CO5611113A2 - Tripeptidos que poseen un eter de hidroxiprolina de una quinolina sustituida para la inhibicion de ns3 (hepatitis c) - Google Patents

Tripeptidos que poseen un eter de hidroxiprolina de una quinolina sustituida para la inhibicion de ns3 (hepatitis c)

Info

Publication number
CO5611113A2
CO5611113A2 CO04085344A CO04085344A CO5611113A2 CO 5611113 A2 CO5611113 A2 CO 5611113A2 CO 04085344 A CO04085344 A CO 04085344A CO 04085344 A CO04085344 A CO 04085344A CO 5611113 A2 CO5611113 A2 CO 5611113A2
Authority
CO
Colombia
Prior art keywords
alkyl
compound
formula
hydroxiprolin
eter
Prior art date
Application number
CO04085344A
Other languages
English (en)
Inventor
Montse Llinas-Brune
J Gorys Vida
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of CO5611113A2 publication Critical patent/CO5611113A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

1.- Un compuesto de fórmula ( I ): en la que R1 es hidroxi o NHSO2R1A en donde R1A es alquilo (C1-8), cicloalquilo (C3-7) o (alquilo (C1-6) -cicloalquilo (C3-7)), que están todos opcionalmente sustituidos de 1 a 3 veces con halo, ciano, nitro, O-alquilo (C1-6), amido, amino o fenilo, o R1A es arilo de C6 o C10 que está opcionalmente sustituido de 1 a 3 veces con halo, ciano, nitro, alquilo (C1-6), O-alquilo (C1-6), amido, amino o fenilo; R2 es cicloalquilo (C4-6); R3 es t-butilo o cicloalquilo (C5-6) y R4 es cicloalquilo (C4-6), o una sal farmacéuticamente aceptable del mismo.2.- El compuesto de fórmula I según la reivindicación 1, en el que R1 es hidroxi, NHSO2Me, NHSO2-ciclopropilo o NHSO2 - Ph .3.- El compuesto de fórmula I según la reivindicación 2, en el que R1 es NHSO2-ciclopropilo o NHSO2-Ph.4.- El compuesto de fórmula I según la reivindicación 2, en el que R1 es hidroxi.5.- El compuesto de fórmula I según una cualquiera de las reivindicaciones 1 a 4, en el que R2 es ciclopentilo o ciclohexilo.6.- El compuesto de fórmula I según la reivindicación 5, en el que R2 es ciclopentilo.
CO04085344A 2002-02-01 2004-08-31 Tripeptidos que poseen un eter de hidroxiprolina de una quinolina sustituida para la inhibicion de ns3 (hepatitis c) CO5611113A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002370396A CA2370396A1 (en) 2002-02-01 2002-02-01 Hepatitis c inhibitor tri-peptides

Publications (1)

Publication Number Publication Date
CO5611113A2 true CO5611113A2 (es) 2006-02-28

Family

ID=27626587

Family Applications (1)

Application Number Title Priority Date Filing Date
CO04085344A CO5611113A2 (es) 2002-02-01 2004-08-31 Tripeptidos que poseen un eter de hidroxiprolina de una quinolina sustituida para la inhibicion de ns3 (hepatitis c)

Country Status (30)

Country Link
EP (1) EP1474441B1 (es)
JP (1) JP4060801B2 (es)
KR (1) KR20040097990A (es)
CN (1) CN100430414C (es)
AR (1) AR038383A1 (es)
AT (1) ATE358137T1 (es)
AU (1) AU2003202347B2 (es)
BR (1) BR0307408A (es)
CA (1) CA2370396A1 (es)
CO (1) CO5611113A2 (es)
DE (1) DE60312824T2 (es)
DK (1) DK1474441T3 (es)
EA (1) EA007742B1 (es)
EC (1) ECSP045226A (es)
ES (1) ES2285085T3 (es)
HR (1) HRP20040697A2 (es)
IL (1) IL163130A (es)
MX (1) MXPA04007515A (es)
MY (1) MY127791A (es)
NO (1) NO20043643L (es)
NZ (1) NZ534689A (es)
PE (1) PE20031012A1 (es)
PL (1) PL371324A1 (es)
RS (1) RS67204A (es)
SA (1) SA03240005B1 (es)
TW (1) TW200400199A (es)
UA (1) UA77758C2 (es)
UY (1) UY27636A1 (es)
WO (1) WO2003064456A1 (es)
ZA (1) ZA200405933B (es)

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