BR112015021012A8 - usos de gama-hidroxibutirato (ghb) ou um sal do mesmo - Google Patents

usos de gama-hidroxibutirato (ghb) ou um sal do mesmo Download PDF

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Publication number
BR112015021012A8
BR112015021012A8 BR112015021012A BR112015021012A BR112015021012A8 BR 112015021012 A8 BR112015021012 A8 BR 112015021012A8 BR 112015021012 A BR112015021012 A BR 112015021012A BR 112015021012 A BR112015021012 A BR 112015021012A BR 112015021012 A8 BR112015021012 A8 BR 112015021012A8
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Brazil
Prior art keywords
ghb
salt
found
administration
gamma hydroxybutyrate
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BR112015021012A
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English (en)
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BR112015021012A2 (pt
Inventor
Eller Mark
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Jazz Pharmaceuticals Ireland Ltd
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Application filed by Jazz Pharmaceuticals Ireland Ltd filed Critical Jazz Pharmaceuticals Ireland Ltd
Publication of BR112015021012A2 publication Critical patent/BR112015021012A2/pt
Publication of BR112015021012A8 publication Critical patent/BR112015021012A8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medical Informatics (AREA)
  • Primary Health Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Toxicology (AREA)

Abstract

resumo “administração de gama hidroxibutirato com transportador de monocarboxilatos” a presente invenção refere-se a uma modalidade para melhorar a segurança e eficácia da administração de ghb ou um sal do mesmo a um paciente. verificou-se que a administração concomitante de um inibidor de mct, tal como diclofenaco, valproato ou ibuprofeno, afetará a administração de ghb. por exemplo, verificou-se que o diclofenaco diminui o efeito de ghb no corpo, dessa forma, causando potencialmente uma condição insegura. além disso, verificou-se que o valproato aumenta o efeito de ghb sobre o corpo, dessa forma, causando potencialmente uma condição insegura.
BR112015021012A 2013-03-01 2014-02-28 usos de gama-hidroxibutirato (ghb) ou um sal do mesmo BR112015021012A8 (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361771557P 2013-03-01 2013-03-01
US201361777873P 2013-03-12 2013-03-12
US13/837,714 US9050302B2 (en) 2013-03-01 2013-03-15 Method of administration of gamma hydroxybutyrate with monocarboxylate transporters
US13/873,000 US8952029B2 (en) 2013-03-01 2013-04-29 Method of administration of gamma hydroxybutyrate with monocarboxylate transporters
US13/872,997 US8772306B1 (en) 2013-03-01 2013-04-29 Method of administration of gamma hydroxybutyrate with monocarboxylate transporters
PCT/US2014/019217 WO2014134380A1 (en) 2013-03-01 2014-02-28 Administration of gamma hydroxybutyrate with monocarboxylate transporters

Publications (2)

Publication Number Publication Date
BR112015021012A2 BR112015021012A2 (pt) 2017-07-18
BR112015021012A8 true BR112015021012A8 (pt) 2019-11-26

Family

ID=51031733

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015021012A BR112015021012A8 (pt) 2013-03-01 2014-02-28 usos de gama-hidroxibutirato (ghb) ou um sal do mesmo

Country Status (22)

Country Link
US (10) US9050302B2 (pt)
EP (3) EP3695833A1 (pt)
JP (1) JP6433440B2 (pt)
KR (1) KR102239042B1 (pt)
CN (2) CN111317730A (pt)
AU (1) AU2014223373B2 (pt)
BR (1) BR112015021012A8 (pt)
CA (1) CA2902948C (pt)
CY (2) CY1120086T1 (pt)
DK (2) DK2961399T3 (pt)
ES (2) ES2775779T3 (pt)
HK (2) HK1215539A1 (pt)
HR (1) HRP20200215T1 (pt)
IL (1) IL240874B (pt)
LT (1) LT3335708T (pt)
MX (1) MX2015011242A (pt)
PL (2) PL3335708T3 (pt)
PT (2) PT2961399T (pt)
SG (1) SG11201505029QA (pt)
SI (1) SI3335708T1 (pt)
TW (1) TWI619492B (pt)
WO (1) WO2014134380A1 (pt)

Cited By (8)

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Publication number Priority date Publication date Assignee Title
US11400065B2 (en) 2019-03-01 2022-08-02 Flamel Ireland Limited Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11839597B2 (en) 2016-07-22 2023-12-12 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11766418B2 (en) 2016-07-22 2023-09-26 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11826335B2 (en) 2016-07-22 2023-11-28 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11839597B2 (en) 2016-07-22 2023-12-12 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11896572B2 (en) 2016-07-22 2024-02-13 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11400065B2 (en) 2019-03-01 2022-08-02 Flamel Ireland Limited Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics

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PT2961399T (pt) 2018-02-21
CY1122992T1 (el) 2021-10-29
US20170049731A1 (en) 2017-02-23
US10213400B2 (en) 2019-02-26
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US20190274980A1 (en) 2019-09-12
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IL240874B (en) 2019-06-30
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US20220193015A1 (en) 2022-06-23
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US11986446B2 (en) 2024-05-21
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US9050302B2 (en) 2015-06-09
BR112015021012A2 (pt) 2017-07-18
PT3335708T (pt) 2020-03-17
EP3695833A1 (en) 2020-08-19
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