BR112013010268A2 - método de produção de ácido 2,4-dihidroxibutírico (2,4-dhb), malato quinase, malato semialdeído desidrogenase, dhb desidrogenase, sequência de ácido nucleico isolado, gene quimérico, vetor de expressão, microorganismo hospedeiro, uso de uma metilbutiraldeído redutase ou de uma semialdeído succínico redutase, uso de uma malato quinase, uso de malato semialdeído desidrogenase, 4-fosfo-malato - Google Patents
método de produção de ácido 2,4-dihidroxibutírico (2,4-dhb), malato quinase, malato semialdeído desidrogenase, dhb desidrogenase, sequência de ácido nucleico isolado, gene quimérico, vetor de expressão, microorganismo hospedeiro, uso de uma metilbutiraldeído redutase ou de uma semialdeído succínico redutase, uso de uma malato quinase, uso de malato semialdeído desidrogenase, 4-fosfo-malatoInfo
- Publication number
- BR112013010268A2 BR112013010268A2 BR112013010268A BR112013010268A BR112013010268A2 BR 112013010268 A2 BR112013010268 A2 BR 112013010268A2 BR 112013010268 A BR112013010268 A BR 112013010268A BR 112013010268 A BR112013010268 A BR 112013010268A BR 112013010268 A2 BR112013010268 A2 BR 112013010268A2
- Authority
- BR
- Brazil
- Prior art keywords
- malate
- dehydrogenase
- dhb
- semialdehyde
- reductase
- Prior art date
Links
- 229940049920 malate Drugs 0.000 title 5
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 title 4
- 101710088194 Dehydrogenase Proteins 0.000 title 2
- 102000001253 Protein Kinase Human genes 0.000 title 2
- 108060006633 protein kinase Proteins 0.000 title 2
- 101710138112 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase Proteins 0.000 title 1
- IUNJCFABHJZSKB-UHFFFAOYSA-N 2,4-Dihydroxybenzaldehyde Natural products OC1=CC=C(C=O)C(O)=C1 IUNJCFABHJZSKB-UHFFFAOYSA-N 0.000 title 1
- UFYGCFHQAXXBCF-UHFFFAOYSA-N 2,4-dihydroxybutanoic acid Chemical compound OCCC(O)C(O)=O UFYGCFHQAXXBCF-UHFFFAOYSA-N 0.000 title 1
- BYGQBDHUGHBGMD-UHFFFAOYSA-N 2-methylbutanal Chemical compound CCC(C)C=O BYGQBDHUGHBGMD-UHFFFAOYSA-N 0.000 title 1
- 108010093796 4-hydroxybutyrate dehydrogenase Proteins 0.000 title 1
- 102100028443 Aflatoxin B1 aldehyde reductase member 2 Human genes 0.000 title 1
- 108091028043 Nucleic acid sequence Proteins 0.000 title 1
- 108090000854 Oxidoreductases Proteins 0.000 title 1
- 239000013604 expression vector Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 244000005700 microbiome Species 0.000 title 1
- 150000007523 nucleic acids Chemical group 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/095—Compounds containing the structure P(=O)-O-acyl, P(=O)-O-heteroatom, P(=O)-O-CN
- C07F9/096—Compounds containing the structure P(=O)-O-C(=X)- (X = O, S, Se)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
- C12Y207/02004—Aspartate kinase (2.7.2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/01011—Aspartate-semialdehyde dehydrogenase (1.2.1.11)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/01018—Malonate-semialdehyde dehydrogenase (acetylating) (1.2.1.18)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IBPCT/IB2010/003153 | 2010-10-28 | ||
| IBPCT/IB10/03153 | 2010-10-28 | ||
| IBPCT/IB11/01559 | 2011-05-23 | ||
| IBPCT/IB2011/001559 | 2011-05-23 | ||
| PCT/IB2011/002870 WO2012056318A1 (en) | 2010-10-28 | 2011-10-27 | A method of production of 2,4-dihydroxybutyric acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112013010268A2 true BR112013010268A2 (pt) | 2016-07-05 |
| BR112013010268B1 BR112013010268B1 (pt) | 2020-09-08 |
Family
ID=45464014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013010268-3A BR112013010268B1 (pt) | 2010-10-28 | 2011-10-27 | Método de produção de ácido 2,4-dihidroxibutírico (2,4-dhb), malato quinase e seu uso, malato semialdeído desidrogenase e seu uso, dhb desidrogenase, sequência de ácido nucleico isolado, gene quimérico, vetor de expressão, microorganismo hospedeiro, processo de produção de 2,4-dhb, uso de uma metilbutiraldeído redutase ou de uma semialdeído succínico redutase |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9238829B2 (pt) |
| EP (1) | EP2633038B1 (pt) |
| JP (2) | JP6071887B2 (pt) |
| KR (1) | KR101990014B1 (pt) |
| CN (2) | CN103270155B (pt) |
| AR (1) | AR083589A1 (pt) |
| BR (1) | BR112013010268B1 (pt) |
| ES (1) | ES2631554T3 (pt) |
| RU (1) | RU2626531C2 (pt) |
| TW (1) | TWI626311B (pt) |
| WO (1) | WO2012056318A1 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103270155B (zh) * | 2010-10-28 | 2016-02-10 | 安迪苏法国联合股份有限公司 | 2,4-二羟基丁酸的生产方法 |
| BR112014026149A2 (pt) | 2012-04-26 | 2017-07-18 | Adisseo France Sas | método para a preparação de 2,4-ácido dihidroxibutírico (2,4-dhb) e microrganismo. |
| CN104685058B (zh) | 2012-06-04 | 2020-07-07 | 基因组股份公司 | 制造4-羟基丁酸酯、1，4-丁二醇和相关化合物的微生物和方法 |
| RU2645260C2 (ru) | 2012-07-11 | 2018-02-19 | Адиссео Франс С.А.С. | Способ получения 2,4-дигидроксибутирата |
| WO2014009432A2 (en) | 2012-07-11 | 2014-01-16 | Institut National Des Sciences Appliquées | A microorganism modified for the production of 1,3-propanediol |
| CN102864196B (zh) * | 2012-10-09 | 2014-07-02 | 南京工业大学 | 一种二氢乳清酸酶法制备α-天冬氨酰小肽的方法 |
| CN108486082A (zh) * | 2012-10-18 | 2018-09-04 | 中粮生物化学（安徽）股份有限公司 | 天冬氨酸激酶iii突变体及其宿主细胞和应用 |
| JP2016165225A (ja) * | 2013-07-09 | 2016-09-15 | 味の素株式会社 | 有用物質の製造方法 |
| CN107771214B (zh) * | 2015-04-07 | 2022-01-18 | 代谢探索者公司 | 用于具有增加的2,4-二羟基丁酸外排物的优化的2,4-二羟基丁酸产生的修饰的微生物 |
| EP3280694B1 (en) | 2015-04-07 | 2021-11-24 | Metabolic Explorer | Modified microorganism for the optimized production of 2,4-dihydroxyburyrate |
| WO2016210281A1 (en) | 2015-06-25 | 2016-12-29 | Dynamic Food Ingredients Corporation | Method for the production of 2,4-dihydroxybutyric acid |
| CN108624627B (zh) * | 2017-03-22 | 2021-07-30 | 中国科学院天津工业生物技术研究所 | 催化甲酸合成甲醛酶的制备及其应用 |
| WO2021162099A1 (ja) * | 2020-02-14 | 2021-08-19 | 国立大学法人神戸大学 | 組換え微細藻及び微細藻を用いた有機酸の製造方法 |
| CN112322597B (zh) * | 2020-11-23 | 2022-08-23 | 天津法莫西生物医药科技有限公司 | 一种羰基还原酶突变体及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07155184A (ja) * | 1993-12-08 | 1995-06-20 | Ajinomoto Co Inc | 発酵法によるｌ−リジンの製造法 |
| JP4088982B2 (ja) * | 1996-10-15 | 2008-05-21 | 味の素株式会社 | 発酵法によるｌ−アミノ酸の製造法 |
| DE10014546A1 (de) * | 2000-03-23 | 2001-09-27 | Degussa | Für das dapC-Gen kodierende Nukleotidsequenzen und Verfahren zur Herstellung von L-Lysin |
| CN101208427A (zh) * | 2003-05-30 | 2008-06-25 | 米克罗比亚股份有限公司 | 氨基酸制备的方法和组合物 |
| RU2275424C2 (ru) * | 2003-12-05 | 2006-04-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Способ получения l-треонина с использованием бактерий, принадлежащих к роду escherichia |
| DE102006017760A1 (de) * | 2006-03-24 | 2007-09-27 | Ufz-Umweltforschungszentrum Leipzig-Halle Gmbh | Verfahren zur enzymatischen Herstellung von 2-Hydroxy-2-methylcarbonsäuren |
| KR100837842B1 (ko) * | 2006-08-10 | 2008-06-13 | 씨제이제일제당 (주) | 아스파테이트 세미알데히드 디하이드로게나아제 활성이증가된 ｌ-쓰레오닌 생산 미생물 및 이를 이용한ｌ-쓰레오닌 생산 방법 |
| AU2008229076B2 (en) | 2007-03-16 | 2014-05-15 | Genomatica, Inc. | Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors |
| AU2009320163B2 (en) * | 2008-10-27 | 2014-10-02 | Butamax(Tm) Advanced Biofuels Llc | Carbon pathway optimized production hosts for the production of isobutanol |
| CN103270155B (zh) * | 2010-10-28 | 2016-02-10 | 安迪苏法国联合股份有限公司 | 2,4-二羟基丁酸的生产方法 |
-
2011
- 2011-10-27 CN CN201180052237.9A patent/CN103270155B/zh active Active
- 2011-10-27 EP EP11805587.0A patent/EP2633038B1/en active Active
- 2011-10-27 CN CN201610007101.0A patent/CN105505892B/zh active Active
- 2011-10-27 BR BR112013010268-3A patent/BR112013010268B1/pt active IP Right Grant
- 2011-10-27 RU RU2013123481A patent/RU2626531C2/ru active
- 2011-10-27 WO PCT/IB2011/002870 patent/WO2012056318A1/en active Application Filing
- 2011-10-27 KR KR1020137012492A patent/KR101990014B1/ko active IP Right Grant
- 2011-10-27 ES ES11805587.0T patent/ES2631554T3/es active Active
- 2011-10-27 JP JP2013535529A patent/JP6071887B2/ja active Active
- 2011-10-27 US US13/882,372 patent/US9238829B2/en active Active
- 2011-10-28 TW TW100139345A patent/TWI626311B/zh active
- 2011-10-28 AR ARP110103991A patent/AR083589A1/es active IP Right Grant
-
2015
- 2015-11-18 US US14/945,046 patent/US10358663B2/en active Active
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2016
- 2016-11-01 JP JP2016214205A patent/JP6345747B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2633038B1 (en) | 2017-04-05 |
| CN105505892B (zh) | 2019-03-26 |
| CN105505892A (zh) | 2016-04-20 |
| CN103270155B (zh) | 2016-02-10 |
| RU2013123481A (ru) | 2014-12-10 |
| JP6345747B2 (ja) | 2018-06-20 |
| US10358663B2 (en) | 2019-07-23 |
| KR20140091463A (ko) | 2014-07-21 |
| JP2017070285A (ja) | 2017-04-13 |
| CN103270155A (zh) | 2013-08-28 |
| US20130273623A1 (en) | 2013-10-17 |
| RU2626531C2 (ru) | 2017-07-28 |
| US9238829B2 (en) | 2016-01-19 |
| JP2013543727A (ja) | 2013-12-09 |
| US20160153013A1 (en) | 2016-06-02 |
| WO2012056318A1 (en) | 2012-05-03 |
| TWI626311B (zh) | 2018-06-11 |
| JP6071887B2 (ja) | 2017-02-01 |
| AR083589A1 (es) | 2013-03-06 |
| ES2631554T3 (es) | 2017-09-01 |
| BR112013010268B1 (pt) | 2020-09-08 |
| KR101990014B1 (ko) | 2019-06-17 |
| TW201221648A (en) | 2012-06-01 |
| EP2633038A1 (en) | 2013-09-04 |
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