BR112015021364A2 - polipeptídeos de leptina canina modificados - Google Patents
polipeptídeos de leptina canina modificadosInfo
- Publication number
- BR112015021364A2 BR112015021364A2 BR112015021364A BR112015021364A BR112015021364A2 BR 112015021364 A2 BR112015021364 A2 BR 112015021364A2 BR 112015021364 A BR112015021364 A BR 112015021364A BR 112015021364 A BR112015021364 A BR 112015021364A BR 112015021364 A2 BR112015021364 A2 BR 112015021364A2
- Authority
- BR
- Brazil
- Prior art keywords
- modified canine
- leptin polypeptides
- canine leptin
- polypeptides
- modified
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2264—Obesity-gene products, e.g. leptin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Abstract
resumo patente de invenção: "polipeptídeos de leptina canina modificados". a presente invenção refere-se a polipeptídeos de leptina canina modificados e formulações e usos dos mesmos incluindo polipeptídeos de leptina canina modificados por polietilenoglicol (peg), em que a porção química peg é fixada de modo covalente a um resíduo de para-acetil-fenilalanina (paf) do polipeptídeo e composições relacionadas e métodos úteis no tratamento de obesidade de animal de estimação e outros distúrbios relacionados à leptina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361779337P | 2013-03-13 | 2013-03-13 | |
PCT/US2014/024706 WO2014165189A2 (en) | 2013-03-13 | 2014-03-12 | Modified canine leptin polypeptides |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015021364A2 true BR112015021364A2 (pt) | 2017-10-10 |
Family
ID=50680127
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015021364A BR112015021364A2 (pt) | 2013-03-13 | 2014-03-12 | polipeptídeos de leptina canina modificados |
Country Status (16)
Country | Link |
---|---|
US (1) | US10105447B2 (pt) |
EP (1) | EP2970424B1 (pt) |
JP (2) | JP6423852B2 (pt) |
KR (1) | KR20150126035A (pt) |
CN (1) | CN105121461A (pt) |
AU (1) | AU2014248617B2 (pt) |
BR (1) | BR112015021364A2 (pt) |
CA (1) | CA2901928C (pt) |
DK (1) | DK2970424T3 (pt) |
ES (1) | ES2642624T3 (pt) |
HU (1) | HUE033443T2 (pt) |
IL (1) | IL240964B (pt) |
MX (1) | MX2015012631A (pt) |
PL (1) | PL2970424T3 (pt) |
PT (1) | PT2970424T (pt) |
WO (1) | WO2014165189A2 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20230346957A1 (en) * | 2020-01-08 | 2023-11-02 | Bristol-Myers Squibb Company | Fgf-21 conjugate formulations |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR19990087392A (ko) | 1996-03-01 | 1999-12-27 | 스티븐 엠. 오드레 | 개 ob 단백질 조성물 및 방법 |
JP2000279171A (ja) | 1999-03-30 | 2000-10-10 | Morinaga & Co Ltd | イヌ肥満遺伝子、その遺伝子産物とその製造法及び測定試薬と測定法 |
WO2001021647A2 (en) * | 1999-09-22 | 2001-03-29 | Genset | Methods of screening for compounds that modulate the lsr-leptin interaction and their use in the prevention and treatment of obesity-related diseases |
JP4444113B2 (ja) | 2002-10-16 | 2010-03-31 | ザ スクリップス リサーチ インスティテュート | ケトアミノ酸の部位特異的蛋白質組込み方法 |
CN101113175A (zh) | 2007-04-28 | 2008-01-30 | 中国科学院西北高原生物研究所 | 鼠兔家族瘦素蛋白及其cDNA序列 |
MX344166B (es) | 2008-02-08 | 2016-12-07 | Ambrx Inc | Leptina-polipeptidos modificados y sus usos. |
JP5413766B2 (ja) * | 2008-03-10 | 2014-02-12 | 株式会社シバヤギ | レプチン測定方法 |
PE20121643A1 (es) | 2009-07-31 | 2012-11-25 | Bayer Healthcare Llc | Polipeptidos del factor ix modificados y usos de los mismos |
-
2014
- 2014-03-12 CA CA2901928A patent/CA2901928C/en not_active Expired - Fee Related
- 2014-03-12 US US14/765,931 patent/US10105447B2/en not_active Expired - Fee Related
- 2014-03-12 ES ES14722420.8T patent/ES2642624T3/es active Active
- 2014-03-12 BR BR112015021364A patent/BR112015021364A2/pt not_active Application Discontinuation
- 2014-03-12 HU HUE14722420A patent/HUE033443T2/en unknown
- 2014-03-12 MX MX2015012631A patent/MX2015012631A/es unknown
- 2014-03-12 KR KR1020157027899A patent/KR20150126035A/ko not_active Application Discontinuation
- 2014-03-12 CN CN201480014677.9A patent/CN105121461A/zh active Pending
- 2014-03-12 DK DK14722420.8T patent/DK2970424T3/en active
- 2014-03-12 JP JP2016501613A patent/JP6423852B2/ja not_active Expired - Fee Related
- 2014-03-12 PL PL14722420T patent/PL2970424T3/pl unknown
- 2014-03-12 WO PCT/US2014/024706 patent/WO2014165189A2/en active Application Filing
- 2014-03-12 PT PT147224208T patent/PT2970424T/pt unknown
- 2014-03-12 AU AU2014248617A patent/AU2014248617B2/en not_active Ceased
- 2014-03-12 EP EP14722420.8A patent/EP2970424B1/en not_active Not-in-force
-
2015
- 2015-08-31 IL IL240964A patent/IL240964B/en not_active IP Right Cessation
-
2017
- 2017-02-03 JP JP2017018481A patent/JP6434071B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2901928A1 (en) | 2014-10-09 |
IL240964B (en) | 2019-07-31 |
JP2017110024A (ja) | 2017-06-22 |
JP6423852B2 (ja) | 2018-11-14 |
PT2970424T (pt) | 2017-08-25 |
IL240964A0 (en) | 2015-11-30 |
JP2016514144A (ja) | 2016-05-19 |
WO2014165189A3 (en) | 2014-11-27 |
CA2901928C (en) | 2017-10-10 |
HUE033443T2 (en) | 2017-11-28 |
PL2970424T3 (pl) | 2017-11-30 |
MX2015012631A (es) | 2016-06-21 |
WO2014165189A2 (en) | 2014-10-09 |
JP6434071B2 (ja) | 2018-12-05 |
US10105447B2 (en) | 2018-10-23 |
AU2014248617B2 (en) | 2016-05-19 |
DK2970424T3 (en) | 2017-07-31 |
AU2014248617A1 (en) | 2015-09-17 |
EP2970424A2 (en) | 2016-01-20 |
CN105121461A (zh) | 2015-12-02 |
KR20150126035A (ko) | 2015-11-10 |
US20150366983A1 (en) | 2015-12-24 |
ES2642624T3 (es) | 2017-11-17 |
EP2970424B1 (en) | 2017-06-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B25A | Requested transfer of rights approved |
Owner name: AMBRX, INC. (US) , ELANCO US INC. (US) |
|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |