BR0212211A - Diagnóstico de carcinomas - Google Patents
Diagnóstico de carcinomasInfo
- Publication number
- BR0212211A BR0212211A BR0212211A BR0212211A BR0212211A BR 0212211 A BR0212211 A BR 0212211A BR 0212211 A BR0212211 A BR 0212211A BR 0212211 A BR0212211 A BR 0212211A BR 0212211 A BR0212211 A BR 0212211A
- Authority
- BR
- Brazil
- Prior art keywords
- he4a
- soluble
- individual
- detecting
- provides
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57449—Specifically defined cancers of ovaries
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
Abstract
"DIAGNóSTICO DE CARCINOMAS". A invenção conduz a composições e métodos para detecção de uma condição maligna, e refere-se a descoberta de formas solúveis e superficiais celulares de polipeptídeos HE4a, incluindo HE4a que é superexpressado em carcinomas ovarianos. Em particular, a invenção providencia uma seq³ência de ácido nucléico codificando HE4a, e também providencia um método de seleção critérios a quanto à presença de uma condição maligna num indivíduo, detectando a reatividade de um anticorpo específico para um polipeptídeo HE4a com uma molécula de ocorrência natural na forma solúvel e/ou de superfície celular numa amostra, de um tal indivíduo, e por seleção criteriosa de hibridização usando uma seq³ência de nucleotídeo de HE4a, bem como outras vantagens relacionadas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31653701P | 2001-08-29 | 2001-08-29 | |
PCT/EP2002/009653 WO2003021273A2 (en) | 2001-08-29 | 2002-08-29 | Diagnosis of carcinomas |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0212211A true BR0212211A (pt) | 2004-08-17 |
Family
ID=23229467
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0212211A BR0212211A (pt) | 2001-08-29 | 2002-08-29 | Diagnóstico de carcinomas |
Country Status (12)
Country | Link |
---|---|
US (4) | US7270960B2 (pt) |
EP (3) | EP2913673B1 (pt) |
JP (5) | JP2005501549A (pt) |
KR (1) | KR20040062534A (pt) |
CN (1) | CN1813188A (pt) |
BR (1) | BR0212211A (pt) |
CA (1) | CA2459077C (pt) |
ES (1) | ES2628952T3 (pt) |
HK (1) | HK1214346A1 (pt) |
MX (1) | MXPA04001963A (pt) |
RU (1) | RU2004109149A (pt) |
WO (1) | WO2003021273A2 (pt) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002071928A2 (en) * | 2001-03-14 | 2002-09-19 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer |
US7270960B2 (en) * | 2001-08-29 | 2007-09-18 | Pacific Northwest Research Institute | Diagnosis of ovarian carcinomas |
CN1839205B (zh) * | 2003-05-29 | 2012-05-16 | 千年药品公司 | 用于鉴定、评估、预防和治疗乳腺癌的组合物、试剂盒及方法 |
CA2536918A1 (en) | 2003-08-26 | 2005-03-03 | Leland Shapiro | Compositions of, and methods for, alpha-1 antitrypsin fc fusion molecules |
EP2261667A3 (en) * | 2003-10-07 | 2011-05-25 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules and proteins for the identification, assessment, prevention, and their therapy of ovarian cancer |
US20060014221A1 (en) * | 2004-01-21 | 2006-01-19 | Fujirebio Diagnostics, Inc. | Detection of urinary mesothelin-/megakaryocyte potentiating factor-related peptides for assessment of mesothelioma |
US20060014211A1 (en) * | 2004-01-21 | 2006-01-19 | Fujirebio Diagnostics, Inc. | Detection of mesothelin-/megakaryocyte potentiating factor-related peptides for assessment of the peritoneum and the peritoneal cavity |
WO2007011363A2 (en) * | 2004-08-11 | 2007-01-25 | Trubion Pharmaceuticals, Inc. | Binding domain fusion proteins |
WO2006119155A2 (en) * | 2005-05-02 | 2006-11-09 | The Brigham And Women's Hospital, Inc. | Diagnostic serum antibody profiling |
ATE438856T1 (de) * | 2005-06-22 | 2009-08-15 | Univ Johns Hopkins | Biomarker für eierstockkrebs: mit ctap3 verwandte proteine |
EP2423321A3 (en) | 2006-01-04 | 2012-03-14 | Fujirebio America, Inc. | Use of HE4 and other biochemical markers for assessment of endometrial and uterine cancers |
JP2009524438A (ja) * | 2006-01-27 | 2009-07-02 | トライパス イメージング インコーポレイテッド | 卵巣癌を有する可能性の高い患者を同定するための方法およびそのための組成物 |
US7811778B2 (en) | 2006-09-06 | 2010-10-12 | Vanderbilt University | Methods of screening for gastrointestinal cancer |
EP2121761A1 (en) * | 2007-03-09 | 2009-11-25 | Tripath Imaging, Inc. | He4 monoclonal antibodies and methods for their use |
US8455189B2 (en) * | 2007-03-29 | 2013-06-04 | Jeffrey W. Allard | Use of HE4 for assessment of breast cancers |
US8642347B2 (en) * | 2008-01-31 | 2014-02-04 | The Brigham And Women's Hospital, Inc. | Urinary CA125 peptides as biomarkers of ovarian cancer |
US8476026B2 (en) * | 2008-04-01 | 2013-07-02 | The Brigham And Women's Hospital, Inc. | Biomarkers of ovarian cancer |
US8993347B2 (en) | 2009-12-17 | 2015-03-31 | Cornell University | Methods for detecting antibodies in mucosal samples and device for sampling mucosal material |
US20130095503A1 (en) * | 2010-01-05 | 2013-04-18 | University Of Cincinnati | Serum spla2-iia as diagnosis marker for prostate and lung cancer |
CA2809368C (en) * | 2010-08-26 | 2021-08-24 | University Of Washington Through Its Center For Commercialization | Methods for detecting anti-he4 antibodies and methods of diagnosis and/or prognosis of conditions associated with he4-expressing cells |
KR102074141B1 (ko) * | 2011-02-17 | 2020-02-07 | 후지레비오 다이어그노스틱스, 인코포레이티드 | HE4a의 결정을 위해 사용되는 조성물들 및 방법들 |
CN103582815A (zh) * | 2011-02-24 | 2014-02-12 | 佛米利昂公司 | 用于卵巢癌的生物标志物组、诊断方法和测试试剂盒 |
WO2012170513A2 (en) * | 2011-06-06 | 2012-12-13 | Women & Infants' Hospital Of Rhode Island | He4 based therapy for malignant disease |
KR102103476B1 (ko) | 2011-06-24 | 2020-04-23 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도 |
RU2639526C2 (ru) | 2011-06-28 | 2017-12-21 | ИНХИБРКС ЭлЭлСи | Слитые полипептиды, содержащие домен wap, и способы их применения |
US10400029B2 (en) | 2011-06-28 | 2019-09-03 | Inhibrx, Lp | Serpin fusion polypeptides and methods of use thereof |
UA124083C2 (uk) | 2011-06-28 | 2021-07-21 | ІНГІБРЕКС, Інк. | Злитий серпіновий поліпептид і спосіб його застосування |
CN107011439B (zh) | 2011-07-15 | 2020-11-10 | 卫材R&D管理有限公司 | 抗叶酸受体α抗体及其应用 |
EP2802653A4 (en) | 2012-01-10 | 2015-09-02 | Univ Colorado Regents | ALPHA-1 ANTITRYPSIN FUSION MOLECULE COMPOSITIONS, METHODS AND USES THEREOF |
CN103575902B (zh) * | 2012-08-03 | 2015-07-29 | 河南生生医疗器械有限公司 | 一种时间分辨荧光法四项综合检测卵巢癌试剂盒及其应用 |
WO2016011143A1 (en) * | 2014-07-15 | 2016-01-21 | Temple University Of The Commonwealth System Of Higher Education | Stabilized peptide fragments from redoxin proteins as cancer biomarkers |
EP3339326A4 (en) * | 2015-08-21 | 2019-01-09 | Carsgen Therapeutics Limited | ENTIRELY HUMAN ANTI-MESOTHELIN ANTIBODIES AND IMMUNE EFFECTIVE CELLS TARGETING THE MESOTHELIN |
RU2641094C1 (ru) * | 2016-12-22 | 2018-01-15 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова" Министерства здравоохранения Российской Федерации | Способ ранней диагностики серозной карциномы яичника высокой степени злокачественности на основании изменения клеточного состава эпителия маточной трубы |
WO2020018381A1 (en) | 2018-07-18 | 2020-01-23 | The Regents Of The University Of California | Kidney injury treatment |
JPWO2020203478A1 (pt) * | 2019-04-02 | 2020-10-08 | ||
JPWO2021261483A1 (pt) * | 2020-06-23 | 2021-12-30 | ||
EP4403634A1 (en) * | 2021-09-16 | 2024-07-24 | Qmine Co., Ltd. | Antisense compound that regulates expression of wfdc2 |
WO2023043220A1 (ko) * | 2021-09-16 | 2023-03-23 | 주식회사 큐마인 | Wfdc2의 발현을 조절하는 안티센스 화합물 |
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2002
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- 2002-08-29 RU RU2004109149/15A patent/RU2004109149A/ru not_active Application Discontinuation
- 2002-08-29 WO PCT/EP2002/009653 patent/WO2003021273A2/en active Application Filing
- 2002-08-29 BR BR0212211A patent/BR0212211A/pt not_active Application Discontinuation
- 2002-08-29 EP EP14179937.9A patent/EP2913673B1/en not_active Expired - Lifetime
- 2002-08-29 MX MXPA04001963A patent/MXPA04001963A/es unknown
- 2002-08-29 EP EP20020797648 patent/EP1421388A2/en not_active Withdrawn
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- 2002-08-29 KR KR10-2004-7003017A patent/KR20040062534A/ko not_active Application Discontinuation
- 2002-08-29 EP EP20100184645 patent/EP2322933A1/en not_active Withdrawn
- 2002-08-29 CN CNA028192680A patent/CN1813188A/zh active Pending
- 2002-08-29 JP JP2003525305A patent/JP2005501549A/ja not_active Withdrawn
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- 2009-08-06 US US12/536,975 patent/US9090712B2/en not_active Expired - Lifetime
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JP2012161317A (ja) | 2012-08-30 |
CA2459077C (en) | 2018-06-05 |
ES2628952T3 (es) | 2017-08-04 |
EP2913673B1 (en) | 2017-05-31 |
JP2005501549A (ja) | 2005-01-20 |
WO2003021273A3 (en) | 2003-12-04 |
KR20040062534A (ko) | 2004-07-07 |
US9090712B2 (en) | 2015-07-28 |
JP2016065870A (ja) | 2016-04-28 |
US20100047818A1 (en) | 2010-02-25 |
JP2009195240A (ja) | 2009-09-03 |
WO2003021273A2 (en) | 2003-03-13 |
MXPA04001963A (es) | 2005-02-17 |
US7270960B2 (en) | 2007-09-18 |
EP2322933A1 (en) | 2011-05-18 |
HK1214346A1 (zh) | 2016-07-22 |
EP1421388A2 (en) | 2004-05-26 |
RU2004109149A (ru) | 2005-05-10 |
US20090104684A1 (en) | 2009-04-23 |
EP2913673A1 (en) | 2015-09-02 |
JP5797136B2 (ja) | 2015-10-21 |
CA2459077A1 (en) | 2003-03-13 |
JP2014081386A (ja) | 2014-05-08 |
US20030108965A1 (en) | 2003-06-12 |
US20160033512A1 (en) | 2016-02-04 |
CN1813188A (zh) | 2006-08-02 |
JP5188443B2 (ja) | 2013-04-24 |
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