PE20030337A1 - Indan-1-onas sustituidas en c2 y sus derivados, procedimiento para su preparacion y su utilizacion como medicamentos - Google Patents

Indan-1-onas sustituidas en c2 y sus derivados, procedimiento para su preparacion y su utilizacion como medicamentos

Info

Publication number
PE20030337A1
PE20030337A1 PE2002000809A PE2002000809A PE20030337A1 PE 20030337 A1 PE20030337 A1 PE 20030337A1 PE 2002000809 A PE2002000809 A PE 2002000809A PE 2002000809 A PE2002000809 A PE 2002000809A PE 20030337 A1 PE20030337 A1 PE 20030337A1
Authority
PE
Peru
Prior art keywords
derivatives
preparation
indan
onas
medicines
Prior art date
Application number
PE2002000809A
Other languages
English (en)
Inventor
Martin Bickel
Volker Krone
Gerhard Jaehne
Matthias Gossel
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of PE20030337A1 publication Critical patent/PE20030337A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A INDAN-1-ONA SUSTITUIDA EN C2 DE FORMULA I DONDE R1, R2, R3, R4 SON H, F, Cl, Br, I, CN, N3, NO2, OH, O-ALQUILO C1-C8, O-CICLOALQUILO C3-C8, O-CH2-FENILO, O-FENILO, ENTRE OTROS; X ES S, SO, SO2; Y ES (CH2)p; p ES 0-3; R5 ES CF3, ALQUILO C1-C18, CICLOALQUILO C3-C4, (CH2)rCOR6, CH2-CH(NHR7)-COR8, FENILO, NAFTILO, BIFENILO, HETEROCICLO, r ES 1-6; R6 ES OH, O-ALQUILO C1-C6, NH2; R7 ES H, CO-ALQUILO C1-C4; R8 ES OH, O-ALQUILO C1-C6, NH2, R9 ES F, Cl, Br, CN, CF3, ALQUILO C1-C18, CICLOALQUILO C3-C4, (CH2)rCOR6, r ES 9-16. EXCEPTO LOS COMPUESTOS I CUANDO R1, R2, R3, R4 SON H; X-Y-R5 ES FENILO; R9 ES FENILO. SON COMPUESTOS PREFERIDOS 5-CLORO-2-FLUORO-2-METANOSULFONIL-INDAN-1-ONA; 2-BENCIL5-CLORO-2-METANOSULFONIL-INDAN-1-ONA. TAMBIEN SE REFIERE A UN PROCESO PARA LA RPEPARACION. LOS COMPUESTOS SON ANOREXICOS, TIENEN EFECTO SOBRE EL METABOLISMO DE GRASAS Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE OBESIDAD, DIABETES
PE2002000809A 2001-08-31 2002-08-23 Indan-1-onas sustituidas en c2 y sus derivados, procedimiento para su preparacion y su utilizacion como medicamentos PE20030337A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10142665A DE10142665B4 (de) 2001-08-31 2001-08-31 C2-Disubstituierte Indan-1-one und ihre Derivate

Publications (1)

Publication Number Publication Date
PE20030337A1 true PE20030337A1 (es) 2003-05-22

Family

ID=7697235

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000809A PE20030337A1 (es) 2001-08-31 2002-08-23 Indan-1-onas sustituidas en c2 y sus derivados, procedimiento para su preparacion y su utilizacion como medicamentos

Country Status (11)

Country Link
US (1) US7081467B2 (es)
EP (1) EP1423359B1 (es)
JP (1) JP4250079B2 (es)
AT (1) ATE473962T1 (es)
AU (1) AU2002336983B2 (es)
CA (1) CA2458524C (es)
DE (2) DE10142665B4 (es)
IL (1) IL160604A0 (es)
MX (1) MXPA04001851A (es)
PE (1) PE20030337A1 (es)
WO (1) WO2003020697A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2880887B1 (fr) * 2005-01-14 2009-01-30 Merck Sante Soc Par Actions Si Derives d'hydroxyphenols, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique
CN112574078B (zh) * 2020-12-14 2022-09-13 湖南工程学院 2-砜基-2，3-二氢-1-茚酮及其衍生物及合成方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS516724A (en) * 1974-07-06 1976-01-20 Konishiroku Photo Ind Harogenkaginshashinkankozairyo
SE7700500L (sv) * 1976-01-20 1977-07-21 Hoechst Ag Tiazolidinderivat och forfarande for deras framstellning
DE2640358A1 (de) * 1976-09-08 1978-03-16 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
GB8713768D0 (en) 1987-06-12 1987-07-15 May & Baker Ltd Compositions of matter
US5232940A (en) 1985-12-20 1993-08-03 Hatton Leslie R Derivatives of N-phenylpyrazoles
GB8531485D0 (en) 1985-12-20 1986-02-05 May & Baker Ltd Compositions of matter
KR0170567B1 (ko) 1992-12-17 1999-02-18 알렌 제이. 스피겔 부신피질자극호르몬-유리 인자 길항물질 활성을 갖는 피라졸 및 피라졸로피리미딘
ATE260241T1 (de) 1995-12-06 2004-03-15 Venantius Ltd Indanverbindungen mit relaxierender wirkung auf die glatten muskeln und/oder mit mastzellen stabilisiernder und/oder entzuendungshemmender wirkung
CA2241567A1 (en) 1996-01-17 1997-07-24 Novo Nordisk A/S Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use
GB9604691D0 (en) 1996-03-05 1996-05-01 Rhone Poulenc Agriculture New processes for preparing pesticidal intermediates
CA2468374C (en) 1996-08-30 2010-12-21 Novo-Nordisk A/S Glp-1 derivatives
ES2199366T3 (es) 1996-12-31 2004-02-16 Dr. Reddy's Laboratories Ltd. Compuestos heterociclicos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen y su uso en el tratamiento de diabetes y enfermedades relacionadas.
JP3507509B2 (ja) 1997-03-03 2004-03-15 ローヌ−プーラン・アグロ 農薬中間体の製造方法
JP2002510300A (ja) 1997-06-05 2002-04-02 ヴィーナンティアス・リミテッド インダン化合物及びそれらの医薬学的使用
HUP0003999A3 (en) 1997-07-16 2003-03-28 Novo Nordisk As Fused 1,2,4-thiadiazine derivatives, their preparation, their use and pharmaceutical compositions containing them
DE19831878C2 (de) * 1998-07-17 2001-05-17 Aventis Pharma Gmbh Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19844547C2 (de) * 1998-09-29 2002-11-07 Aventis Pharma Gmbh Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19908539A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Polycyclische 2-Amino-Dihydrothiazolsysteme, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP1078632A1 (en) 1999-08-16 2001-02-28 Sanofi-Synthelabo Use of monoamine oxydase inhibitors for the manufacture of drugs intended for the treatment of obesity

Also Published As

Publication number Publication date
DE50214537D1 (de) 2010-08-26
DE10142665A1 (de) 2003-03-27
AU2002336983B2 (en) 2008-02-14
EP1423359A1 (de) 2004-06-02
DE10142665B4 (de) 2004-05-06
US20030153609A1 (en) 2003-08-14
JP2005525298A (ja) 2005-08-25
ATE473962T1 (de) 2010-07-15
CA2458524C (en) 2010-12-14
CA2458524A1 (en) 2003-03-13
US7081467B2 (en) 2006-07-25
MXPA04001851A (es) 2004-06-15
WO2003020697A1 (de) 2003-03-13
EP1423359B1 (de) 2010-07-14
JP4250079B2 (ja) 2009-04-08
IL160604A0 (en) 2004-07-25

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