BR0213990A - Derivados de piperazina tendo atividade antagonìstica de sst1 - Google Patents
Derivados de piperazina tendo atividade antagonìstica de sst1Info
- Publication number
- BR0213990A BR0213990A BR0213990-1A BR0213990A BR0213990A BR 0213990 A BR0213990 A BR 0213990A BR 0213990 A BR0213990 A BR 0213990A BR 0213990 A BR0213990 A BR 0213990A
- Authority
- BR
- Brazil
- Prior art keywords
- sst1
- antagonistic activity
- piperazine derivatives
- compounds
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
- C07D311/90—Xanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
- C07D335/12—Thioxanthenes
- C07D335/20—Thioxanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0127008.1A GB0127008D0 (en) | 2001-11-09 | 2001-11-09 | Organic compounds |
| PCT/EP2002/012514 WO2003040125A1 (en) | 2001-11-09 | 2002-11-08 | Piperazine derivatives having sst1 antagonistic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0213990A true BR0213990A (pt) | 2004-08-31 |
Family
ID=9925528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0213990-1A BR0213990A (pt) | 2001-11-09 | 2002-11-08 | Derivados de piperazina tendo atividade antagonìstica de sst1 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7271168B2 (enExample) |
| EP (1) | EP1446399B1 (enExample) |
| JP (1) | JP4199668B2 (enExample) |
| CN (1) | CN1269811C (enExample) |
| AR (1) | AR037521A1 (enExample) |
| AT (1) | ATE294787T1 (enExample) |
| BR (1) | BR0213990A (enExample) |
| CA (1) | CA2465680A1 (enExample) |
| DE (1) | DE60204044T2 (enExample) |
| ES (1) | ES2240830T3 (enExample) |
| GB (1) | GB0127008D0 (enExample) |
| MY (1) | MY136297A (enExample) |
| PE (1) | PE20030539A1 (enExample) |
| PT (1) | PT1446399E (enExample) |
| TW (1) | TWI259085B (enExample) |
| WO (1) | WO2003040125A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7390813B1 (en) | 2001-12-21 | 2008-06-24 | Xenon Pharmaceuticals Inc. | Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents |
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| BRPI0515477A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos bicìclicos e o uso dos mesmos como inibidores de estaroil-coa-desaturase (scd) |
| AU2005286846A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
| WO2006101521A2 (en) | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| US7951805B2 (en) | 2004-09-20 | 2011-05-31 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| US8071603B2 (en) | 2004-09-20 | 2011-12-06 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| AU2005286647A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| AR051026A1 (es) | 2004-09-20 | 2006-12-13 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| EP2316458A1 (en) | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| JP2009513563A (ja) | 2005-06-03 | 2009-04-02 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ヒトのステアロイル−ＣｏＡデサチュラーゼ阻害剤としてのアミノチアゾール誘導体 |
| GB0514615D0 (en) | 2005-07-15 | 2005-08-24 | Novartis Ag | Organic compounds |
| ES2541528T3 (es) | 2008-11-19 | 2015-07-21 | Forum Pharmaceuticals Inc. | Tratamiento de trastornos cognitivos con (R)-7-cloro-N-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida y sales farmacéuticamente aceptables de la misma |
| JP5749797B2 (ja) | 2010-05-17 | 2015-07-15 | フォルム ファーマシューティカルズ、インコーポレイテッド | （ｒ）−７−クロロ−ｎ−（キヌクリジン−３−イル）ベンゾ［ｂ］チオフェン−２−カルボキサミド塩酸塩一水和物の結晶形 |
| CA2872005A1 (en) | 2012-05-08 | 2013-11-14 | Forum Pharmaceuticals, Inc. | Methods of maintaining, treating or improving cognitive function |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5495047A (en) | 1991-07-10 | 1996-02-27 | Merck, Sharp & Dohme (Ltd.) | Fused tricyclic compounds, pharmaceutical compositions containing them and their use in therapy |
-
2001
- 2001-11-09 GB GBGB0127008.1A patent/GB0127008D0/en not_active Ceased
-
2002
- 2002-11-07 PE PE2002001085A patent/PE20030539A1/es not_active Application Discontinuation
- 2002-11-07 TW TW091132777A patent/TWI259085B/zh not_active IP Right Cessation
- 2002-11-07 AR ARP020104273A patent/AR037521A1/es not_active Application Discontinuation
- 2002-11-08 ES ES02787612T patent/ES2240830T3/es not_active Expired - Lifetime
- 2002-11-08 JP JP2003542171A patent/JP4199668B2/ja not_active Expired - Fee Related
- 2002-11-08 DE DE60204044T patent/DE60204044T2/de not_active Expired - Lifetime
- 2002-11-08 WO PCT/EP2002/012514 patent/WO2003040125A1/en not_active Ceased
- 2002-11-08 AT AT02787612T patent/ATE294787T1/de not_active IP Right Cessation
- 2002-11-08 EP EP02787612A patent/EP1446399B1/en not_active Expired - Lifetime
- 2002-11-08 CA CA002465680A patent/CA2465680A1/en not_active Abandoned
- 2002-11-08 PT PT02787612T patent/PT1446399E/pt unknown
- 2002-11-08 US US10/494,898 patent/US7271168B2/en not_active Expired - Fee Related
- 2002-11-08 BR BR0213990-1A patent/BR0213990A/pt not_active Application Discontinuation
- 2002-11-08 CN CNB028236912A patent/CN1269811C/zh not_active Expired - Fee Related
- 2002-11-08 MY MYPI20024185A patent/MY136297A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1446399B1 (en) | 2005-05-04 |
| ES2240830T3 (es) | 2005-10-16 |
| US7271168B2 (en) | 2007-09-18 |
| JP2005516898A (ja) | 2005-06-09 |
| CA2465680A1 (en) | 2003-05-15 |
| HK1068338A1 (en) | 2005-04-29 |
| JP4199668B2 (ja) | 2008-12-17 |
| DE60204044D1 (de) | 2005-06-09 |
| AR037521A1 (es) | 2004-11-17 |
| CN1596251A (zh) | 2005-03-16 |
| US20060079527A1 (en) | 2006-04-13 |
| TW200300088A (en) | 2003-05-16 |
| WO2003040125A1 (en) | 2003-05-15 |
| EP1446399A1 (en) | 2004-08-18 |
| GB0127008D0 (en) | 2002-01-02 |
| CN1269811C (zh) | 2006-08-16 |
| PT1446399E (pt) | 2005-09-30 |
| ATE294787T1 (de) | 2005-05-15 |
| PE20030539A1 (es) | 2003-08-13 |
| MY136297A (en) | 2008-09-30 |
| TWI259085B (en) | 2006-08-01 |
| DE60204044T2 (de) | 2006-01-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR0214666A (pt) | Derivados de acetileno tendo atividade antagonìstica de mglur5 | |
| PT1413582E (pt) | Pirrolobenzodiazepinas dimericas | |
| BR0213990A (pt) | Derivados de piperazina tendo atividade antagonìstica de sst1 | |
| DK1392666T3 (da) | Biologisk aktive methylenblåt-derivater | |
| BR0115605A (pt) | Derivados de naftaleno | |
| DE60012188D1 (de) | Fungizide | |
| PT931788E (pt) | Inibidores de metaloprotease | |
| DK0944643T3 (da) | Oxyiminopregnancarbolactoner. | |
| EA199900279A1 (ru) | Производные бензамида и их применение в качестве лекарственных средств с лтв4-антагонистической активностью | |
| BR0207278A (pt) | Derivados de ftalazinona-piperidina como inibidores de pde4 | |
| BR0114252A (pt) | Derivados de nitrosodifenilamina | |
| SE0004245D0 (sv) | Novel compounds and their use | |
| BRPI0413094A (pt) | derivados de quinolina e seu uso em terapia | |
| BR9909739A (pt) | Benzotiadiazóis e derivados | |
| BR0112521A (pt) | Indolquinazolinonas | |
| BG102623A (bg) | Нови производни на бензоилгуанидина, методи за тяхното получаване и приложението им за производството на ле- карствени средства | |
| TR200201128T2 (tr) | PDE4 inhibitörleri olarak tetrahidrotiyopiranfitalazinon türevleri. | |
| BR0211903A (pt) | Isoxazolopiridinonas | |
| BR0115996A (pt) | Sulfamidotienopirimidinas | |
| BRPI0415034A (pt) | derivados de aminopiridina como inibidores de não-sintase induzìveis | |
| EA200301101A1 (ru) | Производные пиперазина и их применение в качестве ингибиторов pde4 | |
| BR0308201A (pt) | Derivados de quinolina | |
| SV2002000302A (es) | Nuevos derivados de amidas heterociclicas ref. pc 10561/20140/bb | |
| DE60043228D1 (de) | Herstellungsverfahren von 2-cyanopyridinen | |
| TR200001122T2 (tr) | Farmasötikler olarak bifenil türevleri. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
| B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |