BR0212607A - Agonistas retinóides ii de uréia substituìda - Google Patents
Agonistas retinóides ii de uréia substituìdaInfo
- Publication number
- BR0212607A BR0212607A BR0212607-9A BR0212607A BR0212607A BR 0212607 A BR0212607 A BR 0212607A BR 0212607 A BR0212607 A BR 0212607A BR 0212607 A BR0212607 A BR 0212607A
- Authority
- BR
- Brazil
- Prior art keywords
- retinoid agonists
- cancer
- urea
- replaced
- dermatological disorders
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title abstract 2
- 239000004202 carbamide Substances 0.000 title abstract 2
- -1 urea retinoid Chemical class 0.000 title 1
- 206010014561 Emphysema Diseases 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000004492 retinoid derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32296201P | 2001-09-18 | 2001-09-18 | |
| PCT/EP2002/010181 WO2003024920A1 (en) | 2001-09-18 | 2002-09-11 | Substituted urea retinoid agonists ii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0212607A true BR0212607A (pt) | 2004-08-17 |
Family
ID=23257206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0212607-9A BR0212607A (pt) | 2001-09-18 | 2002-09-11 | Agonistas retinóides ii de uréia substituìda |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6838472B2 (OSRAM) |
| EP (1) | EP1430023B1 (OSRAM) |
| JP (1) | JP4410562B2 (OSRAM) |
| KR (1) | KR100891224B1 (OSRAM) |
| CN (1) | CN1301968C (OSRAM) |
| AR (1) | AR036532A1 (OSRAM) |
| AT (1) | ATE427929T1 (OSRAM) |
| AU (1) | AU2002340886B2 (OSRAM) |
| BR (1) | BR0212607A (OSRAM) |
| CA (1) | CA2458266C (OSRAM) |
| DE (1) | DE60231888D1 (OSRAM) |
| ES (1) | ES2325063T3 (OSRAM) |
| MX (1) | MXPA04002305A (OSRAM) |
| PL (1) | PL209697B1 (OSRAM) |
| RU (1) | RU2303027C2 (OSRAM) |
| WO (1) | WO2003024920A1 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1889830A1 (en) | 2006-07-10 | 2008-02-20 | Pharmeste S.r.l. | Biarylcarboxyarylamides as vanilloid-1 receptor modulators |
| EP1889837A1 (en) * | 2006-07-10 | 2008-02-20 | Pharmeste S.r.l. | VR1 vanilloid receptor antagonists with a iononic substructure |
| PL2613776T3 (pl) | 2010-09-01 | 2021-01-11 | Thomas Jefferson University | Kompozycja oraz sposób naprawy i regeneracji mięśni |
| CN109589324B (zh) | 2012-11-08 | 2022-06-14 | 国立大学法人山口大学 | 角结膜病症的治疗剂 |
| CN105377258B (zh) | 2013-05-22 | 2020-08-28 | 国立大学法人山口大学 | 视网膜脉络膜病症的抑制剂 |
| ES2963348T3 (es) | 2016-06-08 | 2024-03-26 | Clementia Pharmaceuticals Inc | Métodos para tratar la osificación heterotópica |
| BR112019009929A2 (pt) | 2016-11-16 | 2019-08-20 | Clementia Pharmaceuticals Inc | métodos para inibir a formação de um osteocondroma, para reduzir o tamanho de um osteocondroma, para desacelerar o crescimento de um osteocondroma e para reduzir hiperplasia de cartilagem |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU87821A1 (fr) | 1990-10-12 | 1992-05-25 | Cird Galderma | Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique |
| HUT62558A (en) * | 1991-07-01 | 1993-05-28 | Sandoz Ag | Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same |
| US5648514A (en) * | 1994-12-29 | 1997-07-15 | Allergan | Substituted acetylenes having retinoid-like biological activity |
| US5599967A (en) * | 1994-12-29 | 1997-02-04 | Allergan | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity |
| US6093742A (en) | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
| JO2178B1 (en) | 1999-10-19 | 2003-04-23 | اف . هوفمان لاروش ايه جي | Treatment of emphysema using rar selective retinoid antagonists |
-
2002
- 2002-09-11 PL PL370459A patent/PL209697B1/pl not_active IP Right Cessation
- 2002-09-11 WO PCT/EP2002/010181 patent/WO2003024920A1/en not_active Ceased
- 2002-09-11 ES ES02774599T patent/ES2325063T3/es not_active Expired - Lifetime
- 2002-09-11 RU RU2004111789/04A patent/RU2303027C2/ru not_active IP Right Cessation
- 2002-09-11 EP EP02774599A patent/EP1430023B1/en not_active Expired - Lifetime
- 2002-09-11 JP JP2003528768A patent/JP4410562B2/ja not_active Expired - Fee Related
- 2002-09-11 KR KR1020047003921A patent/KR100891224B1/ko not_active Expired - Fee Related
- 2002-09-11 BR BR0212607-9A patent/BR0212607A/pt not_active IP Right Cessation
- 2002-09-11 CA CA2458266A patent/CA2458266C/en not_active Expired - Fee Related
- 2002-09-11 AT AT02774599T patent/ATE427929T1/de active
- 2002-09-11 DE DE60231888T patent/DE60231888D1/de not_active Expired - Lifetime
- 2002-09-11 AU AU2002340886A patent/AU2002340886B2/en not_active Ceased
- 2002-09-11 MX MXPA04002305A patent/MXPA04002305A/es active IP Right Grant
- 2002-09-11 CN CNB028178327A patent/CN1301968C/zh not_active Expired - Fee Related
- 2002-09-16 AR ARP020103489A patent/AR036532A1/es not_active Application Discontinuation
- 2002-09-17 US US10/244,885 patent/US6838472B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2458266C (en) | 2011-03-15 |
| CN1555357A (zh) | 2004-12-15 |
| KR20040035808A (ko) | 2004-04-29 |
| AR036532A1 (es) | 2004-09-15 |
| ATE427929T1 (de) | 2009-04-15 |
| AU2002340886B2 (en) | 2008-01-31 |
| CA2458266A1 (en) | 2003-03-27 |
| US20030125383A1 (en) | 2003-07-03 |
| JP2005503411A (ja) | 2005-02-03 |
| CN1301968C (zh) | 2007-02-28 |
| PL209697B1 (pl) | 2011-10-31 |
| EP1430023B1 (en) | 2009-04-08 |
| JP4410562B2 (ja) | 2010-02-03 |
| DE60231888D1 (de) | 2009-05-20 |
| RU2004111789A (ru) | 2005-10-20 |
| KR100891224B1 (ko) | 2009-04-01 |
| PL370459A1 (en) | 2005-05-30 |
| WO2003024920A1 (en) | 2003-03-27 |
| RU2303027C2 (ru) | 2007-07-20 |
| MXPA04002305A (es) | 2004-06-29 |
| ES2325063T3 (es) | 2009-08-25 |
| US6838472B2 (en) | 2005-01-04 |
| EP1430023A1 (en) | 2004-06-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9812753A (pt) | Combinação farmacêutica, uso da mesma, processo para tratamento de uma doença inflamatória, e, composição farmacêutica | |
| BR0115427A (pt) | Composto, composição farmacêutica, métodos para inibir a liberação de peptìdeo beta-amilóide e/ou sua sìntese, para tratar a doença de alzheimer, e para prevenir a doença e o progresso da doença de alzheimer, e, uso de um composto | |
| BRPI0406883A (pt) | Composto, composição farmacêutica, método de tratar um distúrbio, e, uso de um composto | |
| BRPI0013478B8 (pt) | medicamento compreendendo inibidor pde e uso de roflumilast | |
| AU2002225772A1 (en) | Therapeutic agents and methods of use thereof for treating an amyloidogenic disease | |
| BR0212042A (pt) | Composto, composição farmacêutica, método de tratamento ou prevenção de doenças, e, uso de um composto | |
| MA25809A1 (fr) | Derives d'arylmethylamine pour usage comme inhibiteurs de tryptase | |
| BR9814923A (pt) | Método para tratamento de doença de alzheimer | |
| BRPI0412029A (pt) | formulações para microprojeções revestidas contendo contra-ìons não-voláteis | |
| BR0210568A (pt) | Conjugado, uso de um conjugado, composição farmacêutica, e, método para tratar câncer em um mamìfero | |
| BR0214962A (pt) | Composição para tratar distúrbios neurocerebrovasculares | |
| BRPI0114344B8 (pt) | composto retinóide, seu uso, sua composição farmacêutica e seu processo de preparação | |
| BR0009564A (pt) | Utilização de inibidores da cyp2d6 em terapias de combinação | |
| WO2002011764A3 (en) | PHARMACEUTICAL COMPOSITIONS | |
| BR0312729A (pt) | Novos derivados de indol-3-enxofre | |
| BR0307050A (pt) | Composto, composição farmacêutica, métodos para o tratamento de doenças mediadas por prostaglandina d2, para o tratamento de congestão nasal, para o tratamento de asma alérgica, e para o tratamento de rinite alérgica, sal farmaceuticamente aceitável, e, uso de um composto ou sal | |
| BR0114913A (pt) | Inibidores de metaloproteinase de espiro-pirimidina-2,4,6-triona | |
| EA200201276A1 (ru) | Производные арилметиламина для использования в качестве ингибиторов триптазы | |
| BR9909138A (pt) | Combinação para o tratamento de dependência de álcool e drogas contendo um antagonista de opióide e um modulador de complexo receptor de nmda | |
| BR0316458A (pt) | Composto, composição farmacêutica, método de tratamento ou prevenção de doenças, método para intensificar a cognição em um paciente saudável, e, uso de um composto | |
| BR9908510A (pt) | Uso de um composto, composto, processo para a preparação de um composto, composição farmacêutica, e, processo de tratar um paciente que sofre de, ou em risco de, uma doença micobacteriana | |
| BRPI0411176A (pt) | combinação farmacêutica consistindo de modafinil e outra droga | |
| PT832081E (pt) | Compostos biciclicos aromaticos | |
| BRPI0411864A (pt) | combinação de inibidores de src quinase e agentes quimioterápicos para o tratamento de doenças proliferativas | |
| AU4179399A (en) | Use of nmda antagonists and/or sodium channel antagonists for the treatment of inflammatory disorders |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 11A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014. |