BR0308407A - Compostos de quinazolina úteis em terapia - Google Patents
Compostos de quinazolina úteis em terapiaInfo
- Publication number
- BR0308407A BR0308407A BR0308407-8A BR0308407A BR0308407A BR 0308407 A BR0308407 A BR 0308407A BR 0308407 A BR0308407 A BR 0308407A BR 0308407 A BR0308407 A BR 0308407A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- het
- cycloalkyl
- optionally substituted
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
"COMPOSTOS DE QUINAZOLINA úTEIS EM TERAPIA". Compostos de fórmula (I) ou seus sais ou solvatos farmaceuticamente aceitáveis, em que: R^ 1^ representa alquila-C~ 1-4~; R^ 2^ representa halogênio, alquila-C~ 1-4~, cicloalquila-C~ 3-6~, cicloalquilóxi-C~ 3-6~, -SO~ 2~(alquila-C~ 1-4~), alquilóxi-C~ 1-4~ opcionalmente substituído, Het ou -OHet; R^ 3^ representa um grupo bicíclico de fórmula em que X e Y são selecionados de C e N, desde que pelo menos um deles seja C; O anel A em conjunto com X e Y representa um anel aromático de 5 ou 6 membros que contém 0, 1, 2 ou 3 átomos de azoto no anel; n é 0, 1 ou 2; L representa uma ligação direta, alquileno-C~ 1-4~ ou alcoxialquileno-C~ 1-4~; R^ 4^ representa H, -NR^ 5^R^ 6^ cicloalquila-C~ 3-6~, -OR^ 7^, Het^ 1^ ou Het^ 4^; R^ 5^ e R^ 6^ são selecionados de forma independente de H, cicloalquila-C~ 3-6~, cicloalquila-C~ 3-6~-alquileno-C~ 1-4~, -SO~ 2~ (alquila-C~ 1-4~) e alquila-C~ 1-4~ opcionalmente substituído; R^ 7^ é-selecionado de H, alquila-C~ 1-4~, alcoxialquila-C~ 1-4~, cicloalquila-C~ 3-6~, Het^ 2^ e alquila-C~ 1-4~-Het^ 3^; R^ 8^ é H ou alquila-C~ 1-4~-; Het, Het^ 1^ Het^ 2^ e Het~ 3^ representam de forma independente um grupo heterocíclico saturado de 4 a 7 membros opcionalmente substituído que pode ser mono- ou bicíclico e que contém um ou mais heteroátomos selecionados de N, O ou S; Het^ 4^ representa um grupo heterocíclico, insaturado de 5 ou 6 membros opcionalmente substituído que contém um ou mais heteroátomos selecionados de N, O ou S; R^ 9^ é H ou alquila-C~ 1-4~; R^ 10^ e R^ 11^ são selecionados de forma independente de H e alquila-C~ 1-4~; são úteis para o tratamento de hipertensão, enfarto do miocárdio, disfunção eréctil masculina (MED), hiperlipidemia, arritmia cardíaca, glaucoma e hiperplasia prostática benigna (BPH). São igualmente úteis para o tratamento da disfunção da excitação sexual feminina (FSAD).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0206033.3A GB0206033D0 (en) | 2002-03-14 | 2002-03-14 | Compounds useful in therapy |
PCT/IB2003/000998 WO2003076427A1 (en) | 2002-03-14 | 2003-03-05 | Quinazoline compounds useful in therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0308407A true BR0308407A (pt) | 2005-01-11 |
Family
ID=9932974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0308407-8A BR0308407A (pt) | 2002-03-14 | 2003-03-05 | Compostos de quinazolina úteis em terapia |
Country Status (19)
Country | Link |
---|---|
US (1) | US6936619B2 (pt) |
EP (1) | EP1483257B1 (pt) |
JP (1) | JP2005532275A (pt) |
AR (1) | AR038949A1 (pt) |
AT (1) | ATE339414T1 (pt) |
AU (1) | AU2003209594A1 (pt) |
BR (1) | BR0308407A (pt) |
CA (1) | CA2479016A1 (pt) |
DE (1) | DE60308332T2 (pt) |
ES (1) | ES2271618T3 (pt) |
GB (1) | GB0206033D0 (pt) |
GT (1) | GT200300059A (pt) |
HN (1) | HN2003000100A (pt) |
MX (1) | MXPA04008939A (pt) |
PA (1) | PA8569501A1 (pt) |
PE (1) | PE20040265A1 (pt) |
TW (1) | TW200305420A (pt) |
UY (1) | UY27711A1 (pt) |
WO (1) | WO2003076427A1 (pt) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6900220B2 (en) * | 2001-01-02 | 2005-05-31 | Syntex (U.S.A.) Llc | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists |
ES2270143T3 (es) * | 2002-08-07 | 2007-04-01 | Novartis Ag | Compuestos organicos como agentes para el tratamiento de condiciones mediadas por aldosterona. |
US20040132728A1 (en) * | 2002-09-17 | 2004-07-08 | Pfizer Inc | Combinations of atorvastatin and alpha1adrenergic receptor antagonists |
GB0221579D0 (en) * | 2002-09-17 | 2002-10-23 | Pfizer Ltd | Combinations of atorvastatin and, adrenergic receptor antagonists |
GB0225908D0 (en) * | 2002-11-06 | 2002-12-11 | Pfizer Ltd | Treatment of female sexual dysfunction |
AU2004255585A1 (en) * | 2003-07-02 | 2005-01-20 | F. Hoffmann-La Roche Ag | 5-substituted quinazolinone derivatives |
TW200530235A (en) | 2003-12-24 | 2005-09-16 | Renovis Inc | Bicycloheteroarylamine compounds as ion channel ligands and uses thereof |
WO2005089804A2 (en) * | 2004-03-16 | 2005-09-29 | Pfizer Limited | Combinations of hmg-coa reductase inhibitors and alpha1 adrenergic receptor antagonists |
EP1595881A1 (en) * | 2004-05-12 | 2005-11-16 | Pfizer Limited | Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands |
US7793137B2 (en) | 2004-10-07 | 2010-09-07 | Cisco Technology, Inc. | Redundant power and data in a wired data telecommunincations network |
FR2870846B1 (fr) | 2004-05-25 | 2006-08-04 | Sanofi Synthelabo | Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique |
US7402596B2 (en) | 2005-03-24 | 2008-07-22 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
CA2606760C (en) | 2005-05-04 | 2014-12-23 | Renovis, Inc. | Tetrahydronaphthyridine and tetrahydropyrido[4,3-d]pyrimidine compounds and compositions thereof useful in the treatment of conditions associated with neurological and inflammatory disorders and disfunctions |
EP1790646A1 (fr) * | 2005-11-24 | 2007-05-30 | Sanofi-Aventis | Derives de Isoquinoline et Benzo[h]Isoquinoline, leur preparation et leur utilisation en thérapeutique en tant qu'antagonistes du recepteur de l'histamine H3. |
PT2118074E (pt) | 2007-02-01 | 2014-03-20 | Resverlogix Corp | Compostos para a prevenção e tratamento de doenças cardiovasculares |
US20080186971A1 (en) * | 2007-02-02 | 2008-08-07 | Tarari, Inc. | Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic |
WO2008123963A1 (en) | 2007-04-02 | 2008-10-16 | Renovis, Inc. | Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof |
ES2427999T3 (es) | 2007-04-17 | 2013-11-05 | Evotec Ag | Compuestos heterocíclicos 2-cianofenil-condensados y composiciones y usos de los mismos |
US9603848B2 (en) | 2007-06-08 | 2017-03-28 | Senomyx, Inc. | Modulation of chemosensory receptors and ligands associated therewith |
US7928111B2 (en) * | 2007-06-08 | 2011-04-19 | Senomyx, Inc. | Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors |
US8859538B2 (en) * | 2007-06-21 | 2014-10-14 | Cara Therapeutics, Inc. | Uses of substituted imidazoheterocycles |
MY146924A (en) | 2007-06-21 | 2012-10-15 | Cara Therapeutics Inc | Substituted imidazoheterocycles |
WO2009011904A1 (en) * | 2007-07-19 | 2009-01-22 | Renovis, Inc. | Compounds useful as faah modulators and uses thereof |
CN101417999A (zh) * | 2007-10-25 | 2009-04-29 | 上海恒瑞医药有限公司 | 哌嗪类衍生物,其制备方法及其在医药上的应用 |
WO2009063992A1 (ja) | 2007-11-15 | 2009-05-22 | Takeda Pharmaceutical Company Limited | 縮合ピリジン誘導体およびその用途 |
WO2010014666A2 (en) | 2008-07-31 | 2010-02-04 | Senomyx, Inc. | Processes and intermediates for making sweet taste enhancers |
CA3146333A1 (en) | 2009-03-18 | 2010-09-23 | Resverlogix Corp. | Phenyl-quinazolin-4(3h)-one and phenyl-pyrido[2,3-d]pyrimidin-4(3h)-one derivatives and compositions thereof useful as anti-inflammatory agents |
LT2421533T (lt) | 2009-04-22 | 2018-12-27 | Resverlogix Corp. | Nauji priešuždegiminiai agentai |
US8691827B2 (en) | 2009-08-17 | 2014-04-08 | Merck Sharp & Dohme Corp. | Amino tetrahydro-pyridopyrimidine PDE10 inhibitors |
EP2766345B1 (en) | 2011-10-14 | 2016-03-16 | Bristol-Myers Squibb Company | Substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
PE20191204A1 (es) | 2012-08-06 | 2019-09-10 | Firmenich Incorporated | Modificador del sabor dulce |
WO2014060852A2 (en) * | 2012-10-15 | 2014-04-24 | Resverlogix Corp. | Compounds useful in the synthesis of benzamide compounds |
JO3155B1 (ar) | 2013-02-19 | 2017-09-20 | Senomyx Inc | معدِّل نكهة حلوة |
TN2016000254A1 (en) * | 2013-12-20 | 2017-10-06 | Esteve Labor Dr | Fused imidazolyl derivatives, their preparation and use as medicaments. |
CA2943889A1 (en) * | 2014-05-28 | 2015-12-03 | F. Hoffmann-La Roche Ag | 5-oxa-2-azabicyclo[2.2.2]octan-4-yl and 5-oxa-2-azabicyclo[2.2.1]heptan-4-yl derivatives as taar1 modulators |
WO2016147053A1 (en) | 2015-03-13 | 2016-09-22 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
CN105153048B (zh) * | 2015-07-31 | 2017-10-24 | 苏州大学 | 一种2,4‑喹唑啉二酮类化合物的制备方法 |
CN105237455A (zh) * | 2015-10-14 | 2016-01-13 | 湖南华腾制药有限公司 | 一种3-取代氮杂环丁烷的制备方法 |
MY196319A (en) | 2015-12-17 | 2023-03-24 | Merck Patent Gmbh | Polycyclic TLR7/8 Antagonists and use Thereof in the Treatment of Immune Disorders |
JP6950534B2 (ja) * | 2016-01-29 | 2021-10-13 | 小野薬品工業株式会社 | テトラヒドロナフタレン誘導体 |
WO2018031434A1 (en) * | 2016-08-08 | 2018-02-15 | Merck Patent Gmbh | Tlr7/8 antagonists and uses thereof |
WO2020033420A1 (en) | 2018-08-07 | 2020-02-13 | Firmenich Incorporated | 5-substituted 4-amino-1h-benzo[c][1,2,6]thiadiazine 2,2-dioxides and formulations and uses thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4085213A (en) * | 1976-01-28 | 1978-04-18 | Pfizer Inc. | Tetrazolo[A]quinazol-5-ones antiallergy and antiulcer agents |
GB9526546D0 (en) * | 1995-12-23 | 1996-02-28 | Pfizer Ltd | Compounds useful in therapy |
GB9700504D0 (en) * | 1997-01-11 | 1997-02-26 | Pfizer Ltd | Pharmaceutical compounds |
CN1237060C (zh) * | 2001-01-02 | 2006-01-18 | 弗·哈夫曼-拉罗切有限公司 | 用作α1A/B肾上腺素能受体拮抗剂的喹唑酮衍生物 |
-
2002
- 2002-03-14 GB GBGB0206033.3A patent/GB0206033D0/en not_active Ceased
-
2003
- 2003-03-05 BR BR0308407-8A patent/BR0308407A/pt not_active IP Right Cessation
- 2003-03-05 ES ES03743965T patent/ES2271618T3/es not_active Expired - Lifetime
- 2003-03-05 DE DE60308332T patent/DE60308332T2/de not_active Expired - Fee Related
- 2003-03-05 JP JP2003574644A patent/JP2005532275A/ja not_active Withdrawn
- 2003-03-05 AU AU2003209594A patent/AU2003209594A1/en not_active Abandoned
- 2003-03-05 EP EP03743965A patent/EP1483257B1/en not_active Expired - Lifetime
- 2003-03-05 WO PCT/IB2003/000998 patent/WO2003076427A1/en active IP Right Grant
- 2003-03-05 MX MXPA04008939A patent/MXPA04008939A/es unknown
- 2003-03-05 AT AT03743965T patent/ATE339414T1/de not_active IP Right Cessation
- 2003-03-05 CA CA002479016A patent/CA2479016A1/en not_active Abandoned
- 2003-03-11 UY UY27711A patent/UY27711A1/es not_active Application Discontinuation
- 2003-03-11 PE PE2003000247A patent/PE20040265A1/es not_active Application Discontinuation
- 2003-03-12 US US10/387,106 patent/US6936619B2/en not_active Expired - Fee Related
- 2003-03-12 AR ARP030100858A patent/AR038949A1/es unknown
- 2003-03-13 TW TW092105474A patent/TW200305420A/zh unknown
- 2003-03-13 HN HN2003000100A patent/HN2003000100A/es unknown
- 2003-03-14 PA PA20038569501A patent/PA8569501A1/es unknown
- 2003-03-14 GT GT200300059A patent/GT200300059A/es unknown
Also Published As
Publication number | Publication date |
---|---|
MXPA04008939A (es) | 2004-11-26 |
CA2479016A1 (en) | 2003-09-18 |
DE60308332D1 (de) | 2006-10-26 |
PE20040265A1 (es) | 2004-05-01 |
GT200300059A (es) | 2003-10-15 |
GB0206033D0 (en) | 2002-04-24 |
EP1483257B1 (en) | 2006-09-13 |
EP1483257A1 (en) | 2004-12-08 |
UY27711A1 (es) | 2003-10-31 |
WO2003076427A1 (en) | 2003-09-18 |
US6936619B2 (en) | 2005-08-30 |
ES2271618T3 (es) | 2007-04-16 |
HN2003000100A (es) | 2003-12-15 |
ATE339414T1 (de) | 2006-10-15 |
DE60308332T2 (de) | 2007-01-11 |
PA8569501A1 (es) | 2003-12-10 |
AU2003209594A1 (en) | 2003-09-22 |
US20040029859A1 (en) | 2004-02-12 |
TW200305420A (en) | 2003-11-01 |
JP2005532275A (ja) | 2005-10-27 |
AR038949A1 (es) | 2005-02-02 |
WO2003076427A8 (en) | 2004-10-07 |
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