HUP0303751A2 - N-fenil-pirimidin-amin-származékok alkalmazása hízósejt alapú betegségekhez hasonló allergiás rendellenességek kezelésére alkalmas gyógyszerkészítmények előállítására - Google Patents

N-fenil-pirimidin-amin-származékok alkalmazása hízósejt alapú betegségekhez hasonló allergiás rendellenességek kezelésére alkalmas gyógyszerkészítmények előállítására

Info

Publication number
HUP0303751A2
HUP0303751A2 HU0303751A HUP0303751A HUP0303751A2 HU P0303751 A2 HUP0303751 A2 HU P0303751A2 HU 0303751 A HU0303751 A HU 0303751A HU P0303751 A HUP0303751 A HU P0303751A HU P0303751 A2 HUP0303751 A2 HU P0303751A2
Authority
HU
Hungary
Prior art keywords
phenyl
preparation
pharmaceutical compositions
mast cell
compositions suitable
Prior art date
Application number
HU0303751A
Other languages
English (en)
Inventor
Atsushi Komiyama
Kenichi Koike
Kouichi Takeuchi
Original Assignee
Novartis Ag.
The Government Of The United States Of America
Oregon Health And Science University
Atsushi Komiyama
Kenichi Koike
Kouichi Takeuchi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag., The Government Of The United States Of America, Oregon Health And Science University, Atsushi Komiyama, Kenichi Koike, Kouichi Takeuchi filed Critical Novartis Ag.
Publication of HUP0303751A2 publication Critical patent/HUP0303751A2/hu
Publication of HUP0303751A3 publication Critical patent/HUP0303751A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

A találmány tárgya (I) általános képletű N-fenil-2pirimidin-amin-származékok szabad formában vagy gyógyászatilag alkalmazható sóformában való alkalmazása allergiás nátha, allergiás bőrgyulladás,gyógyszer- -allergia, élelmiszer allergia, angiödéma, urtikária,hirtelen csecsemőhalál szindróma, bronchopulmonáris aspergillozis,szklerózis multiplex, vagy mastocytozis kezelésére alkalmasgyógyszerkészítmény előállítására. A szubsztituensek előnyösjelentései: R1, R3, R5, R6, R8 hidrogénatom, R2 piridil-csoport, R4 alkil-csoport, R7 helyettesített benzoil-amino-csoport. Ó
HU0303751A 2001-04-05 2002-04-05 Use of n-phenyl-2-pyrimidineamine derivatives for preparation of pharmaceutical compositions suitable for treating mast cell-based diseases like allergic disorders HUP0303751A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0108606.5A GB0108606D0 (en) 2001-04-05 2001-04-05 Organic compounds
PCT/US2002/010742 WO2002080925A1 (en) 2001-04-05 2002-04-05 Use of n-phenyl-2-pyrimidineamine derivativea against mast cell-based diseases like allergic disorders

Publications (2)

Publication Number Publication Date
HUP0303751A2 true HUP0303751A2 (hu) 2005-04-28
HUP0303751A3 HUP0303751A3 (en) 2005-06-28

Family

ID=9912339

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303751A HUP0303751A3 (en) 2001-04-05 2002-04-05 Use of n-phenyl-2-pyrimidineamine derivatives for preparation of pharmaceutical compositions suitable for treating mast cell-based diseases like allergic disorders

Country Status (18)

Country Link
EP (1) EP1389113A1 (hu)
KR (2) KR20090034998A (hu)
CN (1) CN1529602A (hu)
AU (1) AU2002307140B2 (hu)
BR (1) BR0208663A (hu)
CA (1) CA2443092A1 (hu)
CZ (1) CZ20032705A3 (hu)
GB (1) GB0108606D0 (hu)
HU (1) HUP0303751A3 (hu)
IL (1) IL158061A0 (hu)
MX (1) MXPA03009058A (hu)
NO (1) NO325454B1 (hu)
NZ (1) NZ528934A (hu)
PL (1) PL363080A1 (hu)
RU (1) RU2304436C2 (hu)
SK (1) SK12312003A3 (hu)
WO (1) WO2002080925A1 (hu)
ZA (1) ZA200307563B (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004537542A (ja) 2001-06-29 2004-12-16 アブ サイエンス 炎症性腸疾患（ｉｂｄ）を治療するための、チロシンキナーゼ阻害剤の使用
US7727731B2 (en) 2001-06-29 2010-06-01 Ab Science Potent, selective and non toxic c-kit inhibitors
CA2452371A1 (en) 2001-06-29 2003-01-09 Ab Science Use of tyrosine kinase inhibitors for treating allergic diseases
DK1401415T3 (da) 2001-06-29 2006-10-16 Ab Science Anvendelse af N-phenyl-2-pyrimidinamin-derivater til behandling af inflammatoriske sygdomme
GB0201882D0 (en) * 2002-01-28 2002-03-13 Novartis Ag Organic compounds
WO2003080061A1 (en) * 2002-03-21 2003-10-02 Dana-Farber Cancer Institute, Inc. Inhibition of cell death responses induced by oxidative stress
US20050239852A1 (en) 2002-08-02 2005-10-27 Ab Science 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors
US8450302B2 (en) 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
DE602004013283D1 (de) * 2003-02-27 2008-06-05 Ab Science Diagnostisches verfahren der mastozytose
AU2003232650A1 (en) * 2003-05-06 2004-11-26 Il Yang Pharm Co., Ltd. N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof
TWI324604B (en) 2003-06-18 2010-05-11 Novartis Ag New use of staurosporine derivatives
WO2005115385A1 (en) * 2004-05-24 2005-12-08 Ab Science Use of c-kit inhibitors for treating acne
WO2006021458A2 (en) * 2004-08-27 2006-03-02 Gpc Biotech Ag Pyrimidine derivatives
KR101376875B1 (ko) * 2005-05-02 2014-03-27 노파르티스 아게 전신 비만세포증의 치료를 위한 피리미딜아미노벤즈아미드유도체의 용도
KR100845278B1 (ko) * 2006-08-04 2008-07-09 포항공과대학교 산학협력단 비만 세포의 활성을 유도하는 펩타이드 및 이를 포함하는면역조절제
DK2417972T3 (en) * 2009-04-06 2017-08-14 Neurotech Pharmaceuticals Co Ltd PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF COMBUSTION DAMAGE
CN103058935B (zh) * 2013-01-15 2015-05-06 四川大学 一种嘧啶类化合物及其制备方法和用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO4940418A1 (es) * 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso

Also Published As

Publication number Publication date
RU2304436C2 (ru) 2007-08-20
CA2443092A1 (en) 2002-10-17
MXPA03009058A (es) 2004-11-22
RU2003130635A (ru) 2005-02-10
NO20034414L (no) 2003-12-04
KR20040007485A (ko) 2004-01-24
NO20034414D0 (no) 2003-10-02
AU2002307140B2 (en) 2006-02-16
IL158061A0 (en) 2004-03-28
CZ20032705A3 (en) 2004-06-16
SK12312003A3 (sk) 2004-02-03
ZA200307563B (en) 2004-04-21
NZ528934A (en) 2006-10-27
WO2002080925A1 (en) 2002-10-17
EP1389113A1 (en) 2004-02-18
CN1529602A (zh) 2004-09-15
GB0108606D0 (en) 2001-05-23
KR20090034998A (ko) 2009-04-08
BR0208663A (pt) 2004-03-09
NO325454B1 (no) 2008-05-05
PL363080A1 (en) 2004-11-15
HUP0303751A3 (en) 2005-06-28

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FD9A Lapse of provisional protection due to non-payment of fees