BR112015002077A2 - método para preparar ácido 1-amino-3-[18f]-fluorociclobutano carboxílico, e, sistema e cassete para realizar o método - Google Patents
método para preparar ácido 1-amino-3-[18f]-fluorociclobutano carboxílico, e, sistema e cassete para realizar o métodoInfo
- Publication number
- BR112015002077A2 BR112015002077A2 BR112015002077A BR112015002077A BR112015002077A2 BR 112015002077 A2 BR112015002077 A2 BR 112015002077A2 BR 112015002077 A BR112015002077 A BR 112015002077A BR 112015002077 A BR112015002077 A BR 112015002077A BR 112015002077 A2 BR112015002077 A2 BR 112015002077A2
- Authority
- BR
- Brazil
- Prior art keywords
- cassette
- amino
- preparing
- carboxylic acid
- carrying
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
- A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J16/00—Chemical processes in general for reacting liquids with non- particulate solids, e.g. sheet material; Apparatus specially adapted therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
- B01J19/245—Stationary reactors without moving elements inside placed in series
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
- B01J19/248—Reactors comprising multiple separated flow channels
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
- C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
- G21G1/10—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by bombardment with electrically charged particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/24—Stationary reactors without moving elements inside
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/24—Stationary reactors without moving elements inside
- B01J2219/2401—Reactors comprising multiple separate flow channels
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1214220.4A GB201214220D0 (en) | 2012-08-09 | 2012-08-09 | Radiosynthesis |
| PCT/EP2013/066570 WO2014023775A1 (en) | 2012-08-09 | 2013-08-07 | Preparation of 18f-fluciclovine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015002077A2 true BR112015002077A2 (pt) | 2017-07-04 |
Family
ID=46935146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015002077A BR112015002077A2 (pt) | 2012-08-09 | 2013-08-07 | método para preparar ácido 1-amino-3-[18f]-fluorociclobutano carboxílico, e, sistema e cassete para realizar o método |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9359288B2 (https=) |
| EP (1) | EP2885271A1 (https=) |
| JP (1) | JP6574379B2 (https=) |
| KR (1) | KR102109225B1 (https=) |
| CN (2) | CN108997169A (https=) |
| AU (1) | AU2013301499B2 (https=) |
| BR (1) | BR112015002077A2 (https=) |
| CA (1) | CA2878636A1 (https=) |
| GB (2) | GB201214220D0 (https=) |
| IL (1) | IL236312A0 (https=) |
| IN (1) | IN2014DN10962A (https=) |
| MX (2) | MX388930B (https=) |
| RU (1) | RU2640805C2 (https=) |
| WO (1) | WO2014023775A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2823063C (en) * | 2010-12-29 | 2020-08-11 | Ge Healthcare Limited | A method for preparation of f for use in a radiofluorination reaction |
| US11534494B2 (en) | 2011-12-21 | 2022-12-27 | Ge Healthcare Limited | Formulation and method of synthesis |
| GB201411569D0 (en) | 2014-06-30 | 2014-08-13 | Ge Healthcare Ltd | Novel formulation and method of synthesis |
| GB201214220D0 (en) | 2012-08-09 | 2012-09-19 | Ge Healthcare Ltd | Radiosynthesis |
| JP6755862B2 (ja) * | 2015-06-05 | 2020-09-16 | 日本メジフィジックス株式会社 | 放射性標識化合物の製造装置及び製造方法 |
| GB201621864D0 (en) | 2016-12-21 | 2017-02-01 | Ge Healthcare Ltd | Solid phase conditioning |
| CN106770883B (zh) * | 2017-01-03 | 2019-01-29 | 原子高科股份有限公司 | 一种氟[18f]化钠注射液放化纯的薄层色谱分析方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5808146A (en) * | 1995-11-09 | 1998-09-15 | Emory University | Amino acid analogs for tumor imaging |
| NZ572936A (en) * | 2006-05-11 | 2011-01-28 | Nihon Mediphysics Co Ltd | Process for production of [18F]1-amino-3-fluorocyclobutanecarboxylic acid, [18F]FACBC |
| KR101408727B1 (ko) * | 2006-12-27 | 2014-06-17 | 니혼 메디피직스 가부시키가이샤 | 방사성 할로겐 표식 유기 화합물의 전구체 화합물의 제조 방법 |
| TWI406674B (zh) | 2007-02-13 | 2013-09-01 | 日本藥學物理公司 | Method for manufacturing diagnostic radiographic diagnostic agents |
| KR101583544B1 (ko) * | 2007-12-19 | 2016-01-08 | 니혼 메디피직스 가부시키가이샤 | 방사성 불소 표식 유기 화합물의 제조방법 |
| SG2014012686A (en) * | 2009-10-08 | 2014-06-27 | Ge Healthcare Ltd | Purification method |
| DK2646411T3 (en) * | 2010-11-29 | 2017-10-16 | Blue Earth Diagnostics Ltd | PREPARATION OF PET PRECURSOR |
| GB201021530D0 (en) * | 2010-12-20 | 2011-02-02 | Ge Healthcare Ltd | Purification of precursor compound by crystallisation |
| US9061977B2 (en) | 2010-12-20 | 2015-06-23 | Ge Healthcare Limited | Purification of precursor compound by crystallisation |
| GB201021523D0 (en) * | 2010-12-20 | 2011-02-02 | Ge Healthcare Ltd | Process simplification for precursor compound |
| CA2823063C (en) | 2010-12-29 | 2020-08-11 | Ge Healthcare Limited | A method for preparation of f for use in a radiofluorination reaction |
| GB201214220D0 (en) | 2012-08-09 | 2012-09-19 | Ge Healthcare Ltd | Radiosynthesis |
-
2012
- 2012-08-09 GB GBGB1214220.4A patent/GB201214220D0/en not_active Ceased
-
2013
- 2013-08-07 WO PCT/EP2013/066570 patent/WO2014023775A1/en not_active Ceased
- 2013-08-07 BR BR112015002077A patent/BR112015002077A2/pt not_active Application Discontinuation
- 2013-08-07 KR KR1020157003004A patent/KR102109225B1/ko active Active
- 2013-08-07 MX MX2019012139A patent/MX388930B/es unknown
- 2013-08-07 IN IN10962DEN2014 patent/IN2014DN10962A/en unknown
- 2013-08-07 CN CN201810568649.1A patent/CN108997169A/zh active Pending
- 2013-08-07 MX MX2015001724A patent/MX368668B/es active IP Right Grant
- 2013-08-07 RU RU2015101998A patent/RU2640805C2/ru active
- 2013-08-07 CA CA2878636A patent/CA2878636A1/en not_active Abandoned
- 2013-08-07 CN CN201380041838.9A patent/CN104507905A/zh active Pending
- 2013-08-07 GB GB1501016.8A patent/GB2519026B/en active Active
- 2013-08-07 EP EP13750668.9A patent/EP2885271A1/en not_active Withdrawn
- 2013-08-07 JP JP2015525884A patent/JP6574379B2/ja active Active
- 2013-08-07 US US14/420,493 patent/US9359288B2/en active Active
- 2013-08-07 AU AU2013301499A patent/AU2013301499B2/en active Active
-
2014
- 2014-12-17 IL IL236312A patent/IL236312A0/en unknown
-
2016
- 2016-06-06 US US15/173,839 patent/US10023525B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20150232415A1 (en) | 2015-08-20 |
| IN2014DN10962A (https=) | 2015-09-18 |
| WO2014023775A1 (en) | 2014-02-13 |
| RU2640805C2 (ru) | 2018-01-12 |
| US10023525B2 (en) | 2018-07-17 |
| US20160355460A1 (en) | 2016-12-08 |
| MX388930B (es) | 2025-03-20 |
| JP2015530985A (ja) | 2015-10-29 |
| CN104507905A (zh) | 2015-04-08 |
| MX2015001724A (es) | 2015-04-14 |
| GB2519026B (en) | 2019-09-04 |
| MX368668B (es) | 2019-10-10 |
| RU2015101998A (ru) | 2016-09-27 |
| GB201214220D0 (en) | 2012-09-19 |
| EP2885271A1 (en) | 2015-06-24 |
| KR102109225B1 (ko) | 2020-05-11 |
| AU2013301499B2 (en) | 2017-08-31 |
| CA2878636A1 (en) | 2014-02-13 |
| JP6574379B2 (ja) | 2019-09-11 |
| GB2519026A (en) | 2015-04-08 |
| US9359288B2 (en) | 2016-06-07 |
| IL236312A0 (en) | 2015-02-26 |
| MX2019012139A (es) | 2019-12-09 |
| KR20150039204A (ko) | 2015-04-09 |
| AU2013301499A1 (en) | 2015-01-22 |
| CN108997169A (zh) | 2018-12-14 |
| GB201501016D0 (en) | 2015-03-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |