BR0209911A - ácido nucléico e sequência de proteìna do fator de crescimento epidérmico bovino e seus usos - Google Patents
ácido nucléico e sequência de proteìna do fator de crescimento epidérmico bovino e seus usosInfo
- Publication number
- BR0209911A BR0209911A BR0209911-0A BR0209911A BR0209911A BR 0209911 A BR0209911 A BR 0209911A BR 0209911 A BR0209911 A BR 0209911A BR 0209911 A BR0209911 A BR 0209911A
- Authority
- BR
- Brazil
- Prior art keywords
- begf
- bovine
- protein
- growth factor
- nucleotide sequence
- Prior art date
Links
- 241000283690 Bos taurus Species 0.000 title abstract 7
- 102000004169 proteins and genes Human genes 0.000 title abstract 6
- 102000009024 Epidermal Growth Factor Human genes 0.000 title abstract 4
- 108091005461 Nucleic proteins Chemical group 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 150000007523 nucleic acids Chemical group 0.000 title abstract 3
- 101800003838 Epidermal growth factor Proteins 0.000 title abstract 2
- 229940116977 epidermal growth factor Drugs 0.000 title abstract 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 239000002773 nucleotide Substances 0.000 abstract 3
- 125000003729 nucleotide group Chemical group 0.000 abstract 3
- 230000006820 DNA synthesis Effects 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 206010022678 Intestinal infections Diseases 0.000 abstract 1
- 241000235058 Komagataella pastoris Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 235000002595 Solanum tuberosum Nutrition 0.000 abstract 1
- 244000061456 Solanum tuberosum Species 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 235000015278 beef Nutrition 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 235000013365 dairy product Nutrition 0.000 abstract 1
- 102000038379 digestive enzymes Human genes 0.000 abstract 1
- 108091007734 digestive enzymes Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 230000035800 maturation Effects 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 235000015816 nutrient absorption Nutrition 0.000 abstract 1
- 235000012015 potatoes Nutrition 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
- 239000013589 supplement Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/153—Nucleic acids; Hydrolysis products or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Physiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Fodder In General (AREA)
Abstract
"áCIDO NUCLéICO E SEQuêNCIA DE PROTEìNA DO FATOR DE CRESCIMENTO EPIDéRMICO BOVINO E SEUS USOS". A invenção provê uma seq³ência de nucleotídeos do fator de crescimento epidérmico bovino (bEGF) e a seq³ência de aminoácidos deduzida da proteína codificada. A invenção provê adicionalmente a seq³ência de nucleotídeos do bEGF maduro e a proteína bEGF madura deduzida. A invenção estende-se aos ácidos nucléicos, proteínas, e fragmentos funcionalmente equivalentes homólogos a seq³ência de nucleotídeo do gene bEGF e proteína bEGF, respectivamente. O EGF bovino pode ser expresso em microrganismos tais como E. coli ou P. pastoris, e plantas hospedeiras, tais como batata. A atividade do bEGF recombinante pode ser confirmada usando um ensaio de proliferação celular/síntese de DNA. O EGF bovino demonstra utilidade em gado de corte e na produção de vacas leiteiras como um suplemento na ração dos animais da fazenda para promover o crescimento; para prevenir ou tratar infecções intestinais; para estimular a maturação precoce das células do intestino para secretar um espectro apropriado das enzimas digestivas; e para aumentar a absorção de nutrientes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29213601P | 2001-05-18 | 2001-05-18 | |
| PCT/CA2002/000724 WO2002095029A2 (en) | 2001-05-18 | 2002-05-17 | Nucleic acid and protein sequences of bovine epidermal growth factor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0209911A true BR0209911A (pt) | 2004-06-29 |
Family
ID=23123376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0209911-0A BR0209911A (pt) | 2001-05-18 | 2002-05-17 | ácido nucléico e sequência de proteìna do fator de crescimento epidérmico bovino e seus usos |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6967090B2 (pt) |
| EP (1) | EP1395658A2 (pt) |
| JP (1) | JP2004536589A (pt) |
| KR (1) | KR20040089454A (pt) |
| CN (1) | CN1527879A (pt) |
| BR (1) | BR0209911A (pt) |
| CA (1) | CA2446398A1 (pt) |
| MX (1) | MXPA03010572A (pt) |
| NZ (1) | NZ529806A (pt) |
| WO (1) | WO2002095029A2 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005095451A1 (en) * | 2004-03-31 | 2005-10-13 | Commonwealth Scientific And Industrial Research Organisation | Nucleotide and amino acid sequences for ruminant epidermal growth factor |
| AU2005229155B2 (en) * | 2004-03-31 | 2011-06-09 | Commonwealth Scientific And Industrial Research Organisation | Nucleotide and amino acid sequences for ruminant epidermal growth factor |
| DE102005015005A1 (de) * | 2005-04-01 | 2006-10-05 | Qiagen Gmbh | Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe |
| CN102747097B (zh) * | 2012-05-07 | 2013-10-09 | 陕西东大生化科技有限责任公司 | Ⅰ型人胶原蛋白和表皮生长因子双表达载体及其表达纯化方法 |
| CN110172433B (zh) * | 2019-05-12 | 2021-07-30 | 华中农业大学 | 一种产猪表皮生长因子的重组枯草芽孢杆菌工程菌及应用 |
| CN110607306A (zh) * | 2019-10-15 | 2019-12-24 | 赛法特（长沙）生物技术有限公司 | 一种重组猪表皮生长因子的表达方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5096825A (en) * | 1983-01-12 | 1992-03-17 | Chiron Corporation | Gene for human epidermal growth factor and synthesis and expression thereof |
| CA1299103C (en) * | 1986-03-07 | 1992-04-21 | Robert Joseph Collier | Method and compositions for increasing mammary parenchyma |
| DE3781682T2 (de) | 1986-12-11 | 1993-01-21 | British Tech Group | Verbesserungen im gebrauch oder in bezug auf den gebrauch von egf. |
| JPH02104293A (ja) | 1988-06-24 | 1990-04-17 | Earth Chem Corp Ltd | ウサギ上皮細胞成長因子 |
| GB9105446D0 (en) | 1991-03-14 | 1991-05-01 | British Bio Technology | Proteins and nucleic acids |
| US5753622A (en) * | 1995-05-10 | 1998-05-19 | University Technologies International, Inc. | Use of epidermal growth factor as a gastrointestinal therapeutic agent |
| US5785990A (en) * | 1995-07-10 | 1998-07-28 | Merrick's, Inc. | Feed fortifier and enhancer for preruminant calves and method of using same |
-
2002
- 2002-05-17 BR BR0209911-0A patent/BR0209911A/pt not_active IP Right Cessation
- 2002-05-17 CA CA002446398A patent/CA2446398A1/en not_active Abandoned
- 2002-05-17 KR KR10-2003-7015051A patent/KR20040089454A/ko not_active Application Discontinuation
- 2002-05-17 US US10/150,648 patent/US6967090B2/en not_active Expired - Fee Related
- 2002-05-17 EP EP02727118A patent/EP1395658A2/en not_active Ceased
- 2002-05-17 JP JP2002592490A patent/JP2004536589A/ja active Pending
- 2002-05-17 MX MXPA03010572A patent/MXPA03010572A/es unknown
- 2002-05-17 WO PCT/CA2002/000724 patent/WO2002095029A2/en not_active Application Discontinuation
- 2002-05-17 CN CNA028141741A patent/CN1527879A/zh active Pending
- 2002-05-17 NZ NZ529806A patent/NZ529806A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20030059802A1 (en) | 2003-03-27 |
| KR20040089454A (ko) | 2004-10-21 |
| CA2446398A1 (en) | 2002-11-28 |
| WO2002095029A3 (en) | 2003-05-30 |
| NZ529806A (en) | 2005-08-26 |
| US6967090B2 (en) | 2005-11-22 |
| WO2002095029A2 (en) | 2002-11-28 |
| MXPA03010572A (es) | 2005-03-07 |
| JP2004536589A (ja) | 2004-12-09 |
| CN1527879A (zh) | 2004-09-08 |
| EP1395658A2 (en) | 2004-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 6A., 7A., E 8A. ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2060 DE 29/06/2010. |
|
| B15K | Others concerning applications: alteration of classification |
Ipc: C07K 14/485 (2006.01), A23K 10/16 (2016.01), A23K |