BR112015022762A2 - composto éster de ácido guanidino benzóico - Google Patents

composto éster de ácido guanidino benzóico

Info

Publication number
BR112015022762A2
BR112015022762A2 BR112015022762A BR112015022762A BR112015022762A2 BR 112015022762 A2 BR112015022762 A2 BR 112015022762A2 BR 112015022762 A BR112015022762 A BR 112015022762A BR 112015022762 A BR112015022762 A BR 112015022762A BR 112015022762 A2 BR112015022762 A2 BR 112015022762A2
Authority
BR
Brazil
Prior art keywords
acid ester
benzoic acid
ester compound
agent
prevention
Prior art date
Application number
BR112015022762A
Other languages
English (en)
Other versions
BR112015022762B1 (pt
BR112015022762A8 (pt
Inventor
Fujiyasu Jiro
Kaneko Osamu
Sasamura Satoshi
Yamaki Susumu
Satou Tomohki
Imaizumi Tomoyoshi
Asano Toru
Urano Yasuharu
Koike Yuka
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of BR112015022762A2 publication Critical patent/BR112015022762A2/pt
Publication of BR112015022762A8 publication Critical patent/BR112015022762A8/pt
Publication of BR112015022762B1 publication Critical patent/BR112015022762B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D333/40—Thiophene-2-carboxylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

resumo “composto éster de ácido guanidino benzóico” [problema] fornecer um composto que seja útil como um agente para a pre-venção e / ou tratamento de doenças renais. [meios para solução] os presentes inventores estudaram compostos com uma atividade inibidora de tripsina, e confirmaram que um composto de éster de ácido guanidino benzóico tem uma atividade inibidora de tripsina, completando as-sim a presente invenção. o composto de éster de ácido guanidino benzóico da pre-sente invenção pode ser utilizado como um agente para a prevenção e / ou trata-mento de doenças renais (por exemplo, doença renal crônica, nefrite aguda, insufi-ciência renal aguda, e semelhantes) como um agente que irá substituir a terapêuti-ca com dieta de baixa proteína, e / ou como um agente para a prevenção e / ou tra-tamento de doenças relacionadas com a tripsina (por exemplo, pancreatite crônica, doença do refluxo gastroesofágico, encefalopatia hepática, gripe, e semelhantes).
BR112015022762-7A 2013-03-13 2014-03-13 Composto de éster do ácido guanidinobenzóico, composição farmacêutica, e, uso do composto BR112015022762B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013-050011 2013-03-13
JP2013050011 2013-03-13
PCT/JP2014/056601 WO2014142219A1 (ja) 2013-03-13 2014-03-13 グアニジノ安息香酸エステル化合物

Publications (3)

Publication Number Publication Date
BR112015022762A2 true BR112015022762A2 (pt) 2017-07-18
BR112015022762A8 BR112015022762A8 (pt) 2018-01-23
BR112015022762B1 BR112015022762B1 (pt) 2022-08-16

Family

ID=51536870

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015022762-7A BR112015022762B1 (pt) 2013-03-13 2014-03-13 Composto de éster do ácido guanidinobenzóico, composição farmacêutica, e, uso do composto

Country Status (30)

Country Link
US (1) US9969709B2 (pt)
EP (1) EP2975023B1 (pt)
JP (1) JP6314129B2 (pt)
KR (1) KR102145649B1 (pt)
CN (1) CN105051008B (pt)
AU (1) AU2014230583B2 (pt)
BR (1) BR112015022762B1 (pt)
CA (1) CA2905606C (pt)
CY (1) CY1120552T1 (pt)
DK (1) DK2975023T3 (pt)
ES (1) ES2684045T3 (pt)
HK (1) HK1216246A1 (pt)
HR (1) HRP20181371T1 (pt)
HU (1) HUE039526T2 (pt)
IL (1) IL241541B (pt)
LT (1) LT2975023T (pt)
MX (1) MX2015012604A (pt)
MY (1) MY194604A (pt)
PH (1) PH12015502023B1 (pt)
PL (1) PL2975023T3 (pt)
PT (1) PT2975023T (pt)
RS (1) RS57568B1 (pt)
RU (1) RU2661895C2 (pt)
SG (2) SG11201507411TA (pt)
SI (1) SI2975023T1 (pt)
TR (1) TR201809418T4 (pt)
TW (1) TWI666196B (pt)
UA (1) UA118668C2 (pt)
WO (1) WO2014142219A1 (pt)
ZA (1) ZA201506745B (pt)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2975023T3 (en) 2013-03-13 2018-08-20 Takeda Pharmaceuticals Co Guanidine benzoic acid ester compound
US9428470B2 (en) 2014-02-13 2016-08-30 Takeda Pharmaceutical Company Limited Heterocyclic compound
US9346776B2 (en) * 2014-02-13 2016-05-24 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
JP2018080109A (ja) * 2015-03-16 2018-05-24 武田薬品工業株式会社 治療剤
EP3275874B1 (en) * 2015-03-27 2019-10-30 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
CN105218289B (zh) * 2015-10-15 2017-08-01 浙江大学 一种不饱和脂肪酸原位加氢脱羧制备长链烷烃的方法
US11465965B2 (en) 2017-11-02 2022-10-11 Ube Industries, Ltd. Double-headed protease inhibitor

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Also Published As

Publication number Publication date
HK1216246A1 (zh) 2016-10-28
WO2014142219A1 (ja) 2014-09-18
RU2015143562A (ru) 2017-04-19
DK2975023T3 (en) 2018-08-20
BR112015022762B1 (pt) 2022-08-16
EP2975023B1 (en) 2018-05-30
HRP20181371T1 (hr) 2018-10-19
PH12015502023A1 (en) 2016-01-18
AU2014230583A1 (en) 2015-10-01
JPWO2014142219A1 (ja) 2017-02-16
US20160031847A1 (en) 2016-02-04
KR20150130392A (ko) 2015-11-23
BR112015022762A8 (pt) 2018-01-23
SI2975023T1 (sl) 2018-10-30
CN105051008A (zh) 2015-11-11
KR102145649B1 (ko) 2020-08-18
TWI666196B (zh) 2019-07-21
EP2975023A4 (en) 2016-08-03
HUE039526T2 (hu) 2019-01-28
PT2975023T (pt) 2018-07-27
LT2975023T (lt) 2018-08-10
SG11201507411TA (en) 2015-10-29
PH12015502023B1 (en) 2016-01-18
CA2905606C (en) 2021-03-09
SG10201707504VA (en) 2017-10-30
TR201809418T4 (tr) 2018-07-23
US9969709B2 (en) 2018-05-15
ES2684045T3 (es) 2018-10-01
UA118668C2 (uk) 2019-02-25
CY1120552T1 (el) 2019-07-10
PL2975023T3 (pl) 2018-11-30
ZA201506745B (en) 2017-04-26
JP6314129B2 (ja) 2018-04-18
CN105051008B (zh) 2018-05-29
AU2014230583B2 (en) 2017-09-28
MY194604A (en) 2022-12-06
TW201522291A (zh) 2015-06-16
CA2905606A1 (en) 2014-09-18
EP2975023A1 (en) 2016-01-20
IL241541B (en) 2019-06-30
RU2661895C2 (ru) 2018-07-23
RS57568B1 (sr) 2018-10-31
MX2015012604A (es) 2016-10-13

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