BR112014001309A2 - pulverização do ferimento - Google Patents

pulverização do ferimento

Info

Publication number
BR112014001309A2
BR112014001309A2 BR112014001309A BR112014001309A BR112014001309A2 BR 112014001309 A2 BR112014001309 A2 BR 112014001309A2 BR 112014001309 A BR112014001309 A BR 112014001309A BR 112014001309 A BR112014001309 A BR 112014001309A BR 112014001309 A2 BR112014001309 A2 BR 112014001309A2
Authority
BR
Brazil
Prior art keywords
myoglobin
hemoglobin
composition
spraying
wound
Prior art date
Application number
BR112014001309A
Other languages
English (en)
Other versions
BR112014001309B1 (pt
Inventor
Pötzschke Harald
Sander Michael
Original Assignee
Sastomed Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46604251&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014001309(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sastomed Gmbh filed Critical Sastomed Gmbh
Publication of BR112014001309A2 publication Critical patent/BR112014001309A2/pt
Publication of BR112014001309B1 publication Critical patent/BR112014001309B1/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028Polypeptides; Proteins; Degradation products thereof
    • A61L26/0047Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41Porphyrin- or corrin-ring-containing peptides
    • A61K38/42Haemoglobins; Myoglobins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061Use of materials characterised by their function or physical properties
    • A61L26/0066Medicaments; Biocides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061Use of materials characterised by their function or physical properties
    • A61L26/0076Sprayable compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403Regulation parameters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00Devices for applying media, e.g. remedies, on the human body
    • A61M35/003Portable hand-held applicators having means for dispensing or spreading integral media
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795Porphyrin- or corrin-ring-containing peptides
    • C07K14/805Haemoglobins; Myoglobins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412Tissue-regenerating or healing or proliferative agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/04Liquids
    • A61M2202/0413Blood
    • A61M2202/0429Red blood cells; Erythrocytes
    • A61M2202/0433Free haemoglobin
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04CROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT PUMPS
    • F04C2270/00Control; Monitoring or safety arrangements
    • F04C2270/04Force
    • F04C2270/041Controlled or regulated

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

resumo patente de invenção: "pulverização do ferimento". a presente invenção refere-se a uma composição, compreendendo hemoglobina ou mioglobina, em que em pelo menos 40% da referida hemoglobina ou mioglobina o sítio de ligação de oxigênio é carregado por um ligante de não o2, e pelo menos um outro ingrediente, um método para a preparação da referida composição e o uso de hemoglobina ou mioglobina carregada com um ligante de não oxigênio para o tratamento externo de ferimentos. 20282558v1
BR112014001309-8A 2011-07-23 2012-07-23 Composição para pulverização de ferimento, seu processo de preparação, processo para purificação um veículo de oxigênio, e uso de hemoglobina ou mioglobina BR112014001309B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11006057.1A EP2550973B1 (en) 2011-07-23 2011-07-23 Wound spray
EP11006057.1 2011-07-23
PCT/EP2012/003086 WO2013013799A1 (en) 2011-07-23 2012-07-23 Wound spray

Publications (2)

Publication Number Publication Date
BR112014001309A2 true BR112014001309A2 (pt) 2017-02-21
BR112014001309B1 BR112014001309B1 (pt) 2020-02-18

Family

ID=46604251

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014001309-8A BR112014001309B1 (pt) 2011-07-23 2012-07-23 Composição para pulverização de ferimento, seu processo de preparação, processo para purificação um veículo de oxigênio, e uso de hemoglobina ou mioglobina

Country Status (22)

Country Link
US (3) US10646613B2 (pt)
EP (2) EP2550973B1 (pt)
JP (1) JP5995970B2 (pt)
KR (1) KR101900991B1 (pt)
CN (2) CN103781488A (pt)
AU (1) AU2012289237B2 (pt)
BR (1) BR112014001309B1 (pt)
CA (1) CA2842487C (pt)
CL (1) CL2014000172A1 (pt)
CO (1) CO6940380A2 (pt)
EA (1) EA030017B1 (pt)
ES (2) ES2432075T3 (pt)
HK (1) HK1177902A1 (pt)
HU (1) HUE029928T2 (pt)
IL (1) IL230160A (pt)
MX (1) MX2014000900A (pt)
MY (1) MY165035A (pt)
PE (1) PE20141577A1 (pt)
PL (2) PL2550973T3 (pt)
UA (1) UA113290C2 (pt)
WO (1) WO2013013799A1 (pt)
ZA (1) ZA201400078B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10729748B2 (en) 2012-01-13 2020-08-04 Mölnlycke Health Care Ab Scarring reducing wound treatment
EP2614833A1 (en) * 2012-01-13 2013-07-17 SastoMed GmbH Scarring reducing wound treatment
DE102013014651A1 (de) * 2013-09-03 2015-03-05 Sanguibiotech Gmbh Zubereitungen zur verbesserten Gewebe-Oxygenierung durch peritoneale Beatmung
EP3421044A1 (en) 2017-06-26 2019-01-02 SastoMed GmbH Oxygen carriers for the treatment of skin indispositions
AU2018304174A1 (en) 2017-07-18 2020-02-06 VirTech Bio, Inc. Blood substitutes comprising hemoglobin and methods of making
GB201818811D0 (en) 2018-11-19 2019-01-02 Smith & Nephew Method of immobilising a protein on a substrate
US11506658B2 (en) 2019-04-24 2022-11-22 Progenitec, Inc. System for analysis of body fluids and wound-associated biomolecules
CN113609885A (zh) * 2020-06-22 2021-11-05 王英婷 自适应舱门开关控制系统及方法
CN117100905A (zh) * 2023-10-25 2023-11-24 润方(北京)生物医药研究院有限公司 促进伤口愈合的敷料

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE441893C (de) 1927-03-14 Max Mueller Selbstdockendes Schwimmdock mit dreiteiligem Bodenkasten
DE357665C (de) 1919-05-08 1922-08-29 Felten & Guilleaume Carlswerk Isoliermasse zur Abdichtung elektrischer Leitungen und Kabel
DE371435C (de) 1921-05-15 1923-03-15 Norske Molybdenprodukter A S Verfahren zur Reduktion von Molybdaen-Schwefelverbindungen
DE384110C (de) 1922-09-19 1923-11-03 Fallert & Co A G Vorrichtung zum Zentrieren der Spindel einer Massewalze in der Giessflasche
US2527210A (en) 1944-01-25 1950-10-24 John O Bower Hemoglobin solution and method
DE1970137U (de) 1967-04-01 1967-10-12 Guenter Friebe Satz kombinierbarer moebel-bauelemente.
DE3320752A1 (de) 1983-06-09 1984-12-13 Wolfgang Prof. Dr.Dr. 6500 Mainz Barnikol Lumineszierende schichten zur verwendung in vorrichtungen zur bestimmung der sauerstoffkonzentration in gasen und dergleichen durch messung der lumineszensverringerung
US4776991A (en) * 1986-08-29 1988-10-11 The United States Of America As Represented By The Secretary Of The Navy Scaled-up production of liposome-encapsulated hemoglobin
DE3714351A1 (de) 1987-04-29 1988-11-17 Barnikol Wolfgang Verfahren zur modifikation, insbesondere zur polymerisation von haemoglobin in vitro
GB8710598D0 (en) * 1987-05-05 1987-06-10 Star Medical Diagnostics Ltd Hemoglobin based blood substitute
DE3841105C2 (de) 1988-12-07 1994-09-01 Wolfgang Karl Richard Barnikol Verfahren zur Aufreinigung und Modifikation von polymerisiertem Hämoglobin
US5840851A (en) * 1993-07-23 1998-11-24 Plomer; J. Jeffrey Purification of hemoglobin
DE4418937C2 (de) 1994-02-28 2003-07-17 Roesler Draht Ag Klappgelenkmatte
US5476764A (en) * 1994-09-16 1995-12-19 The Regents Of The University Of California Method using CO for extending the useful shelf-life of refrigerated red blood cells
EP1211261A3 (en) 1995-03-23 2004-03-17 Biopure Corporation Stable polymerized hemoglobin blood-substitute
JPH11513709A (ja) 1995-10-26 1999-11-24 バクスター・インターナショナル・インコーポレイテッド 創傷治療の促進におけるヘモグロビンの治療的使用
DE19701037A1 (de) * 1997-01-15 1998-07-16 Sanguibiotech Ag Mit Schutzliganden der Sauerstoffbindungsstellen versehene Hämoglobine als künstliche Sauerstoffträger zur direkten biologisch-medizinischen Anwendung und Verfahren zu ihrer Herstellung
EP0854151A1 (de) 1997-01-20 1998-07-22 SanguiBioTech AG Verfahren zur Gewinnung einheitlicher Fraktionen hyperpolymerer Hämoglobine
DE19933275A1 (de) * 1999-07-14 2001-01-18 Fresenius Ag Verwendung von Hämoglobin-Derivaten zur Bestimmung des Plasma- und/oder Blutvolumens
US6670323B1 (en) 1999-11-12 2003-12-30 Baxter International, Inc. Reduced side-effect hemoglobin compositions
DE10031741A1 (de) * 2000-06-29 2002-01-17 Sanguibio Tech Ag Einen Sauerstoffträger, ausgewählt aus Hämoglobin oder Hämoglobin- und Myoglobin-enthaltende Zubereitung als Externum zur natürlichen Regeneration der Haut bei Sauerstoff-Mangel
DE10031742A1 (de) 2000-06-29 2002-01-17 Sanguibio Tech Ag Verfahren zur Herstellung künstlicher Sauerstoffträger aus kovalent vernetzten Hämoglobinen mit verbesserten funktionellen Eigenschaften durch Vernetzung in Anwesenheit chemisch nicht reagierender Effektoren der Sauerstoffaffinität der Hämoglobine
DE10031744A1 (de) 2000-06-29 2002-01-17 Sanguibio Tech Ag Mit Blutplasma verträgliche, vernetzte und mit Polyalkylenoxiden konjugierte Säugetierhämoglobine als künstliche medizinische Sauerstoffträger, ihre Herstellung und ihre Verwendung
DE10031740A1 (de) 2000-06-29 2002-02-14 Sanguibio Tech Ag Künstliche Sauerstoffträger aus vernetztem modifizierten Human- oder Schweinehämoglobin mit verbesserten Eigenschaften, Verfahren zu ihrer technisch einfachen Herstellung aus gereinigtem Material in hohen Ausbeuten, sowie deren Verwendung
US6518010B2 (en) * 2001-02-28 2003-02-11 Biopure Corporation Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier
DE10212321A1 (de) 2002-03-20 2003-10-09 Sanguibio Tech Ag Verwendung eines oder mehrerer von Plasma und Zellwandbestandteilen befreiten natürlichen oder modifizierten Sauerstoffbinder zur externen Behandlung offener, insbesondere chronischer Wunden
IL149611A (en) 2002-05-13 2011-07-31 Safetin Ltd Method for extended storage of viable and pathogen-safe blood and blood components using carbon monoxide
CN1905901A (zh) 2004-01-29 2007-01-31 学校法人庆应义塾 红细胞功能修饰物质
CN1786018B (zh) * 2005-12-12 2011-06-22 天津协和生物科技发展有限公司 高纯度血红蛋白的分离纯化与病毒灭活工艺
US20100035798A1 (en) * 2006-09-15 2010-02-11 The Ohio State University Research Foundation Methods and compositions for the topical oxygenation of hypoxic tissue
FR2917292B1 (fr) * 2007-06-18 2014-06-13 Centre Nat Rech Scient Utilisation d'une hemoglobine pour la preparation de pansements, et pansements ainsi prepares
NO2440239T3 (pt) 2009-06-09 2018-02-10
CN101948630B (zh) * 2010-09-10 2013-02-27 合肥工业大学 利用畜禽血液制备碳氧血红蛋白的方法

Also Published As

Publication number Publication date
HK1177902A1 (en) 2013-08-30
US10646613B2 (en) 2020-05-12
US20160228602A1 (en) 2016-08-11
EP2550973A1 (en) 2013-01-30
MX2014000900A (es) 2014-05-30
EP2550973B1 (en) 2013-08-28
BR112014001309B1 (pt) 2020-02-18
JP5995970B2 (ja) 2016-09-21
EP2734223A1 (en) 2014-05-28
EA201490319A1 (ru) 2014-05-30
HUE029928T2 (en) 2017-04-28
CO6940380A2 (es) 2014-05-09
CN108752468B (zh) 2023-06-30
JP2014521615A (ja) 2014-08-28
PL2734223T3 (pl) 2017-09-29
KR20140045498A (ko) 2014-04-16
CL2014000172A1 (es) 2014-08-29
NZ619177A (en) 2016-04-29
US20200230285A1 (en) 2020-07-23
US20140221944A1 (en) 2014-08-07
ES2432075T8 (es) 2014-12-29
WO2013013799A1 (en) 2013-01-31
MY165035A (en) 2018-02-28
AU2012289237A1 (en) 2014-01-16
EA030017B1 (ru) 2018-06-29
KR101900991B1 (ko) 2018-09-20
ES2593530T3 (es) 2016-12-09
US11116868B2 (en) 2021-09-14
CA2842487C (en) 2021-02-02
CN103781488A (zh) 2014-05-07
US10471175B2 (en) 2019-11-12
ZA201400078B (en) 2015-11-25
CA2842487A1 (en) 2013-01-31
PE20141577A1 (es) 2014-11-29
CN108752468A (zh) 2018-11-06
ES2432075T3 (es) 2013-11-29
PL2550973T3 (pl) 2014-03-31
EP2734223B1 (en) 2016-08-31
AU2012289237B2 (en) 2017-03-16
IL230160A (en) 2017-12-31
UA113290C2 (xx) 2017-01-10

Similar Documents

Publication Publication Date Title
BR112014001309A2 (pt) pulverização do ferimento
BR112015008480A2 (pt) compostos de benzeno substituído
UY31765A (es) Dihidropirazolonas sustituidas y su uso
BR112015022197A8 (pt) uso de um composto para fabricação de um medicamento ou composição farmacêutica para o tratamento de cataplexia
CU24056B1 (es) Dihidropirazolonas sustituidas para el tratamiento de enfermedades cardiovasculares y hematológicas
NI201500142A (es) Derivados de 3-acetilamino-1 (fenil-heteroaril-aminocarbonil o fenil-heteroaril-carbonilamino) benceno para el tratamiento de desordenes hiperproliferativos.
CR20120596A (es) 5-fluoro-1h-pirazolopiridinas sustituidas y su uso
MX2015013727A (es) Composicion para preparacion de uso externo con permeabilidad transdermica mejorada.
BR112014031866A2 (pt) Composição farmacêutica intramamária para utilização no tratamento ou prevenção da mastite em um mamífero não humano e composição farmacêutica de fosfomicina e de pelo menos um anti-microbiano
BR112015029367A2 (pt) terapia combinada compreendendo oxazolidinona-quinolonas para uso no tratamento de infecções bacterianas
CU20130072A7 (es) 1 h-pirazol-5-olato sódico sustituido
FR2978665B1 (fr) Composition antiseptique
UY33568A (es) Compuestos que interactuan con proteina reguladora de glucocinasa para el tratamiento de diabetes.
EA201301308A1 (ru) Комбинация для лечения сахарного диабета
BR112015027992A2 (pt) uso de ácido petroselínico para combater desordens estéticas da figura do corpo
WO2018094023A3 (en) Cyclic dipeptides and wound healing
AU2013367193A8 (en) Wound healing accelerator
WO2014205127A3 (en) Cellular factors involved in the cytotoxicity of staphylococcus aureus leukocidins: novel therapeutic targets
NZ712540A (en) Phenyl derivative having s1p2 antagonistic activity
BR112015000942A2 (pt) uso de inibidores de vegfr-3 para tratamento de carcinoma hepatocelular
BR112015021565A2 (pt) gel de ácido salicílico
WO2014074765A3 (en) Vitamin c, vitamin k, a polyphenol, and combinations thereof for wound healing
BR112015023872A2 (pt) composição compreendendo arabinogalactano e poliofenóis de árvores de lariço
MX2013011561A (es) Compuestos de benzodioxepina y benzodioxina que interactuan con la proteina reguladora de glucocinasa para el tratamiento de diabetes.
WO2015057964A3 (en) Modulation of mrtf-a activity in pathologic fibrosis and wound healing

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/07/2012, OBSERVADAS AS CONDICOES LEGAIS.