BR0209267A - Pirimidinas fundidas como antagonistas do fator de liberação de corticotropina (crf) - Google Patents
Pirimidinas fundidas como antagonistas do fator de liberação de corticotropina (crf)Info
- Publication number
- BR0209267A BR0209267A BR0209267-0A BR0209267A BR0209267A BR 0209267 A BR0209267 A BR 0209267A BR 0209267 A BR0209267 A BR 0209267A BR 0209267 A BR0209267 A BR 0209267A
- Authority
- BR
- Brazil
- Prior art keywords
- crf
- antagonists
- releasing factor
- corticotropin releasing
- fused pyrimidines
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0463—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0465—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0110570A GB0110570D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
GB0110567A GB0110567D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
GB0110569A GB0110569D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
GB0117401A GB0117401D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
GB0117399A GB0117399D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
GB0117420A GB0117420D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
GB0203201A GB0203201D0 (en) | 2002-02-11 | 2002-02-11 | Chemical compounds |
GB0206834A GB0206834D0 (en) | 2002-03-22 | 2002-03-22 | Chemical compounds |
PCT/GB2002/002029 WO2002088095A1 (en) | 2001-04-30 | 2002-04-30 | Fused pyrimidines as antagonists of the corticotropin releasing factor (crf) |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0209267A true BR0209267A (pt) | 2004-06-15 |
Family
ID=27571152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0209267-0A BR0209267A (pt) | 2001-04-30 | 2002-04-30 | Pirimidinas fundidas como antagonistas do fator de liberação de corticotropina (crf) |
Country Status (19)
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002100863A1 (en) * | 2001-06-12 | 2002-12-19 | Glaxo Group Limited | Corticotropin releasing factor antagonists |
GB0117396D0 (en) * | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
JP2006515334A (ja) * | 2003-01-16 | 2006-05-25 | エスビー ファームコ プエルト リコ インコーポレーテッド | CRF受容体アンタゴニストとしてのヘテロアリール置換ピロロ[2,3−b]ピリジン誘導体 |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
GB0308208D0 (en) * | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
CN100372851C (zh) * | 2003-05-05 | 2008-03-05 | 弗·哈夫曼-拉罗切有限公司 | 具有crf活性的稠合的嘧啶衍生物 |
WO2005013997A1 (en) | 2003-08-12 | 2005-02-17 | F. Hoffmann-La Roche Ag | Spiro-substituted tetrahydroquinazolines as corticotropin releasing factor (cfr) antagonists |
WO2005014557A1 (en) * | 2003-08-12 | 2005-02-17 | F.Hoffmann-La Roche Ag | Tetrahydroquinazoline derivatives as cfr antagonists |
CN1938309B (zh) * | 2003-12-22 | 2011-11-09 | 史密斯克莱.比奇曼(科克)有限公司 | Crf受体拮抗剂及其相关方法 |
RU2006128580A (ru) * | 2004-01-06 | 2008-02-20 | Тайсо Фармасьютикал Ко., Лтд. (Jp) | Производные тиенопиримидина и тиенопиридина, замещенные циклической аминогруппой |
CN1926140A (zh) * | 2004-03-05 | 2007-03-07 | 大正制药株式会社 | 吡咯并嘧啶衍生物 |
RU2389731C2 (ru) | 2004-06-02 | 2010-05-20 | Такеда Фармасьютикал Компани Лимитед | Конденсированное гетероциклическое соединение |
RU2007102683A (ru) * | 2004-06-25 | 2008-07-27 | Тайсо Фармасьютикал Ко., Лтд. (Jp) | Производные пирролпиримидина и пирролпиридина, замещенные тетрагидропиридином, в качестве антагонистов crf |
ATE430746T1 (de) * | 2004-10-19 | 2009-05-15 | Smithkline Beecham Cork Ltd | Crf-rezeptor-antagonisten und zugehörige verfahren |
GB0519957D0 (en) * | 2005-09-30 | 2005-11-09 | Sb Pharmco Inc | Chemical compound |
US8088779B2 (en) * | 2005-09-30 | 2012-01-03 | Smithkline Beecham (Cork) Limited | Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as corticotropin-releasing factor (CRF) receptor antagonists |
US9303040B2 (en) | 2006-07-06 | 2016-04-05 | Array Biopharma Inc. | Substituted piperazines as AKT inhibitors |
CA2656618C (en) * | 2006-07-06 | 2014-08-26 | Array Biopharma Inc. | Cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
JP5231410B2 (ja) | 2006-07-06 | 2013-07-10 | アレイ バイオファーマ、インコーポレイテッド | Aktプロテインキナーゼ阻害剤としてのジヒドロフロピリミジン |
EP2043744A2 (en) * | 2006-07-13 | 2009-04-08 | SmithKline Beecham Corporation | Chemical compounds |
DE102007004303A1 (de) | 2006-08-04 | 2008-02-07 | Osram Opto Semiconductors Gmbh | Dünnfilm-Halbleiterbauelement und Bauelement-Verbund |
CA3089569C (en) | 2007-06-04 | 2023-12-05 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
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EP2173723B3 (en) * | 2007-07-05 | 2014-11-19 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
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2002
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- 2002-04-30 IL IL15806202A patent/IL158062A0/xx unknown
- 2002-04-30 AT AT02722478T patent/ATE386727T1/de not_active IP Right Cessation
- 2002-04-30 EP EP02722478A patent/EP1383747B1/en not_active Expired - Lifetime
- 2002-04-30 WO PCT/GB2002/002029 patent/WO2002088095A1/en active IP Right Grant
- 2002-04-30 US US10/476,368 patent/US7279474B2/en not_active Expired - Fee Related
- 2002-04-30 CN CNA028107462A patent/CN1649848A/zh active Pending
- 2002-04-30 AU AU2002253357A patent/AU2002253357B2/en not_active Ceased
- 2002-04-30 JP JP2002585397A patent/JP2004528349A/ja active Pending
- 2002-04-30 MX MXPA03009938A patent/MXPA03009938A/es active IP Right Grant
- 2002-04-30 CA CA002446514A patent/CA2446514A1/en not_active Abandoned
- 2002-04-30 HU HU0304054A patent/HUP0304054A2/hu unknown
- 2002-04-30 DE DE60225127T patent/DE60225127T2/de not_active Expired - Fee Related
- 2002-04-30 CZ CZ20032946A patent/CZ20032946A3/cs unknown
- 2002-04-30 BR BR0209267-0A patent/BR0209267A/pt not_active IP Right Cessation
- 2002-04-30 KR KR10-2003-7014160A patent/KR20040015206A/ko not_active Application Discontinuation
- 2002-04-30 AR ARP020101597A patent/AR033295A1/es unknown
- 2002-04-30 PL PL02366934A patent/PL366934A1/xx not_active Application Discontinuation
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2003
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NO20034836L (no) | 2003-10-29 |
EP1383747A1 (en) | 2004-01-28 |
CA2446514A1 (en) | 2002-11-07 |
EP1383747B1 (en) | 2008-02-20 |
DE60225127D1 (en) | 2008-04-03 |
ES2301633T3 (es) | 2008-07-01 |
KR20040015206A (ko) | 2004-02-18 |
IL158062A0 (en) | 2004-03-28 |
NO20034836D0 (no) | 2003-10-29 |
AU2002253357B2 (en) | 2006-08-24 |
US20040176400A1 (en) | 2004-09-09 |
MXPA03009938A (es) | 2005-09-07 |
PL366934A1 (en) | 2005-02-07 |
US7279474B2 (en) | 2007-10-09 |
WO2002088095A1 (en) | 2002-11-07 |
CZ20032946A3 (en) | 2004-05-12 |
CN1649848A (zh) | 2005-08-03 |
AR033295A1 (es) | 2003-12-10 |
JP2004528349A (ja) | 2004-09-16 |
DE60225127T2 (de) | 2009-02-19 |
ATE386727T1 (de) | 2008-03-15 |
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