BR112014014544A2 - usos de análogos de 4'-desferritiocina - Google Patents

usos de análogos de 4'-desferritiocina

Info

Publication number
BR112014014544A2
BR112014014544A2 BR112014014544A BR112014014544A BR112014014544A2 BR 112014014544 A2 BR112014014544 A2 BR 112014014544A2 BR 112014014544 A BR112014014544 A BR 112014014544A BR 112014014544 A BR112014014544 A BR 112014014544A BR 112014014544 A2 BR112014014544 A2 BR 112014014544A2
Authority
BR
Brazil
Prior art keywords
analogs
desferritiocin
desferritiocine
stroke
certain embodiments
Prior art date
Application number
BR112014014544A
Other languages
English (en)
Portuguese (pt)
Inventor
J Bergeron Raymond
Original Assignee
Univ Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida filed Critical Univ Florida
Publication of BR112014014544A2 publication Critical patent/BR112014014544A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BR112014014544A 2011-12-16 2012-12-14 usos de análogos de 4'-desferritiocina BR112014014544A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161576920P 2011-12-16 2011-12-16
PCT/US2012/069795 WO2013090750A1 (en) 2011-12-16 2012-12-14 Uses of 4'-desferrithiocin analogs

Publications (1)

Publication Number Publication Date
BR112014014544A2 true BR112014014544A2 (pt) 2017-06-13

Family

ID=48613217

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014014544A BR112014014544A2 (pt) 2011-12-16 2012-12-14 usos de análogos de 4'-desferritiocina

Country Status (11)

Country Link
US (3) US20140343110A1 (enExample)
EP (2) EP2790697B1 (enExample)
JP (4) JP6539046B2 (enExample)
KR (1) KR102111176B1 (enExample)
CN (2) CN113398126A (enExample)
AU (4) AU2012352025B2 (enExample)
BR (1) BR112014014544A2 (enExample)
CA (1) CA2859406C (enExample)
ES (1) ES2761200T3 (enExample)
MX (1) MX368275B (enExample)
WO (1) WO2013090750A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2614086T3 (es) 2005-04-04 2017-05-29 University Of Florida Research Foundation, Inc. Análogos de poliéter de desferritiocina
NZ579994A (en) 2007-03-15 2011-09-30 Univ Florida Desferrithiocin polyether analogues useful in the treatment of pathological conditions responsive to chelation or sequestration of trivalent metal
WO2013090750A1 (en) 2011-12-16 2013-06-20 University Of Florida Research Foundation, Inc. Uses of 4'-desferrithiocin analogs
AU2014352780A1 (en) * 2013-11-22 2016-06-09 University Of Florida Research Foundation, Inc. Desferrithiocin analogs and uses thereof
CA2984250A1 (en) * 2015-04-27 2016-11-03 University Of Florida Research Foundation, Incorporated Metabolically programmed metal chelators and uses thereof
JP6795998B2 (ja) * 2017-02-10 2020-12-02 日本放送協会 Ｍｔｆ測定装置およびそのプログラム

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3274207A (en) 1966-09-20 Processes for preparing thiazole carboxylic acids
US3809754A (en) 1968-12-31 1974-05-07 Medial De Toledo & Cie Method of treating diseases of the mucous membrane using compounds of a thiazolidine carboxylic acid and pharmaceutical preparations thereof
US3882110A (en) 1969-06-11 1975-05-06 Roussel Uclaf Novel 2-alkyl-5-thiazole-carboxylic acid derivatives
DE2045818A1 (de) 1969-09-17 1971-04-08 Godo Shusei Kabushiki Kaisha, Tokio Aeruginoinsäure und Verfahren zu ihrer Herstellung
FR2141526B1 (enExample) 1971-06-14 1975-05-30 Roussel Uclaf
DE2245560A1 (de) 1972-09-16 1974-03-21 Basf Ag Verfahren zur herstellung von 4alkoxycarbonyl-2-thiazolinen
AU528115B2 (en) 1978-04-08 1983-04-14 Santen Pharmaceutical Co. Ltd. Antihypertensive 4-thiazolidine/carboxylic acids
US4270537A (en) 1979-11-19 1981-06-02 Romaine Richard A Automatic hypodermic syringe
DE3002989A1 (de) 1980-01-29 1981-07-30 Hoechst Ag, 6000 Frankfurt Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels
JPS5758682A (en) 1980-07-28 1982-04-08 Ciba Geigy Ag Thiazoline derivatives, manufacture and medicinal composition containing same
EP0045281B1 (de) 1980-07-28 1985-05-08 Ciba-Geigy Ag Thiazolinderivate und Verfahren zu ihrer Herstellung
JPS5772975A (en) 1980-10-24 1982-05-07 Kureha Chem Ind Co Ltd 2-substituted phenylthiazole derviative, and medicine for peptic ulcer containing said derivative as active component
US4367233A (en) 1981-10-02 1983-01-04 American Home Products Corporation Inhibitors of mammalian collagenase
JPS62501769A (ja) 1984-12-18 1987-07-16 デイビツト　ラビン 細胞毒性アルデヒドとベニシラミンとの反応性成物を含有する抗腫瘍組成物及びその使用方法
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
HU200177B (en) 1985-06-18 1990-04-28 Biogal Gyogyszergyar Process for producing thiazolidinecarboxylic acids and pharmaceutical compositions comprising such compounds
US4736060A (en) 1985-08-06 1988-04-05 Nippon Rikagakuyakuhin Co., Ltd. Method for optical resolution of DL-cysteine and (R,S)-1-(1-naphthyl) ethylamine
EP0214933A3 (de) 1985-09-03 1989-05-24 Ciba-Geigy Ag Kombinationspräparate zur Behandlung von Malaria
EP0214101A3 (de) 1985-09-03 1989-05-31 Ciba-Geigy Ag Verwendung von Eisen(III)-Chelatoren vom Typ Desferrioxamin B und Desferriferrithiocin zur Behandlung von Malaria
JPS62142168A (ja) 1985-10-16 1987-06-25 Mitsubishi Chem Ind Ltd チアゾ−ル誘導体及びそれを有効成分とするロイコトリエンきつ抗剤
DE3621540A1 (de) 1986-06-27 1988-01-07 Basf Ag Chinolinderivate, verfahren zu ihrer herstellung, diese enthaltende mikrobizide und ihre verwendung zur bekaempfung von bakterien und pilzen
CA1283827C (en) 1986-12-18 1991-05-07 Giorgio Cirelli Appliance for injection of liquid formulations
GB8704027D0 (en) 1987-02-20 1987-03-25 Owen Mumford Ltd Syringe needle combination
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US4940460A (en) 1987-06-19 1990-07-10 Bioject, Inc. Patient-fillable and non-invasive hypodermic injection device assembly
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
DE3735757A1 (de) 1987-10-22 1989-05-03 Degussa Optisch aktive salze aus einem substituierten thiazolidin-4-carboxylat und 3-chlor-2-hydroxypropyltrimethylammonium, deren herstellung und verwendung
ES2047149T3 (es) 1988-01-20 1994-02-16 Ciba Geigy Ag Procedimiento para la obtencion de compuestos complejos.
US5339163A (en) 1988-03-16 1994-08-16 Canon Kabushiki Kaisha Automatic exposure control device using plural image plane detection areas
FR2638359A1 (fr) 1988-11-03 1990-05-04 Tino Dalto Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau
US5182402A (en) 1988-11-07 1993-01-26 Imperial Chemical Industries Plc Herbicidal compositions
GB8826035D0 (en) 1988-11-07 1988-12-14 Ici Plc Herbicidal compositions
US5106992A (en) 1989-07-28 1992-04-21 E. R. Squibb & Sons, Inc. 3,5-dihydroxypentanoic acid derivatives useful as antihypercholesterolemic agents and method for preparing same
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5190521A (en) 1990-08-22 1993-03-02 Tecnol Medical Products, Inc. Apparatus and method for raising a skin wheal and anesthetizing skin
NL9001955A (nl) 1990-09-05 1992-04-01 Cedona Pharm Bv Nieuwe thiazolidinederivaten.
US5393777A (en) 1990-11-15 1995-02-28 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University Deferration using anguibactin siderophore
DE69132944T2 (de) 1990-11-30 2002-11-21 Otsuka Pharmaceutical Co., Ltd. Azolederivate als Inhibitor von Superoxide-Radikalen
DE122008000051I1 (de) 1990-11-30 2009-02-05 Teijin Ltd 2-arylthiazolderivat sowie dieses enthaltendes arzneimittel
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
FR2677021B1 (fr) 1991-05-31 1993-10-01 Upsa Laboratoires Nouveaux derives de thiazole antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant.
GB9118204D0 (en) 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
SE9102652D0 (sv) 1991-09-13 1991-09-13 Kabi Pharmacia Ab Injection needle arrangement
US5328483A (en) 1992-02-27 1994-07-12 Jacoby Richard M Intradermal injection device with medication and needle guard
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5569189A (en) 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
US5334144A (en) 1992-10-30 1994-08-02 Becton, Dickinson And Company Single use disposable needleless injector
WO1994011367A1 (en) 1992-11-16 1994-05-26 University Of Florida Research Foundation Inc. 2-(pyrid-2'-yl)-2-thiazoline-4(s)-carboxylic acid derivatives
US5840739A (en) 1992-11-16 1998-11-24 University Of Florida Research Foundation, Inc. Thiazoline acid derivatives
DE4301356A1 (de) 1993-01-20 1994-07-21 Basf Ag Verfahren zur Herstellung von 2-Alkyl-4-fluormethyl-thiazolcarbonsäure-alkylestern
WO1995024176A1 (en) 1994-03-07 1995-09-14 Bioject, Inc. Ampule filling device
US5466220A (en) 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device
US5599302A (en) 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5893397A (en) 1996-01-12 1999-04-13 Bioject Inc. Medication vial/syringe liquid-transfer apparatus
FR2749583B1 (fr) 1996-06-07 1998-08-21 Lipha Nouveaux derives de thiazolidine -2,4- dione substitues, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant
US20020049316A1 (en) 1997-04-29 2002-04-25 Halbert Stacie Marie Protease inhibitors
US5993412A (en) 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
MA26618A1 (fr) 1998-04-09 2004-12-20 Smithkline Beecham Corp Composes et compositions pharmaceutiques pour le traitement du paludisme
US6147070A (en) 1998-06-05 2000-11-14 Facchini; Francesco Methods and compositions for controlling iron stores to treat and cure disease states
US6083966A (en) 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
US6159983A (en) 1998-09-18 2000-12-12 University Of Florida Method and composition for treatment of inflammatory bowel disease
CN1585639A (zh) 1998-09-21 2005-02-23 佛罗里达大学研究基金会 抗疟疾制剂
US6251927B1 (en) 1999-04-20 2001-06-26 Medinox, Inc. Methods for treatment of sickle cell anemia
DE19948434A1 (de) 1999-10-08 2001-06-07 Gruenenthal Gmbh Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine
US7141589B2 (en) 2001-08-23 2006-11-28 The United States Of America As Represented By The Department Of Health And Human Services Methods of inhibiting formation of vascular channels and methods of inhibiting proliferation
US7160855B2 (en) 2002-03-14 2007-01-09 Children's Hospital & Research Center At Oakland Enhancement of iron chelation therapy
WO2004017959A2 (en) 2002-08-22 2004-03-04 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
US20040044220A1 (en) 2002-08-22 2004-03-04 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
AU2004270261B2 (en) 2003-09-09 2008-12-04 University Of Florida Research Foundation, Inc. Polyamine-metal chelator conjugates
WO2005034949A1 (en) * 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
US7552880B2 (en) 2004-08-05 2009-06-30 Continental Automotive Systems Us, Inc. Fuel injector with a deep-drawn thin shell connector member and method of connecting components
CA2587558A1 (en) 2004-11-19 2006-05-26 Shiva Biomedical, Llc Methods of treating erythropoietin-resistance
ES2614086T3 (es) 2005-04-04 2017-05-29 University Of Florida Research Foundation, Inc. Análogos de poliéter de desferritiocina
US20080194518A1 (en) 2005-12-23 2008-08-14 MOOKERJEE Pradip Antimicrobial Compositions
CN101129381B (zh) 2006-08-25 2012-02-01 天津和美生物技术有限公司 含β-内酰胺类抗生素和离子螯合剂的抗生素复方
WO2008130395A2 (en) 2006-12-12 2008-10-30 University Of Florida Desferrithiocin analogue actinide decorporation agents
NZ579994A (en) 2007-03-15 2011-09-30 Univ Florida Desferrithiocin polyether analogues useful in the treatment of pathological conditions responsive to chelation or sequestration of trivalent metal
FR2922210A1 (fr) 2007-10-11 2009-04-17 Univ Louis Pasteur Etablisseme Nouveaux composes, preparation et utilisations
WO2009140215A2 (en) 2008-05-11 2009-11-19 Geraghty, Erin Method for treating drug-resistant bacterial and other infections with clioquinol, phanquinone, and related compounds
US20110189260A1 (en) 2008-05-30 2011-08-04 University Of Cincinnati Use of zinc chelators to inhibit biofilm formation
CA2728636A1 (en) 2008-07-14 2010-01-21 Ferrokin Biosciences, Inc. Salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents
JP2013500342A (ja) 2009-07-27 2013-01-07 フェロキン バイオサイエンシーズ，インク． 金属キレート化剤としてのデサザデスフェロチオシンポリエーテルアナログのプロドラッグ
JP5925679B2 (ja) 2009-08-25 2016-05-25 ユニバーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイティド デスフェリチオシンポリエーテル類似体およびその使用
NZ603774A (en) 2010-05-04 2014-11-28 Ferrokin Biosciences Inc Desazadesferrothiocin analogues as metal chelation agents
WO2012027794A2 (en) 2010-09-01 2012-03-08 The Mental Health Research Institute Of Victoria Method of treatment and agents useful for same
TW201338777A (zh) 2011-12-09 2013-10-01 Ferrokin Biosciences Inc 用於治療金屬過載之經口調配物
WO2013090766A1 (en) 2011-12-16 2013-06-20 University Of Florida Research Foundation, Inc. Uses of 3'-desferrithiocin analogs
WO2013090750A1 (en) * 2011-12-16 2013-06-20 University Of Florida Research Foundation, Inc. Uses of 4'-desferrithiocin analogs
US10017533B2 (en) 2012-08-15 2018-07-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Cytotoxic titanium and vanadium complexes
WO2014134701A1 (en) 2013-03-07 2014-09-12 Kane Biotech Inc. Antimicrobial-antibiofilm compositions and methods of use thereof
AU2014352780A1 (en) 2013-11-22 2016-06-09 University Of Florida Research Foundation, Inc. Desferrithiocin analogs and uses thereof
DE102014002484A1 (de) 2014-02-19 2015-08-20 Lucas Automotive Gmbh Kraftfahrzeugbremse, insbesondere kombiniert hydraulisch und elektromechanisch betätigbare Kraftfahrzeugbremse, mit mehrstufiger Spindel
CA2984250A1 (en) 2015-04-27 2016-11-03 University Of Florida Research Foundation, Incorporated Metabolically programmed metal chelators and uses thereof

Also Published As

Publication number Publication date
AU2012352025B2 (en) 2018-01-18
AU2018202374B2 (en) 2019-12-19
JP2019206537A (ja) 2019-12-05
CN104114170B (zh) 2021-07-06
EP2790697A4 (en) 2015-08-12
JP2021185140A (ja) 2021-12-09
US20220105078A1 (en) 2022-04-07
JP6539046B2 (ja) 2019-07-03
CN113398126A (zh) 2021-09-17
WO2013090750A1 (en) 2013-06-20
CA2859406C (en) 2020-08-25
KR20140103149A (ko) 2014-08-25
EP3620161A1 (en) 2020-03-11
US20140343110A1 (en) 2014-11-20
US11931346B2 (en) 2024-03-19
AU2020201924A1 (en) 2020-04-02
AU2018202374A1 (en) 2018-04-26
JP2018027947A (ja) 2018-02-22
EP2790697A1 (en) 2014-10-22
AU2021282444A1 (en) 2021-12-23
JP2015500839A (ja) 2015-01-08
KR102111176B1 (ko) 2020-05-15
EP2790697B1 (en) 2019-10-23
JP6987399B2 (ja) 2022-01-05
ES2761200T3 (es) 2020-05-19
CN104114170A (zh) 2014-10-22
CA2859406A1 (en) 2013-06-20
US20170209420A1 (en) 2017-07-27
MX368275B (es) 2019-09-26
AU2012352025A1 (en) 2014-07-17
HK1203355A1 (en) 2015-10-30
MX2014007200A (es) 2014-11-25

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]