BR0208663A - Uso de derivados de n-fenil-2-pirimidina-amina contra doenças com base em mastócito tal como distúrbios alérgicos - Google Patents

Uso de derivados de n-fenil-2-pirimidina-amina contra doenças com base em mastócito tal como distúrbios alérgicos

Info

Publication number
BR0208663A
BR0208663A BR0208663-8A BR0208663A BR0208663A BR 0208663 A BR0208663 A BR 0208663A BR 0208663 A BR0208663 A BR 0208663A BR 0208663 A BR0208663 A BR 0208663A
Authority
BR
Brazil
Prior art keywords
phenyl
amine derivatives
pyrimidine amine
based diseases
allergic disorders
Prior art date
Application number
BR0208663-8A
Other languages
English (en)
Inventor
Kenichi Koike
Atsushi Komiyama
Kovichi Takeuchi
Michael Heinrich
Motowo Nakajima
Original Assignee
Novartis Ag
Us Gov Veterans Affairs
Kenichi Koike
Atsushi Komiyama
Kovichi Takeuchi
Univ Oregon Health & Science
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Us Gov Veterans Affairs, Kenichi Koike, Atsushi Komiyama, Kovichi Takeuchi, Univ Oregon Health & Science filed Critical Novartis Ag
Publication of BR0208663A publication Critical patent/BR0208663A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

"USO DE DERIVADOS DE N-FENIL-2-PIRIMIDINA-AMINA CONTRA DOENçAS COM BASE EM MASTóCITO TAL COMO DISTúRBIOS ALéRGICOS". A presente invenção refere-se ao de derivados de N-fenil-2-pirimidino-amina da fórmula I onde os símbolos e substituintes têm os significados conforme aqui dado na forma livre ou na forma de sal farmaceuticamente aceitável na fabricação de composição farmacêutica para o tratamento de rinite alérgica, dermatite alérgica, alergia à droga ou alergia a alimento, angioedema, urticária, síndrome da morte de bebê repentina, aspergilose broncopulmonar, esclerose múltipla ou mastocitose.
BR0208663-8A 2001-04-05 2002-04-05 Uso de derivados de n-fenil-2-pirimidina-amina contra doenças com base em mastócito tal como distúrbios alérgicos BR0208663A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0108606.5A GB0108606D0 (en) 2001-04-05 2001-04-05 Organic compounds
PCT/US2002/010742 WO2002080925A1 (en) 2001-04-05 2002-04-05 Use of n-phenyl-2-pyrimidineamine derivativea against mast cell-based diseases like allergic disorders

Publications (1)

Publication Number Publication Date
BR0208663A true BR0208663A (pt) 2004-03-09

Family

ID=9912339

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0208663-8A BR0208663A (pt) 2001-04-05 2002-04-05 Uso de derivados de n-fenil-2-pirimidina-amina contra doenças com base em mastócito tal como distúrbios alérgicos

Country Status (18)

Country Link
EP (1) EP1389113A1 (pt)
KR (2) KR20090034998A (pt)
CN (1) CN1529602A (pt)
AU (1) AU2002307140B2 (pt)
BR (1) BR0208663A (pt)
CA (1) CA2443092A1 (pt)
CZ (1) CZ20032705A3 (pt)
GB (1) GB0108606D0 (pt)
HU (1) HUP0303751A3 (pt)
IL (1) IL158061A0 (pt)
MX (1) MXPA03009058A (pt)
NO (1) NO325454B1 (pt)
NZ (1) NZ528934A (pt)
PL (1) PL363080A1 (pt)
RU (1) RU2304436C2 (pt)
SK (1) SK12312003A3 (pt)
WO (1) WO2002080925A1 (pt)
ZA (1) ZA200307563B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE330608T1 (de) 2001-06-29 2006-07-15 Ab Science Die verwendung von n-phenyl-2-pyrimidine-amine derivaten zur behandlung von entzündlichen erkrankungen
US7678805B2 (en) 2001-06-29 2010-03-16 Ab Science Use of tyrosine kinase inhibitors for treating inflammatory bowel diseases (IBD)
US7700610B2 (en) 2001-06-29 2010-04-20 Ab Science Use of tyrosine kinase inhibitors for treating allergic diseases
JP2005500041A (ja) 2001-06-29 2005-01-06 アブ サイエンス 強力で選択的かつ非毒性のｃ−ｋｉｔ阻害剤
GB0201882D0 (en) * 2002-01-28 2002-03-13 Novartis Ag Organic compounds
US20060128720A1 (en) * 2002-03-21 2006-06-15 Kufe Donald W Inhibition of cell death responses induced by oxidative stress
US8450302B2 (en) 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
ATE375342T1 (de) 2002-08-02 2007-10-15 Ab Science 2-(3-aminoaryl)amino-4-aryl-thiazole und ihre verwendung als c-kit inhibitoren
WO2004076693A1 (en) * 2003-02-27 2004-09-10 Ab Science Tailored treatment suitable for different forms of mastocytosis
AU2003232650A1 (en) * 2003-05-06 2004-11-26 Il Yang Pharm Co., Ltd. N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof
TWI324604B (en) 2003-06-18 2010-05-11 Novartis Ag New use of staurosporine derivatives
WO2005115385A1 (en) * 2004-05-24 2005-12-08 Ab Science Use of c-kit inhibitors for treating acne
US20080187575A1 (en) * 2004-08-27 2008-08-07 Bert Klebl Pyrimidine Derivatives
US20080176879A1 (en) * 2005-05-02 2008-07-24 Leila Alland Pyrimidylaminobenzamide Derivatives For Sytemic Mastocytosis
KR100845278B1 (ko) * 2006-08-04 2008-07-09 포항공과대학교 산학협력단 비만 세포의 활성을 유도하는 펩타이드 및 이를 포함하는면역조절제
ES2633691T3 (es) * 2009-04-06 2017-09-22 Neurotech Pharmaceuticals Co., Ltd. Composición farmacéutica para tratar o prevenir lesiones por quemaduras
CN103058935B (zh) * 2013-01-15 2015-05-06 四川大学 一种嘧啶类化合物及其制备方法和用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO4940418A1 (es) * 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso

Also Published As

Publication number Publication date
RU2003130635A (ru) 2005-02-10
CA2443092A1 (en) 2002-10-17
SK12312003A3 (sk) 2004-02-03
RU2304436C2 (ru) 2007-08-20
NO20034414D0 (no) 2003-10-02
IL158061A0 (en) 2004-03-28
KR20040007485A (ko) 2004-01-24
AU2002307140B2 (en) 2006-02-16
NO20034414L (no) 2003-12-04
CN1529602A (zh) 2004-09-15
ZA200307563B (en) 2004-04-21
WO2002080925A1 (en) 2002-10-17
NO325454B1 (no) 2008-05-05
CZ20032705A3 (en) 2004-06-16
HUP0303751A3 (en) 2005-06-28
HUP0303751A2 (hu) 2005-04-28
NZ528934A (en) 2006-10-27
MXPA03009058A (es) 2004-11-22
PL363080A1 (en) 2004-11-15
KR20090034998A (ko) 2009-04-08
EP1389113A1 (en) 2004-02-18
GB0108606D0 (en) 2001-05-23

Similar Documents

Publication Publication Date Title
BR0208663A (pt) Uso de derivados de n-fenil-2-pirimidina-amina contra doenças com base em mastócito tal como distúrbios alérgicos
ATE452129T1 (de) N-phenyl-2-pyrimidine-amine derivatives
HUS000503I2 (hu) Midosztaurin vagy annak egy sója
BRPI0413427A (pt) derivados de piridilpirrol ativos como inibidores da cinase
BRPI0409641A (pt) 1-4-diazepinas substituìdas e seu uso
UY27592A1 (es) Nuevo uso
ATE407928T1 (de) Amino-phtalazinon derivate, anwendung als kinase inhibitoren, herstellung und pharmazeutische zusammensetzung
CY1117667T1 (el) 3,4-διαρυλπυραζολια ως αναστολεις κινασης πρωτεϊνης
BRPI0416801A (pt) derivados de 1h-imidazoquinolina como inibidores de proteìna sinase
NO20092737L (no) Substituerte pyrazolo-kinazolinderivater, fremgangsmate for deres fremstilling og deres anvendelse som kinase-inhibitorer
ATE454372T1 (de) Am histamin-h3-rezeptor wirksame mittel, herstellung und therapeutische anwendungen
NO20076460L (no) Nye fluorenderivater, sammensetninger inneholdende nevnte derivater og anvendelse derav
PA8604301A1 (es) Derivados de 2-amino-piridina utiles para el tratamiento de enfermedades
MY148108A (en) Medicaments for the treatment or prevention of fibrotic diseases
NO20063047L (no) Vandige ciclesonidsuspensjoner for forstoving
UA92181C2 (ru) Производные пиримидина и их применение в терапии и в производстве лекарственного средства для предотвращения и/или лечения болезни альцгеймера
EA200702282A1 (ru) Комбинация феррохина и производного артемизинина для лечения малярии
ATE367387T1 (de) Verwendung von oxindolderivaten zur behandlung von mit demenz in zusammenhang stehenden krankheiten, alzheimer-krankheit und mit glycogensynthasekinase-3 assoziierten leiden
TW200732304A (en) Piperidine derivatives
ATE495159T1 (de) Diaminocyclohexan- und diaminocyclopentanderivate
BR0317519A (pt) Composição farmacêutica para anestesia local e uso da mesma
DE502005008500D1 (de) Verwendung von lavendelöl zur prophylaxe und behandlung von somatisierungsstörungen und von posttraumatischer stresserkrankung
ATE325809T1 (de) Amidderivate der 2-amino-3-hydroxy-4-tert-leucyl- amino-5-phenyl-pentansäure
ATE453638T1 (de) Amidinderivate von 2-heteroarylchinazolinen und chinolinen; wirksame analgetika und entzündungshemmende mittel
PE20030337A1 (es) Indan-1-onas sustituidas en c2 y sus derivados, procedimiento para su preparacion y su utilizacion como medicamentos

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A(S) 9A ANUIDADE(S)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2103 DE 26/04/2011.