BR112012005423B1 - Composição farmacêutica compreendendo um componente relacionado a ácido hialurônico, seringa e método para sua fabricação - Google Patents

Composição farmacêutica compreendendo um componente relacionado a ácido hialurônico, seringa e método para sua fabricação Download PDF

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Publication number
BR112012005423B1
BR112012005423B1 BR112012005423-6A BR112012005423A BR112012005423B1 BR 112012005423 B1 BR112012005423 B1 BR 112012005423B1 BR 112012005423 A BR112012005423 A BR 112012005423A BR 112012005423 B1 BR112012005423 B1 BR 112012005423B1
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BR
Brazil
Prior art keywords
composition
harc
hyaluronic acid
tah
shelf life
Prior art date
Application number
BR112012005423-6A
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English (en)
Portuguese (pt)
Other versions
BR112012005423A2 (pt
Inventor
Grace Chang
Elizabeth Voschin
Li-Ping Yu
Eugene Skrabut
Original Assignee
Genzyme Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corporation filed Critical Genzyme Corporation
Publication of BR112012005423A2 publication Critical patent/BR112012005423A2/pt
Publication of BR112012005423B1 publication Critical patent/BR112012005423B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
BR112012005423-6A 2009-09-10 2010-08-10 Composição farmacêutica compreendendo um componente relacionado a ácido hialurônico, seringa e método para sua fabricação BR112012005423B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/556,869 US8273725B2 (en) 2009-09-10 2009-09-10 Stable hyaluronan/steroid formulation
US12/556,869 2009-09-10
PCT/US2010/044975 WO2011031402A1 (en) 2009-09-10 2010-08-10 Stable hyaluronan/steroid formulation

Publications (2)

Publication Number Publication Date
BR112012005423A2 BR112012005423A2 (pt) 2017-07-04
BR112012005423B1 true BR112012005423B1 (pt) 2022-09-13

Family

ID=43648224

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012005423-6A BR112012005423B1 (pt) 2009-09-10 2010-08-10 Composição farmacêutica compreendendo um componente relacionado a ácido hialurônico, seringa e método para sua fabricação

Country Status (8)

Country Link
US (2) US8273725B2 (https=)
EP (2) EP2475251B1 (https=)
JP (2) JP6121717B2 (https=)
CN (1) CN102573468B (https=)
AR (1) AR078281A1 (https=)
BR (1) BR112012005423B1 (https=)
MX (1) MX2012002830A (https=)
WO (1) WO2011031402A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2633978A1 (en) 2005-12-14 2007-06-21 Anika Therapeutics, Inc. Bioabsorbable implant of hyaluronic acid derivative for treatment of osteochondral and chondral defects
CN102573941B (zh) 2009-07-30 2014-10-29 卡比兰生物外科公司 改性透明质酸聚合物组合物和相关的方法
ES2537411T3 (es) 2011-04-20 2015-06-08 Carbylan Therapeutics, Inc. Composiciones formadoras de gel in situ
TWI424007B (zh) 2011-12-22 2014-01-21 Ind Tech Res Inst 使膠體交聯的方法與藉由此方法形成之經交聯的膠體
WO2014110454A1 (en) * 2013-01-11 2014-07-17 Carbylan Biosurgery, Inc. Stabilized compositions comprising hyaluronic acid
IT201600075246A1 (it) * 2016-07-19 2018-01-19 Jointherapeutics S R L Composizioni comprendenti una matrice polisaccaridica per il rilascio controllato di principi attivi.
CN106983733A (zh) * 2017-03-08 2017-07-28 江苏富泽药业有限公司 曲安奈德plga缓释微球注射剂、其制备方法及其在制备治疗骨关节炎疼痛药物中的应用
KR20190038368A (ko) 2017-09-29 2019-04-08 주식회사 엘지화학 히알루론산 기반 하이드로겔 약제학적 안정화 조성물 및 그 제조방법
CN118021719A (zh) * 2022-11-11 2024-05-14 北京华视诺维医疗科技有限公司 一种曲安奈德组合物及其制备方法
WO2025068242A1 (en) * 2023-09-25 2025-04-03 Hyamedix Dexamethasone delivery system

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US4582865A (en) 1984-12-06 1986-04-15 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
SE8501022L (sv) 1985-03-01 1986-09-02 Pharmacia Ab Format alster och forfarande for dess framstellning
US4713448A (en) 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
US4851521A (en) 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
IT1198449B (it) 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
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IT1260154B (it) 1992-07-03 1996-03-28 Lanfranco Callegaro Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)
US5616568A (en) 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
US5621093A (en) 1995-06-06 1997-04-15 Anika Research, Inc. Steam-sterilizing solid hyaluronic acid
US5827937A (en) 1995-07-17 1998-10-27 Q Med Ab Polysaccharide gel composition
TW577758B (en) 1997-10-27 2004-03-01 Ssp Co Ltd Intra-articular preparation for the treatment of arthropathy
SE9704186D0 (sv) 1997-11-14 1997-11-14 Astra Ab New composition of matter
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Also Published As

Publication number Publication date
CN102573468B (zh) 2015-05-20
EP2475251A4 (en) 2012-10-24
WO2011031402A1 (en) 2011-03-17
BR112012005423A2 (pt) 2017-07-04
EP3622820B1 (en) 2026-02-18
JP2013504570A (ja) 2013-02-07
JP2015172095A (ja) 2015-10-01
EP3622820A1 (en) 2020-03-18
US20110059918A1 (en) 2011-03-10
CN102573468A (zh) 2012-07-11
MX2012002830A (es) 2012-04-10
US8680073B2 (en) 2014-03-25
US20120316131A1 (en) 2012-12-13
EP2475251B1 (en) 2019-07-17
JP6121717B2 (ja) 2017-04-26
AR078281A1 (es) 2011-10-26
EP2475251A1 (en) 2012-07-18
US8273725B2 (en) 2012-09-25

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08G Application fees: restoration [chapter 8.7 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: A01N 43/04

Ipc: A61K 31/58 (2006.01), A61K 31/728 (2006.01), A61K

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07B Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 10/08/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.