BR112013030909A2 - compostos de imidazopiridina - Google Patents

compostos de imidazopiridina

Info

Publication number
BR112013030909A2
BR112013030909A2 BR112013030909A BR112013030909A BR112013030909A2 BR 112013030909 A2 BR112013030909 A2 BR 112013030909A2 BR 112013030909 A BR112013030909 A BR 112013030909A BR 112013030909 A BR112013030909 A BR 112013030909A BR 112013030909 A2 BR112013030909 A2 BR 112013030909A2
Authority
BR
Brazil
Prior art keywords
action
guanylate cyclase
soluble guanylate
imidazopyridine compounds
prevention
Prior art date
Application number
BR112013030909A
Other languages
English (en)
Inventor
Eisuke Nozawa
Hiroshi Shibata
Ippei Sato
Kazuhiko Ohne
Kenichiro Imamura
Kyoichi Maeno
Maiko Iida
Takeshi Hanazawa
Tsubasa Watanabe
Yoshimasa Imamura
Yuji Koga
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of BR112013030909A2 publication Critical patent/BR112013030909A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

resumo “compostos de imidazopiridina” [problema] um excelente fármaco para o tratamento ou prevenção de doenças cardiovasculares, com base na ação pontencializadora da produção de devido à ação de ativação da guanilato ciclase solúvel, é fornecido. [meios para solução] verificou-se que os compostos de imidazopiridina tendo um grupo carbamoil na posição 3 e um substituinte ligado à posição 8 por meio de um átomo de oxigênio em um esqueleto de imidazo [1,2-a] piridina apresenta uma ação pontencializadora da produção de cgmp por uma ação de ativação da guanilato ciclase solúvel potente, e é útil como um fármaco para o tratamento ou prevenção de várias doenças cardiovasculares relacionadas com a guanilato ciclase solúvel, completando, assim, a presente invenção.
BR112013030909A 2011-05-30 2012-05-29 compostos de imidazopiridina BR112013030909A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011119826 2011-05-30
JP2011287682 2011-12-28
PCT/JP2012/063695 WO2012165399A1 (ja) 2011-05-30 2012-05-29 イミダゾピリジン化合物

Publications (1)

Publication Number Publication Date
BR112013030909A2 true BR112013030909A2 (pt) 2016-12-06

Family

ID=47259254

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013030909A BR112013030909A2 (pt) 2011-05-30 2012-05-29 compostos de imidazopiridina

Country Status (16)

Country Link
US (1) US9447090B2 (pt)
EP (1) EP2716642B1 (pt)
JP (1) JP5975025B2 (pt)
KR (1) KR20140040774A (pt)
CN (1) CN103608347B (pt)
AR (1) AR086589A1 (pt)
BR (1) BR112013030909A2 (pt)
CA (1) CA2836202A1 (pt)
EA (1) EA201391769A1 (pt)
ES (1) ES2597034T3 (pt)
IL (1) IL229513A0 (pt)
MX (1) MX2013014082A (pt)
PL (1) PL2716642T3 (pt)
PT (1) PT2716642T (pt)
TW (1) TW201311685A (pt)
WO (1) WO2012165399A1 (pt)

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Also Published As

Publication number Publication date
CA2836202A1 (en) 2012-12-06
TW201311685A (zh) 2013-03-16
CN103608347B (zh) 2016-04-27
WO2012165399A1 (ja) 2012-12-06
KR20140040774A (ko) 2014-04-03
EP2716642A4 (en) 2014-12-03
PT2716642T (pt) 2016-10-17
ES2597034T3 (es) 2017-01-13
EP2716642B1 (en) 2016-07-20
JPWO2012165399A1 (ja) 2015-02-23
MX2013014082A (es) 2014-03-21
EA201391769A1 (ru) 2014-04-30
JP5975025B2 (ja) 2016-08-23
CN103608347A (zh) 2014-02-26
US20140088080A1 (en) 2014-03-27
IL229513A0 (en) 2014-01-30
AR086589A1 (es) 2014-01-08
EP2716642A1 (en) 2014-04-09
PL2716642T3 (pl) 2017-01-31
US9447090B2 (en) 2016-09-20

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