BR112014031028A2 - Proteína de ligação ao antígeno isolado, ácido nucléico isolado, vetor de expressão, célula hospedeira, método para produzir uma proteína de ligação ao antígeno, composição, método para reduzir ou bloquear a atividade de miostatina, activin a ou gdf-11, método para aumentar a firmeza da massa muscular ou aumentar a proporção da firmeza da massa muscular para massa adiposo em um indivíduo necessitado do referido tratamento, método para tratar ou prevenir uma doença prejudicial do músculo em um indivíduo sofrendo do referido distúrbio e anticorpo receptor duplo antagonista - Google Patents
Proteína de ligação ao antígeno isolado, ácido nucléico isolado, vetor de expressão, célula hospedeira, método para produzir uma proteína de ligação ao antígeno, composição, método para reduzir ou bloquear a atividade de miostatina, activin a ou gdf-11, método para aumentar a firmeza da massa muscular ou aumentar a proporção da firmeza da massa muscular para massa adiposo em um indivíduo necessitado do referido tratamento, método para tratar ou prevenir uma doença prejudicial do músculo em um indivíduo sofrendo do referido distúrbio e anticorpo receptor duplo antagonistaInfo
- Publication number
- BR112014031028A2 BR112014031028A2 BR112014031028A BR112014031028A BR112014031028A2 BR 112014031028 A2 BR112014031028 A2 BR 112014031028A2 BR 112014031028 A BR112014031028 A BR 112014031028A BR 112014031028 A BR112014031028 A BR 112014031028A BR 112014031028 A2 BR112014031028 A2 BR 112014031028A2
- Authority
- BR
- Brazil
- Prior art keywords
- antigen
- binding protein
- muscle
- individual
- isolated
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 5
- 201000010099 disease Diseases 0.000 title abstract 4
- 230000009977 dual effect Effects 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 239000002253 acid Substances 0.000 title abstract 2
- 239000013604 expression vector Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 210000003205 muscle Anatomy 0.000 title 3
- 108010059616 Activins Proteins 0.000 title 1
- 102100040898 Growth/differentiation factor 11 Human genes 0.000 title 1
- 101710194452 Growth/differentiation factor 11 Proteins 0.000 title 1
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 title 1
- 102100026818 Inhibin beta E chain Human genes 0.000 title 1
- 108010056852 Myostatin Proteins 0.000 title 1
- 239000000488 activin Substances 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 230000000903 blocking effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 102000005962 receptors Human genes 0.000 abstract 4
- 108020003175 receptors Proteins 0.000 abstract 4
- 230000001575 pathological effect Effects 0.000 abstract 3
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 102000025171 antigen binding proteins Human genes 0.000 abstract 1
- 108091000831 antigen binding proteins Proteins 0.000 abstract 1
- 230000037257 muscle growth Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261658237P | 2012-06-11 | 2012-06-11 | |
| PCT/US2013/045245 WO2013188448A2 (en) | 2012-06-11 | 2013-06-11 | Dual receptor antagonistic antigen-binding proteins and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014031028A2 true BR112014031028A2 (pt) | 2017-08-15 |
Family
ID=49758865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014031028A BR112014031028A2 (pt) | 2012-06-11 | 2013-06-11 | Proteína de ligação ao antígeno isolado, ácido nucléico isolado, vetor de expressão, célula hospedeira, método para produzir uma proteína de ligação ao antígeno, composição, método para reduzir ou bloquear a atividade de miostatina, activin a ou gdf-11, método para aumentar a firmeza da massa muscular ou aumentar a proporção da firmeza da massa muscular para massa adiposo em um indivíduo necessitado do referido tratamento, método para tratar ou prevenir uma doença prejudicial do músculo em um indivíduo sofrendo do referido distúrbio e anticorpo receptor duplo antagonista |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US9453080B2 (enExample) |
| EP (3) | EP2859114B1 (enExample) |
| JP (1) | JP2015525230A (enExample) |
| KR (1) | KR20150030706A (enExample) |
| CN (1) | CN104540961A (enExample) |
| AU (1) | AU2013274347B2 (enExample) |
| BR (1) | BR112014031028A2 (enExample) |
| CA (1) | CA2877669A1 (enExample) |
| CL (1) | CL2014003372A1 (enExample) |
| CO (1) | CO7240399A2 (enExample) |
| EA (1) | EA201492282A1 (enExample) |
| HK (1) | HK1208499A1 (enExample) |
| IL (1) | IL236133A0 (enExample) |
| MA (1) | MA37761A1 (enExample) |
| MX (1) | MX2014015195A (enExample) |
| NZ (1) | NZ703724A (enExample) |
| PE (1) | PE20150642A1 (enExample) |
| PH (1) | PH12014502754A1 (enExample) |
| SG (2) | SG11201408228QA (enExample) |
| TN (2) | TN2015000448A1 (enExample) |
| WO (1) | WO2013188448A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9453080B2 (en) | 2012-06-11 | 2016-09-27 | Amgen Inc. | Dual receptor antagonistic antigen-binding proteins and uses thereof |
| LT3835310T (lt) | 2012-09-13 | 2024-04-25 | Bristol-Myers Squibb Company | Fibronektino pagrindo karkaso domeno baltymai, kurie rišasi prie miostatino |
| JP2017538701A (ja) * | 2014-12-08 | 2017-12-28 | ノバルティス アーゲー | サルコペニアの治療のためのミオスタチンまたはアクチビンアンタゴニスト |
| GB201500464D0 (en) * | 2015-01-12 | 2015-02-25 | Crescendo Biolog Ltd | Method of producing optimised therapeutic molecules |
| CN109311998A (zh) * | 2016-02-22 | 2019-02-05 | 阿塞勒隆制药公司 | 用于增加免疫活性的ActRII拮抗剂 |
| KR102457751B1 (ko) | 2016-03-10 | 2022-10-21 | 악셀레론 파마 인코포레이티드 | 액티빈 타입 2 수용체 결합 단백질 및 이의 용도 |
| EP3538123A4 (en) | 2016-11-10 | 2020-10-14 | Keros Therapeutics, Inc. | ACTIVIN RECEPTOR TYPE IIA VARIANTS AND THEIR METHODS OF USE |
| JOP20190152A1 (ar) * | 2016-12-21 | 2019-06-20 | Novartis Ag | مضادات الميوستاتين، الآكتيفين أو مستقبلات الآكتيفين للاستخدام في علاج السمنة والحالات ذات الصلة |
| EP3593144A1 (en) * | 2017-03-10 | 2020-01-15 | UCL Business Ltd | Method relating to myostatin pathway inhibition |
| WO2018183376A1 (en) * | 2017-03-28 | 2018-10-04 | Rigel Pharmaceuticals, Inc. | Acvr2a-specific antibody and method of use thereof |
| CA3082146A1 (en) | 2017-11-09 | 2019-05-16 | Keros Therapeutics, Inc. | Activin receptor type iia variants and methods of use thereof |
| CN120399032A (zh) | 2018-01-12 | 2025-08-01 | 科乐斯疗法公司 | 激活素受体iib型变体及其使用方法 |
| EP3790572A4 (en) | 2018-05-09 | 2022-03-16 | Keros Therapeutics, Inc. | ACTIVIN RECEPTOR TYPE IIA VARIANTS AND METHODS OF USE THEREOF |
| JP7669291B2 (ja) * | 2019-05-30 | 2025-04-28 | アクセレロン ファーマ インコーポレーテッド | Ａｃｔｒｉｉ結合性タンパク質及びその使用 |
| WO2021189006A1 (en) * | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Methods of using activin receptor type iia variants |
| EP4121088A4 (en) * | 2020-03-20 | 2024-07-03 | Keros Therapeutics, Inc. | Methods of using activin receptor type iib variants |
| CN116802298A (zh) * | 2021-01-13 | 2023-09-22 | 安斯泰来制药株式会社 | 与ActRIIA、ActRIIB和Fn14结合的多特异性抗体 |
| WO2025027052A1 (en) | 2023-07-31 | 2025-02-06 | Sixpeaks Bio Ag | Antibody conjugates and fusion proteins |
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-
2013
- 2013-06-11 US US14/407,421 patent/US9453080B2/en active Active
- 2013-06-11 CA CA2877669A patent/CA2877669A1/en not_active Abandoned
- 2013-06-11 MA MA37761A patent/MA37761A1/fr unknown
- 2013-06-11 WO PCT/US2013/045245 patent/WO2013188448A2/en not_active Ceased
- 2013-06-11 SG SG11201408228QA patent/SG11201408228QA/en unknown
- 2013-06-11 EP EP13804428.4A patent/EP2859114B1/en active Active
- 2013-06-11 SG SG10201610356YA patent/SG10201610356YA/en unknown
- 2013-06-11 MX MX2014015195A patent/MX2014015195A/es unknown
- 2013-06-11 EA EA201492282A patent/EA201492282A1/ru unknown
- 2013-06-11 CN CN201380042597.XA patent/CN104540961A/zh active Pending
- 2013-06-11 BR BR112014031028A patent/BR112014031028A2/pt not_active IP Right Cessation
- 2013-06-11 TN TN2015000448A patent/TN2015000448A1/en unknown
- 2013-06-11 HK HK15108981.7A patent/HK1208499A1/xx unknown
- 2013-06-11 KR KR1020157000579A patent/KR20150030706A/ko not_active Withdrawn
- 2013-06-11 EP EP18203126.0A patent/EP3498857A1/en active Pending
- 2013-06-11 AU AU2013274347A patent/AU2013274347B2/en not_active Expired - Fee Related
- 2013-06-11 PE PE2014002415A patent/PE20150642A1/es not_active Application Discontinuation
- 2013-06-11 JP JP2015517364A patent/JP2015525230A/ja not_active Withdrawn
- 2013-06-11 NZ NZ703724A patent/NZ703724A/en not_active IP Right Cessation
- 2013-06-11 EP EP19169804.2A patent/EP3540070A1/en active Pending
-
2014
- 2014-12-08 IL IL236133A patent/IL236133A0/en unknown
- 2014-12-09 PH PH12014502754A patent/PH12014502754A1/en unknown
- 2014-12-10 TN TN2014000513A patent/TN2014000513A1/fr unknown
- 2014-12-11 CL CL2014003372A patent/CL2014003372A1/es unknown
-
2015
- 2015-01-08 CO CO15003908A patent/CO7240399A2/es unknown
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2016
- 2016-08-25 US US15/247,792 patent/US10266598B2/en active Active
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2019
- 2019-03-05 US US16/293,254 patent/US10981999B2/en active Active
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2021
- 2021-03-18 US US17/205,144 patent/US20210340262A1/en not_active Abandoned
-
2023
- 2023-10-19 US US18/381,745 patent/US20240327526A1/en active Pending
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