BR112013020648B1 - sistema e método para processar microesferas usando um hidrociclone - Google Patents
sistema e método para processar microesferas usando um hidrociclone Download PDFInfo
- Publication number
- BR112013020648B1 BR112013020648B1 BR112013020648A BR112013020648A BR112013020648B1 BR 112013020648 B1 BR112013020648 B1 BR 112013020648B1 BR 112013020648 A BR112013020648 A BR 112013020648A BR 112013020648 A BR112013020648 A BR 112013020648A BR 112013020648 B1 BR112013020648 B1 BR 112013020648B1
- Authority
- BR
- Brazil
- Prior art keywords
- suspension
- microspheres
- fluid
- fluid outlet
- inlet
- Prior art date
Links
- 239000004005 microsphere Substances 0.000 title claims abstract description 198
- 238000000034 method Methods 0.000 title claims abstract description 68
- 238000012545 processing Methods 0.000 title claims abstract description 27
- 239000000725 suspension Substances 0.000 claims abstract description 219
- 239000012530 fluid Substances 0.000 claims abstract description 146
- 238000004891 communication Methods 0.000 claims abstract description 18
- 239000012510 hollow fiber Substances 0.000 claims description 43
- 239000002904 solvent Substances 0.000 claims description 40
- 230000001186 cumulative effect Effects 0.000 claims description 12
- 238000005406 washing Methods 0.000 claims description 12
- 230000003247 decreasing effect Effects 0.000 claims description 3
- 230000003134 recirculating effect Effects 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 abstract description 14
- 239000013543 active substance Substances 0.000 abstract description 13
- 239000007788 liquid Substances 0.000 abstract description 12
- 239000002245 particle Substances 0.000 description 106
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 53
- 239000012071 phase Substances 0.000 description 43
- 230000008569 process Effects 0.000 description 32
- 239000003814 drug Substances 0.000 description 27
- 229940079593 drug Drugs 0.000 description 27
- 239000003085 diluting agent Substances 0.000 description 19
- 229960003722 doxycycline Drugs 0.000 description 17
- XQTWDDCIUJNLTR-CVHRZJFOSA-N doxycycline monohydrate Chemical compound O.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]1[C@H]2O XQTWDDCIUJNLTR-CVHRZJFOSA-N 0.000 description 17
- 239000000203 mixture Substances 0.000 description 16
- 239000000047 product Substances 0.000 description 16
- 238000009826 distribution Methods 0.000 description 15
- 238000004519 manufacturing process Methods 0.000 description 15
- 238000001914 filtration Methods 0.000 description 12
- JYVNDCLJHKQUHE-UHFFFAOYSA-N hydroxymethyl acetate Chemical compound CC(=O)OCO JYVNDCLJHKQUHE-UHFFFAOYSA-N 0.000 description 12
- 238000009472 formulation Methods 0.000 description 9
- 238000010586 diagram Methods 0.000 description 8
- 239000000839 emulsion Substances 0.000 description 8
- 239000011859 microparticle Substances 0.000 description 8
- 241000700159 Rattus Species 0.000 description 7
- 238000002156 mixing Methods 0.000 description 7
- 239000012466 permeate Substances 0.000 description 7
- 238000013268 sustained release Methods 0.000 description 7
- 239000012730 sustained-release form Substances 0.000 description 7
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 230000012447 hatching Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000004094 surface-active agent Substances 0.000 description 6
- 239000004372 Polyvinyl alcohol Substances 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000011049 filling Methods 0.000 description 4
- 238000004108 freeze drying Methods 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 230000002572 peristaltic effect Effects 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 239000003623 enhancer Substances 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 210000002540 macrophage Anatomy 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 3
- 229920001515 polyalkylene glycol Polymers 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 239000013557 residual solvent Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 239000002033 PVDF binder Substances 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 238000010924 continuous production Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000013020 final formulation Substances 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 230000004962 physiological condition Effects 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000004886 process control Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102100030500 Heparin cofactor 2 Human genes 0.000 description 1
- 101710153650 Heparin cofactor 2 Proteins 0.000 description 1
- 239000004705 High-molecular-weight polyethylene Substances 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 239000006057 Non-nutritive feed additive Substances 0.000 description 1
- 108010020346 Polyglutamic Acid Proteins 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 1
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 238000004500 asepsis Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000005112 continuous flow technique Methods 0.000 description 1
- 239000002577 cryoprotective agent Substances 0.000 description 1
- 229940097362 cyclodextrins Drugs 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000000280 densification Methods 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 229960004667 ethyl cellulose Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- -1 fatty acid esters Chemical class 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229940100242 glycol stearate Drugs 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 238000000589 high-performance liquid chromatography-mass spectrometry Methods 0.000 description 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 229940067631 phospholipid Drugs 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920001281 polyalkylene Polymers 0.000 description 1
- 229920002643 polyglutamic acid Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 description 1
- JAJWGJBVLPIOOH-IZYKLYLVSA-M sodium taurocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 JAJWGJBVLPIOOH-IZYKLYLVSA-M 0.000 description 1
- 229940045946 sodium taurodeoxycholate Drugs 0.000 description 1
- YXHRQQJFKOHLAP-FVCKGWAHSA-M sodium;2-[[(4r)-4-[(3r,5r,8r,9s,10s,12s,13r,14s,17r)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 YXHRQQJFKOHLAP-FVCKGWAHSA-M 0.000 description 1
- 235000011067 sorbitan monolaureate Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004546 suspension concentrate Substances 0.000 description 1
- 210000005222 synovial tissue Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04F—PUMPING OF FLUID BY DIRECT CONTACT OF ANOTHER FLUID OR BY USING INERTIA OF FLUID TO BE PUMPED; SIPHONS
- F04F5/00—Jet pumps, i.e. devices in which flow is induced by pressure drop caused by velocity of another fluid flow
- F04F5/44—Component parts, details, or accessories not provided for in, or of interest apart from, groups F04F5/02 - F04F5/42
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
Landscapes
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Fluid Mechanics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
- Cyclones (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/028,764 US8708159B2 (en) | 2011-02-16 | 2011-02-16 | Manufacture of microspheres using a hydrocyclone |
| PCT/US2012/025378 WO2012112747A2 (en) | 2011-02-16 | 2012-02-16 | Manufacture of microspheres using a hydrocyclone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112013020648A2 BR112013020648A2 (pt) | 2016-10-18 |
| BR112013020648B1 true BR112013020648B1 (pt) | 2019-09-03 |
Family
ID=46636079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013020648A BR112013020648B1 (pt) | 2011-02-16 | 2012-02-16 | sistema e método para processar microesferas usando um hidrociclone |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8708159B2 (https=) |
| EP (1) | EP2675559B1 (https=) |
| JP (2) | JP6180327B2 (https=) |
| CN (1) | CN103732318B (https=) |
| AU (1) | AU2012217620B2 (https=) |
| BR (1) | BR112013020648B1 (https=) |
| ES (1) | ES2807350T3 (https=) |
| MX (1) | MX2013009056A (https=) |
| WO (1) | WO2012112747A2 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8764978B2 (en) | 2001-07-16 | 2014-07-01 | Foret Plasma Labs, Llc | System for treating a substance with wave energy from an electrical arc and a second source |
| US10188119B2 (en) | 2001-07-16 | 2019-01-29 | Foret Plasma Labs, Llc | Method for treating a substance with wave energy from plasma and an electrical arc |
| CA2683165C (en) | 2006-04-05 | 2013-06-11 | Foret Plasma Labs, Llc | System, method and apparatus for treating liquids with wave energy from plasma |
| US9761413B2 (en) | 2007-10-16 | 2017-09-12 | Foret Plasma Labs, Llc | High temperature electrolysis glow discharge device |
| US11806686B2 (en) | 2007-10-16 | 2023-11-07 | Foret Plasma Labs, Llc | System, method and apparatus for creating an electrical glow discharge |
| US9516736B2 (en) | 2007-10-16 | 2016-12-06 | Foret Plasma Labs, Llc | System, method and apparatus for recovering mining fluids from mining byproducts |
| US9051820B2 (en) | 2007-10-16 | 2015-06-09 | Foret Plasma Labs, Llc | System, method and apparatus for creating an electrical glow discharge |
| US8278810B2 (en) | 2007-10-16 | 2012-10-02 | Foret Plasma Labs, Llc | Solid oxide high temperature electrolysis glow discharge cell |
| US10267106B2 (en) | 2007-10-16 | 2019-04-23 | Foret Plasma Labs, Llc | System, method and apparatus for treating mining byproducts |
| US8074439B2 (en) | 2008-02-12 | 2011-12-13 | Foret Plasma Labs, Llc | System, method and apparatus for lean combustion with plasma from an electrical arc |
| US9560731B2 (en) | 2007-10-16 | 2017-01-31 | Foret Plasma Labs, Llc | System, method and apparatus for an inductively coupled plasma Arc Whirl filter press |
| US9230777B2 (en) | 2007-10-16 | 2016-01-05 | Foret Plasma Labs, Llc | Water/wastewater recycle and reuse with plasma, activated carbon and energy system |
| US9185787B2 (en) | 2007-10-16 | 2015-11-10 | Foret Plasma Labs, Llc | High temperature electrolysis glow discharge device |
| US10244614B2 (en) | 2008-02-12 | 2019-03-26 | Foret Plasma Labs, Llc | System, method and apparatus for plasma arc welding ceramics and sapphire |
| US8904749B2 (en) | 2008-02-12 | 2014-12-09 | Foret Plasma Labs, Llc | Inductively coupled plasma arc device |
| US8708159B2 (en) * | 2011-02-16 | 2014-04-29 | Oakwood Laboratories, Llc | Manufacture of microspheres using a hydrocyclone |
| US9499443B2 (en) * | 2012-12-11 | 2016-11-22 | Foret Plasma Labs, Llc | Apparatus and method for sintering proppants |
| CN105189919B (zh) | 2013-03-12 | 2017-12-01 | 弗雷特等离子实验室公司 | 用于烧结支撑剂的设备和方法 |
| WO2014144309A1 (en) * | 2013-03-15 | 2014-09-18 | Oakwood Laboratories | Sustained release microspheres and method of producing the same |
| WO2019209883A1 (en) * | 2018-04-23 | 2019-10-31 | Graybug Vision, Inc. | Improved continuous microparticle manufacture |
| DE102018207441B4 (de) * | 2018-05-15 | 2022-08-18 | Bayerische Motoren Werke Aktiengesellschaft | Verfahren zum Analysieren der in einem Betriebsfluid einer Vorrichtung enthaltenen Partikel sowie Vorrichtung zum Durchführen des Verfahrens |
| EP3993898B1 (en) * | 2019-07-01 | 2025-10-15 | Oakwood Laboratories, Llc | System and method for making microspheres and emulsions |
| CN112494456B (zh) * | 2020-12-16 | 2022-05-03 | 西南石油大学 | 一种乙基纤维素中空微囊 |
| CA3267932A1 (en) | 2022-10-05 | 2024-04-11 | Mireca Medicines Gmbh | MICROPARCEL AND IMPLANT FORMULATIONS FOR ANALOGUE CGMP THERAPY |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3869559A (en) * | 1970-04-13 | 1975-03-04 | Thomas P Clark | Process for separation and cleaning of edible vegetable products |
| FR2381896A1 (fr) * | 1977-02-24 | 1978-09-22 | Elf Aquitaine | Recuperation des fluides de forage |
| US4279743A (en) * | 1979-11-15 | 1981-07-21 | University Of Utah | Air-sparged hydrocyclone and method |
| US4810264A (en) * | 1984-02-23 | 1989-03-07 | Shell Oil Company | Process for cleaning and splitting particle-containing fluid with an adjustable cyclone separator |
| GB9221329D0 (en) * | 1992-10-10 | 1992-11-25 | Delta Biotechnology Ltd | Preparation of further diagnostic agents |
| US6051256A (en) * | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| GB9513659D0 (en) * | 1995-07-05 | 1995-09-06 | Advanced Assured Homes 17 Plc | Improvements in or relating to ultrasonic processors |
| JP3969771B2 (ja) * | 1996-10-29 | 2007-09-05 | 英人 吉田 | 液体サイクロンおよび液体サイクロンを用いた分離方法 |
| US5945126A (en) | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
| US6270802B1 (en) | 1998-10-28 | 2001-08-07 | Oakwood Laboratories L.L.C. | Method and apparatus for formulating microspheres and microcapsules |
| US6705757B2 (en) | 1999-11-12 | 2004-03-16 | Alkermes Controlled Therapeutics, Inc. Ii | Method and apparatus for preparing microparticles using in-line solvent extraction |
| AU2001252588A1 (en) * | 2000-04-28 | 2001-11-12 | Tanabe Seiyaku Co., Ltd. | Method for preparing microsphere |
| FR2815540B1 (fr) | 2000-10-19 | 2005-06-10 | Separex Sa | Procede de fabrication de tres fines particules constituees d'un principe insere dans une molecule hote |
| IT1319693B1 (it) * | 2000-12-15 | 2003-10-23 | Eni Spa | Procedimento per la separazione di microsfere di vetro cave da fanghiche le contengono. |
| GB0219815D0 (en) * | 2002-08-24 | 2002-10-02 | Accentus Plc | Preparation of small crystals |
| ATE482755T1 (de) * | 2002-07-22 | 2010-10-15 | Mba Polymers Inc | Steuerung der medienteilchengrösse bei trennungen in dichten medienschlämmen |
| JP2004053552A (ja) * | 2002-07-24 | 2004-02-19 | Toray Ind Inc | 液体流通装置内の液体流動状態の非破壊検査方法 |
| US6962006B2 (en) | 2002-12-19 | 2005-11-08 | Acusphere, Inc. | Methods and apparatus for making particles using spray dryer and in-line jet mill |
| US6892887B2 (en) * | 2003-02-10 | 2005-05-17 | Alpine Mud Products Corp | Polymer drilling bead recovery system and related methods |
| US6902593B2 (en) * | 2003-02-26 | 2005-06-07 | Kellogg Brown And Root, Inc. | Separation device to remove fine particles |
| JP2005227429A (ja) * | 2004-02-12 | 2005-08-25 | Fuji Photo Film Co Ltd | 写真廃液の処理装置及び方法 |
| US20090104274A1 (en) * | 2005-03-01 | 2009-04-23 | Ajay Khopade | Process of making microspheres |
| US7520342B2 (en) * | 2006-03-23 | 2009-04-21 | M-I L.L.C. | Recovery system |
| US7438142B2 (en) * | 2006-03-23 | 2008-10-21 | M-I Llc | Recovery system |
| EP1920765A1 (en) * | 2006-11-07 | 2008-05-14 | Medigene AG | Liposome preparation by single-pass process |
| US20130045393A1 (en) * | 2007-07-12 | 2013-02-21 | Dsm Ip Assets B.V. | Organic nano-particles and process for their preparation |
| AU2008279129A1 (en) * | 2007-07-24 | 2009-01-29 | Nexbio, Inc. | Technology for the preparation of microparticles |
| KR100917185B1 (ko) | 2007-11-13 | 2009-09-15 | (주)아모레퍼시픽 | 고분자 입자제조장치, 고분자입자 제조방법 및 이 방법에의해 제조된 고분자 입자를 포함하는 조성물 |
| WO2010030868A1 (en) * | 2008-09-11 | 2010-03-18 | Surmodics Pharmaceuticals, Inc. | Solvent extraction microencapsulation with tunable extraction rates |
| CN101502818A (zh) * | 2009-03-05 | 2009-08-12 | 煤炭科学研究总院唐山研究院 | 一种粗煤泥水力分级分选一体化装置及分级分选系统 |
| KR100924236B1 (ko) | 2009-06-23 | 2009-10-29 | 충남대학교산학협력단 | 균일한 입도분포를 가지는 초미세입자의 신규한 제조방법 및 장치 |
| US8708159B2 (en) * | 2011-02-16 | 2014-04-29 | Oakwood Laboratories, Llc | Manufacture of microspheres using a hydrocyclone |
-
2011
- 2011-02-16 US US13/028,764 patent/US8708159B2/en active Active
-
2012
- 2012-02-16 AU AU2012217620A patent/AU2012217620B2/en active Active
- 2012-02-16 CN CN201280009305.8A patent/CN103732318B/zh active Active
- 2012-02-16 BR BR112013020648A patent/BR112013020648B1/pt active IP Right Grant
- 2012-02-16 JP JP2013554593A patent/JP6180327B2/ja active Active
- 2012-02-16 ES ES12747099T patent/ES2807350T3/es active Active
- 2012-02-16 EP EP12747099.5A patent/EP2675559B1/en active Active
- 2012-02-16 MX MX2013009056A patent/MX2013009056A/es active IP Right Grant
- 2012-02-16 WO PCT/US2012/025378 patent/WO2012112747A2/en not_active Ceased
-
2017
- 2017-03-06 JP JP2017041674A patent/JP6359138B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US8708159B2 (en) | 2014-04-29 |
| WO2012112747A3 (en) | 2012-11-15 |
| AU2012217620A1 (en) | 2013-08-29 |
| EP2675559A4 (en) | 2018-01-24 |
| CN103732318B (zh) | 2016-04-13 |
| AU2012217620B2 (en) | 2016-11-17 |
| EP2675559B1 (en) | 2020-06-10 |
| JP6359138B2 (ja) | 2018-07-18 |
| JP2014511265A (ja) | 2014-05-15 |
| EP2675559A2 (en) | 2013-12-25 |
| JP6180327B2 (ja) | 2017-08-16 |
| US20120205293A1 (en) | 2012-08-16 |
| JP2017148800A (ja) | 2017-08-31 |
| BR112013020648A2 (pt) | 2016-10-18 |
| ES2807350T3 (es) | 2021-02-22 |
| MX2013009056A (es) | 2013-12-02 |
| WO2012112747A2 (en) | 2012-08-23 |
| CN103732318A (zh) | 2014-04-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112013020648B1 (pt) | sistema e método para processar microesferas usando um hidrociclone | |
| Duarte et al. | Preparation of acetazolamide composite microparticles by supercritical anti-solvent techniques | |
| US20130193598A1 (en) | High-temperature spray drying process and apparatus | |
| PT106237A (pt) | Produção de partículas substancialmente monodispersas utilizando moagem e separação por membranas | |
| CN102970978A (zh) | 活性药物成分的颗粒加工方法 | |
| PT1440082E (pt) | Processamento de fluidos supercríticos: preparação de micropartículas de proteína e sua estabilização | |
| JP6949488B2 (ja) | 超音波前駆体の調製方法 | |
| CN105796492B (zh) | 利伐沙班纳米混悬剂及其制备方法 | |
| JP2015500202A (ja) | 懸濁液から固形物を濾過し乾燥させ収容するための装置 | |
| RU2590693C1 (ru) | Способ получения нанокапсул адаптогенов в пектине | |
| CN106361724B (zh) | 一种20(R)-人参皂苷Rg3缓释纳米微球组合及其制备方法 | |
| CN107708673B (zh) | 聚合物微球生产工艺 | |
| CN106344508A (zh) | 一种莪术醇纳米混悬剂及其制备方法和应用 | |
| Elizondo et al. | Preparation of biodegradable poly (methyl vinyl ether-co-maleic anhydride) nanostructured microparticles by precipitation with a compressed antisolvent | |
| CN103263385A (zh) | 一种塞来昔布长效纳米注射剂及其制备方法 | |
| Carr et al. | Particle formation of budesonide from alcohol-modified subcritical water solutions | |
| KR102947969B1 (ko) | 생리 활성 물질이 균일하게 분산된 마이크로스피어 및 그것을 함유하는 서방성 제제 | |
| US8207236B2 (en) | Method for the production of porous particles | |
| Xie et al. | Recent progress of supercritical carbon dioxide in producing natural nanomaterials | |
| CN105919975A (zh) | 一种莽草酸核壳结构纳米制剂及其制备方法 | |
| Sheng et al. | Continuous and scalable process for the production of hollow crystals of a poorly water-soluble active pharmaceutical ingredient for dissolution enhancement and inhaled delivery | |
| RU2622752C1 (ru) | Способ получения нанокапсул сухого экстракта шпината | |
| RU2632428C1 (ru) | Способ получения нанокапсул сухого экстракта топинамбура в ксантановой камеди | |
| CN105943506A (zh) | 一种可吸收自致孔注射用微球及其制备方法 | |
| CN115414493A (zh) | 一种纳米乳剂及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/02/2012, OBSERVADAS AS CONDICOES LEGAIS. (CO) 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/02/2012, OBSERVADAS AS CONDICOES LEGAIS |