BR112012011539A8 - formulação para a combinação de hgh e rhigf-1 - Google Patents
formulação para a combinação de hgh e rhigf-1Info
- Publication number
- BR112012011539A8 BR112012011539A8 BR112012011539A BR112012011539A BR112012011539A8 BR 112012011539 A8 BR112012011539 A8 BR 112012011539A8 BR 112012011539 A BR112012011539 A BR 112012011539A BR 112012011539 A BR112012011539 A BR 112012011539A BR 112012011539 A8 BR112012011539 A8 BR 112012011539A8
- Authority
- BR
- Brazil
- Prior art keywords
- combination
- hgh
- formulation
- rhigf
- relates
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000009472 formulation Methods 0.000 title abstract 3
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 101150088952 IGF1 gene Proteins 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26185909P | 2009-11-17 | 2009-11-17 | |
| PCT/EP2010/006996 WO2011060922A1 (en) | 2009-11-17 | 2010-11-17 | Formulation for hgh and rhigf-1 combination |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112012011539A2 BR112012011539A2 (pt) | 2016-06-28 |
| BR112012011539A8 true BR112012011539A8 (pt) | 2017-12-26 |
Family
ID=43661042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012011539A BR112012011539A8 (pt) | 2009-11-17 | 2010-11-17 | formulação para a combinação de hgh e rhigf-1 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20120270782A1 (enExample) |
| EP (1) | EP2501367B1 (enExample) |
| JP (2) | JP6084036B2 (enExample) |
| KR (1) | KR101614983B1 (enExample) |
| CN (1) | CN102665691B (enExample) |
| AU (1) | AU2010321225B2 (enExample) |
| BR (1) | BR112012011539A8 (enExample) |
| CA (1) | CA2780554C (enExample) |
| ES (1) | ES2532007T3 (enExample) |
| IN (1) | IN2012DN02861A (enExample) |
| MX (1) | MX2012005195A (enExample) |
| RU (1) | RU2558821C2 (enExample) |
| UA (1) | UA108994C2 (enExample) |
| WO (1) | WO2011060922A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2532089T3 (es) | 2005-06-02 | 2015-03-24 | Ipsen Biopharmaceuticals, Inc. | GH e IGF-1 para el tratamiento de trastornos del crecimiento |
| JP6363949B2 (ja) * | 2011-07-25 | 2018-07-25 | サンド アクチェンゲゼルシャフト | 少なくとも中性塩および生物薬学的タンパク質を含む、水性製剤 |
| US9216219B2 (en) | 2012-06-12 | 2015-12-22 | Novartis Ag | Anti-BAFFR antibody formulation |
| CN104371019B (zh) | 2013-08-13 | 2019-09-10 | 鸿运华宁（杭州）生物医药有限公司 | 一种能与glp-1r特异性结合的抗体及其与glp-1的融合蛋白质 |
| CN114569716A (zh) * | 2014-10-23 | 2022-06-03 | 美国安进公司 | 降低药物制剂的粘度 |
| WO2016115561A1 (en) * | 2015-01-18 | 2016-07-21 | Biogen Ma Inc. | Formulations and screening of biological therapeutic agents |
| AU2016218759B2 (en) * | 2015-02-11 | 2021-11-25 | Gmax Biopharm Llc. | Stabilized solution preparation of pharmaceutical GLP-1R antibody fusion protein |
| EP3443346B1 (en) * | 2016-04-13 | 2023-08-30 | Medimmune, LLC | Use of amino acids as stabilizing compounds in pharmaceutical compositions containing high concentrations of protein-based therapeutic agents |
| US20210087236A1 (en) * | 2016-08-15 | 2021-03-25 | The University Of North Carolina At Chapel Hill | Tardigrade disordered proteins as protein stabilizers |
| US11459401B2 (en) | 2016-10-06 | 2022-10-04 | Amgen Inc. | Reduced viscosity protein pharmaceutical formulations |
| US10953074B2 (en) * | 2017-01-08 | 2021-03-23 | Richard D. Lippman | Composition and method for improving sensorineural hearing |
| JP7377596B2 (ja) | 2017-02-22 | 2023-11-10 | アムジエン・インコーポレーテツド | 低粘度、高濃度エボロクマブ製剤及びそれらの製造方法 |
| WO2021214688A1 (en) * | 2020-04-22 | 2021-10-28 | Zion Medical B.V. | Pharmaceutical compositions and anti-viral uses thereof |
| WO2022086953A1 (en) * | 2020-10-19 | 2022-04-28 | Oak Hill Bio Limited | Compositions suitable for use in neonates |
| US20240132511A1 (en) * | 2021-02-12 | 2024-04-25 | Neuren Pharmaceuticals Limited | Treatments of prader-willi syndrome |
| MX2024006318A (es) * | 2021-11-26 | 2024-08-14 | Genexine Inc | Formulacion para administracion de alta concentracion de proteina de fusion de hormona del crecimiento. |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL71991A (en) | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
| US5763394A (en) * | 1988-04-15 | 1998-06-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
| US5681814A (en) * | 1990-06-07 | 1997-10-28 | Genentech, Inc. | Formulated IGF-I Composition |
| US5126324A (en) | 1990-06-07 | 1992-06-30 | Genentech, Inc. | Method of enhancing growth in patients using combination therapy |
| US5374620A (en) * | 1990-06-07 | 1994-12-20 | Genentech, Inc. | Growth-promoting composition and its use |
| SE9201073D0 (sv) * | 1992-04-03 | 1992-04-03 | Kabi Pharmacia Ab | Protein formulation |
| DE69334134T2 (de) * | 1992-07-31 | 2007-12-20 | Genentech, Inc., South San Francisco | Wässrige Formulierung enthaltend Menschliches Wachstumshormon |
| US6207640B1 (en) * | 1994-04-07 | 2001-03-27 | Genentech, Inc. | Treatment of partial growth hormone insensitivity syndrome |
| KR19980701351A (ko) * | 1995-01-13 | 1998-05-15 | 슈타르 피아 | 성장호르몬 및 Ｘ-Ｌｙｓ를 함유하는 안정화된 약제조제물(A STABILIZED PHARMACEUTICAL FORMULATION COMPRISING A GROWTH HORMONE AND X-Lys |
| US6767892B1 (en) * | 1997-11-07 | 2004-07-27 | Chrion Corporation | Compositions providing for increased IGF-I solubility |
| AU1384799A (en) * | 1997-11-07 | 1999-05-31 | Chiron Corporation | Novel igf-i composition and its use |
| MXPA02000404A (es) * | 1999-07-12 | 2004-05-21 | Grandis Biotech Gmbh | Formulaciones de hormona de crecimiento. |
| ATE464062T1 (de) * | 1999-10-04 | 2010-04-15 | Novartis Vaccines & Diagnostic | Stabilisierte flüssige pharmazeutische zusammensetzung enthaltend tfpi |
| EP1478394B1 (en) * | 2002-02-27 | 2008-07-30 | Immunex Corporation | Stabilized TNFR-Fc composition comprising arginine |
| AR040529A1 (es) * | 2002-07-09 | 2005-04-13 | Grandis Biotech Gmbh | Formulaciones de hgh en alta concentracion que contienen 1,2-propilenglicol |
| ES2532089T3 (es) * | 2005-06-02 | 2015-03-24 | Ipsen Biopharmaceuticals, Inc. | GH e IGF-1 para el tratamiento de trastornos del crecimiento |
| KR20110128957A (ko) * | 2005-11-01 | 2011-11-30 | 와이어쓰 엘엘씨 | 약물 재구성 또는 희석을 위한 염화나트륨 용액 |
| BRPI0621841B8 (pt) * | 2006-07-06 | 2021-05-25 | Daewoong Co Ltd | formulação líquida |
| WO2009136568A1 (ja) * | 2008-05-08 | 2009-11-12 | 味の素株式会社 | タンパク質のリフォールディング方法 |
-
2010
- 2010-11-17 CN CN201080052050.4A patent/CN102665691B/zh not_active Expired - Fee Related
- 2010-11-17 WO PCT/EP2010/006996 patent/WO2011060922A1/en not_active Ceased
- 2010-11-17 ES ES10784450.8T patent/ES2532007T3/es active Active
- 2010-11-17 RU RU2012124985/15A patent/RU2558821C2/ru not_active IP Right Cessation
- 2010-11-17 AU AU2010321225A patent/AU2010321225B2/en not_active Ceased
- 2010-11-17 BR BR112012011539A patent/BR112012011539A8/pt not_active Application Discontinuation
- 2010-11-17 KR KR1020127015526A patent/KR101614983B1/ko not_active Expired - Fee Related
- 2010-11-17 US US13/513,858 patent/US20120270782A1/en not_active Abandoned
- 2010-11-17 JP JP2012539223A patent/JP6084036B2/ja not_active Expired - Fee Related
- 2010-11-17 UA UAA201207340A patent/UA108994C2/uk unknown
- 2010-11-17 MX MX2012005195A patent/MX2012005195A/es active IP Right Grant
- 2010-11-17 IN IN2861DEN2012 patent/IN2012DN02861A/en unknown
- 2010-11-17 CA CA2780554A patent/CA2780554C/en not_active Expired - Fee Related
- 2010-11-17 EP EP10784450.8A patent/EP2501367B1/en not_active Not-in-force
-
2015
- 2015-10-30 JP JP2015215192A patent/JP6143827B2/ja not_active Expired - Fee Related
-
2016
- 2016-09-30 US US15/281,361 patent/US20170143834A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2780554C (en) | 2017-08-15 |
| RU2012124985A (ru) | 2013-12-27 |
| JP6084036B2 (ja) | 2017-02-22 |
| AU2010321225A1 (en) | 2012-06-07 |
| EP2501367A1 (en) | 2012-09-26 |
| JP2016020395A (ja) | 2016-02-04 |
| IN2012DN02861A (enExample) | 2015-07-24 |
| CN102665691B (zh) | 2015-05-27 |
| KR101614983B1 (ko) | 2016-04-22 |
| MX2012005195A (es) | 2012-06-12 |
| CA2780554A1 (en) | 2011-05-26 |
| WO2011060922A1 (en) | 2011-05-26 |
| BR112012011539A2 (pt) | 2016-06-28 |
| KR20120104251A (ko) | 2012-09-20 |
| US20170143834A1 (en) | 2017-05-25 |
| JP2013510893A (ja) | 2013-03-28 |
| HK1175711A1 (en) | 2013-07-12 |
| AU2010321225B2 (en) | 2015-12-03 |
| CN102665691A (zh) | 2012-09-12 |
| ES2532007T3 (es) | 2015-03-23 |
| JP6143827B2 (ja) | 2017-06-07 |
| EP2501367B1 (en) | 2015-01-21 |
| RU2558821C2 (ru) | 2015-08-10 |
| UA108994C2 (uk) | 2015-07-10 |
| US20120270782A1 (en) | 2012-10-25 |
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| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.20 NA RPI NO 2529 DE 25/06/2019 POR TER SIDO INDEVIDA. |
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| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |