BR112012018669A2 - Proteína rv3616c modificada, uso de uma proteína rv3616c modificada, polinucleotídeo, uso de um polinucleotídeo, composição farmacêutica, composição imunogênica, proteína de fusão, e, polipeptídeo. - Google Patents
Proteína rv3616c modificada, uso de uma proteína rv3616c modificada, polinucleotídeo, uso de um polinucleotídeo, composição farmacêutica, composição imunogênica, proteína de fusão, e, polipeptídeo.Info
- Publication number
- BR112012018669A2 BR112012018669A2 BR112012018669A BR112012018669A BR112012018669A2 BR 112012018669 A2 BR112012018669 A2 BR 112012018669A2 BR 112012018669 A BR112012018669 A BR 112012018669A BR 112012018669 A BR112012018669 A BR 112012018669A BR 112012018669 A2 BR112012018669 A2 BR 112012018669A2
- Authority
- BR
- Brazil
- Prior art keywords
- polynucleotide
- protein
- modified rv3616c
- modified
- rv3616c protein
- Prior art date
Links
- 108091033319 polynucleotide Proteins 0.000 title abstract 4
- 102000040430 polynucleotide Human genes 0.000 title abstract 4
- 239000002157 polynucleotide Substances 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108020001507 fusion proteins Proteins 0.000 title abstract 2
- 230000002163 immunogen Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 101100445599 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) espA gene Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000007420 reactivation Effects 0.000 abstract 1
- 201000008827 tuberculosis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29871010P | 2010-01-27 | 2010-01-27 | |
| PCT/EP2011/051158 WO2011092253A1 (en) | 2010-01-27 | 2011-01-27 | Modified tuberculosis antigens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012018669A2 true BR112012018669A2 (pt) | 2017-09-05 |
Family
ID=44318698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012018669A BR112012018669A2 (pt) | 2010-01-27 | 2011-01-27 | Proteína rv3616c modificada, uso de uma proteína rv3616c modificada, polinucleotídeo, uso de um polinucleotídeo, composição farmacêutica, composição imunogênica, proteína de fusão, e, polipeptídeo. |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US8932600B2 (enExample) |
| EP (1) | EP2528621B1 (enExample) |
| JP (2) | JP6010463B2 (enExample) |
| KR (1) | KR20120129927A (enExample) |
| CN (1) | CN102869372B (enExample) |
| AU (1) | AU2011209399B2 (enExample) |
| BR (1) | BR112012018669A2 (enExample) |
| CA (1) | CA2786969C (enExample) |
| CO (1) | CO6650338A2 (enExample) |
| CY (1) | CY1119518T1 (enExample) |
| DK (1) | DK2528621T3 (enExample) |
| EA (1) | EA201290590A1 (enExample) |
| ES (1) | ES2614266T3 (enExample) |
| HR (1) | HRP20161608T1 (enExample) |
| HU (1) | HUE031184T2 (enExample) |
| LT (1) | LT2528621T (enExample) |
| MX (1) | MX2012008790A (enExample) |
| MY (1) | MY156697A (enExample) |
| PH (1) | PH12012501550A1 (enExample) |
| PL (1) | PL2528621T3 (enExample) |
| PT (1) | PT2528621T (enExample) |
| SG (1) | SG182573A1 (enExample) |
| SI (1) | SI2528621T1 (enExample) |
| UA (1) | UA110103C2 (enExample) |
| WO (1) | WO2011092253A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2315773T (lt) | 2008-07-25 | 2016-11-10 | Glaxosmithkline Biologicals S.A. | Polipeptidai, polinukleotidai ir kompozicijos, skirti naudoti latentinės tuberkuliozės gydymui |
| EP2315597B1 (en) | 2008-07-25 | 2017-08-23 | GlaxoSmithKline Biologicals S.A. | Novel compositions and methods |
| PL2315834T3 (pl) | 2008-07-25 | 2018-12-31 | Glaxosmithkline Biologicals S.A. | Białko rv2386c związane z gruźlicą, jego kompozycje i zastosowania |
| CN102869372B (zh) * | 2010-01-27 | 2016-01-20 | 葛兰素史密丝克莱恩生物有限公司 | 经修饰的结核抗原 |
| GB201116248D0 (en) | 2011-09-20 | 2011-11-02 | Glaxosmithkline Biolog Sa | Liposome production using isopropanol |
| WO2013123579A1 (en) * | 2012-02-24 | 2013-08-29 | Mcmaster University | Adenovirus-based tuberculosis vaccine and its use |
| CN103467582A (zh) * | 2012-06-08 | 2013-12-25 | 同济大学 | 结核杆菌重要抗原的高通量筛选及其在结核病诊断中的应用 |
| CN105431166B (zh) * | 2013-06-25 | 2020-09-18 | 国际艾滋病疫苗行动组织公司 | 结核病组合物和其使用方法 |
| US10857219B2 (en) | 2014-03-28 | 2020-12-08 | The Board Of Regents Of The University Of Oklahoma | Compositions comprising soluble HLA/M. tuberculosis-specific ligand complexes and methods of production and use thereof |
| GB201405921D0 (en) * | 2014-04-02 | 2014-05-14 | Glaxosmithkline Biolog Sa | Novel methods for inducing an immune response |
| GB201513176D0 (en) * | 2015-07-27 | 2015-09-09 | Glaxosmithkline Biolog Sa | Novel methods for inducing an immune response |
| CN105675863B (zh) * | 2016-02-17 | 2017-10-20 | 遵义医学院附属医院 | 一组耐多药结核病诊断标志物及其用途 |
| US10428122B2 (en) | 2016-06-16 | 2019-10-01 | International Aids Vaccine Initiative, Inc. | Tuberculosis compositions and methods of treating or preventing tuberculosis |
| CN106546737A (zh) * | 2016-10-24 | 2017-03-29 | 广州迪澳医疗科技有限公司 | 一种体外检测活动性结核的方法 |
| GB201618432D0 (en) * | 2016-11-01 | 2016-12-14 | Matn Scient Ltd | Detection and treatment of demyelinating diseases |
| WO2018104313A1 (en) | 2016-12-07 | 2018-06-14 | Glaxosmithkline Biologicals Sa | Novel process |
| GB201621686D0 (en) | 2016-12-20 | 2017-02-01 | Glaxosmithkline Biologicals Sa | Novel methods for inducing an immune response |
| GB201707700D0 (en) | 2017-05-12 | 2017-06-28 | Glaxosmithkline Biologicals Sa | Dried composition |
| EP3630176A1 (en) | 2017-05-30 | 2020-04-08 | GlaxoSmithKline Biologicals S.A. | Methods for manufacturing an adjuvant |
| EP3717001A1 (en) | 2017-12-01 | 2020-10-07 | GlaxoSmithKline Biologicals S.A. | Saponin purification |
| CN109966170B (zh) * | 2018-02-13 | 2022-04-15 | 深圳高尚科美生物科技有限公司 | 包含生物大分子的柔性脂质体化妆品及其制备方法 |
| US20220235095A1 (en) | 2019-06-05 | 2022-07-28 | Glaxosmithkline Biologicals Sa | Saponin purification |
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| GB202318595D0 (en) * | 2023-12-05 | 2024-01-17 | Sec Dep For Environment Food And Rural Affairs Acting Through Animal And Plant Health Agency | Diagnostic proteins and reagents |
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| US9051890B2 (en) | 2013-10-28 | 2015-06-09 | Ford Global Technologies, Llc | Method for estimating charge air cooler condensation storage with an intake oxygen sensor |
| US9903268B2 (en) | 2015-04-02 | 2018-02-27 | Ford Global Technologies, Llc | Internal combustion engine with two-stage supercharging capability and with exhaust-gas aftertreatment arrangement, and method for operating an internal combustion engine |
| US9810514B2 (en) | 2015-09-08 | 2017-11-07 | Deufol Sunman Inc. | Ammunition carrier consumer package |
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2011
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