BR0313304A - Processo para a preparação de intermediários de antibiótico à base de quinolona - Google Patents
Processo para a preparação de intermediários de antibiótico à base de quinolonaInfo
- Publication number
- BR0313304A BR0313304A BR0313304-4A BR0313304A BR0313304A BR 0313304 A BR0313304 A BR 0313304A BR 0313304 A BR0313304 A BR 0313304A BR 0313304 A BR0313304 A BR 0313304A
- Authority
- BR
- Brazil
- Prior art keywords
- quinolone antibiotic
- preparation
- quinolone
- alkenyl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Quinoline Compounds (AREA)
Abstract
"PROCESSO PARA A PREPARAçãO DE INTERMEDIáRIOS DE ANTIBIóTICO à BASE DE QUINOLONA". A presente invenção refere-se a um processo para preparação de um intermediário de antibiótico à base de quinolona que tem a seguinte fórmula: sendo que R é alquila C~ 1~-C~ 2~, fluoroalquila C~ 1~-C~ 2~, alquenila C~ 2~-C~ 4~, metóxi, cloro ou bromo, R^ 1^ é uma unidade selecionada do grupo consistindo em alquila C~ 1~-C~ 2~, alquenila C~ 2~-C~ 3~, cicloalquila C~ 3~-C~ 5~ e fenila, sendo que cada uma destas pode ser substituída por um ou mais átomos de flúor, e sendo que o dito processo inclui a etapa de ciclização de uma mistura de precursores de quinolona, a qual contém um intermediário de 2-etóxi substituído que tem a seguinte fórmula: na presença de um agente sililante.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40118402P | 2002-08-05 | 2002-08-05 | |
| PCT/US2003/024258 WO2004013103A2 (en) | 2002-08-05 | 2003-08-05 | Process for preparing quinolone antibiotic intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0313304A true BR0313304A (pt) | 2005-06-14 |
Family
ID=31495936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0313304-4A BR0313304A (pt) | 2002-08-05 | 2003-08-05 | Processo para a preparação de intermediários de antibiótico à base de quinolona |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6803469B2 (pt) |
| EP (1) | EP1532114A2 (pt) |
| JP (1) | JP5035863B2 (pt) |
| CN (1) | CN100406443C (pt) |
| AU (1) | AU2003254303B2 (pt) |
| BR (1) | BR0313304A (pt) |
| CA (1) | CA2493287C (pt) |
| IL (1) | IL166133A (pt) |
| MA (1) | MA27287A1 (pt) |
| MX (1) | MXPA05001422A (pt) |
| NO (1) | NO331850B1 (pt) |
| NZ (1) | NZ537504A (pt) |
| PL (1) | PL375488A1 (pt) |
| RU (1) | RU2289576C2 (pt) |
| WO (1) | WO2004013103A2 (pt) |
| ZA (1) | ZA200501380B (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004108680A1 (ja) * | 2003-06-06 | 2004-12-16 | Daiichi Pharmaceutical Co., Ltd. | 光学活性なキノロンカルボン酸誘導体の製造中間体およびその製造法 |
| AR054608A1 (es) | 2005-08-08 | 2007-06-27 | Actelion Pharmaceuticals Ltd | Derivados de oxazolidinona enlazados a quinolonas como antibacterianos |
| BRPI0709772B8 (pt) * | 2006-03-28 | 2021-05-25 | The Protecter & Gamble Company | sais de malato e polimorfos do ácido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-diidro-8-metóxi-4-oxo-3-quinolinocarboxílico |
| US7528264B2 (en) * | 2006-03-28 | 2009-05-05 | The Procter & Gamble Company | Hydride reduction process for preparing quinolone intermediates |
| BRPI0709220A2 (pt) * | 2006-03-28 | 2011-07-12 | Procter & Gamble | processo de acoplamento para preparo de intermediários de quinolona |
| WO2008033836A2 (en) | 2006-09-12 | 2008-03-20 | Gilead Sciences, Inc. | Process and intermediates for preparing integrase inhibitors |
| US8658183B2 (en) | 2007-08-09 | 2014-02-25 | Taigen Biotechnology Company, Ltd. | Antimicrobial parenteral formulation |
| AR068403A1 (es) | 2007-09-11 | 2009-11-18 | Gilead Sciences Inc | Proceso e intermediarios para la preparacion de inhibidores de integrasa |
| EP2303271B1 (en) | 2008-07-01 | 2018-11-07 | Taigen Biotechnology Co., Ltd. | Treatment of antibiotic-resistant bacteria infection |
| WO2013157018A1 (en) | 2012-04-18 | 2013-10-24 | Indian Institute Of Technology Madras | A process for the preparation of the core structure in quinolone and napthyridone class of antibiotics |
| EP2880017B1 (en) | 2012-08-03 | 2016-10-05 | Gilead Sciences, Inc. | Process and intermediates for preparing integrase inhibitors |
| ITUB20151256A1 (it) * | 2015-05-28 | 2016-11-28 | Olon Spa | Processo industriale per la preparazione di enzalutamide |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3501247A1 (de) * | 1985-01-16 | 1986-07-17 | Bayer Ag, 5090 Leverkusen | Aminoacrylsaeure-derivate |
| AU3154095A (en) | 1994-08-02 | 1996-03-04 | Procter & Gamble Company, The | Process for making quinolonyl lactam antimicrobials and novel intermediate compounds |
| NZ290721A (en) | 1994-08-02 | 1999-03-29 | Procter & Gamble | Process for making quinolone-containing antimicrobial compounds |
| WO2002048113A1 (en) | 2000-12-14 | 2002-06-20 | The Procter & Gamble Company | Cyclization process step in the making of quinolones and naphthyridines |
-
2003
- 2003-07-30 US US10/630,608 patent/US6803469B2/en not_active Expired - Lifetime
- 2003-08-05 RU RU2005106247/04A patent/RU2289576C2/ru active
- 2003-08-05 CA CA2493287A patent/CA2493287C/en not_active Expired - Lifetime
- 2003-08-05 AU AU2003254303A patent/AU2003254303B2/en not_active Expired
- 2003-08-05 EP EP03767106A patent/EP1532114A2/en not_active Ceased
- 2003-08-05 BR BR0313304-4A patent/BR0313304A/pt not_active IP Right Cessation
- 2003-08-05 WO PCT/US2003/024258 patent/WO2004013103A2/en active Application Filing
- 2003-08-05 NZ NZ537504A patent/NZ537504A/en not_active IP Right Cessation
- 2003-08-05 PL PL03375488A patent/PL375488A1/xx not_active Application Discontinuation
- 2003-08-05 CN CNB038170124A patent/CN100406443C/zh not_active Expired - Lifetime
- 2003-08-05 JP JP2004526355A patent/JP5035863B2/ja not_active Expired - Lifetime
- 2003-08-05 MX MXPA05001422A patent/MXPA05001422A/es active IP Right Grant
-
2005
- 2005-01-04 IL IL166133A patent/IL166133A/en not_active IP Right Cessation
- 2005-01-31 MA MA28078A patent/MA27287A1/fr unknown
- 2005-02-16 ZA ZA2005/01380A patent/ZA200501380B/en unknown
- 2005-03-02 NO NO20051126A patent/NO331850B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA05001422A (es) | 2005-04-11 |
| CN100406443C (zh) | 2008-07-30 |
| JP5035863B2 (ja) | 2012-09-26 |
| WO2004013103A2 (en) | 2004-02-12 |
| CA2493287A1 (en) | 2004-02-12 |
| MA27287A1 (fr) | 2005-04-01 |
| US6803469B2 (en) | 2004-10-12 |
| IL166133A0 (en) | 2006-01-15 |
| NZ537504A (en) | 2006-11-30 |
| AU2003254303B2 (en) | 2007-11-01 |
| JP2005538119A (ja) | 2005-12-15 |
| NO331850B1 (no) | 2012-04-23 |
| US20040063952A1 (en) | 2004-04-01 |
| RU2005106247A (ru) | 2005-08-10 |
| EP1532114A2 (en) | 2005-05-25 |
| WO2004013103A3 (en) | 2004-04-08 |
| RU2289576C2 (ru) | 2006-12-20 |
| CN1668599A (zh) | 2005-09-14 |
| ZA200501380B (en) | 2005-11-30 |
| AU2003254303A1 (en) | 2004-02-23 |
| CA2493287C (en) | 2011-01-11 |
| NO20051126L (no) | 2005-03-02 |
| PL375488A1 (en) | 2005-11-28 |
| IL166133A (en) | 2011-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014. |