BR112015024393A2 - sal de derivado de pirazoloquinolina e cristal deste - Google Patents
sal de derivado de pirazoloquinolina e cristal desteInfo
- Publication number
- BR112015024393A2 BR112015024393A2 BR112015024393A BR112015024393A BR112015024393A2 BR 112015024393 A2 BR112015024393 A2 BR 112015024393A2 BR 112015024393 A BR112015024393 A BR 112015024393A BR 112015024393 A BR112015024393 A BR 112015024393A BR 112015024393 A2 BR112015024393 A2 BR 112015024393A2
- Authority
- BR
- Brazil
- Prior art keywords
- acid
- crystal
- derivative salt
- salt
- pyrazoloquinoline derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/145—Maleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
resumo patente de invenção para "sal de derivado de pirazoloquinolina e cristal deste" a presente invenção proporciona um sal de (s)-7-(2-metoxi-3,5-dimetilpiridin-4-il)-1-(tetraidrofuran-3-il)-1h-pirazolo[4,3-c]quinolin-4(5h)-ona e um ácido selecionado a partir do grupo que consiste em ácido clorídrico, ácido bromídrico, ácido sulfúrico, ácido nítrico, ácido fosfórico, ácido malônico, ácido maleico, ácido tartárico, ácido metanossulfônico, ácido benzenossulfônico e ácido toluenossulfônico; ou um cristal deste que pode ser potencialmente usado como substância farmacológica em produtos farmacêuticos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013079639 | 2013-04-05 | ||
PCT/JP2014/059853 WO2014163147A1 (ja) | 2013-04-05 | 2014-04-03 | ピラゾロキノリン誘導体の塩およびその結晶 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015024393A2 true BR112015024393A2 (pt) | 2017-10-24 |
Family
ID=51658438
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015024393A BR112015024393A2 (pt) | 2013-04-05 | 2014-04-03 | sal de derivado de pirazoloquinolina e cristal deste |
Country Status (13)
Country | Link |
---|---|
US (1) | US9573947B2 (pt) |
EP (1) | EP2982675B1 (pt) |
JP (1) | JP5666755B1 (pt) |
KR (1) | KR101997955B1 (pt) |
CN (1) | CN105121440B (pt) |
AU (1) | AU2014250392B2 (pt) |
BR (1) | BR112015024393A2 (pt) |
CA (1) | CA2907971C (pt) |
ES (1) | ES2645149T3 (pt) |
MX (1) | MX359843B (pt) |
RU (1) | RU2655171C2 (pt) |
SG (1) | SG11201507897SA (pt) |
WO (1) | WO2014163147A1 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017090716A1 (ja) * | 2015-11-26 | 2017-06-01 | 持田製薬株式会社 | ピラゾール誘導体の結晶 |
AU2018276568A1 (en) * | 2017-06-01 | 2019-11-07 | Eisai R&D Management Co., Ltd. | Dementia therapeutic agent combining pyrazoloquinoline derivative and memantine |
KR20200010220A (ko) * | 2017-06-01 | 2020-01-30 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 피라졸로퀴놀린 유도체를 함유하는 루이소체 질병 치료제 |
MX2019013198A (es) | 2017-06-01 | 2020-01-20 | Eisai R&D Man Co Ltd | Composicion farmaceutica que comprende un inhibidor de (s)-7-(2metoxi-3,5-dimetilpiridin-4-il)-1-(tetrahidrofuran-3-il)- 1h-pirazolo[4,3-c]quinolin-4(5h)-ona (pde9). |
SG10202113198TA (en) | 2017-06-01 | 2021-12-30 | Eisai R&D Man Co Ltd | Dementia therapeutic agent combining pyrazoloquinoline derivative and donepezil |
US11530218B2 (en) | 2020-01-20 | 2022-12-20 | Incyte Corporation | Spiro compounds as inhibitors of KRAS |
WO2021231526A1 (en) | 2020-05-13 | 2021-11-18 | Incyte Corporation | Fused pyrimidine compounds as kras inhibitors |
US11767320B2 (en) | 2020-10-02 | 2023-09-26 | Incyte Corporation | Bicyclic dione compounds as inhibitors of KRAS |
AU2022367432A1 (en) | 2021-10-14 | 2024-05-02 | Incyte Corporation | Quinoline compounds as inhibitors of kras |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05132484A (ja) | 1991-04-26 | 1993-05-28 | Otsuka Pharmaceut Factory Inc | ピラゾロキノリン及びピラゾロナフチリジン誘導体 |
JP2828506B2 (ja) | 1994-05-24 | 1998-11-25 | エフ・ホフマン−ラ ロシュ アーゲー | 三環式ジカルボニル誘導体 |
AU2003250539A1 (en) * | 2002-08-07 | 2004-02-25 | Mitsubishi Pharma Corporation | Dihydropyrazolopyridine compounds |
RU2426734C2 (ru) | 2003-10-03 | 2011-08-20 | Зм Инновейтив Пропертиз Компани | Пиразолопиридины и их аналоги |
WO2005118583A1 (en) | 2004-05-28 | 2005-12-15 | Millennium Pharmaceuticals, Inc. | 2, 5-dihydro-pyrazolo`4, 3-c!quinolin-4-ones as chk-1 inhibitors |
JP2006045118A (ja) * | 2004-08-04 | 2006-02-16 | Mochida Pharmaceut Co Ltd | 新規ピラゾロキノロン誘導体 |
CN101268073B (zh) | 2005-09-15 | 2011-10-19 | Aska制药株式会社 | 杂环化合物、制备方法及其用途 |
ES2536906T3 (es) | 2006-12-13 | 2015-05-29 | Aska Pharmaceutical Co., Ltd. | Derivado de quinoxalina |
NZ580904A (en) | 2007-05-11 | 2012-02-24 | Pfizer | Amino-heterocyclic compounds for inhibiting pde9 |
UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
CN102341399A (zh) | 2009-03-05 | 2012-02-01 | 安斯泰来制药株式会社 | 喹喔啉化合物 |
JP5542196B2 (ja) | 2009-03-31 | 2014-07-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 1−複素環−1,5−ジヒドロ−ピラゾロ[3,4−d]ピリミジン−4−オン誘導体及びpde9aモジュレーターとしてのそれらの使用 |
ES2583528T3 (es) * | 2010-09-07 | 2016-09-21 | Astellas Pharma Inc. | Compuesto de pirazoloquinolina |
JP6042060B2 (ja) | 2011-09-26 | 2016-12-14 | サノフイ | ピラゾロキノリノン誘導体、その調製および治療上の使用 |
PT2573073E (pt) * | 2011-09-26 | 2015-02-05 | Sanofi Sa | Derivados de pirazoloquinolinona, sua preparação e sua utilização terapêutica |
PL2769980T3 (pl) * | 2011-10-07 | 2016-07-29 | Eisai R&D Man Co Ltd | Pochodna pirazolochinoliny jako inhibitory PDE9 |
-
2014
- 2014-04-03 RU RU2015140619A patent/RU2655171C2/ru active
- 2014-04-03 EP EP14780139.3A patent/EP2982675B1/en active Active
- 2014-04-03 CN CN201480017423.2A patent/CN105121440B/zh active Active
- 2014-04-03 JP JP2014538559A patent/JP5666755B1/ja active Active
- 2014-04-03 BR BR112015024393A patent/BR112015024393A2/pt not_active Application Discontinuation
- 2014-04-03 ES ES14780139.3T patent/ES2645149T3/es active Active
- 2014-04-03 WO PCT/JP2014/059853 patent/WO2014163147A1/ja active Application Filing
- 2014-04-03 KR KR1020157026005A patent/KR101997955B1/ko active IP Right Grant
- 2014-04-03 US US14/778,695 patent/US9573947B2/en active Active
- 2014-04-03 AU AU2014250392A patent/AU2014250392B2/en active Active
- 2014-04-03 CA CA2907971A patent/CA2907971C/en active Active
- 2014-04-03 SG SG11201507897SA patent/SG11201507897SA/en unknown
- 2014-04-03 MX MX2015013620A patent/MX359843B/es active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
SG11201507897SA (en) | 2015-11-27 |
CA2907971A1 (en) | 2014-10-09 |
EP2982675B1 (en) | 2017-08-16 |
MX359843B (es) | 2018-10-12 |
EP2982675A1 (en) | 2016-02-10 |
EP2982675A4 (en) | 2016-08-10 |
AU2014250392B2 (en) | 2018-03-01 |
JP5666755B1 (ja) | 2015-02-12 |
KR101997955B1 (ko) | 2019-07-08 |
WO2014163147A1 (ja) | 2014-10-09 |
RU2015140619A (ru) | 2017-05-11 |
RU2655171C2 (ru) | 2018-05-24 |
KR20150138203A (ko) | 2015-12-09 |
AU2014250392A1 (en) | 2015-10-15 |
CN105121440B (zh) | 2017-05-24 |
RU2015140619A3 (pt) | 2018-03-26 |
US9573947B2 (en) | 2017-02-21 |
JPWO2014163147A1 (ja) | 2017-02-16 |
CA2907971C (en) | 2020-12-29 |
CN105121440A (zh) | 2015-12-02 |
US20160046623A1 (en) | 2016-02-18 |
ES2645149T3 (es) | 2017-12-04 |
MX2015013620A (es) | 2016-02-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B12B | Appeal against refusal [chapter 12.2 patent gazette] |