BR112014026853A2 - corante que absorve uv polimerizável estável para lente intraocular - Google Patents

corante que absorve uv polimerizável estável para lente intraocular

Info

Publication number
BR112014026853A2
BR112014026853A2 BR112014026853A BR112014026853A BR112014026853A2 BR 112014026853 A2 BR112014026853 A2 BR 112014026853A2 BR 112014026853 A BR112014026853 A BR 112014026853A BR 112014026853 A BR112014026853 A BR 112014026853A BR 112014026853 A2 BR112014026853 A2 BR 112014026853A2
Authority
BR
Brazil
Prior art keywords
group
intraocular lens
carbon atoms
hydrogen atom
general formula
Prior art date
Application number
BR112014026853A
Other languages
English (en)
Other versions
BR112014026853B1 (pt
Inventor
Tamura Masahiro
Oshita Takahide
Original Assignee
Kowa Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co filed Critical Kowa Co
Publication of BR112014026853A2 publication Critical patent/BR112014026853A2/pt
Publication of BR112014026853B1 publication Critical patent/BR112014026853B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/62—Monocarboxylic acids having ten or more carbon atoms; Derivatives thereof
    • C08F220/68—Esters
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C09B69/106—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing an azo dye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2002/16965—Lens includes ultraviolet absorber
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
    • C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
    • C07C245/08—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
    • C08F220/603—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen and containing oxygen in addition to the carbonamido oxygen and nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/24—Homopolymers or copolymers of amides or imides
    • C08L33/26—Homopolymers or copolymers of acrylamide or methacrylamide
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B29/00—Monoazo dyes prepared by diazotising and coupling
    • C09B29/0003—Monoazo dyes prepared by diazotising and coupling from diazotized anilines
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B29/00—Monoazo dyes prepared by diazotising and coupling
    • C09B29/10—Monoazo dyes prepared by diazotising and coupling from coupling components containing hydroxy as the only directing group
    • C09B29/12—Monoazo dyes prepared by diazotising and coupling from coupling components containing hydroxy as the only directing group of the benzene series

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

1/1 resumo “corante que absorve uv polimerizável estável para lente intraocular” um monômero corante polimerizável que absorve uv é fornecido, que é excelente em estabilidade sob condições alcalinas e que está disponível para um polímero de material aproveitável para uma lente intraocular. o composto, que é representado pela seguinte fórmula geral (1), é usado como um monômero polimerizável que absorve uv disponível para um polímero de material para uma lente intraocular: (na fórmula geral (1), r1 é um átomo de hidrogênio, um grupo hidróxi, um grupo carbóxi, um grupo alquila tendo 1 a 8 átomos de carbono, um grupo alcóxi tendo 1 a 8 átomos de carbono, um grupo de ácido sulfônico, ou um grupo benzilóxi, r2 é um átomo de hidrogênio, um grupo hidróxi, ou um grupo alcóxi tendo 1 a 4 átomos de carbono, e r3 é representado pela seguinte fórmula (2)): (na fórmula geral (2), r4 é um átomo de hidrogênio ou um grupo metila, e r5 é uma ligação simples ou um grupo alquileno tendo 1 a 4 átomos de carbono que pode ter um substituinte ou substituintes.)
BR112014026853-3A 2012-04-27 2013-04-30 corante que absorve uv polimerizável estável para lente intraocular BR112014026853B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012102960 2012-04-27
JP2012-102960 2012-04-27
PCT/JP2013/062537 WO2013162042A1 (ja) 2012-04-27 2013-04-30 安定な眼内レンズ用重合性紫外線吸収色素

Publications (2)

Publication Number Publication Date
BR112014026853A2 true BR112014026853A2 (pt) 2017-06-27
BR112014026853B1 BR112014026853B1 (pt) 2021-05-11

Family

ID=49483336

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014026853-3A BR112014026853B1 (pt) 2012-04-27 2013-04-30 corante que absorve uv polimerizável estável para lente intraocular

Country Status (14)

Country Link
US (1) US9365501B2 (pt)
EP (1) EP2857459B1 (pt)
JP (1) JP5998208B2 (pt)
KR (1) KR102089816B1 (pt)
CN (1) CN104284942B (pt)
AU (1) AU2013253368B2 (pt)
BR (1) BR112014026853B1 (pt)
ES (1) ES2657477T3 (pt)
HK (1) HK1203990A1 (pt)
IL (1) IL235330A (pt)
IN (1) IN2014DN09900A (pt)
RU (1) RU2635918C1 (pt)
SG (1) SG11201406978RA (pt)
WO (1) WO2013162042A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6492367B2 (ja) * 2013-10-30 2019-04-03 興和株式会社 重合性紫外線吸収色素の製造方法
JP6492368B2 (ja) * 2013-10-30 2019-04-03 興和株式会社 重合性紫外線吸収色素の製造方法
PL3140332T3 (pl) 2014-05-07 2020-06-29 Tubitak Formulacja i sposób wytwarzania do produkcji soczewek wewnątrzgałkowych (IOL)
WO2018099416A1 (zh) * 2016-11-30 2018-06-07 东莞东阳光科研发有限公司 偶氮化合物、聚合物和它们的制备方法及用途
WO2018177329A1 (zh) * 2017-03-29 2018-10-04 东莞东阳光科研发有限公司 可聚合染料化合物、制备方法、含该染料的聚合物及用途
JP6466031B1 (ja) 2018-01-31 2019-02-06 株式会社メニコン 眼内レンズ用材料
US20220105011A1 (en) * 2019-02-21 2022-04-07 The Regents Of The University Of Colorado, A Body Corporate Antimicrobial azo compounds and uses thereof
CN116970288A (zh) * 2023-06-10 2023-10-31 水木聚力接枝纺织新技术(深圳)有限公司 一种水溶性丙烯酰胺型氨基c酸染料及其合成方法和用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0728911B2 (ja) 1988-05-06 1995-04-05 株式会社メニコン 眼用レンズを着色するための重合性色素並びにそれを用いた着色眼用レンズ材料の製造法及び着色眼用レンズ材料
JP2604799B2 (ja) 1988-05-27 1997-04-30 株式会社メニコン 眼内レンズ材料
JP2753067B2 (ja) 1988-09-16 1998-05-18 株式会社メニコン 眼用レンズ用重合性紫外線吸収性色素並びにそれを用いた眼用レンズ材料
JP2685980B2 (ja) 1990-11-26 1997-12-08 株式会社メニコン 紫外線吸収性眼内レンズ
JPH0588120A (ja) * 1991-09-27 1993-04-09 Tokyo Keikaku:Kk ソフトコンタクトレンズ
JP2604799Y2 (ja) 1993-01-12 2000-06-05 株式会社クボタ 金属管の端面防食ゴム
JPH0728911A (ja) 1993-07-09 1995-01-31 Fujitsu Social Sci Lab:Kk 帳票送受信システムおよび帳票送受信システムにおける帳票送受信方法
JP3805853B2 (ja) 1997-03-13 2006-08-09 株式会社メニコン 重合性色素及びそれを用いた着色眼用レンズ材料
JP3449406B2 (ja) 1999-04-07 2003-09-22 Ｈｏｙａヘルスケア株式会社 新規ピラゾロン化合物およびそれを用いた眼用プラスチックレンズ
DE60212965T2 (de) 2001-04-27 2007-10-25 Millipore Corp., Billerica Vernetzte multipolymere beschichtung
WO2003008011A1 (en) * 2001-04-27 2003-01-30 Millipore Corporation Crosslinked multipolymer coating
JP2003253248A (ja) 2002-03-01 2003-09-10 Dainichiseika Color & Chem Mfg Co Ltd 紫外線吸収剤及び重合体結合ベンゾトリアゾール系紫外線吸収剤、製造方法、処理物品および処理方法
JP4291296B2 (ja) 2005-04-08 2009-07-08 株式会社メニコン 新規重合性染料およびそれを含む眼用レンズ
RU2434648C2 (ru) * 2006-10-13 2011-11-27 Алькон, Инк. Интраокулярные линзы с уникальной отсечкой сине-фиолетового света и уникальными характеристиками пропускания синего света
WO2009044853A1 (ja) * 2007-10-04 2009-04-09 Menicon Co., Ltd. 眼用レンズ用着色剤、眼用レンズ用材料、眼用レンズの製造方法および眼用レンズ
TWI453199B (zh) 2008-11-04 2014-09-21 Alcon Inc 用於眼用鏡片材料之紫外光／可見光吸收劑
TWI473629B (zh) 2010-01-18 2015-02-21 Alcon Inc 用於眼用晶體材料之可見光吸收劑
JP6492368B2 (ja) * 2013-10-30 2019-04-03 興和株式会社 重合性紫外線吸収色素の製造方法

Also Published As

Publication number Publication date
SG11201406978RA (en) 2015-01-29
BR112014026853B1 (pt) 2021-05-11
RU2635918C1 (ru) 2017-11-17
JPWO2013162042A1 (ja) 2015-12-24
AU2013253368B2 (en) 2017-02-16
KR102089816B1 (ko) 2020-03-16
EP2857459B1 (en) 2017-12-27
CN104284942B (zh) 2016-09-07
IN2014DN09900A (pt) 2015-08-07
CN104284942A (zh) 2015-01-14
AU2013253368A1 (en) 2014-12-11
ES2657477T3 (es) 2018-03-05
EP2857459A1 (en) 2015-04-08
US20150094439A1 (en) 2015-04-02
EP2857459A4 (en) 2016-02-24
KR20150005650A (ko) 2015-01-14
JP5998208B2 (ja) 2016-09-28
US9365501B2 (en) 2016-06-14
WO2013162042A1 (ja) 2013-10-31
IL235330A (en) 2017-10-31
HK1203990A1 (en) 2015-11-06

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