BR112014018485A2 - - Google Patents
Info
- Publication number
- BR112014018485A2 BR112014018485A2 BR112014018485A BR112014018485A BR112014018485A2 BR 112014018485 A2 BR112014018485 A2 BR 112014018485A2 BR 112014018485 A BR112014018485 A BR 112014018485A BR 112014018485 A BR112014018485 A BR 112014018485A BR 112014018485 A2 BR112014018485 A2 BR 112014018485A2
- Authority
- BR
- Brazil
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261595006P | 2012-02-03 | 2012-02-03 | |
PCT/US2013/024356 WO2013116657A1 (en) | 2012-02-03 | 2013-02-01 | USE OF LAQUINIMOD FOR TREATING CROHN'S DISEASE PATIENTS WHO FAILED FIRST-LINE ANTI-TNFα THERAPY |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014018485A2 true BR112014018485A2 (US07223432-20070529-C00017.png) | 2017-06-20 |
BR112014018485A8 BR112014018485A8 (pt) | 2017-07-11 |
Family
ID=48903432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014018485A BR112014018485A8 (pt) | 2012-02-03 | 2013-02-01 | Uso de laquinimod para tratar pacientes com a doença de crohn que falharam com a primeira linha de terapia anti-tnf |
Country Status (16)
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2234485T3 (pl) | 2007-12-20 | 2014-06-30 | Teva Pharma | Stabilne preparaty lakwinimodu |
SG10201500639TA (en) | 2010-01-27 | 2015-03-30 | Arena Pharm Inc | Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
SG11201401330YA (en) | 2011-10-12 | 2014-05-29 | Teva Pharma | Treatment of multiple sclerosis with combination of laquinimod and fingolimod |
EP2744498A4 (en) | 2012-02-16 | 2014-12-03 | Teva Pharma | N-ETHYL-N-PHENYL-1,2-DIHYDRO-4,5-DI-HYDROXY-1-METHYL-2-OXO-3-CHINOLINE CARBOXAMIDE AND THE PREPARATION AND USE THEREOF |
TW201400117A (zh) | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療gaba媒介之疾病之拉喹莫德(laquinimod) |
US8975279B2 (en) | 2012-11-07 | 2015-03-10 | Teva Pharmaceutical Industries, Ltd. | Amine salts of laquinimod |
EP2970129A2 (en) | 2013-03-14 | 2016-01-20 | Teva Pharmaceutical Industries Ltd. | Crystals of laquinimod sodium and improved process for the manufacture thereof |
WO2015109083A1 (en) * | 2014-01-17 | 2015-07-23 | Teva Pharmaceutical Industries Ltd. | Treatment of crohn's disease using low doses of laquinimod |
UY36099A (es) | 2014-04-29 | 2016-02-29 | Teva Pharma | Laquinimod para el tratamiento de pacientes con esclerosis múltiple remitente recurrente (rrms) con un alto grado de discapacidad |
DK3310760T3 (da) | 2015-06-22 | 2022-10-24 | Arena Pharm Inc | Krystallinsk L-argininsalt af (R)-2-(7-(4-cyclopentyl-3-(trifluormethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3- yl)eddikesyre til anvendelse ved S1P1-receptor-associerede lidelser |
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US20220023258A1 (en) * | 2018-11-30 | 2022-01-27 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
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BR112012000568A2 (pt) | 2009-06-19 | 2015-10-06 | Teva Pharma | tratamento da esclerose múltipla com laquinimod |
CA2769623A1 (en) * | 2009-07-30 | 2011-02-03 | Teva Pharmaceutical Industries Ltd. | Treatment of crohn's disease with laquinimod |
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EP2542080B1 (en) | 2010-03-03 | 2016-08-31 | Teva Pharmaceutical Industries Ltd. | Treatment of lupus arthritis using laquinimod |
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KR20140054129A (ko) | 2011-07-28 | 2014-05-08 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드와 인터페론-베타의 병용에 의한 다발성 경화증의 치료 |
SG11201401330YA (en) | 2011-10-12 | 2014-05-29 | Teva Pharma | Treatment of multiple sclerosis with combination of laquinimod and fingolimod |
EP2744498A4 (en) | 2012-02-16 | 2014-12-03 | Teva Pharma | N-ETHYL-N-PHENYL-1,2-DIHYDRO-4,5-DI-HYDROXY-1-METHYL-2-OXO-3-CHINOLINE CARBOXAMIDE AND THE PREPARATION AND USE THEREOF |
US20130259856A1 (en) | 2012-03-27 | 2013-10-03 | Teva Pharmaceutical Industries, Ltd. | Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate |
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TW201350467A (zh) | 2012-05-08 | 2013-12-16 | Teva Pharma | N-乙基-4-羥基-1-甲基-5-(甲基(2,3,4,5,6-五羥基己基)胺基)-2-側氧-n-苯基-1,2-二氫喹啉-3-甲醯胺 |
TW201400117A (zh) | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
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AR091706A1 (es) | 2012-07-11 | 2015-02-25 | Teva Pharma | Formulaciones de laquinimod sin agentes alcalinizantes |
UY34896A (es) | 2012-07-12 | 2014-02-28 | Teva Pharma | Tratamiento de la esclerosis múltiple con una combinación de laquinimod y fampridina |
TW201410243A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療大麻素受體型1(cb1)媒介之疾病之拉喹莫德(laquinimod) |
TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療gaba媒介之疾病之拉喹莫德(laquinimod) |
EP2961406A4 (en) | 2012-10-12 | 2017-01-04 | Teva Pharmaceutical Industries Ltd. | Laquinimod for reducing thalamic damage in multiple sclerosis |
US8975279B2 (en) | 2012-11-07 | 2015-03-10 | Teva Pharmaceutical Industries, Ltd. | Amine salts of laquinimod |
CA2900503A1 (en) | 2013-02-15 | 2014-08-21 | Teva Pharmaceutical Industries Ltd. | Treatment of multiple sclerosis with laquinimod |
JP2016513665A (ja) | 2013-03-14 | 2016-05-16 | テバ ファーマシューティカル インダストリーズ リミティド | ラキニモドの経皮製剤 |
EP2970129A2 (en) | 2013-03-14 | 2016-01-20 | Teva Pharmaceutical Industries Ltd. | Crystals of laquinimod sodium and improved process for the manufacture thereof |
WO2015109083A1 (en) * | 2014-01-17 | 2015-07-23 | Teva Pharmaceutical Industries Ltd. | Treatment of crohn's disease using low doses of laquinimod |
-
2013
- 2013-02-01 US US13/757,004 patent/US9161935B2/en active Active
- 2013-02-01 CA CA2862865A patent/CA2862865A1/en not_active Abandoned
- 2013-02-01 CN CN201610357641.1A patent/CN106063787A/zh active Pending
- 2013-02-01 WO PCT/US2013/024356 patent/WO2013116657A1/en active Application Filing
- 2013-02-01 KR KR1020147024856A patent/KR20140138694A/ko not_active Application Discontinuation
- 2013-02-01 JP JP2014555758A patent/JP2015505564A/ja not_active Withdrawn
- 2013-02-01 CN CN201380007766.6A patent/CN104093310A/zh active Pending
- 2013-02-01 TW TW102104087A patent/TW201345527A/zh unknown
- 2013-02-01 SG SG11201404214QA patent/SG11201404214QA/en unknown
- 2013-02-01 MX MX2014009373A patent/MX2014009373A/es unknown
- 2013-02-01 AU AU2013214909A patent/AU2013214909A1/en not_active Abandoned
- 2013-02-01 EA EA201491460A patent/EA201491460A1/ru unknown
- 2013-02-01 BR BR112014018485A patent/BR112014018485A8/pt not_active IP Right Cessation
- 2013-02-01 EP EP13744015.2A patent/EP2811832A4/en not_active Withdrawn
- 2013-02-01 AR ARP130100296A patent/AR089862A1/es unknown
-
2014
- 2014-07-08 IL IL233557A patent/IL233557A0/en unknown
-
2015
- 2015-04-10 HK HK15103524.2A patent/HK1202776A1/xx unknown
- 2015-08-25 US US14/835,123 patent/US20150359788A1/en not_active Abandoned
-
2017
- 2017-01-24 AU AU2017200472A patent/AU2017200472A1/en not_active Abandoned
- 2017-05-26 JP JP2017104049A patent/JP2017200926A/ja not_active Withdrawn
- 2017-06-26 US US15/633,132 patent/US20170290822A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EA201491460A1 (ru) | 2015-01-30 |
CA2862865A1 (en) | 2013-08-08 |
EP2811832A1 (en) | 2014-12-17 |
TW201345527A (zh) | 2013-11-16 |
KR20140138694A (ko) | 2014-12-04 |
JP2017200926A (ja) | 2017-11-09 |
MX2014009373A (es) | 2014-08-27 |
CN106063787A (zh) | 2016-11-02 |
US20130203807A1 (en) | 2013-08-08 |
IL233557A0 (en) | 2014-08-31 |
SG11201404214QA (en) | 2014-08-28 |
JP2015505564A (ja) | 2015-02-23 |
US20150359788A1 (en) | 2015-12-17 |
AR089862A1 (es) | 2014-09-24 |
AU2017200472A1 (en) | 2017-02-09 |
BR112014018485A8 (pt) | 2017-07-11 |
HK1202776A1 (en) | 2015-10-09 |
EP2811832A4 (en) | 2015-09-23 |
AU2013214909A1 (en) | 2014-09-18 |
CN104093310A (zh) | 2014-10-08 |
US20170290822A1 (en) | 2017-10-12 |
WO2013116657A1 (en) | 2013-08-08 |
US9161935B2 (en) | 2015-10-20 |
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