BR112014018378A8 - Processo contínuo para a preparação de um comprimido compreendendo ácido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol5-il) ciclopropanocarboxamido)-3-metilpiridin-2-il)benzoico - Google Patents

Processo contínuo para a preparação de um comprimido compreendendo ácido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol5-il) ciclopropanocarboxamido)-3-metilpiridin-2-il)benzoico

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Publication number
BR112014018378A8
BR112014018378A8 BR112014018378A BR112014018378A BR112014018378A8 BR 112014018378 A8 BR112014018378 A8 BR 112014018378A8 BR 112014018378 A BR112014018378 A BR 112014018378A BR 112014018378 A BR112014018378 A BR 112014018378A BR 112014018378 A8 BR112014018378 A8 BR 112014018378A8
Authority
BR
Brazil
Prior art keywords
tablet
difluorobenzo
methylpyridin
preparation
benzoic acid
Prior art date
Application number
BR112014018378A
Other languages
English (en)
Other versions
BR112014018378B1 (pt
BR112014018378A2 (pt
Inventor
Jacobus Verwijis Marinus
Original Assignee
Vertex Pharma
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Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of BR112014018378A8 publication Critical patent/BR112014018378A8/pt
Publication of BR112014018378A2 publication Critical patent/BR112014018378A2/pt
Publication of BR112014018378B1 publication Critical patent/BR112014018378B1/pt

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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Abstract

COMPRIMIDO PARA ADMINISTRAÇÃO ORAL COMPREENDENDO ÁCIDO 3-(6-(1-(2,2- DIFLUOROBENZO[D][1,3]DIOXOL-5-IL) CICLOPROPANOCARBOXAMIDO)-3-METILPIRIDIN-2-IL)BENZOICO, PROCESSO CONTÍNUO PARA A PREPARAÇÃO DO MESMO, COMPOSIÇÃO FARMACÊUTICA, KIT E USO. A presente invenção refere-se a um comprimido que compreende o Composto 1, ácido (3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol5-il) ciclopropanocarboxamido)-3-metilpiridin-2-il)benzoico), uma carga, um desintegrador, um tensoativo, um lubrificante e ao menos um dentre um ligante e um deslizante, sendo que o comprimido é adequado para administração oral a um paciente que necessita do mesmo para tratar uma doença mediada por CFTR como, por exemplo, fibrose cística. A presente invenção também se refere a um processo contínuo para preparar o referido comprimido, a um kit que compreende o referido comprimido e um agente terapêutico separado ou composição farmacêutica do mesmo, a uma composição farmacêutica, bem como ao uso do Composto 1 na preparação de um comprimido para tratamento ou de diminuição da gravidade de uma doença em um paciente.
BR112014018378-3A 2012-01-25 2013-01-25 Processo contínuo para a preparação de um comprimido compreendendo ácido 3-(6-(1-(2,2- difluorobenzo[d][1,3]dioxol5-il) ciclopropanocarboxamido)-3-metilpiridin-2-il)benzoico BR112014018378B1 (pt)

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US201261691898P 2012-08-22 2012-08-22
US61/691,898 2012-08-22
US201261708691P 2012-10-02 2012-10-02
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PCT/US2013/023100 WO2013112804A1 (en) 2012-01-25 2013-01-25 Formulations of 3-(6-(1-(2.2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid

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SG11201404404QA (en) 2014-10-30
WO2013112804A1 (en) 2013-08-01
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US20130186801A1 (en) 2013-07-25
MX355183B (es) 2018-04-09
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AU2013212003B2 (en) 2017-05-25
CA2862859A1 (en) 2013-08-01
AU2013212003C1 (en) 2018-02-08
BR112014018378B1 (pt) 2022-05-31
UA114619C2 (uk) 2017-07-10
RU2644723C2 (ru) 2018-02-13
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US20220354797A1 (en) 2022-11-10
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CN108066306B (zh) 2021-09-07
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LT2806859T (lt) 2019-10-25
US20200085750A1 (en) 2020-03-19
PL2806859T3 (pl) 2019-11-29
CL2014001979A1 (es) 2015-04-10
US20180008546A1 (en) 2018-01-11
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BR112014018378A2 (pt) 2021-06-08
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