BR112014016624A2 - forma de dosagem sólida compreendendo nicotina com perturbação organoléptica reduzida - Google Patents

forma de dosagem sólida compreendendo nicotina com perturbação organoléptica reduzida

Info

Publication number
BR112014016624A2
BR112014016624A2 BR112014016624A BR112014016624A BR112014016624A2 BR 112014016624 A2 BR112014016624 A2 BR 112014016624A2 BR 112014016624 A BR112014016624 A BR 112014016624A BR 112014016624 A BR112014016624 A BR 112014016624A BR 112014016624 A2 BR112014016624 A2 BR 112014016624A2
Authority
BR
Brazil
Prior art keywords
nicotine
dosage form
disturbance
solid dosage
film coating
Prior art date
Application number
BR112014016624A
Other languages
English (en)
Other versions
BR112014016624A8 (pt
Inventor
Hugerth Andreas
Nicklasson Fredrik
Lindell Katarina
Thyresson Kristina
Original Assignee
Mcneil Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mcneil Ab filed Critical Mcneil Ab
Publication of BR112014016624A2 publication Critical patent/BR112014016624A2/pt
Publication of BR112014016624A8 publication Critical patent/BR112014016624A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Inorganic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

resumo patente de invenção: "forma de dosagem sólida compreendendo nicotina com perturbação organoléptica reduzida". a presente invenção refere-se a forma de dosagem farmacêutica sólida para a liberação de nicotina dentro da cavidade oral compreendendo um núcleo encapsulado por, pelo menos, um revestimento de filme, em que o núcleo compreende nicotina e em que o revestimento de filme compreende pelo menos um polímero formador de filme e pelo menos um componente para redução de uma ou mais sensações organolepticamente perturbadoras, e em que o pelo menos um revestimento de filme está desprovido de nicotina e desprovido de tampão.
BR112014016624A 2012-01-05 2013-01-07 forma de dosagem sólida compreendendo nicotina com perturbação organoléptica reduzida BR112014016624A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE1200017 2012-01-05
PCT/SE2013/050005 WO2013103318A1 (en) 2012-01-05 2013-01-07 Solid nicotine-comprising dosage form with reduced organoleptic disturbance

Publications (2)

Publication Number Publication Date
BR112014016624A2 true BR112014016624A2 (pt) 2017-06-13
BR112014016624A8 BR112014016624A8 (pt) 2017-07-04

Family

ID=48744083

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014016624A BR112014016624A8 (pt) 2012-01-05 2013-01-07 forma de dosagem sólida compreendendo nicotina com perturbação organoléptica reduzida

Country Status (19)

Country Link
US (1) US20130177646A1 (pt)
EP (1) EP2800557B1 (pt)
JP (1) JP6169609B2 (pt)
KR (1) KR102056041B1 (pt)
CN (1) CN104053433A (pt)
AR (1) AR089670A1 (pt)
AU (1) AU2013206983B2 (pt)
BR (1) BR112014016624A8 (pt)
CA (1) CA2862497C (pt)
DK (1) DK2800557T3 (pt)
ES (1) ES2848534T3 (pt)
HK (1) HK1201448A1 (pt)
HU (1) HUE053063T2 (pt)
MX (1) MX370218B (pt)
NZ (1) NZ626672A (pt)
PH (1) PH12014501446A1 (pt)
PL (1) PL2800557T3 (pt)
WO (1) WO2013103318A1 (pt)
ZA (1) ZA201405745B (pt)

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EP3003285B1 (en) * 2013-06-03 2022-02-16 McNeil AB Solid pharmaceutical dosage form for release of at least two active pharmaceutical ingredients in the oral cavity
WO2015068058A1 (en) * 2013-11-06 2015-05-14 Rk Technology & Investments Pte. Ltd. Tobacco free 'niconuts'and the process thereof
KR20170003926A (ko) * 2014-04-08 2017-01-10 산사 코포레이션 (바베이도스) 인코포레이티드 니코틴 제형 및 이의 제조방법
CN104489916B (zh) * 2014-12-02 2016-06-01 云南中烟工业有限责任公司 红醋栗提取物在卷烟中的应用
US9585835B1 (en) 2015-09-16 2017-03-07 Sansa Corporation (Barbados) Inc. Inhalable nicotine formulations and methods of making and using the same
US10149844B2 (en) 2015-09-16 2018-12-11 Philip Morris Products S.A. Inhalable nicotine formulations, and methods of making and using thereof
CN109562075A (zh) 2016-07-05 2019-04-02 葛兰素史克消费保健（美国）控股有限责任公司 包含快速释放外包衣的口服剂型
CN110650732A (zh) 2017-05-22 2020-01-03 强生消费者公司 锭剂剂型
AU2018378648B2 (en) 2017-12-08 2021-06-03 Fertin Pharma A/S Nicotine tablet
BR112020011238A2 (pt) * 2017-12-08 2021-01-05 Fertin Pharma A/S Formulação de nicotina oral sólida para alívio de desejo de nicotina de início rápido, formulação de nicotina oral sólida para uso na atenuação do desejo de nicotina, método de atenuação do desejo de nicotina e bolsa oral
US11793230B2 (en) 2019-12-09 2023-10-24 Nicoventures Trading Limited Oral products with improved binding of active ingredients
US11826462B2 (en) 2019-12-09 2023-11-28 Nicoventures Trading Limited Oral product with sustained flavor release
CA3160750A1 (en) 2019-12-09 2021-06-17 Anthony Richard Gerardi Oral product comprising a cannabinoid
US11969502B2 (en) 2019-12-09 2024-04-30 Nicoventures Trading Limited Oral products
US11872231B2 (en) 2019-12-09 2024-01-16 Nicoventures Trading Limited Moist oral product comprising an active ingredient
US11883527B2 (en) 2019-12-09 2024-01-30 Nicoventures Trading Limited Oral composition and method of manufacture
US11672862B2 (en) 2019-12-09 2023-06-13 Nicoventures Trading Limited Oral products with reduced irritation
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US11889856B2 (en) 2019-12-09 2024-02-06 Nicoventures Trading Limited Oral foam composition
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Also Published As

Publication number Publication date
PH12014501446B1 (en) 2014-10-08
DK2800557T3 (da) 2021-02-15
PL2800557T3 (pl) 2021-06-14
CN104053433A (zh) 2014-09-17
CA2862497C (en) 2020-04-14
PH12014501446A1 (en) 2014-10-08
CA2862497A1 (en) 2013-07-11
AU2013206983B2 (en) 2017-10-05
US20130177646A1 (en) 2013-07-11
EP2800557B1 (en) 2020-12-30
ZA201405745B (en) 2016-06-29
ES2848534T3 (es) 2021-08-10
AU2013206983A1 (en) 2014-07-03
HUE053063T2 (hu) 2021-06-28
MX370218B (es) 2019-12-05
JP6169609B2 (ja) 2017-07-26
NZ626672A (en) 2016-11-25
KR20140108728A (ko) 2014-09-12
BR112014016624A8 (pt) 2017-07-04
RU2014132174A (ru) 2016-02-27
KR102056041B1 (ko) 2019-12-16
WO2013103318A1 (en) 2013-07-11
AR089670A1 (es) 2014-09-10
EP2800557A1 (en) 2014-11-12
HK1201448A1 (en) 2015-09-04
EP2800557A4 (en) 2015-09-09
RU2623018C2 (ru) 2017-06-21
JP2015503581A (ja) 2015-02-02
MX2014008271A (es) 2014-10-06

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
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