BR112015002072A2 - composição sólida à base de ferro para uso em condições de deficiência de ferro - Google Patents

composição sólida à base de ferro para uso em condições de deficiência de ferro

Info

Publication number
BR112015002072A2
BR112015002072A2 BR112015002072A BR112015002072A BR112015002072A2 BR 112015002072 A2 BR112015002072 A2 BR 112015002072A2 BR 112015002072 A BR112015002072 A BR 112015002072A BR 112015002072 A BR112015002072 A BR 112015002072A BR 112015002072 A2 BR112015002072 A2 BR 112015002072A2
Authority
BR
Brazil
Prior art keywords
iron
solid composition
present
composition
based solid
Prior art date
Application number
BR112015002072A
Other languages
English (en)
Other versions
BR112015002072B1 (pt
Inventor
Lacorte Andrea
Tarantino Germano
Original Assignee
Alesco Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alesco Srl filed Critical Alesco Srl
Publication of BR112015002072A2 publication Critical patent/BR112015002072A2/pt
Publication of BR112015002072B1 publication Critical patent/BR112015002072B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Pretreatment Of Seeds And Plants (AREA)

Abstract

resumo patente de invenção: "composição sólida à base de ferro para uso em condições de deficiência de ferro". a presente invenção refere-se a uma composição à base de ferro, para uso em condições de deficiência absoluta ou relativa de ferro. em particular, a presente invenção refere-se a uma composição sólida, de preferência sob a forma de pó ou granulado, para uso no tratamento de distúrbios ou doenças relacionadas com a ou derivadas a partir de uma deficiência de ferro. a composição da presente invenção é adequada para pacientes pediátricos, adolescentes, atletas, homens, mulheres, mulheres grávidas e idosos. finalmente, a presente invenção refere-se a um processo para a preparação da referida composição sólida.
BR112015002072-0A 2012-07-31 2013-07-30 Composição sólida para uso no tratamento de distúrbios ou doenças relacionadas com uma deficiência de ferro BR112015002072B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI2012A001350 2012-07-31
IT001350A ITMI20121350A1 (it) 2012-07-31 2012-07-31 Composizione solido a base di ferro per uso nelle condizioni di deficienza di ferro.
PCT/IB2013/001659 WO2014009806A1 (en) 2012-07-31 2013-07-30 Solid composition comprising iron for use in iron deficient conditions

Publications (2)

Publication Number Publication Date
BR112015002072A2 true BR112015002072A2 (pt) 2017-07-04
BR112015002072B1 BR112015002072B1 (pt) 2022-11-01

Family

ID=46982695

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112015002072-0A BR112015002072B1 (pt) 2012-07-31 2013-07-30 Composição sólida para uso no tratamento de distúrbios ou doenças relacionadas com uma deficiência de ferro
BR122022015143-4A BR122022015143B1 (pt) 2012-07-31 2013-07-30 Método para preparar uma composição sólida à base de ferro

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR122022015143-4A BR122022015143B1 (pt) 2012-07-31 2013-07-30 Método para preparar uma composição sólida à base de ferro

Country Status (24)

Country Link
US (2) US10183077B2 (pt)
EP (2) EP2879667B1 (pt)
JP (1) JP6232426B2 (pt)
CN (2) CN104602674A (pt)
BR (2) BR112015002072B1 (pt)
CA (1) CA2879681C (pt)
CY (2) CY1121435T1 (pt)
DK (2) DK3498265T3 (pt)
EA (1) EA027684B1 (pt)
ES (2) ES2719252T3 (pt)
HR (2) HRP20190461T1 (pt)
HU (2) HUE052036T2 (pt)
IL (2) IL236793A0 (pt)
IN (1) IN2015MN00127A (pt)
IT (1) ITMI20121350A1 (pt)
LT (2) LT2879667T (pt)
MA (1) MA20150375A1 (pt)
ME (1) ME03349B (pt)
PL (2) PL3498265T3 (pt)
PT (2) PT3498265T (pt)
RS (2) RS61069B1 (pt)
SI (2) SI3498265T1 (pt)
TR (1) TR201903899T4 (pt)
WO (1) WO2014009806A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20121350A1 (it) 2012-07-31 2014-02-01 Alesco Srl Composizione solido a base di ferro per uso nelle condizioni di deficienza di ferro.
ITMI20131483A1 (it) * 2013-09-09 2015-03-10 Alesco Srl Composizioni in forma solida a base di minerali e formulazioni orosolubili contenenti le stesse.
JP6299689B2 (ja) * 2014-07-24 2018-03-28 三生医薬株式会社 生体吸収促進剤含有組成物
JP6459129B2 (ja) * 2015-04-13 2019-01-30 富田製薬株式会社 ピロリン酸第二鉄含有粉末及びその製造方法
WO2017090198A1 (ja) * 2015-11-27 2017-06-01 太陽化学株式会社 鉄含有粉末組成物
IT201700085412A1 (it) * 2017-07-26 2019-01-26 Pharmanutra S P A Composizione per uso nella prevenzione e nel trattamento di patologie dell'apparato cardiovascolare
IT201700089258A1 (it) * 2017-08-02 2019-02-02 Pharmanutra S P A Composizione per uso nella prevenzione e nel trattamento di carenza di ferro
IT201800006288A1 (it) * 2018-06-13 2019-12-13 Composizioni comprendenti minerali sucrosomiali contenenti sali minerali per uso nelle condizioni di deficienza di tali minerali
IT201900020316A1 (it) 2019-11-04 2021-05-04 Alesco Srl Uso di berberina sucrosomiale® e sue composizioni nel trattamento di alterazioni del metabolismo glucidico
IT201900020300A1 (it) 2019-11-04 2021-05-04 Alesco Srl Uso di berberina sucrosomiale® e sue composizioni nel trattamento di dislipidemie
IT201900020290A1 (it) 2019-11-04 2021-05-04 Alesco Srl Berberina sucrosomiale®, sue composizioni e loro uso
IT201900021564A1 (it) * 2019-11-19 2021-05-19 Neilos S R L Composizione nutraceutica o farmaceutica comprendente ferro pirofosfato per l’uso nel trattamento e/o nella prevenzione di condizioni o patologie caratterizzate da carenza di ferro
IT201900023016A1 (it) * 2019-12-04 2021-06-04 Alesco Srl Formulazioni comprendenti un minerale e un polisaccaride, loro composizioni e loro uso nella supplementazione di detto minerale
IT201900022989A1 (it) 2019-12-04 2021-06-04 Alesco Srl Formulazione in forma solida di cromo, sue composizioni e usi
WO2022118274A1 (en) * 2020-12-03 2022-06-09 Neilos S.r.l. Compositions for the use in the treatment and/or prevention of iron deficiency conditions or diseases
IT202100005981A1 (it) 2021-03-12 2022-09-12 Pharmanutra S P A Composizione a base di ferro per uso in un trattamento di una infiammazione gastrointestinale in soggetti sottoposti ad un trattamento di una deficienza di ferro
IT202100011084A1 (it) 2021-04-30 2022-10-30 Pharmanutra S P A Composizione nutraceutica per uso nel trattamento della stanchezza cronica/fatigue post covid-19
WO2023033750A1 (en) * 2021-08-30 2023-03-09 Ilko Ilac Sanayi Ve Ticaret A.S. Preservative free liquid formulation of lipozomal iron
WO2024166011A1 (en) * 2023-02-07 2024-08-15 Alesco S.R.L. New iron and acacia gum oral compositions, process for their preparation and their use in iron deficiency conditions

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998011877A1 (en) 1996-09-18 1998-03-26 Dragoco, Inc. Liposome encapsulated active agent dry powder composition
EP0870435B1 (en) 1996-10-03 2004-01-14 TAIYO KAGAKU Co., LTD. Mineral composition
JP2000300213A (ja) 1999-04-21 2000-10-31 Taiyo Kagaku Co Ltd ミネラル組成物及びミネラル強化飲食品
US6521247B1 (en) * 1999-08-13 2003-02-18 Warner Chilcott Laboratories Ireland Limited Dual iron containing nutritional supplement
JP2007224054A (ja) * 2004-02-02 2007-09-06 Taiyo Kagaku Co Ltd 鉄組成物
WO2005082167A1 (en) * 2004-02-27 2005-09-09 Taiyo Kagaku Co., Ltd. Minera-containing composition and method of use thereof
JP4627999B2 (ja) * 2004-02-27 2011-02-09 太陽化学株式会社 坑酸化剤
JP2006340613A (ja) * 2005-06-07 2006-12-21 Taiyo Kagaku Co Ltd 鉄強化用組成物
JP2006340612A (ja) * 2005-06-07 2006-12-21 Taiyo Kagaku Co Ltd ミネラル強化用組成物
JP4738410B2 (ja) * 2005-06-22 2011-08-03 太陽化学株式会社 鉄強化用組成物
AU2006331590B2 (en) * 2005-12-23 2012-07-26 Ajay Gupta Parenteral nutrition composition containing iron
JP4673235B2 (ja) * 2006-02-16 2011-04-20 太陽化学株式会社 鉄強化食品用組成物
WO2008037365A1 (en) * 2006-09-28 2008-04-03 Bayer Consumer Care Ag Mixture of iron and copper salts masking metallic taste
JP5865903B2 (ja) * 2010-06-09 2016-02-17 エミスフェアー・テクノロジーズ・インク 経口鉄欠乏療法
WO2012097155A1 (en) 2011-01-14 2012-07-19 Chiasma Inc. Improved pharmaceutical compositions for delivery of ferric iron compounds, and methods of use thereof
ITMI20121350A1 (it) 2012-07-31 2014-02-01 Alesco Srl Composizione solido a base di ferro per uso nelle condizioni di deficienza di ferro.
US9594814B2 (en) 2012-09-07 2017-03-14 Splunk Inc. Advanced field extractor with modification of an extracted field

Also Published As

Publication number Publication date
ITMI20121350A1 (it) 2014-02-01
ME03349B (me) 2019-10-20
JP2015523409A (ja) 2015-08-13
CA2879681A1 (en) 2014-01-16
US10183077B2 (en) 2019-01-22
CY1121435T1 (el) 2020-05-29
CN104602674A (zh) 2015-05-06
SI3498265T1 (sl) 2021-02-26
ES2719252T3 (es) 2019-07-09
IL265561B (en) 2021-02-28
DK2879667T3 (en) 2019-04-15
TR201903899T4 (tr) 2019-04-22
HRP20190461T1 (hr) 2019-06-14
RS61069B1 (sr) 2020-12-31
US20150250885A1 (en) 2015-09-10
HRP20201802T1 (hr) 2021-03-19
EA201590204A1 (ru) 2015-06-30
PT3498265T (pt) 2020-11-16
JP6232426B2 (ja) 2017-11-15
EP3498265B1 (en) 2020-09-30
BR112015002072B1 (pt) 2022-11-01
EP3498265A1 (en) 2019-06-19
CA2879681C (en) 2022-06-21
BR122022015143B1 (pt) 2023-05-09
PT2879667T (pt) 2019-04-15
ES2830428T3 (es) 2021-06-03
HUE052036T2 (hu) 2021-04-28
DK3498265T3 (da) 2020-11-16
WO2014009806A1 (en) 2014-01-16
RS58647B1 (sr) 2019-05-31
IL265561A (en) 2019-05-30
EA027684B1 (ru) 2017-08-31
IL236793A0 (en) 2015-03-31
EP2879667B1 (en) 2019-01-16
CN111265546A (zh) 2020-06-12
HUE042698T2 (hu) 2019-07-29
US10765752B2 (en) 2020-09-08
US20190105393A1 (en) 2019-04-11
IN2015MN00127A (pt) 2015-10-16
PL3498265T3 (pl) 2021-03-08
CY1123610T1 (el) 2022-03-24
MA20150375A1 (fr) 2015-10-30
SI2879667T1 (sl) 2019-07-31
LT2879667T (lt) 2019-05-10
EP2879667A1 (en) 2015-06-10
PL2879667T3 (pl) 2019-07-31
LT3498265T (lt) 2021-01-25

Similar Documents

Publication Publication Date Title
BR112015002072A2 (pt) composição sólida à base de ferro para uso em condições de deficiência de ferro
PH12019502269A1 (en) Quinazoline derivatives for the treatment of viral infections and further diseases
PH12015500106B1 (en) Novel 5-aminotetrahydroquinoline-2-carboxylic acids and use thereof
BR112015010072A2 (pt) imizado[1,2-a]piridinacarboxamidas substituídas com amino e sua utilização
IL237369A0 (en) Methods for treating Alzheimer's disease and pharmaceutical compositions thereof
WO2012080729A3 (en) Casein kinase 1delta (ck1delta) inhibitors and their use in the treatment of neurodegenerative diseases such as tauopathies
EP2582676A4 (en) POSITIVE ALLOSTERIC TETRAHYDROCHINOLINE AMID M1 RECEPTOR MODULATORS
SG10201808102WA (en) Bicyclic heterocycle compounds and their uses in therapy
MX2011009539A (es) 2-acetamido-5-aril-1,2,4-triazolonas sustituidas y su uso.
UA115558C2 (uk) Алкілпіримідинові похідні для лікування вірусних інфекцій та подальших захворювань
EA201590663A1 (ru) ПРОИЗВОДНЫЕ ПИРРОЛО[3,2-d]ПИРИМИДИНА ДЛЯ ЛЕЧЕНИЯ ВИРУСНЫХ ИНФЕКЦИЙ И ДРУГИХ ЗАБОЛЕВАНИЙ
MD20150035A2 (ro) Inhibitori de tirozinkinaza Bruton
MX343687B (es) Compuestos sulfonamida tricíclica y métodos para su fabricación y uso.
GT201200250A (es) Ariltriazolonas ligadas a bisarilo y su uso
EP2576578A4 (en) POLYMORPHES OF 2'-O-FUCOSYLLACTOSE AND MANUFACTURE THEREOF
MX2014008706A (es) Compuestos tricíclicos de sulfonamida y métodos para elaborarlos y usarlos.
BR112015024846A2 (pt) composições para utilização no estímulo do crescimento ósseo
EA201400392A1 (ru) ПРОИЗВОДНЫЕ 6-ЗАМЕЩЕННЫХ ТРИАЗОЛОПИРИДАЗИНОВ КАК АГОНИСТЫ Rev-Erb
MX2014008705A (es) Compuestos tricíclicos de sulfona y métodos para elaborarlos y utilizarlos.
PH12016500065A1 (en) Benzyl-1h-pyrazolo[3,4-b]pyridines and use thereof
BR112014005025A2 (pt) composição farmacêutica para uso no tratamento de uma doença neurodegenerativa
MX2015005732A (es) Compuestos tricíclicos y métodos para hacer y utilizar los mismos.
MX2012000954A (es) Composicion far,aceutica topica que incuye la rel-n-[6-[(2r,6s)-2,6-dimetil-4-morfolinil]-3-piridinil]-2-metil- 4'-(trifluoro-metoxi)-[1,1'-bifenil]-3-carboxamida.
MX2013002118A (es) 2-oxi-quinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3.
TN2016000121A1 (en) Cyclic thienouracil-carboxamides and use thereof

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B15K Others concerning applications: alteration of classification

Ipc: A61K 9/16 (2006.01), A61K 33/26 (2006.01)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/07/2013, OBSERVADAS AS CONDICOES LEGAIS