SG11201507897SA - Salt of pyrazoloquinoline derivative, and crystal thereof - Google Patents
Salt of pyrazoloquinoline derivative, and crystal thereofInfo
- Publication number
- SG11201507897SA SG11201507897SA SG11201507897SA SG11201507897SA SG11201507897SA SG 11201507897S A SG11201507897S A SG 11201507897SA SG 11201507897S A SG11201507897S A SG 11201507897SA SG 11201507897S A SG11201507897S A SG 11201507897SA SG 11201507897S A SG11201507897S A SG 11201507897SA
- Authority
- SG
- Singapore
- Prior art keywords
- salt
- crystal
- pyrazoloquinoline derivative
- pyrazoloquinoline
- derivative
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/145—Maleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013079639 | 2013-04-05 | ||
| PCT/JP2014/059853 WO2014163147A1 (ja) | 2013-04-05 | 2014-04-03 | ピラゾロキノリン誘導体の塩およびその結晶 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201507897SA true SG11201507897SA (en) | 2015-11-27 |
Family
ID=51658438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201507897SA SG11201507897SA (en) | 2013-04-05 | 2014-04-03 | Salt of pyrazoloquinoline derivative, and crystal thereof |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9573947B2 (pt) |
| EP (1) | EP2982675B1 (pt) |
| JP (1) | JP5666755B1 (pt) |
| KR (1) | KR101997955B1 (pt) |
| CN (1) | CN105121440B (pt) |
| AU (1) | AU2014250392B2 (pt) |
| BR (1) | BR112015024393A2 (pt) |
| CA (1) | CA2907971C (pt) |
| ES (1) | ES2645149T3 (pt) |
| MX (1) | MX359843B (pt) |
| RU (1) | RU2655171C2 (pt) |
| SG (1) | SG11201507897SA (pt) |
| WO (1) | WO2014163147A1 (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017090716A1 (ja) * | 2015-11-26 | 2017-06-01 | 持田製薬株式会社 | ピラゾール誘導体の結晶 |
| BR112019023595A2 (pt) * | 2017-06-01 | 2020-05-26 | Eisai R&D Management Co., Ltd. | Agente terapêutico da demência combinando derivados de pirazoloquinolina e memantina |
| KR102627787B1 (ko) * | 2017-06-01 | 2024-01-23 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 피라졸로퀴놀린 유도체와 도네페질을 병용한 치매 치료제 |
| CA3059539A1 (en) * | 2017-06-01 | 2018-12-06 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition comprising pde9 inhibitor |
| TWI784006B (zh) * | 2017-06-01 | 2022-11-21 | 日商衛材R&D企管股份有限公司 | 含有吡唑并喹啉衍生物之路易氏體症治療劑 |
| WO2021150613A1 (en) | 2020-01-20 | 2021-07-29 | Incyte Corporation | Spiro compounds as inhibitors of kras |
| US11739102B2 (en) | 2020-05-13 | 2023-08-29 | Incyte Corporation | Fused pyrimidine compounds as KRAS inhibitors |
| US11767320B2 (en) | 2020-10-02 | 2023-09-26 | Incyte Corporation | Bicyclic dione compounds as inhibitors of KRAS |
| US11939328B2 (en) | 2021-10-14 | 2024-03-26 | Incyte Corporation | Quinoline compounds as inhibitors of KRAS |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05132484A (ja) | 1991-04-26 | 1993-05-28 | Otsuka Pharmaceut Factory Inc | ピラゾロキノリン及びピラゾロナフチリジン誘導体 |
| RU2145606C1 (ru) | 1994-05-24 | 2000-02-20 | Ф.Хоффманн-Ля Рош Аг | Трициклические дикарбонильные производные и лекарственный препарат на их основе |
| BR0313262A (pt) * | 2002-08-07 | 2005-07-12 | Mitsubishi Pharma Corp | Compostos de dihidropirazolpiridina |
| RU2426734C2 (ru) | 2003-10-03 | 2011-08-20 | Зм Инновейтив Пропертиз Компани | Пиразолопиридины и их аналоги |
| WO2005118583A1 (en) | 2004-05-28 | 2005-12-15 | Millennium Pharmaceuticals, Inc. | 2, 5-dihydro-pyrazolo`4, 3-c!quinolin-4-ones as chk-1 inhibitors |
| JP2006045118A (ja) | 2004-08-04 | 2006-02-16 | Mochida Pharmaceut Co Ltd | 新規ピラゾロキノロン誘導体 |
| US8193356B2 (en) | 2005-09-15 | 2012-06-05 | Aska Pharmaceutical Co., Ltd. | Heterocycle compound, and production process and application thereof |
| ES2599054T3 (es) | 2006-12-13 | 2017-01-31 | Aska Pharmaceutical Co., Ltd. | Derivados de quinoxalina |
| ATE540954T1 (de) | 2007-05-11 | 2012-01-15 | Pfizer | Aminoheterocyclische verbindungen |
| UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| BRPI1009287A2 (pt) | 2009-03-05 | 2019-09-24 | Astellas Pharma Inc | composto de quinoxalina |
| MY156377A (en) | 2009-03-31 | 2016-02-15 | Boehringer Ingelheim Int | 1-heterocycl-1, 5-dihydro-pyrazolo [3 , 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| EA023493B1 (ru) | 2010-09-07 | 2016-06-30 | Астеллас Фарма Инк. | Производное пиразолохинолина |
| JP6042060B2 (ja) | 2011-09-26 | 2016-12-14 | サノフイ | ピラゾロキノリノン誘導体、その調製および治療上の使用 |
| PL2573073T3 (pl) * | 2011-09-26 | 2015-04-30 | Sanofi Sa | Pochodne pirazolochinolinonu, ich wytwarzanie i ich zastosowanie terapeutyczne |
| AU2012319549B2 (en) * | 2011-10-07 | 2016-07-28 | Eisai R&D Management Co., Ltd. | Pyrazoloquinoline derivative |
-
2014
- 2014-04-03 CA CA2907971A patent/CA2907971C/en active Active
- 2014-04-03 US US14/778,695 patent/US9573947B2/en active Active
- 2014-04-03 BR BR112015024393A patent/BR112015024393A2/pt not_active Application Discontinuation
- 2014-04-03 ES ES14780139.3T patent/ES2645149T3/es active Active
- 2014-04-03 CN CN201480017423.2A patent/CN105121440B/zh active Active
- 2014-04-03 AU AU2014250392A patent/AU2014250392B2/en active Active
- 2014-04-03 KR KR1020157026005A patent/KR101997955B1/ko active IP Right Grant
- 2014-04-03 RU RU2015140619A patent/RU2655171C2/ru active
- 2014-04-03 JP JP2014538559A patent/JP5666755B1/ja active Active
- 2014-04-03 WO PCT/JP2014/059853 patent/WO2014163147A1/ja active Application Filing
- 2014-04-03 MX MX2015013620A patent/MX359843B/es active IP Right Grant
- 2014-04-03 SG SG11201507897SA patent/SG11201507897SA/en unknown
- 2014-04-03 EP EP14780139.3A patent/EP2982675B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MX359843B (es) | 2018-10-12 |
| ES2645149T3 (es) | 2017-12-04 |
| KR101997955B1 (ko) | 2019-07-08 |
| EP2982675A4 (en) | 2016-08-10 |
| CA2907971A1 (en) | 2014-10-09 |
| BR112015024393A2 (pt) | 2017-10-24 |
| WO2014163147A1 (ja) | 2014-10-09 |
| RU2015140619A3 (pt) | 2018-03-26 |
| US9573947B2 (en) | 2017-02-21 |
| EP2982675A1 (en) | 2016-02-10 |
| KR20150138203A (ko) | 2015-12-09 |
| CA2907971C (en) | 2020-12-29 |
| AU2014250392B2 (en) | 2018-03-01 |
| CN105121440B (zh) | 2017-05-24 |
| EP2982675B1 (en) | 2017-08-16 |
| MX2015013620A (es) | 2016-02-25 |
| US20160046623A1 (en) | 2016-02-18 |
| JPWO2014163147A1 (ja) | 2017-02-16 |
| AU2014250392A1 (en) | 2015-10-15 |
| JP5666755B1 (ja) | 2015-02-12 |
| CN105121440A (zh) | 2015-12-02 |
| RU2015140619A (ru) | 2017-05-11 |
| RU2655171C2 (ru) | 2018-05-24 |
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