PL209697B1 - Pochodne mocznika, środek farmaceutyczny i zastosowanie pochodnych mocznika - Google Patents
Pochodne mocznika, środek farmaceutyczny i zastosowanie pochodnych mocznikaInfo
- Publication number
- PL209697B1 PL209697B1 PL370459A PL37045902A PL209697B1 PL 209697 B1 PL209697 B1 PL 209697B1 PL 370459 A PL370459 A PL 370459A PL 37045902 A PL37045902 A PL 37045902A PL 209697 B1 PL209697 B1 PL 209697B1
- Authority
- PL
- Poland
- Prior art keywords
- tetramethyl
- tetrahydronaphthalen
- alkyl
- ureido
- acid
- Prior art date
Links
- -1 urea retinoid Chemical class 0.000 title description 41
- 239000000556 agonist Substances 0.000 title description 13
- 239000004202 carbamide Substances 0.000 title description 4
- 206010014561 Emphysema Diseases 0.000 claims abstract description 41
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 39
- 238000011282 treatment Methods 0.000 claims abstract description 28
- 201000011510 cancer Diseases 0.000 claims abstract description 24
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 23
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 20
- 239000003814 drug Substances 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- 239000013543 active substance Substances 0.000 claims description 7
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 7
- SZXKVKCBULPYCX-UHFFFAOYSA-N 4-[[2-phenylethyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]amino]benzoic acid Chemical compound C=1C=C2C(C)(C)CCC(C)(C)C2=CC=1N(C(=O)NC=1C=CC(=CC=1)C(O)=O)CCC1=CC=CC=C1 SZXKVKCBULPYCX-UHFFFAOYSA-N 0.000 claims description 6
- 150000003672 ureas Chemical class 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 5
- 125000001544 thienyl group Chemical group 0.000 claims description 5
- MTKKODCXENWAMS-UHFFFAOYSA-N 4-[[2-ethoxyethyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]amino]benzoic acid Chemical compound C=1C=C(C(CCC2(C)C)(C)C)C2=CC=1N(CCOCC)C(=O)NC1=CC=C(C(O)=O)C=C1 MTKKODCXENWAMS-UHFFFAOYSA-N 0.000 claims description 4
- FIKOUKBRWXICOI-UHFFFAOYSA-N 4-[[4-phenylmethoxybutyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]amino]benzoic acid Chemical compound C=1C=C2C(C)(C)CCC(C)(C)C2=CC=1N(C(=O)NC=1C=CC(=CC=1)C(O)=O)CCCCOCC1=CC=CC=C1 FIKOUKBRWXICOI-UHFFFAOYSA-N 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 125000000842 isoxazolyl group Chemical group 0.000 claims description 4
- UXFHEKYMUDNHFN-UHFFFAOYSA-N 4-[[(4-chlorophenyl)methyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]amino]benzoic acid Chemical compound C=1C=C2C(C)(C)CCC(C)(C)C2=CC=1N(C(=O)NC=1C=CC(=CC=1)C(O)=O)CC1=CC=C(Cl)C=C1 UXFHEKYMUDNHFN-UHFFFAOYSA-N 0.000 claims description 3
- RHXVTBCZXIBOEA-UHFFFAOYSA-N 4-[[(4-fluorophenyl)methyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]amino]benzoic acid Chemical compound C=1C=C2C(C)(C)CCC(C)(C)C2=CC=1N(C(=O)NC=1C=CC(=CC=1)C(O)=O)CC1=CC=C(F)C=C1 RHXVTBCZXIBOEA-UHFFFAOYSA-N 0.000 claims description 3
- BXYJENMWABKAQS-UHFFFAOYSA-N 4-[[(4-methoxyphenyl)methyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]amino]benzoic acid Chemical compound C1=CC(OC)=CC=C1CN(C=1C=C2C(C(CCC2(C)C)(C)C)=CC=1)C(=O)NC1=CC=C(C(O)=O)C=C1 BXYJENMWABKAQS-UHFFFAOYSA-N 0.000 claims description 3
- JPDZMVYNYGENOZ-UHFFFAOYSA-N 4-[[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-(thiophen-2-ylmethyl)carbamoyl]amino]benzoic acid Chemical compound C=1C=C2C(C)(C)CCC(C)(C)C2=CC=1N(C(=O)NC=1C=CC(=CC=1)C(O)=O)CC1=CC=CS1 JPDZMVYNYGENOZ-UHFFFAOYSA-N 0.000 claims description 3
- BBLTZMAZYGBBND-UHFFFAOYSA-N 4-[[2-methoxyethyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]amino]benzoic acid Chemical compound C=1C=C(C(CCC2(C)C)(C)C)C2=CC=1N(CCOC)C(=O)NC1=CC=C(C(O)=O)C=C1 BBLTZMAZYGBBND-UHFFFAOYSA-N 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- JOAXJLPFJXJRGQ-UHFFFAOYSA-N 4-[[(5-methyl-1,2-oxazol-3-yl)methyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]amino]benzoic acid Chemical compound O1C(C)=CC(CN(C(=O)NC=2C=CC(=CC=2)C(O)=O)C=2C=C3C(C(CCC3(C)C)(C)C)=CC=2)=N1 JOAXJLPFJXJRGQ-UHFFFAOYSA-N 0.000 claims description 2
- RNPZGAQHGKDHRB-UHFFFAOYSA-N 4-[[3-methoxypropyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]amino]benzoic acid Chemical compound C=1C=C(C(CCC2(C)C)(C)C)C2=CC=1N(CCCOC)C(=O)NC1=CC=C(C(O)=O)C=C1 RNPZGAQHGKDHRB-UHFFFAOYSA-N 0.000 claims description 2
- LHECKCCFNNGHJA-UHFFFAOYSA-N 4-[[4-hydroxybutyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]amino]benzoic acid Chemical compound C=1C=C2C(C)(C)CCC(C)(C)C2=CC=1N(CCCCO)C(=O)NC1=CC=C(C(O)=O)C=C1 LHECKCCFNNGHJA-UHFFFAOYSA-N 0.000 claims description 2
- MUMMFUHTGZMKLE-UHFFFAOYSA-N 4-[[benzyl-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]amino]benzoic acid Chemical compound C=1C=C2C(C)(C)CCC(C)(C)C2=CC=1N(C(=O)NC=1C=CC(=CC=1)C(O)=O)CC1=CC=CC=C1 MUMMFUHTGZMKLE-UHFFFAOYSA-N 0.000 claims description 2
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- 238000007910 systemic administration Methods 0.000 description 1
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- WBWWGRHZICKQGZ-HZAMXZRMSA-N taurocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@@H](O)C1 WBWWGRHZICKQGZ-HZAMXZRMSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- QIQITDHWZYEEPA-UHFFFAOYSA-N thiophene-2-carbonyl chloride Chemical compound ClC(=O)C1=CC=CS1 QIQITDHWZYEEPA-UHFFFAOYSA-N 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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- 238000002054 transplantation Methods 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- JEJAMASKDTUEBZ-UHFFFAOYSA-N tris(1,1,3-tribromo-2,2-dimethylpropyl) phosphate Chemical compound BrCC(C)(C)C(Br)(Br)OP(=O)(OC(Br)(Br)C(C)(C)CBr)OC(Br)(Br)C(C)(C)CBr JEJAMASKDTUEBZ-UHFFFAOYSA-N 0.000 description 1
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- 235000019155 vitamin A Nutrition 0.000 description 1
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- 239000003039 volatile agent Substances 0.000 description 1
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- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32296201P | 2001-09-18 | 2001-09-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL370459A1 PL370459A1 (en) | 2005-05-30 |
| PL209697B1 true PL209697B1 (pl) | 2011-10-31 |
Family
ID=23257206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL370459A PL209697B1 (pl) | 2001-09-18 | 2002-09-11 | Pochodne mocznika, środek farmaceutyczny i zastosowanie pochodnych mocznika |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6838472B2 (OSRAM) |
| EP (1) | EP1430023B1 (OSRAM) |
| JP (1) | JP4410562B2 (OSRAM) |
| KR (1) | KR100891224B1 (OSRAM) |
| CN (1) | CN1301968C (OSRAM) |
| AR (1) | AR036532A1 (OSRAM) |
| AT (1) | ATE427929T1 (OSRAM) |
| AU (1) | AU2002340886B2 (OSRAM) |
| BR (1) | BR0212607A (OSRAM) |
| CA (1) | CA2458266C (OSRAM) |
| DE (1) | DE60231888D1 (OSRAM) |
| ES (1) | ES2325063T3 (OSRAM) |
| MX (1) | MXPA04002305A (OSRAM) |
| PL (1) | PL209697B1 (OSRAM) |
| RU (1) | RU2303027C2 (OSRAM) |
| WO (1) | WO2003024920A1 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1889830A1 (en) | 2006-07-10 | 2008-02-20 | Pharmeste S.r.l. | Biarylcarboxyarylamides as vanilloid-1 receptor modulators |
| EP1889837A1 (en) * | 2006-07-10 | 2008-02-20 | Pharmeste S.r.l. | VR1 vanilloid receptor antagonists with a iononic substructure |
| PL2613776T3 (pl) | 2010-09-01 | 2021-01-11 | Thomas Jefferson University | Kompozycja oraz sposób naprawy i regeneracji mięśni |
| CN109589324B (zh) | 2012-11-08 | 2022-06-14 | 国立大学法人山口大学 | 角结膜病症的治疗剂 |
| CN105377258B (zh) | 2013-05-22 | 2020-08-28 | 国立大学法人山口大学 | 视网膜脉络膜病症的抑制剂 |
| ES2963348T3 (es) | 2016-06-08 | 2024-03-26 | Clementia Pharmaceuticals Inc | Métodos para tratar la osificación heterotópica |
| BR112019009929A2 (pt) | 2016-11-16 | 2019-08-20 | Clementia Pharmaceuticals Inc | métodos para inibir a formação de um osteocondroma, para reduzir o tamanho de um osteocondroma, para desacelerar o crescimento de um osteocondroma e para reduzir hiperplasia de cartilagem |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU87821A1 (fr) | 1990-10-12 | 1992-05-25 | Cird Galderma | Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique |
| HUT62558A (en) * | 1991-07-01 | 1993-05-28 | Sandoz Ag | Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same |
| US5648514A (en) * | 1994-12-29 | 1997-07-15 | Allergan | Substituted acetylenes having retinoid-like biological activity |
| US5599967A (en) * | 1994-12-29 | 1997-02-04 | Allergan | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity |
| US6093742A (en) | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
| JO2178B1 (en) | 1999-10-19 | 2003-04-23 | اف . هوفمان لاروش ايه جي | Treatment of emphysema using rar selective retinoid antagonists |
-
2002
- 2002-09-11 PL PL370459A patent/PL209697B1/pl not_active IP Right Cessation
- 2002-09-11 WO PCT/EP2002/010181 patent/WO2003024920A1/en not_active Ceased
- 2002-09-11 ES ES02774599T patent/ES2325063T3/es not_active Expired - Lifetime
- 2002-09-11 RU RU2004111789/04A patent/RU2303027C2/ru not_active IP Right Cessation
- 2002-09-11 EP EP02774599A patent/EP1430023B1/en not_active Expired - Lifetime
- 2002-09-11 JP JP2003528768A patent/JP4410562B2/ja not_active Expired - Fee Related
- 2002-09-11 KR KR1020047003921A patent/KR100891224B1/ko not_active Expired - Fee Related
- 2002-09-11 BR BR0212607-9A patent/BR0212607A/pt not_active IP Right Cessation
- 2002-09-11 CA CA2458266A patent/CA2458266C/en not_active Expired - Fee Related
- 2002-09-11 AT AT02774599T patent/ATE427929T1/de active
- 2002-09-11 DE DE60231888T patent/DE60231888D1/de not_active Expired - Lifetime
- 2002-09-11 AU AU2002340886A patent/AU2002340886B2/en not_active Ceased
- 2002-09-11 MX MXPA04002305A patent/MXPA04002305A/es active IP Right Grant
- 2002-09-11 CN CNB028178327A patent/CN1301968C/zh not_active Expired - Fee Related
- 2002-09-16 AR ARP020103489A patent/AR036532A1/es not_active Application Discontinuation
- 2002-09-17 US US10/244,885 patent/US6838472B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2458266C (en) | 2011-03-15 |
| CN1555357A (zh) | 2004-12-15 |
| KR20040035808A (ko) | 2004-04-29 |
| AR036532A1 (es) | 2004-09-15 |
| ATE427929T1 (de) | 2009-04-15 |
| AU2002340886B2 (en) | 2008-01-31 |
| CA2458266A1 (en) | 2003-03-27 |
| US20030125383A1 (en) | 2003-07-03 |
| JP2005503411A (ja) | 2005-02-03 |
| CN1301968C (zh) | 2007-02-28 |
| EP1430023B1 (en) | 2009-04-08 |
| JP4410562B2 (ja) | 2010-02-03 |
| DE60231888D1 (de) | 2009-05-20 |
| RU2004111789A (ru) | 2005-10-20 |
| KR100891224B1 (ko) | 2009-04-01 |
| PL370459A1 (en) | 2005-05-30 |
| BR0212607A (pt) | 2004-08-17 |
| WO2003024920A1 (en) | 2003-03-27 |
| RU2303027C2 (ru) | 2007-07-20 |
| MXPA04002305A (es) | 2004-06-29 |
| ES2325063T3 (es) | 2009-08-25 |
| US6838472B2 (en) | 2005-01-04 |
| EP1430023A1 (en) | 2004-06-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Decisions on the lapse of the protection rights |
Effective date: 20120911 |