BR112013023330B8 - Compostos de sulfonamida tendo atividade antagonista trpm8 - Google Patents

Compostos de sulfonamida tendo atividade antagonista trpm8

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Publication number
BR112013023330B8
BR112013023330B8 BR112013023330A BR112013023330A BR112013023330B8 BR 112013023330 B8 BR112013023330 B8 BR 112013023330B8 BR 112013023330 A BR112013023330 A BR 112013023330A BR 112013023330 A BR112013023330 A BR 112013023330A BR 112013023330 B8 BR112013023330 B8 BR 112013023330B8
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monocyclic
ring
aromatic heterocycle
bicyclic
antagonist activity
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BR112013023330A
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English (en)
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BR112013023330B1 (pt
BR112013023330A2 (pt
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Tsuzuki Yasuyuki
Sawamoto Daisuke
Sakamoto Toshiaki
Kato Taku
Niwa Yasuki
Awai Nobumasa
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Mitsubishi Tanabe Pharma Corp
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Publication of BR112013023330A2 publication Critical patent/BR112013023330A2/pt
Publication of BR112013023330B1 publication Critical patent/BR112013023330B1/pt
Publication of BR112013023330B8 publication Critical patent/BR112013023330B8/pt

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  • Nitrogen Condensed Heterocyclic Rings (AREA)
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  • Quinoline Compounds (AREA)
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Abstract

COMPOSTOS DE SULFONAMIDA TENDO ATIVIDADE ANTAGONISTA TRPM8, COMPOSIÇÃO FARMACÊUTICA E USO DOS REFERIDOS COMPOSTOS. A presente invenção refere-se aos compostos de sulfonamida tendo atividade antagonista TRPM8. Um composto de sulfonamida de fórmula (I) ou um sal farmaceuticamente aceitável do mesmo, ou um pro-fármaco do mesmo: (I) em que o Anel A é heterociclo aromático bicíclico composto de (a) piridina que é condensada com benze no, ou (b) piridina que é condensada com heterociclo aromático monocíclico e o Anel A liga-se a uma porção sulfonilamino em um átomo de carbono adjacente ao átomo de nitrogênio do anel de piridina que constitui o Anel A, o Anel B é (a) hidrocarboneto aromático monocíclico ou bicíclico, (b) hidrocarboneto alicíclico monocíclico ou bicíclico, (c) heterociclo aromático monocíclico ou bicíclico, ou (d) heterociclo não aromático monocíclico ou bicíclico, o Anel C é (a) benzeno, ou (b) heterociclo aromático monocíclico, e os outros símbolos são os mesmos definidos na presente invenção.
BR112013023330A 2011-03-16 2012-03-15 Compostos de sulfonamida tendo atividade antagonista trpm8 BR112013023330B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161453396P 2011-03-16 2011-03-16
US61/453,396 2011-03-16
PCT/JP2012/057412 WO2012124825A1 (en) 2011-03-16 2012-03-15 Sulfonamide compounds having trpm8 antagonistic activity

Publications (3)

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BR112013023330A2 BR112013023330A2 (pt) 2017-07-18
BR112013023330B1 BR112013023330B1 (pt) 2021-09-08
BR112013023330B8 true BR112013023330B8 (pt) 2022-09-27

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EP (1) EP2686302B1 (pt)
JP (1) JP5684401B2 (pt)
KR (1) KR101638672B1 (pt)
CN (1) CN103443080B (pt)
AU (1) AU2012229813B2 (pt)
BR (1) BR112013023330B8 (pt)
CA (1) CA2826678C (pt)
DK (1) DK2686302T3 (pt)
ES (1) ES2588752T3 (pt)
HU (1) HUE031585T2 (pt)
MX (1) MX342882B (pt)
PL (1) PL2686302T3 (pt)
PT (1) PT2686302T (pt)
RU (1) RU2563030C2 (pt)
TW (1) TWI519520B (pt)
WO (1) WO2012124825A1 (pt)

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ES2588752T3 (es) 2016-11-04
CA2826678A1 (en) 2012-09-20
EP2686302B1 (en) 2016-08-10
HUE031585T2 (en) 2017-07-28
MX2013010572A (es) 2013-10-03
RU2563030C2 (ru) 2015-09-20
US20140005393A1 (en) 2014-01-02
KR101638672B1 (ko) 2016-07-11
WO2012124825A1 (en) 2012-09-20
CN103443080A (zh) 2013-12-11
JP5684401B2 (ja) 2015-03-11
JP2014508105A (ja) 2014-04-03
MX342882B (es) 2016-10-14
CN103443080B (zh) 2016-10-12
US20150218143A1 (en) 2015-08-06
PL2686302T3 (pl) 2017-01-31
AU2012229813B2 (en) 2015-09-03
AU2012229813A1 (en) 2013-08-29
US8987445B2 (en) 2015-03-24
PT2686302T (pt) 2016-11-02
US9540360B2 (en) 2017-01-10
BR112013023330B1 (pt) 2021-09-08
RU2013146011A (ru) 2015-04-27
KR20140011385A (ko) 2014-01-28
BR112013023330A2 (pt) 2017-07-18
CA2826678C (en) 2016-07-26
TWI519520B (zh) 2016-02-01
DK2686302T3 (en) 2016-10-24
EP2686302A1 (en) 2014-01-22

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