CN103732318B - 使用水力旋流器加工微球 - Google Patents

使用水力旋流器加工微球 Download PDF

Info

Publication number
CN103732318B
CN103732318B CN201280009305.8A CN201280009305A CN103732318B CN 103732318 B CN103732318 B CN 103732318B CN 201280009305 A CN201280009305 A CN 201280009305A CN 103732318 B CN103732318 B CN 103732318B
Authority
CN
China
Prior art keywords
suspension
fluid
microballoon
fluid outlet
outlet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201280009305.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN103732318A (zh
Inventor
B·C·萨鲁
E·C·史密斯
M·史密斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oakwood Laboratories LLC
Original Assignee
Oakwood Laboratories LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oakwood Laboratories LLC filed Critical Oakwood Laboratories LLC
Publication of CN103732318A publication Critical patent/CN103732318A/zh
Application granted granted Critical
Publication of CN103732318B publication Critical patent/CN103732318B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04FPUMPING OF FLUID BY DIRECT CONTACT OF ANOTHER FLUID OR BY USING INERTIA OF FLUID TO BE PUMPED; SIPHONS
    • F04F5/00Jet pumps, i.e. devices in which flow is induced by pressure drop caused by velocity of another fluid flow
    • F04F5/44Component parts, details, or accessories not provided for in, or of interest apart from, groups F04F5/02 - F04F5/42
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04BPOSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00Machines, pumps, or pumping installations having flexible working members
    • F04B43/12Machines, pumps, or pumping installations having flexible working members having peristaltic action

Landscapes

  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Fluid Mechanics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
  • Cyclones (AREA)
CN201280009305.8A 2011-02-16 2012-02-16 使用水力旋流器加工微球 Active CN103732318B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/028,764 2011-02-16
US13/028,764 US8708159B2 (en) 2011-02-16 2011-02-16 Manufacture of microspheres using a hydrocyclone
PCT/US2012/025378 WO2012112747A2 (en) 2011-02-16 2012-02-16 Manufacture of microspheres using a hydrocyclone

Publications (2)

Publication Number Publication Date
CN103732318A CN103732318A (zh) 2014-04-16
CN103732318B true CN103732318B (zh) 2016-04-13

Family

ID=46636079

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280009305.8A Active CN103732318B (zh) 2011-02-16 2012-02-16 使用水力旋流器加工微球

Country Status (9)

Country Link
US (1) US8708159B2 (https=)
EP (1) EP2675559B1 (https=)
JP (2) JP6180327B2 (https=)
CN (1) CN103732318B (https=)
AU (1) AU2012217620B2 (https=)
BR (1) BR112013020648B1 (https=)
ES (1) ES2807350T3 (https=)
MX (1) MX2013009056A (https=)
WO (1) WO2012112747A2 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8764978B2 (en) 2001-07-16 2014-07-01 Foret Plasma Labs, Llc System for treating a substance with wave energy from an electrical arc and a second source
US10188119B2 (en) 2001-07-16 2019-01-29 Foret Plasma Labs, Llc Method for treating a substance with wave energy from plasma and an electrical arc
CA2683165C (en) 2006-04-05 2013-06-11 Foret Plasma Labs, Llc System, method and apparatus for treating liquids with wave energy from plasma
US9761413B2 (en) 2007-10-16 2017-09-12 Foret Plasma Labs, Llc High temperature electrolysis glow discharge device
US11806686B2 (en) 2007-10-16 2023-11-07 Foret Plasma Labs, Llc System, method and apparatus for creating an electrical glow discharge
US9516736B2 (en) 2007-10-16 2016-12-06 Foret Plasma Labs, Llc System, method and apparatus for recovering mining fluids from mining byproducts
US9051820B2 (en) 2007-10-16 2015-06-09 Foret Plasma Labs, Llc System, method and apparatus for creating an electrical glow discharge
US8278810B2 (en) 2007-10-16 2012-10-02 Foret Plasma Labs, Llc Solid oxide high temperature electrolysis glow discharge cell
US10267106B2 (en) 2007-10-16 2019-04-23 Foret Plasma Labs, Llc System, method and apparatus for treating mining byproducts
US8074439B2 (en) 2008-02-12 2011-12-13 Foret Plasma Labs, Llc System, method and apparatus for lean combustion with plasma from an electrical arc
US9560731B2 (en) 2007-10-16 2017-01-31 Foret Plasma Labs, Llc System, method and apparatus for an inductively coupled plasma Arc Whirl filter press
US9230777B2 (en) 2007-10-16 2016-01-05 Foret Plasma Labs, Llc Water/wastewater recycle and reuse with plasma, activated carbon and energy system
US9185787B2 (en) 2007-10-16 2015-11-10 Foret Plasma Labs, Llc High temperature electrolysis glow discharge device
US10244614B2 (en) 2008-02-12 2019-03-26 Foret Plasma Labs, Llc System, method and apparatus for plasma arc welding ceramics and sapphire
US8904749B2 (en) 2008-02-12 2014-12-09 Foret Plasma Labs, Llc Inductively coupled plasma arc device
US8708159B2 (en) * 2011-02-16 2014-04-29 Oakwood Laboratories, Llc Manufacture of microspheres using a hydrocyclone
US9499443B2 (en) * 2012-12-11 2016-11-22 Foret Plasma Labs, Llc Apparatus and method for sintering proppants
CN105189919B (zh) 2013-03-12 2017-12-01 弗雷特等离子实验室公司 用于烧结支撑剂的设备和方法
WO2014144309A1 (en) * 2013-03-15 2014-09-18 Oakwood Laboratories Sustained release microspheres and method of producing the same
WO2019209883A1 (en) * 2018-04-23 2019-10-31 Graybug Vision, Inc. Improved continuous microparticle manufacture
DE102018207441B4 (de) * 2018-05-15 2022-08-18 Bayerische Motoren Werke Aktiengesellschaft Verfahren zum Analysieren der in einem Betriebsfluid einer Vorrichtung enthaltenen Partikel sowie Vorrichtung zum Durchführen des Verfahrens
EP3993898B1 (en) * 2019-07-01 2025-10-15 Oakwood Laboratories, Llc System and method for making microspheres and emulsions
CN112494456B (zh) * 2020-12-16 2022-05-03 西南石油大学 一种乙基纤维素中空微囊
CA3267932A1 (en) 2022-10-05 2024-04-11 Mireca Medicines Gmbh MICROPARCEL AND IMPLANT FORMULATIONS FOR ANALOGUE CGMP THERAPY

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040119179A1 (en) * 2000-10-19 2004-06-24 Michel Perrut Method for making very fine particles consisting of a principle inserted in a host molecule
US20050155541A1 (en) * 2002-05-02 2005-07-21 Mccausland Linda J. Preparation of small crystals
CN101502818A (zh) * 2009-03-05 2009-08-12 煤炭科学研究总院唐山研究院 一种粗煤泥水力分级分选一体化装置及分级分选系统

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3869559A (en) * 1970-04-13 1975-03-04 Thomas P Clark Process for separation and cleaning of edible vegetable products
FR2381896A1 (fr) * 1977-02-24 1978-09-22 Elf Aquitaine Recuperation des fluides de forage
US4279743A (en) * 1979-11-15 1981-07-21 University Of Utah Air-sparged hydrocyclone and method
US4810264A (en) * 1984-02-23 1989-03-07 Shell Oil Company Process for cleaning and splitting particle-containing fluid with an adjustable cyclone separator
GB9221329D0 (en) * 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
GB9513659D0 (en) * 1995-07-05 1995-09-06 Advanced Assured Homes 17 Plc Improvements in or relating to ultrasonic processors
JP3969771B2 (ja) * 1996-10-29 2007-09-05 英人 吉田 液体サイクロンおよび液体サイクロンを用いた分離方法
US5945126A (en) 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
US6705757B2 (en) 1999-11-12 2004-03-16 Alkermes Controlled Therapeutics, Inc. Ii Method and apparatus for preparing microparticles using in-line solvent extraction
AU2001252588A1 (en) * 2000-04-28 2001-11-12 Tanabe Seiyaku Co., Ltd. Method for preparing microsphere
IT1319693B1 (it) * 2000-12-15 2003-10-23 Eni Spa Procedimento per la separazione di microsfere di vetro cave da fanghiche le contengono.
ATE482755T1 (de) * 2002-07-22 2010-10-15 Mba Polymers Inc Steuerung der medienteilchengrösse bei trennungen in dichten medienschlämmen
JP2004053552A (ja) * 2002-07-24 2004-02-19 Toray Ind Inc 液体流通装置内の液体流動状態の非破壊検査方法
US6962006B2 (en) 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
US6892887B2 (en) * 2003-02-10 2005-05-17 Alpine Mud Products Corp Polymer drilling bead recovery system and related methods
US6902593B2 (en) * 2003-02-26 2005-06-07 Kellogg Brown And Root, Inc. Separation device to remove fine particles
JP2005227429A (ja) * 2004-02-12 2005-08-25 Fuji Photo Film Co Ltd 写真廃液の処理装置及び方法
US20090104274A1 (en) * 2005-03-01 2009-04-23 Ajay Khopade Process of making microspheres
US7520342B2 (en) * 2006-03-23 2009-04-21 M-I L.L.C. Recovery system
US7438142B2 (en) * 2006-03-23 2008-10-21 M-I Llc Recovery system
EP1920765A1 (en) * 2006-11-07 2008-05-14 Medigene AG Liposome preparation by single-pass process
US20130045393A1 (en) * 2007-07-12 2013-02-21 Dsm Ip Assets B.V. Organic nano-particles and process for their preparation
AU2008279129A1 (en) * 2007-07-24 2009-01-29 Nexbio, Inc. Technology for the preparation of microparticles
KR100917185B1 (ko) 2007-11-13 2009-09-15 (주)아모레퍼시픽 고분자 입자제조장치, 고분자입자 제조방법 및 이 방법에의해 제조된 고분자 입자를 포함하는 조성물
WO2010030868A1 (en) * 2008-09-11 2010-03-18 Surmodics Pharmaceuticals, Inc. Solvent extraction microencapsulation with tunable extraction rates
KR100924236B1 (ko) 2009-06-23 2009-10-29 충남대학교산학협력단 균일한 입도분포를 가지는 초미세입자의 신규한 제조방법 및 장치
US8708159B2 (en) * 2011-02-16 2014-04-29 Oakwood Laboratories, Llc Manufacture of microspheres using a hydrocyclone

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040119179A1 (en) * 2000-10-19 2004-06-24 Michel Perrut Method for making very fine particles consisting of a principle inserted in a host molecule
US20050155541A1 (en) * 2002-05-02 2005-07-21 Mccausland Linda J. Preparation of small crystals
CN101502818A (zh) * 2009-03-05 2009-08-12 煤炭科学研究总院唐山研究院 一种粗煤泥水力分级分选一体化装置及分级分选系统

Also Published As

Publication number Publication date
US8708159B2 (en) 2014-04-29
WO2012112747A3 (en) 2012-11-15
AU2012217620A1 (en) 2013-08-29
BR112013020648B1 (pt) 2019-09-03
EP2675559A4 (en) 2018-01-24
AU2012217620B2 (en) 2016-11-17
EP2675559B1 (en) 2020-06-10
JP6359138B2 (ja) 2018-07-18
JP2014511265A (ja) 2014-05-15
EP2675559A2 (en) 2013-12-25
JP6180327B2 (ja) 2017-08-16
US20120205293A1 (en) 2012-08-16
JP2017148800A (ja) 2017-08-31
BR112013020648A2 (pt) 2016-10-18
ES2807350T3 (es) 2021-02-22
MX2013009056A (es) 2013-12-02
WO2012112747A2 (en) 2012-08-23
CN103732318A (zh) 2014-04-16

Similar Documents

Publication Publication Date Title
CN103732318B (zh) 使用水力旋流器加工微球
EP2969441B1 (en) Equipment assembly and method of processing particles
CN107960055B (zh) 颗粒的连续制备
Duarte et al. Preparation of acetazolamide composite microparticles by supercritical anti-solvent techniques
CN102164582A (zh) 一种药物纳米颗粒传递系统的制备方法
US10137089B2 (en) Solvent extraction from biodegradable microparticles
TWI411450B (zh) 微粒化方法
JP2012500797A (ja) 多相分散系を処理する方法
US10471013B2 (en) Process for producing polymeric microspheres
JP2012500118A (ja) 微粒子を含む組成物を処理する方法
JP7481259B2 (ja) スプレー溶液の連続調整を伴うスプレードライプロセス
JP5513745B2 (ja) 生物学的分子および担体ポリマーを含む粒子の調製方法
Sheng et al. Continuous and scalable process for the production of hollow crystals of a poorly water-soluble active pharmaceutical ingredient for dissolution enhancement and inhaled delivery
US12357956B2 (en) Particle coating method
HK1232776B (zh) 生物可降解微粒中的溶剂萃取
CN102836128A (zh) 制备水难溶或不溶药物的超细颗粒的方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant