BR0314670A - Métodos e composições de compostos de triazina - Google Patents
Métodos e composições de compostos de triazinaInfo
- Publication number
- BR0314670A BR0314670A BR0314670-7A BR0314670A BR0314670A BR 0314670 A BR0314670 A BR 0314670A BR 0314670 A BR0314670 A BR 0314670A BR 0314670 A BR0314670 A BR 0314670A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- present
- compositions
- methods
- smooth muscle
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical group C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 102100036597 Basement membrane-specific heparan sulfate proteoglycan core protein Human genes 0.000 abstract 2
- 230000028709 inflammatory response Effects 0.000 abstract 2
- 230000035755 proliferation Effects 0.000 abstract 2
- 210000002460 smooth muscle Anatomy 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 108090000054 Syndecan-2 Proteins 0.000 abstract 1
- -1 TRIAZINE COMPOUNDS Chemical class 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 108091005996 glycated proteins Proteins 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 230000004963 pathophysiological condition Effects 0.000 abstract 1
- 108010049224 perlecan Proteins 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract
"MéTODOS E COMPOSIçõES DE COMPOSTOS DE TRIAZINA". A presente invenção relaciona-se aos métodos e às composições compreendendo os compostos que tratam as condições fisiopatológicas que surgem de respostas inflamatórias. Em particular, a presente invenção é dirigida aos compostos que inibem ou bloqueiam a indução produzida por proteína glicada da resposta inflamatória associada à sinalização em células endoteliais. A presente invenção relaciona-se aos compostos que inibem a proliferação do músculo liso. Em particular, a presente invenção é dirigida aos compostos que inibem a proliferação das células do músculo liso por modulação dos HSPGs, tais como o Perlecan. A presente invenção adicionalmente relaciona-se ao uso de compostos para tratar condições oclusivas vasculares, caracterizadas por proliferação do músculo liso, tais como a reestenose e a aterosclerose.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US25338802A | 2002-09-23 | 2002-09-23 | |
US10/390,485 US7173032B2 (en) | 2001-09-21 | 2003-03-17 | Methods and compositions of novel triazine compounds |
PCT/US2003/009356 WO2004026844A1 (en) | 2002-09-23 | 2003-03-26 | Methods and compositions of novel triazine compounds |
Publications (1)
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BR0314670A true BR0314670A (pt) | 2005-08-09 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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BR0314670-7A BR0314670A (pt) | 2002-09-23 | 2003-03-26 | Métodos e composições de compostos de triazina |
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US (3) | US7173032B2 (pt) |
EP (1) | EP1560817A4 (pt) |
JP (2) | JP2006511476A (pt) |
AU (1) | AU2003231975A1 (pt) |
BR (1) | BR0314670A (pt) |
CA (1) | CA2499964A1 (pt) |
RU (1) | RU2005108351A (pt) |
WO (1) | WO2004026844A1 (pt) |
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EP1560817A4 (en) | 2011-05-11 |
RU2005108351A (ru) | 2006-02-27 |
JP2006188533A (ja) | 2006-07-20 |
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CA2499964A1 (en) | 2004-04-01 |
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WO2004026844A9 (en) | 2004-11-11 |
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JP2006511476A (ja) | 2006-04-06 |
EP1560817A1 (en) | 2005-08-10 |
AU2003231975A1 (en) | 2004-04-08 |
US20070099874A1 (en) | 2007-05-03 |
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