BR112012021638A2 - composição livre de conservantes estéril ótica farmacêutica na forma de uma solução aquosa clara. - Google Patents
composição livre de conservantes estéril ótica farmacêutica na forma de uma solução aquosa clara.Info
- Publication number
- BR112012021638A2 BR112012021638A2 BR112012021638A BR112012021638A BR112012021638A2 BR 112012021638 A2 BR112012021638 A2 BR 112012021638A2 BR 112012021638 A BR112012021638 A BR 112012021638A BR 112012021638 A BR112012021638 A BR 112012021638A BR 112012021638 A2 BR112012021638 A2 BR 112012021638A2
- Authority
- BR
- Brazil
- Prior art keywords
- aqueous solution
- free composition
- clear aqueous
- optical
- preservative free
- Prior art date
Links
- 230000003287 optical effect Effects 0.000 title abstract 4
- 239000007864 aqueous solution Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000003755 preservative agent Substances 0.000 title abstract 3
- 230000002335 preservative effect Effects 0.000 title abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 229960003405 ciprofloxacin Drugs 0.000 abstract 1
- 230000003028 elevating effect Effects 0.000 abstract 1
- 229960001347 fluocinolone acetonide Drugs 0.000 abstract 1
- FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
composição livre de conservantes estéril ótica farmacêutica na forma de uma solução aquosa clara. uma composição livre de conservante estéril ótica farmacêutica na forma de uma solução aquosa clara compreendendo 0,01-0,10% (p/v) de acetonida fluocinolona, opcionalmente acompanhada por 0,1-0,8& de ciprofloxacina ou um sal farmaceuticamente aceitável da mesma, um surfactante não iônico, um agente de ajuste de tonicidade e um agente de elevação de viscosidade. é útil para a preservação e/ou tratamento de inflamação ótica, opcionalmente acompanhada pela infecção bacteriana e para administração a partir de recipientes de uso único.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10155005A EP2366408B1 (en) | 2010-03-01 | 2010-03-01 | Aqueous clear solutions of fluocinolone acetonide for treatment of otic inflammation |
EP10155005.1 | 2010-03-01 | ||
PCT/EP2011/052939 WO2011107436A2 (en) | 2010-03-01 | 2011-02-28 | Aqueous clear solutions of fluocinolone acetonide for treatment of otic inflammation |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112012021638A2 true BR112012021638A2 (pt) | 2017-08-08 |
BR112012021638B1 BR112012021638B1 (pt) | 2020-10-27 |
Family
ID=42668238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012021638-4A BR112012021638B1 (pt) | 2010-03-01 | 2011-02-28 | composição livre de conservante estéril ótica farmacêutica na forma de uma solução aquosa clara |
Country Status (16)
Country | Link |
---|---|
US (1) | US8932610B2 (pt) |
EP (1) | EP2366408B1 (pt) |
JP (1) | JP5744922B2 (pt) |
KR (1) | KR101777157B1 (pt) |
CN (1) | CN102811741B (pt) |
AR (1) | AR080368A1 (pt) |
AU (1) | AU2011223095B2 (pt) |
BR (1) | BR112012021638B1 (pt) |
CA (1) | CA2790652C (pt) |
DK (1) | DK2366408T3 (pt) |
ES (1) | ES2391721T3 (pt) |
HK (1) | HK1162145A1 (pt) |
MX (1) | MX2012010009A (pt) |
PL (1) | PL2366408T3 (pt) |
RU (1) | RU2549465C2 (pt) |
WO (1) | WO2011107436A2 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2604413C1 (ru) * | 2015-06-17 | 2016-12-10 | Марина Николаевна Вольгова | Способ лечения хронического аллергического наружного отита |
JP2017008047A (ja) * | 2015-06-25 | 2017-01-12 | 参天製薬株式会社 | 注射剤 |
JP6255134B1 (ja) * | 2016-11-02 | 2017-12-27 | ヴェローチェ・バイオファーマ・エルエルシー | 耳炎の治療のための組成物および方法 |
KR102075694B1 (ko) | 2017-12-18 | 2020-02-10 | 경희대학교 산학협력단 | 시지지움 큐미니 추출물을 유효성분으로 포함하는 난청의 예방 또는 치료용 조성물 |
KR102007096B1 (ko) | 2017-12-18 | 2019-08-02 | 경희대학교 산학협력단 | 비스쿰 오발리포리움 추출물을 유효성분으로 포함하는 난청의 예방 또는 치료용 조성물 |
KR102094228B1 (ko) | 2017-12-18 | 2020-03-27 | 경희대학교 산학협력단 | 운카리아 린초필라 추출물을 유효성분으로 포함하는 난청의 예방 또는 치료용 조성물 |
KR102030123B1 (ko) | 2018-05-31 | 2019-10-08 | 경희대학교 산학협력단 | 난청의 예방 또는 치료용 조성물 |
KR102035845B1 (ko) | 2018-05-31 | 2019-10-23 | 경희대학교 산학협력단 | 난청의 예방 또는 치료용 조성물 |
KR102131044B1 (ko) | 2018-05-31 | 2020-07-08 | 경희대학교 산학협력단 | 난청의 예방 또는 치료용 조성물 |
CN109260152A (zh) * | 2018-11-13 | 2019-01-25 | 禹州市中医院 | 一种盐酸洛美沙星滴耳液 |
CN112022805A (zh) * | 2020-10-20 | 2020-12-04 | 内蒙古盛唐国际蒙医药研究院有限公司 | 一种高稳定性复方醋酸氟轻松酊及其制备方法 |
KR20220091177A (ko) | 2020-12-23 | 2022-06-30 | (주)인비보텍 | 난청의 예방 또는 치료용 조성물 |
KR20220091176A (ko) | 2020-12-23 | 2022-06-30 | (주)인비보텍 | 난청의 예방 또는 치료용 조성물 |
US11672798B2 (en) * | 2021-06-03 | 2023-06-13 | Laboratorios Salvat, S.A. | Ciprofloxacin ophthalmic topical composition for treating ocular disease |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1013180A (en) * | 1962-10-30 | 1965-12-15 | Ici Ltd | Steroid compositions |
US3326808A (en) * | 1965-08-25 | 1967-06-20 | Pfizer & Co C | Antiseptic detergent composition |
GB1133800A (en) * | 1966-11-10 | 1968-11-20 | Ici Ltd | Pharmaceutical compositions |
GB1411432A (en) * | 1972-01-10 | 1975-10-22 | Medisan Ab | Skin treating compositions |
US4013792A (en) * | 1974-04-11 | 1977-03-22 | Warner-Lambert Company | Process for the production of base for topical steroids |
AU7776275A (en) | 1974-04-11 | 1976-08-05 | Warner Lambert Co | Production of base for topical steroids |
US3934013A (en) | 1975-02-21 | 1976-01-20 | Syntex (U.S.A.) Inc. | Pharmaceutical composition |
DE3704907A1 (de) | 1987-02-17 | 1988-08-25 | Bayer Ag | Topisch anwendbare zubereitungen von gyrase-inhibitoren in kombination mit kortikosteroiden |
AU4201189A (en) | 1988-08-26 | 1990-03-23 | Alcon Laboratories, Inc. | Combination of quinolone antibiotics and steroids for topical ophthalmic use |
US5897858A (en) * | 1994-02-03 | 1999-04-27 | Schering-Plough Healthcare Products, Inc. | Nasal spray compositions exhibiting increased retention in the nasal cavity |
NZ309624A (en) | 1995-06-06 | 1999-04-29 | Bayer Ag | Non-irritating, non-sensitizing, non-ototoxic (harmful to the ears) antibacterial compositions |
ES2106680B1 (es) | 1995-08-03 | 1998-07-01 | Vita Invest Sa | Composiciones acuosas conteniendo ciprofloxacino y utilizacion y procedimiento correspondientes. |
CA2289618A1 (en) * | 1997-05-14 | 1998-11-19 | Shin-Ichi Yasueda | Aqueous suspension preparations with excellent redispersibility |
US5997518A (en) * | 1998-01-14 | 1999-12-07 | Laibovitz; Robert A. | Apparatus and method for delivery of small volumes of liquid |
US5990100A (en) * | 1998-03-24 | 1999-11-23 | Panda Pharmaceuticals, L.L.C. | Composition and method for treatment of psoriasis |
AU3843999A (en) | 1998-05-07 | 1999-11-23 | Elan Corporation, Plc | Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems |
US6241969B1 (en) * | 1998-06-26 | 2001-06-05 | Elan Corporation Plc | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
BR0014203A (pt) | 1999-09-24 | 2002-05-21 | Alcon Inc | Formulações de suspensão tópicas contendo ciprofloxacina e dexametasona |
US6235722B1 (en) * | 1999-09-24 | 2001-05-22 | Balakrishnan Jayapathy | Pharmacological preparation |
US20010049366A1 (en) * | 2000-02-09 | 2001-12-06 | Alcon Universal Ltd. | Topical solution formulations containing an antibiotic and a corticosteroid |
ES2396598T3 (es) | 2000-08-25 | 2013-02-22 | Senju Pharmaceutical Co., Ltd. | Preparaciones en forma de suspensiones acuosas |
WO2002022131A1 (fr) * | 2000-09-13 | 2002-03-21 | Santen Pharmaceutical Co., Ltd. | Collyre |
AU2003296378A1 (en) * | 2002-12-06 | 2004-06-30 | Arriva Pharmaceuticals, Inc. | Methods and compositions for treatment of otitis media |
CN1829510A (zh) * | 2003-07-31 | 2006-09-06 | 法马西亚和厄普乔恩公司 | 抗炎剂的可分散性制剂 |
DE10347994A1 (de) * | 2003-10-15 | 2005-06-16 | Pari GmbH Spezialisten für effektive Inhalation | Wässrige Aerosol-Zubereitung |
GB0413954D0 (en) * | 2004-06-22 | 2004-07-28 | Altunkaya Ali | Compositions for topical treatment |
US20090111780A1 (en) | 2007-10-31 | 2009-04-30 | Everett Laboratories, Inc. | Compositions and methods for treatment of ear canal infection and inflammation |
WO2010011466A2 (en) * | 2008-06-27 | 2010-01-28 | Otonomy, Inc. | Controlled-release cns modulating compositions and methods for the treatment of otic disorders |
US8318817B2 (en) * | 2008-07-21 | 2012-11-27 | Otonomy, Inc. | Controlled release antimicrobial compositions and methods for the treatment of otic disorders |
-
2010
- 2010-03-01 ES ES10155005T patent/ES2391721T3/es active Active
- 2010-03-01 PL PL10155005T patent/PL2366408T3/pl unknown
- 2010-03-01 EP EP10155005A patent/EP2366408B1/en active Active
- 2010-03-01 DK DK10155005.1T patent/DK2366408T3/da active
- 2010-03-24 US US12/730,681 patent/US8932610B2/en active Active
-
2011
- 2011-02-28 KR KR1020127025195A patent/KR101777157B1/ko active IP Right Grant
- 2011-02-28 BR BR112012021638-4A patent/BR112012021638B1/pt active IP Right Grant
- 2011-02-28 CN CN201180009966.6A patent/CN102811741B/zh active Active
- 2011-02-28 WO PCT/EP2011/052939 patent/WO2011107436A2/en active Application Filing
- 2011-02-28 AU AU2011223095A patent/AU2011223095B2/en active Active
- 2011-02-28 CA CA2790652A patent/CA2790652C/en active Active
- 2011-02-28 MX MX2012010009A patent/MX2012010009A/es active IP Right Grant
- 2011-02-28 JP JP2012555383A patent/JP5744922B2/ja active Active
- 2011-02-28 RU RU2012141641/15A patent/RU2549465C2/ru active
- 2011-03-01 AR ARP110100633A patent/AR080368A1/es unknown
-
2012
- 2012-03-14 HK HK12102610.2A patent/HK1162145A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU2011223095A1 (en) | 2012-08-16 |
CN102811741B (zh) | 2015-05-13 |
CA2790652C (en) | 2016-11-08 |
JP5744922B2 (ja) | 2015-07-08 |
AR080368A1 (es) | 2012-04-04 |
WO2011107436A3 (en) | 2011-11-10 |
KR20130026430A (ko) | 2013-03-13 |
MX2012010009A (es) | 2012-09-28 |
BR112012021638B1 (pt) | 2020-10-27 |
WO2011107436A2 (en) | 2011-09-09 |
EP2366408B1 (en) | 2012-07-18 |
ES2391721T3 (es) | 2012-11-29 |
US8932610B2 (en) | 2015-01-13 |
AU2011223095B2 (en) | 2015-09-17 |
HK1162145A1 (en) | 2012-08-24 |
CN102811741A (zh) | 2012-12-05 |
US20110212932A1 (en) | 2011-09-01 |
KR101777157B1 (ko) | 2017-09-26 |
PL2366408T3 (pl) | 2013-01-31 |
RU2012141641A (ru) | 2014-04-10 |
CA2790652A1 (en) | 2011-09-09 |
EP2366408A1 (en) | 2011-09-21 |
JP2013521245A (ja) | 2013-06-10 |
RU2549465C2 (ru) | 2015-04-27 |
DK2366408T3 (da) | 2012-10-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112012021638A2 (pt) | composição livre de conservantes estéril ótica farmacêutica na forma de uma solução aquosa clara. | |
BRPI1007379B8 (pt) | composições farmacêuticas para o tratamento ou prevenção de infecções orais por e. coli | |
BR112015029512A2 (pt) | derivados de pirazolopirrolidina e seu uso no tratamento de doenças | |
BR112013003045A2 (pt) | composto e composição farmacêutica e respectivos usos, recipiente estéril e método para preparar composição farmacêutica para administração | |
BR112015029491A2 (pt) | derivados de imidazopirrolidinona e seu uso no tratamento de doença | |
BR112015029401A8 (pt) | derivados de pirazolo-pirrolidin-4-ona, seus usos, e composição e combinação farmacêuticas | |
BR112014030820A2 (pt) | formulação de anticorpos | |
PE20142314A1 (es) | Composiciones intranasales de dexmedetomidina y metodos de uso de ellas | |
CO6680698A2 (es) | Formulación de premezcla de dexmedetomidina | |
EA201492021A1 (ru) | Антительный состав | |
CL2012001583A1 (es) | Preparación oftálmica que comprende: a) povidona yodada, b) un agente refrescante y c) uno o más entre alcanfor, borneol, lubricante, emoliente, antiinflamatorio esteroidal y antinflamatorio no esteroidal; y su uso para el tratamiento y/o profilaxis de un trastorno ocular o una infección. | |
BR112012033077B8 (pt) | Composição farmacêutica para administração intravenosa, uso de uma composição farmacêutica, e, kit | |
BR112015018252A2 (pt) | composição farmacêutica aquosa de dose fixa estável para administração nasal para um ser humano, composição de suspensão aquosa farmacêutica de dose fixa estável para administração nasal para um ser humano, suspensão estável adequada para administração nasal a um ser humano, método para tratar rinite em um ser humano necessitando do mesmo, uso da composição farmacêutica para administração nasal, método para liberar uma composição farmacêutica e kit | |
BR112013008601A8 (pt) | Formulações de emulsão de clevidipina contendo agentes antimicrobianos | |
BR112022019521A2 (pt) | Formulação | |
AR070025A1 (es) | Uso de derivados de 1-amino-alquilciclohexano para el tratamiento del tinnitus coclear y composicion farmaceutica | |
BRPI0916885B8 (pt) | composição farmacêutica | |
BR112013004455A2 (pt) | composições para fornecimento gástrico de agentes ativos | |
CO2019008053A2 (es) | Agente terapéutico para enfermedades del hígado | |
CL2012003341A1 (es) | Composicion farmaceutica de administracion oral que compende bendamustina o un ester, una sal o un solvato de la misma, y un excipiente que es un agente tensioactivo no ionico e hidrofilico; combinacion farmaceutica; y su uso para el tratamiento de leucemia linfocitica cronica y el mieloma multiple, entre otras enfermedades. | |
AR081973A1 (es) | Composiciones y metodos para incrementar la reduccion de microorganismos formadores de esporas | |
BR112016000092A2 (pt) | nanopartículas lipídicas para a cicatrização de feridas | |
BR112012015170A2 (pt) | "derivado de amino-heteroarila, composição farmacêutica, uso de um derivado de amino-heteroarila, e, método para tratamento de dor." | |
BR112014030288A2 (pt) | composição farmacêutica | |
AR086491A1 (es) | Composicion farmaceutica que comprende fexofenadina |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/02/2011, OBSERVADAS AS CONDICOES LEGAIS. |