BR0312658A - Derivados de cinamida - Google Patents

Derivados de cinamida

Info

Publication number
BR0312658A
BR0312658A BR0312658-7A BR0312658A BR0312658A BR 0312658 A BR0312658 A BR 0312658A BR 0312658 A BR0312658 A BR 0312658A BR 0312658 A BR0312658 A BR 0312658A
Authority
BR
Brazil
Prior art keywords
derivatives
cinamide
phenyl
propinamido
mao
Prior art date
Application number
BR0312658-7A
Other languages
English (en)
Inventor
Synese Jolidon
Rosa Maria Rodriguez Sarmiento
Andrew William Thomas
Rene Wyler
Wolfgang Wostl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0312658A publication Critical patent/BR0312658A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"DERIVADOS DE CINAMIDA". A presente invenção refere-se a derivados de 3-fenil-propionamido, 3-fenil-acrilamido e 3-fenil-propinamido, processos para sua preparação, composições contendo os mesmos e os usos dos referidos derivados como inibidores da MAO-B.
BR0312658-7A 2002-07-15 2003-07-07 Derivados de cinamida BR0312658A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02015583 2002-07-15
PCT/EP2003/007231 WO2004007429A1 (en) 2002-07-15 2003-07-07 Cinnamide derivatives

Publications (1)

Publication Number Publication Date
BR0312658A true BR0312658A (pt) 2005-04-26

Family

ID=30011071

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0312658-7A BR0312658A (pt) 2002-07-15 2003-07-07 Derivados de cinamida

Country Status (20)

Country Link
US (1) US6900354B2 (pt)
EP (1) EP1523469B1 (pt)
JP (1) JP4108679B2 (pt)
KR (1) KR20050029206A (pt)
CN (1) CN1305838C (pt)
AR (1) AR040489A1 (pt)
AT (1) ATE410407T1 (pt)
AU (1) AU2003281030B2 (pt)
BR (1) BR0312658A (pt)
CA (1) CA2493372A1 (pt)
DE (1) DE60323981D1 (pt)
ES (1) ES2314219T3 (pt)
MX (1) MXPA05000583A (pt)
PA (1) PA8577201A1 (pt)
PE (1) PE20040667A1 (pt)
PL (1) PL373390A1 (pt)
RU (1) RU2318802C2 (pt)
TW (1) TW200404760A (pt)
UY (1) UY27894A1 (pt)
WO (1) WO2004007429A1 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1588704A1 (en) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
TWI335816B (en) 2004-05-26 2011-01-11 Eisai R&D Man Co Ltd Cinnamide compound
ATE458729T1 (de) * 2004-10-26 2010-03-15 Eisai R&D Man Co Ltd Amorphe form einer zimtsäureamidverbindung
EP2281556A1 (en) 2005-02-25 2011-02-09 F. Hoffmann-La Roche AG Tablets with improved drugs substance dispersibility
US8022249B2 (en) 2005-04-01 2011-09-20 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US8138209B2 (en) * 2005-07-13 2012-03-20 Jenrin Discovery, Inc. Substituted picolinamides as MAO-B inhibitors useful for treating obesity
PL209602B1 (pl) 2005-10-20 2011-09-30 Inst Chemii Bioorg Pan Sposób otrzymywania amidu kwasu 3-(4-hydroksyfenylo)propanowego
AU2006316005A1 (en) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. Process for production of cinnamamide derivative
US20090048448A1 (en) * 2005-11-18 2009-02-19 Ikuo Kushida Salts of cynnamide compound or solvates thereof
MY144960A (en) 2005-11-24 2011-11-30 Eisai R&D Man Co Ltd Morpholine type cinnamide compound
TWI370130B (en) * 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
ZA200803939B (en) * 2005-11-24 2009-10-28 Eisai R&D Man Co Ltd Morpholine type cinnamide compound
TWI378091B (en) * 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
AR062095A1 (es) * 2006-07-28 2008-10-15 Eisai R&D Man Co Ltd Profarmaco de compuesto cinamida
PE20081791A1 (es) * 2007-02-28 2009-02-07 Eisai Randd Man Co Ltd Dos derivados ciclicos de oxomorfolina
CA2687262A1 (en) * 2007-05-16 2008-11-20 Naoyuki Shimomura One-pot production process for cinnamide derivative
US7986144B2 (en) * 2007-07-26 2011-07-26 Schlumberger Technology Corporation Sensor and insulation layer structure for well logging instruments
US7935815B2 (en) * 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
US9453000B2 (en) 2007-08-31 2016-09-27 Eisai R&D Management Co., Ltd. Polycyclic compound
JPWO2009096349A1 (ja) * 2008-01-28 2011-05-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 結晶性のシンナミド化合物またはその塩
NL2005655A (en) 2009-12-09 2011-06-14 Asml Netherlands Bv A lithographic apparatus and a device manufacturing method.
CN104030941B (zh) * 2014-06-23 2016-04-27 常州大学 一种3-（4-羟基苯基）丙酰胺的合成方法
CN107011313B (zh) * 2016-01-27 2021-11-30 天士力医药集团股份有限公司 取代桂皮酰胺衍生物在制备抗焦虑药物中的应用
MX2020007394A (es) 2018-01-10 2020-09-03 Brightseed Inc Metodo para modular el metabolismo.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2645019A1 (pt) * 1989-03-30 1990-10-05 Fournier Innovation Synergie
US5679715A (en) 1995-06-07 1997-10-21 Harris; Richard Y. Method for treating multiple sclerosis
US6239181B1 (en) 1996-03-15 2001-05-29 Somerset Pharmaceuticals, Inc. Method for preventing and treating peripheral neurophathy by administering selegiline
WO2001034172A2 (en) 1999-11-05 2001-05-17 Vela Pharmaceuticals Inc. Methods and compositions for treating reward deficiency syndrome

Also Published As

Publication number Publication date
EP1523469A1 (en) 2005-04-20
CN1305838C (zh) 2007-03-21
US6900354B2 (en) 2005-05-31
ATE410407T1 (de) 2008-10-15
EP1523469B1 (en) 2008-10-08
CA2493372A1 (en) 2004-01-22
PE20040667A1 (es) 2004-09-25
RU2318802C2 (ru) 2008-03-10
PA8577201A1 (es) 2004-02-07
US20040034096A1 (en) 2004-02-19
CN1665774A (zh) 2005-09-07
KR20050029206A (ko) 2005-03-24
RU2005104104A (ru) 2005-10-10
DE60323981D1 (de) 2008-11-20
JP4108679B2 (ja) 2008-06-25
PL373390A1 (en) 2005-08-22
TW200404760A (en) 2004-04-01
ES2314219T3 (es) 2009-03-16
JP2005533092A (ja) 2005-11-04
WO2004007429A1 (en) 2004-01-22
AU2003281030A1 (en) 2004-02-02
UY27894A1 (es) 2003-12-31
AR040489A1 (es) 2005-04-06
AU2003281030B2 (en) 2009-05-28
MXPA05000583A (es) 2005-04-19

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2157 DE 08/05/2012.