação de cantaridina a um indivíduo; formulações; e formulação de cantaridina - Google Patents

sistema para administrar uma formulação de cantaridina a um indivíduo; dispositivo aplicador para administrar uma formulação de cantaridina a um indivíduo; usos de uma formulação de cantaridina; kit para administrar uma formulação de cantaridina a um indivíduo; formulações; e formulação de cantaridina Download PDF

Info

Publication number
BR112016003381A8
BR112016003381A8 BR112016003381A BR112016003381A BR112016003381A8 BR 112016003381 A8 BR112016003381 A8 BR 112016003381A8 BR 112016003381 A BR112016003381 A BR 112016003381A BR 112016003381 A BR112016003381 A BR 112016003381A BR 112016003381 A8 BR112016003381 A8 BR 112016003381A8
Authority
BR
Brazil
Prior art keywords
formulation
individual
administering
cantidine
cantharidine
Prior art date
Application number
BR112016003381A
Other languages
English (en)
Other versions
BR112016003381B1 (pt
Inventor
Davidson Matthew
Original Assignee
Verrica Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Verrica Pharmaceuticals Inc filed Critical Verrica Pharmaceuticals Inc
Publication of BR112016003381A8 publication Critical patent/BR112016003381A8/pt
Publication of BR112016003381B1 publication Critical patent/BR112016003381B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1418—Threaded type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/065—Rigid ampoules, e.g. glass ampoules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/0053—Syringes, pipettes or oral dispensers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/42—Colour properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

resumo método, sistema, kit, e dispositivo aplicador para administrar uma formulação de cantaridina a um indivíduo, método para tratar uma verruga epitelial ou uma lesão cutânea em um indivíduo, formulação e método para tratar uma enfermidade na pele de um indivíduo são fornecidos no presente documento dispositivos, sistemas, kits e métodos para tratar condições patológicas, enfermidades ou doenças da pele, tais como verrugas da pele. em alguns exemplos, um dispositivo para tratar verrugas compreende um reservatório que inclui uma formulação de cantaridina, e um dispositivo aplicador em comunicação fluida com o reservatório que administra a formulação de cantaridina a um indivíduo. 1/1
BR112016003381-7A 2013-08-21 2014-08-21 Formulação de cantaridina para uso no tratamento de doenças da pele em um indivíduo BR112016003381B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361868525P 2013-08-21 2013-08-21
US61/868,525 2013-08-21
PCT/US2014/052184 WO2015027111A1 (en) 2013-08-21 2014-08-21 Compositions, methods and systems for the treatment of cutaneous disorders

Publications (2)

Publication Number Publication Date
BR112016003381A8 true BR112016003381A8 (pt) 2020-02-04
BR112016003381B1 BR112016003381B1 (pt) 2022-07-12

Family

ID=52484176

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016003381-7A BR112016003381B1 (pt) 2013-08-21 2014-08-21 Formulação de cantaridina para uso no tratamento de doenças da pele em um indivíduo

Country Status (11)

Country Link
US (2) US11052064B2 (pt)
EP (2) EP3035992B1 (pt)
JP (3) JP6668240B2 (pt)
KR (3) KR102373297B1 (pt)
CN (2) CN114209688A (pt)
AU (4) AU2014308690B2 (pt)
BR (1) BR112016003381B1 (pt)
CA (1) CA2921957C (pt)
IL (2) IL283432B1 (pt)
MX (2) MX2016002246A (pt)
WO (1) WO2015027111A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014308690B2 (en) 2013-08-21 2019-07-18 Verrica Pharmaceuticals, Inc. Compositions, methods and systems for the treatment of cutaneous disorders
CA2971279C (en) 2014-12-17 2023-09-19 Matthew Davidson Commercially viable synthesis of cantharidin and bioactive cantharidin derivatives
US11168091B2 (en) 2015-01-20 2021-11-09 Verrica Pharmaceuticals Inc. Quantification and preparation of pharmaceutical grade cantharidin
EP3265166A1 (en) * 2015-03-06 2018-01-10 Medical Brands Research B.V. Applicator
WO2016205544A1 (en) * 2015-06-16 2016-12-22 Mayo Foundation For Medical Education And Research Skin care compositions
JP2018536028A (ja) * 2015-10-30 2018-12-06 ダブニー パテンツ エル．エル．シー． 刺青の退色および除去を行うシステム、装置、および方法
IL270900B1 (en) * 2017-06-06 2024-08-01 Verrica Pharmaceuticals Inc Treatment of skin disorders
JP7497980B2 (ja) * 2017-06-15 2024-06-11 ヴェリカ ファーマシューティカルズ インコーポレーテッド 体表面の障害の処置のためのデバイスおよび方法
USD900312S1 (en) 2017-06-15 2020-10-27 Verrica Pharmaceuticals, Inc. Applicator
WO2019086922A1 (en) * 2017-10-31 2019-05-09 Université de Bourgogne Therapeutical compositions for use in the treatment of non- malignant conditions associated with phosphatidylinositol-3- kinase activation: overgrowth spectrum, cutaneous capillary malformations and seborrheic keratoses
JP7399954B2 (ja) * 2018-05-30 2023-12-18 エヴィデルム・インスティテュート・アーベー ウイルス及び真菌により引き起こされる皮膚障害及び爪障害の局所治療用の低刺激性組成物

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US600556A (en) * 1898-03-15 Pyroxylin compound
AU512465B2 (en) 1977-01-05 1980-10-09 Basf Aktiengesellschaft Manufacture of 3-halosulfonylthiophene-carboxylic acid derivatives
US4148874A (en) * 1977-06-13 1979-04-10 The Procter & Gamble Company Dermatological compositions
US4298752A (en) 1980-09-19 1981-11-03 Regents Of The University Of California Cycloadduct precursors of cantharidin and method
US4895727A (en) 1985-05-03 1990-01-23 Chemex Pharmaceuticals, Inc. Pharmaceutical vehicles for exhancing penetration and retention in the skin
JP3117502B2 (ja) * 1991-08-27 2000-12-18 株式会社資生堂 皮膚外用剤
JPH05255367A (ja) 1992-02-28 1993-10-05 Jitsuei O カンタリジン誘導体組成物の製造法及びそれを含む抗ウイルス剤
US5445462A (en) 1993-08-03 1995-08-29 Medi-Flex Hospital Products, Inc. Liquid applicator
WO1995005156A1 (en) * 1993-08-17 1995-02-23 Schering-Plough Healthcare Products, Inc. Compositions for treating corns, calluses and warts
US5590780A (en) * 1995-06-22 1997-01-07 Wheaton Holding, Inc. Unit dose assembly
FR2754175B1 (fr) 1996-10-07 1999-07-02 Oreal Utilisation d'un organopolysiloxane de nature elastomerique associe a une phase organique dans un produit de demaquillage des ongles
US6030633A (en) * 1998-05-18 2000-02-29 West Agro, Inc. Film-forming compositions for protecting animal skin
JPH11335303A (ja) * 1998-05-26 1999-12-07 Lion Corp 苦味増強方法及び皮膚外用剤
US6066124A (en) 1998-11-24 2000-05-23 Caillouette; James C. Control of treatment fluid application to tissue
USD436661S1 (en) 1999-05-20 2001-01-23 Melvin P Berry Suppository applicator
US6337076B1 (en) * 1999-11-17 2002-01-08 Sg Licensing Corporation Method and composition for the treatment of scars
US20030072814A1 (en) * 1999-12-16 2003-04-17 Maibach Howard I. Topical pharmaceutical composition for the treatment of warts
JP2001245964A (ja) 2000-03-02 2001-09-11 Lion Corp 芳香・消臭剤
FR2808662B1 (fr) 2000-05-09 2002-12-20 Delviel Systeme d'application d'une composition sur un element de surface
US6899897B2 (en) * 2001-06-18 2005-05-31 Jaleva, Inc. Gum resin as a carrier for topical application of pharmacologically active agents
US6547467B2 (en) 2001-08-29 2003-04-15 Closure Medical Corporation Microapplicators, delivery systems and methods for adhesives and sealants
US6673031B2 (en) 2001-09-25 2004-01-06 Phillip Mark Liquid applicator
JP2004059446A (ja) 2002-07-25 2004-02-26 Mitsui Chemicals Inc 脂環式化合物及びその製造方法
US20040162533A1 (en) * 2003-02-06 2004-08-19 Alley Kenneth A. Applicator device
JP2006521887A (ja) 2003-03-31 2006-09-28 ニック ジェイ マニーシス 多数回投与液体分配組立体
US20040242770A1 (en) * 2003-04-16 2004-12-02 Feldstein Mikhail M. Covalent and non-covalent crosslinking of hydrophilic polymers and adhesive compositions prepared therewith
US7909808B2 (en) 2003-06-13 2011-03-22 Medlogic Global Limited Dual-ended applicator for dispensing two fluids
US20070111954A1 (en) 2003-07-23 2007-05-17 Cuticeuticals, Inc. Apparatus and method of wart treatment
US20050019418A1 (en) * 2003-07-23 2005-01-27 Crutchfield Charles E. Wart treatment
JP2005187330A (ja) * 2003-12-24 2005-07-14 Lion Corp 歯牙貼布用製品及びゲル組成物の選定方法
FR2865360B1 (fr) 2004-01-22 2006-05-26 Oreal Applicateur comportant un element d'application solidaire, lors de l'utilisation, d'un recipient contenant un produit a appliquer
US20060110415A1 (en) * 2004-11-22 2006-05-25 Bioderm Research Topical Delivery System for Cosmetic and Pharmaceutical Agents
US20050111900A1 (en) 2004-11-30 2005-05-26 Francesca Fazzolari Ampoule and method of use
FR2885779B1 (fr) * 2005-05-23 2007-08-10 Oreal Dispositif de conditionnement et d'application d'un produit cosmetique ou dermatologique
US20070187437A1 (en) 2006-02-10 2007-08-16 Nordson Corporation Dispensing tip for liquid dispensing systems and method of making the same
US20070275045A1 (en) 2006-02-28 2007-11-29 Evans Robin D Composition for the treatment of warts and molluscum contagiosum
JP5132071B2 (ja) * 2006-03-31 2013-01-30 小林製薬株式会社 皮膚外用剤
DE102006034272A1 (de) 2006-07-18 2008-01-24 Aesculap Ag & Co. Kg Flüssigkeitsspender in der Medizin in Form einer Handhabe sowie dessen Verwendung
CN100465176C (zh) 2006-08-18 2009-03-04 芜湖天远科技开发有限责任公司 一种提取斑蝥素的方法
US20080146674A1 (en) * 2006-12-15 2008-06-19 Rosenberg E William Use of gentian violet in treatment of atopic dermatitis
US8518076B2 (en) 2007-01-08 2013-08-27 Advanced Medical Solutions (Plymouth) Limited Surgical adhesive applicator
JP5230023B2 (ja) 2007-01-25 2013-07-10 ハイパーブランチ メディカル テクノロジー， インコーポレイテッド 複数成分製剤などのための塗布器および使用方法
CN100545164C (zh) 2007-02-13 2009-09-30 北京世纪博康医药科技有限公司 斑蝥酸钠的制备工艺
KR101329489B1 (ko) * 2007-04-04 2013-11-13 엘지전자 주식회사 냉장고용 홈바
CN101036774B (zh) 2007-04-17 2010-12-29 贵州益佰制药股份有限公司 一种复方斑蝥口服制剂的检测方法
CN101108853B (zh) 2007-07-27 2010-05-26 贵州大学 斑蝥素分离纯化方法
CN101108854B (zh) 2007-07-27 2010-05-26 贵州大学 一种斑蝥素分离纯化方法
DE102007046600A1 (de) 2007-09-27 2009-04-02 Linhardt Metallwarenfabrik Gmbh & Co Kg Verfahren zum Applizieren eines flüssigen, medizinischen Behandlungsmediums auf einen zu behandelden Bereich sowie Medizinprodukt
US8703104B2 (en) * 2007-10-25 2014-04-22 Ecolab Usa Inc Use of metal astringents for the treatment of hairy heel warts
WO2009072007A2 (en) 2007-12-07 2009-06-11 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
WO2010079513A2 (en) 2009-01-07 2010-07-15 Sanjay Banerji Painless treatment of warts, corns & callus
US9480691B1 (en) * 2009-01-20 2016-11-01 Hill Dermaceuticals, Inc. Topical liquid containing refined peanut oil for treating skin proliferation or inflammation disorders
JP5396125B2 (ja) * 2009-03-30 2014-01-22 有限会社日本健康科学研究センター 被膜形成型製剤
US8609642B2 (en) 2009-06-03 2013-12-17 Ex-Tek, Llc Skin treatment compositions
CN102573816A (zh) * 2009-10-08 2012-07-11 Msd消费保健品公司 低醚组合物及输送装置
CN101798309A (zh) 2009-12-04 2010-08-11 南京泽朗医药科技有限公司 一种从斑蝥中制备斑蝥素的方法
US9918991B2 (en) 2010-01-14 2018-03-20 Hydromer, Inc. Topical antimicrobial compositions and methods of using same
US20120016320A1 (en) * 2010-07-13 2012-01-19 Lin Michael T Method and Device for Liquid Delivery
JP5736730B2 (ja) 2010-10-29 2015-06-17 王子ホールディングス株式会社 粘着シート
US20120148520A1 (en) * 2010-12-10 2012-06-14 Michael Strobel Organic Iodine Complex Durable Barrier With Antimicrobial Preparations
FR2972928B1 (fr) * 2011-03-25 2013-11-29 Urgo Lab Composition contenant une cellulose, une huile vegetale et un solvant volatil, ses utilisations comme pansement
US20120312709A1 (en) * 2011-04-12 2012-12-13 Velcera, Inc. Device for storing and dispensing a medicament, and packaging for containing the same
CN102146086B (zh) 2011-04-12 2012-03-07 贵州金桥药业有限公司 一种斑蝥酸钠的制备方法
US9486829B2 (en) 2011-06-04 2016-11-08 Optmed, Inc. Applicator
CN102268006B (zh) 2011-06-15 2013-08-14 北京联合大学生物化学工程学院 一种复合酶提取斑蝥素的方法
US8871801B2 (en) * 2011-08-01 2014-10-28 Jacob LEVITT Method of treating acquired perforating dermatosis with cantharidin
CN102336765A (zh) 2011-10-11 2012-02-01 江苏四环生物股份有限公司 从斑蝥中提取斑蝥素的方法
CN102526146B (zh) 2012-01-13 2014-02-26 苏州大学 含有人参皂苷和斑蝥素的药物组合物及其用途
CN202730045U (zh) 2012-08-13 2013-02-13 遵义医学院 一种斑蝥素分离纯化的装置
CN202920809U (zh) * 2012-09-27 2013-05-08 合肥诚者成医药科技有限公司 一种治疗尖锐湿疣的软膏
US9463180B2 (en) * 2013-03-14 2016-10-11 Quadex Pharmaceuticals, Llc Treatment of molluscum contagiosum
AU2014308690B2 (en) * 2013-08-21 2019-07-18 Verrica Pharmaceuticals, Inc. Compositions, methods and systems for the treatment of cutaneous disorders
US9994584B2 (en) 2014-10-15 2018-06-12 Lixte Biotechnology, Inc. Process of synthesizing 3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1] heptane-2-carboxylic acid
CA2971279C (en) 2014-12-17 2023-09-19 Matthew Davidson Commercially viable synthesis of cantharidin and bioactive cantharidin derivatives
US11168091B2 (en) 2015-01-20 2021-11-09 Verrica Pharmaceuticals Inc. Quantification and preparation of pharmaceutical grade cantharidin
EP3258908A4 (en) 2015-02-20 2018-08-22 Pedicis Research LLC Compositions and methods for treatment of skin infections
USD771250S1 (en) 2015-12-22 2016-11-08 Adhezion Biomedical, Llc Liquid dispenser with an extended tip
USD772407S1 (en) 2015-12-22 2016-11-22 Adhezion Biomedical, Llc Liquid dispenser having a tapered tip
JP6903062B2 (ja) 2016-01-25 2021-07-14 ポレックス コーポレーション 複数要素の焼結多孔質液体アプリケータニブ
USD801830S1 (en) 2016-05-19 2017-11-07 Adhezion Biomedical, Llc Liquid dispenser
IL270900B1 (en) 2017-06-06 2024-08-01 Verrica Pharmaceuticals Inc Treatment of skin disorders
USD900312S1 (en) 2017-06-15 2020-10-27 Verrica Pharmaceuticals, Inc. Applicator
ES2977612T3 (es) 2017-10-04 2024-08-27 Verrica Pharmaceuticals Inc Síntesis de cantaridina
USD868160S1 (en) 2018-03-26 2019-11-26 Robert Lam Multi-nib marker

Also Published As

Publication number Publication date
AU2014308690A1 (en) 2016-03-10
JP2022137132A (ja) 2022-09-21
EP3035992B1 (en) 2024-05-15
EP4428055A2 (en) 2024-09-11
US11052064B2 (en) 2021-07-06
KR102373297B1 (ko) 2022-03-11
KR20160045086A (ko) 2016-04-26
KR20220037523A (ko) 2022-03-24
WO2015027111A1 (en) 2015-02-26
IL244182B (en) 2021-06-30
KR20230129619A (ko) 2023-09-08
JP7127006B2 (ja) 2022-08-29
IL283432B1 (en) 2024-10-01
CN105636637A (zh) 2016-06-01
JP2020036929A (ja) 2020-03-12
JP2016528015A (ja) 2016-09-15
JP7558223B2 (ja) 2024-09-30
MX2023007194A (es) 2023-06-28
AU2021202518A1 (en) 2021-05-20
AU2019250220A1 (en) 2019-11-07
EP3035992A4 (en) 2017-04-12
CN114209688A (zh) 2022-03-22
JP6668240B2 (ja) 2020-03-18
AU2021202518B2 (en) 2022-12-15
US20160193177A1 (en) 2016-07-07
IL283432A (en) 2021-06-30
IL244182A0 (en) 2016-04-21
AU2023200914A1 (en) 2023-03-23
CA2921957A1 (en) 2015-02-26
US20210386703A1 (en) 2021-12-16
BR112016003381B1 (pt) 2022-07-12
CA2921957C (en) 2021-10-19
EP3035992A1 (en) 2016-06-29
MX2016002246A (es) 2017-04-27
AU2014308690B2 (en) 2019-07-18

Similar Documents

Publication Publication Date Title
BR112016003381A8 (pt) sistema para administrar uma formulação de cantaridina a um indivíduo; dispositivo aplicador para administrar uma formulação de cantaridina a um indivíduo; usos de uma formulação de cantaridina; kit para administrar uma formulação de cantaridina a um indivíduo; formulações; e formulação de cantaridina
CO2018004132A2 (es) Polipéptidos del dominio extracelular de cd80 y su uso en el tratamiento del cáncer
CL2015003801A1 (es) Formulaciones de anticuerpos y metodos
BR112016007476A2 (pt) métodos e dispositivos médicos de conjunto de pixel
BR112016012713A2 (pt) Método para tratamento de câncer em um paciente necessitado, e, método de selecionar um paciente para um método de tratamento
CL2015002567A1 (es) Compuestos y sus usos para modular la hemoglobina
BR112015002933A2 (pt) dispositivo implantável para uso no corpo humano e/ou animal para substituir uma válvula de um órgão.
BR112018070140A2 (pt) sistema de distribuição
CL2015002501A1 (es) Compuestos y usos de estos para la modulación de la hemoglobina
EP4357083A3 (en) Single site robotic device and related systems and methods
BR112015025854A2 (pt) flagelina de roseburia e modulação imunológica
BR112015027282A8 (pt) formulação líquida e kit compreendendo fenfluramina, e usos da mesma no tratamento de síndrome de dravet
DOP2016000109A (es) Formas sólidas de ácido {[5-(3-clorofenil) -3-hidroxipiridin-2-carbonil] amino} acético, composiciones, y usos de las mismas.
UY35427A (es) Compuestos y sus usos en la modulación de la hemoglobina
UY35425A (es) Compuestos y sus usos en la modulación de la hemoglobina
BR112014018421A8 (pt) Composições antimicrobianas compreendendo dgla, 15-ohepa e/ou 15-hetre e métodos de uso das mesmas
BR112015011679A2 (pt) almofada portátil
BR112015032818A2 (pt) sistema para intervenção periférica com acesso radial esquerdo em sala de cirurgia direita e método para sistema de intervenção periférica com acesso radial esquerdo em sala de cirurgia direita
BR112016021023A8 (pt) composições de corticosteroides tópicos
CL2015003563A1 (es) Marcador para trastornos de la esfingomielinasa ácida y sus usos.
BR112015015108A2 (pt) cateter com marcações para facilitar o alinhamento
BR112016010103A8 (pt) métodos, kits e dispositivos de suprimento de fármaco osmótico.
EA201690323A1 (ru) Способы лечения заболеваний уха у детей
BR112017009810A2 (pt) sistema de imageamento médico, dispositivo de sc, e método
BR112016028895A2 (pt) composições biofotônicas termofixas e usos destas

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 21/08/2014, OBSERVADAS AS CONDICOES LEGAIS