BR0307408A - Tripeptìdeos tendo um éter de hidroxipolina de uma quinolina substituìda para a inibição de ns3 (hepatite c) - Google Patents

Tripeptìdeos tendo um éter de hidroxipolina de uma quinolina substituìda para a inibição de ns3 (hepatite c)

Info

Publication number
BR0307408A
BR0307408A BR0307408-0A BR0307408A BR0307408A BR 0307408 A BR0307408 A BR 0307408A BR 0307408 A BR0307408 A BR 0307408A BR 0307408 A BR0307408 A BR 0307408A
Authority
BR
Brazil
Prior art keywords
cycloalkyl
alkyl
inhibition
ether
hydroxypoline
Prior art date
Application number
BR0307408-0A
Other languages
English (en)
Inventor
Montse Llinas-Brunet
Vida J Gorys
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BR0307408A publication Critical patent/BR0307408A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

"TRIPEPTìDEOS TENDO UM éTER DE HIDROXIPROLINA DE UMA QUINOLINA SUBSTITUìDA PARA A INIBIçãO DE NS3 (HEPATITE C)". São descritos aqui os compostos de formula (1): em que R^ 1^ é hidróxi ou NHSO~ 2~R^ 1A~ em que R^ 1A^ é (C~ 1-8~)alquila, (C~ 3-7~)cicloalquila ou {(C~ 1-6~)alquil-(C~ 3-7~)cicloalquila}, que são todos opcionalmente substituídos de 1 a 3 vezes com halo, ciano, nitro, O-(C~ 1-6~,)alquila, amido, amino ou fenila, ou R^ 1A^ é C~ 6~ ou C~ 10~ arila que é opcionalmente substituída de 1 to 3 vezes por halo, ciano, nitro, (C~ 1-6~)alquila, O-(C~ 1-6~) alquila, amido, amino ou fenila; R^ 2^ é (C~ 4-6~)cicloalquila; R^ 3^ é t-butila ou (C~ 5-6~) cicloalquila e R^ 4^ é (C~ 4-6~) cicloalquila; ou um sal farmaceuticamente aceitável destes. Os compostos são úteis como inibidores de NS3 protease de HCV.
BR0307408-0A 2002-02-01 2003-01-24 Tripeptìdeos tendo um éter de hidroxipolina de uma quinolina substituìda para a inibição de ns3 (hepatite c) BR0307408A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002370396A CA2370396A1 (en) 2002-02-01 2002-02-01 Hepatitis c inhibitor tri-peptides
PCT/CA2003/000090 WO2003064456A1 (en) 2002-02-01 2003-01-24 Tripeptides having a hydroxyproline ether of a substituted quinoline for the inhibition of ns3 (hepatitis c)

Publications (1)

Publication Number Publication Date
BR0307408A true BR0307408A (pt) 2004-12-28

Family

ID=27626587

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0307408-0A BR0307408A (pt) 2002-02-01 2003-01-24 Tripeptìdeos tendo um éter de hidroxipolina de uma quinolina substituìda para a inibição de ns3 (hepatite c)

Country Status (30)

Country Link
EP (1) EP1474441B1 (pt)
JP (1) JP4060801B2 (pt)
KR (1) KR20040097990A (pt)
CN (1) CN100430414C (pt)
AR (1) AR038383A1 (pt)
AT (1) ATE358137T1 (pt)
AU (1) AU2003202347B2 (pt)
BR (1) BR0307408A (pt)
CA (1) CA2370396A1 (pt)
CO (1) CO5611113A2 (pt)
DE (1) DE60312824T2 (pt)
DK (1) DK1474441T3 (pt)
EA (1) EA007742B1 (pt)
EC (1) ECSP045226A (pt)
ES (1) ES2285085T3 (pt)
HR (1) HRP20040697A2 (pt)
IL (1) IL163130A (pt)
MX (1) MXPA04007515A (pt)
MY (1) MY127791A (pt)
NO (1) NO20043643L (pt)
NZ (1) NZ534689A (pt)
PE (1) PE20031012A1 (pt)
PL (1) PL371324A1 (pt)
RS (1) RS67204A (pt)
SA (1) SA03240005B1 (pt)
TW (1) TW200400199A (pt)
UA (1) UA77758C2 (pt)
UY (1) UY27636A1 (pt)
WO (1) WO2003064456A1 (pt)
ZA (1) ZA200405933B (pt)

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