BR0208605A - Suspensão coloidal de nanopartìculas à base de copolìmero anfìfilo, para a vetorização de princìpios ativos - Google Patents
Suspensão coloidal de nanopartìculas à base de copolìmero anfìfilo, para a vetorização de princìpios ativosInfo
- Publication number
- BR0208605A BR0208605A BR0208605-0A BR0208605A BR0208605A BR 0208605 A BR0208605 A BR 0208605A BR 0208605 A BR0208605 A BR 0208605A BR 0208605 A BR0208605 A BR 0208605A
- Authority
- BR
- Brazil
- Prior art keywords
- suspension
- triblock copolymer
- active principles
- vectorization
- nanoparticles
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dispersion Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"SUSPENSãO COLOIDAL DE NANOPARTìCULAS à BASE DE COPOLìMERO ANFìFILO, PARA A VETORIZAçãO DE PRINCìPIOS ATIVOS". A invenção refere-se a uma suspensão aquosa, estável em meio fisiológico, de nanopartículas de vetorização PV de princípios ativos PA (por exemplo, insulina). Essas PV são à base de um copolímero tribloco: polietileno-glicol/poliaminoácido hidrófilo/poliaminoácido hidrófobo. Essas partículas de copolímero tribloco podem se associar a um PA, sem desnaturá-lo, depois ampliar esse PA in vivo, de forma controlada e por uma duração muito longa. Isto assegura, portanto, ao PA uma duração de ação muito prolongada. A invenção visa, igualmente, o sólido pulverulento a partir do qual são oriundas as PV, assim como a preparação desse sólido pulverulento e dessa suspensão de PV à base de copolímero tribloco. A invenção refere-se às especialidades farmacêuticas capazes de serem obtidas a partir dessas partículas de vetorização carregadas de princípio ativo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0104512A FR2822834B1 (fr) | 2001-04-02 | 2001-04-02 | Suspension colloidale de nanoparticules a base de copolymeres amphiphile pour la vectorisation de principes actifs et leur mode de preparation |
PCT/FR2002/001045 WO2002078677A1 (fr) | 2001-04-02 | 2002-03-26 | Suspension colloidale de nanoparticules a base d'un copolymere amphiphile |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0208605A true BR0208605A (pt) | 2004-03-09 |
Family
ID=8861882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0208605-0A BR0208605A (pt) | 2001-04-02 | 2002-03-26 | Suspensão coloidal de nanopartìculas à base de copolìmero anfìfilo, para a vetorização de princìpios ativos |
Country Status (11)
Country | Link |
---|---|
US (1) | US7709445B2 (pt) |
EP (1) | EP1372618B1 (pt) |
JP (1) | JP4339595B2 (pt) |
KR (1) | KR20030088488A (pt) |
CN (1) | CN100534419C (pt) |
BR (1) | BR0208605A (pt) |
CA (1) | CA2442532A1 (pt) |
FR (1) | FR2822834B1 (pt) |
IL (1) | IL158090A0 (pt) |
MX (1) | MXPA03009007A (pt) |
WO (1) | WO2002078677A1 (pt) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
US20040005999A1 (en) * | 2002-03-07 | 2004-01-08 | Andreasen Kasper Huus | Polyamino acid-based particle insulin preparation |
US20030211976A1 (en) * | 2002-03-07 | 2003-11-13 | Andreasen Kasper Huus | Polyamino acid-based particle insulin formulation |
FR2862541B1 (fr) * | 2003-11-21 | 2007-04-20 | Flamel Tech Sa | Formulations pharmaceutiques pour la liberation prolongee d'interferons et leurs applications therapeutiques |
FR2862536B1 (fr) * | 2003-11-21 | 2007-11-23 | Flamel Tech Sa | Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques |
FR2862535B1 (fr) * | 2003-11-21 | 2007-11-23 | Flamel Tech Sa | Formulations pharmaceutiques pour la liberation prolongee d'interleukines et leurs applications therapeutiques |
JP4929567B2 (ja) * | 2004-08-05 | 2012-05-09 | コニカミノルタエムジー株式会社 | ポリマーミセル含有製剤の製造方法 |
EP2348096A3 (en) * | 2005-01-04 | 2011-11-09 | Intezyne Technologies Inc. | Synthesis of hybrid block copolymers and uses thereof |
US20110124840A1 (en) * | 2005-02-11 | 2011-05-26 | Kurt Breitenkamp | Synthesis of Homopolymers and Block Copolymers |
ES2259914B1 (es) * | 2005-03-14 | 2007-06-16 | Advanced In Vitro Cell Technologies, S.L. | Nanoparticulas de quitosano y polietilenglicol como sistema de administracion de moleculas biologicamente activas. |
EP1907444B1 (en) | 2005-04-01 | 2009-08-19 | Intezyne Technologies Incorporated | Polymeric micelles for drug delivery |
US20060263328A1 (en) * | 2005-05-19 | 2006-11-23 | Sang Van | Hydrophilic polymers with pendant functional groups and method thereof |
JP2006321763A (ja) * | 2005-05-20 | 2006-11-30 | Hosokawa Funtai Gijutsu Kenkyusho:Kk | 生体適合性ナノ粒子及びその製造方法 |
US8815557B2 (en) * | 2005-07-08 | 2014-08-26 | University Of Chicago | Compositions and methods for refolding of denatured proteins |
CN100365043C (zh) * | 2006-04-06 | 2008-01-30 | 北京理工大学 | ABA型聚肽-b-聚四氢呋喃-b-聚肽三嵌段共聚物的合成 |
CN101489574A (zh) | 2006-07-18 | 2009-07-22 | 那野伽利阿株式会社 | 内包生理活性多肽或蛋白质的高分子聚合物胶束及其制造方法 |
JP5183478B2 (ja) * | 2006-08-31 | 2013-04-17 | ナノキャリア株式会社 | 活性成分内包ポリマーミセル含有経皮組成物、経皮医薬品組成物および経皮化粧品組成物 |
EP2282763B1 (en) * | 2008-04-07 | 2013-12-11 | National Institute Of Immunology | Process for preparing supramolecular calcitonin assemblies (SCA) |
AU2013204152B2 (en) * | 2008-11-06 | 2016-04-14 | Phaserx, Inc. | Multiblock copolymers |
US9464300B2 (en) * | 2008-11-06 | 2016-10-11 | University Of Washington | Multiblock copolymers |
WO2011062965A2 (en) | 2009-11-18 | 2011-05-26 | University Of Washington Through Its Center For Commercialization | Targeting monomers and polymers having targeting blocks |
CN101787120B (zh) * | 2010-03-04 | 2012-01-25 | 中国科学院宁波材料技术与工程研究所 | 三嵌段聚氨基酸及其水凝胶 |
CN102516552B (zh) * | 2011-11-18 | 2014-01-15 | 中山大学 | 一种可降解的酸敏感高分子两亲性阳离子嵌段共聚物与胶束粒子及其制备方法 |
CN103374128B (zh) * | 2012-04-28 | 2016-05-18 | 中国科学院深圳先进技术研究院 | 两亲性三嵌段共聚物、聚合物纳米载体制剂及制备方法 |
US10172796B2 (en) * | 2012-12-03 | 2019-01-08 | Manli International Ltd. | Use of umirolimus and its derivatives for treating cancer |
CN103087311B (zh) * | 2012-12-25 | 2015-04-15 | 深圳先进技术研究院 | 两亲性三嵌段聚合物及其制备方法和应用 |
US20140322428A1 (en) | 2013-03-15 | 2014-10-30 | Leading Edge Innovations, LLC | Compositions having an oil-in-water dispersion of submicron particles to enhance foods and beverages |
JP2016513711A (ja) | 2013-03-15 | 2016-05-16 | リーディング エッジ イノヴェイションズ、エルエルシーLeading Edge Innovations, Llc | 高レベルの水混和性溶媒を含有する、疎水性物質の実質的に界面活性剤を含まないサブミクロン分散液 |
RU2014120626A (ru) * | 2014-05-22 | 2015-11-27 | Владимир Андреевич Сабецкий | Инсулинсодержащий препарат пролонгированного действия |
US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
EP3691779B1 (en) * | 2017-10-06 | 2023-06-07 | Université de Bordeaux | Use of a copolymer for the stabilisation of an emulsion |
FR3084586B1 (fr) * | 2018-08-03 | 2020-11-06 | Adocia | Compositions sous forme d'une solution aqueuse injectable comprenant de l'amyline, un agoniste au recepteur de l'amyline ou un analogue d'amyline et un compose amphiphile porteur de radicaux hydrophobes |
WO2020178695A1 (en) | 2019-03-01 | 2020-09-10 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
FR3100248B1 (fr) * | 2019-09-03 | 2022-01-07 | Univ Bordeaux | Procédé de préparation de polymères et copolymères contrôlés à base de peptides en solution aqueuse |
US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
CN116474742B (zh) * | 2023-04-26 | 2024-01-23 | 天津大学 | 一种用于dna负载的带电多孔微球的制备方法 |
Family Cites Families (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2680749A (en) | 1951-12-01 | 1954-06-08 | Eastman Kodak Co | Water-soluble tocopherol derivatives |
DE1189636B (de) | 1959-12-28 | 1965-03-25 | Licentia Gmbh | UEberspannungsableiter erniedrigter Bauhoehe mit Loeschfunkenstrecke und spannungsabhaengigen Widerstaenden |
GB1024393A (en) | 1963-03-30 | 1966-03-30 | Asahi Chemical Ind | Process for polymerizing n-carboxy-ª-amino acid anhydrides |
GB1202765A (en) | 1967-07-20 | 1970-08-19 | Kyowa Hakko Kogyo Kk | PROCESS FOR THE POLYMERIZATION OF alpha-AMINO ACID-N-CARBOXY ANHYDRIDES |
US3536672A (en) | 1968-10-04 | 1970-10-27 | Kyowa Hakko Kogyo Kk | Process for the polymerization of alpha-amino acid - n - carboxy anhydrides using imidazole initiators |
US4351337A (en) | 1973-05-17 | 1982-09-28 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery device, and process for preparing and using the same |
US4450150A (en) | 1973-05-17 | 1984-05-22 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery depots, and method for preparing and using the same |
US4126628A (en) | 1977-03-28 | 1978-11-21 | Canadian Patents And Development Limited | Acylation of amino acids |
US4342739A (en) | 1979-01-09 | 1982-08-03 | Fuji Photo Film Co., Ltd. | Novel material for immunological assay of biochemical components and a process for the determination of said components |
US4321253A (en) | 1980-08-22 | 1982-03-23 | Beatty Morgan L | Suspension of microencapsulated bacampicillin acid addition salt for oral, especially pediatric, administration |
US4443549A (en) | 1981-10-19 | 1984-04-17 | Molecular Genetics, Inc. | Production of monoclonal antibodies against bacterial adhesins |
HU187215B (en) | 1983-01-26 | 1985-11-28 | Egyt Gyogyszervegyeszeti Gyar | Method for producing pharmaceutical product of high actor content and prolonged effect |
JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
JPH0830004B2 (ja) | 1983-11-14 | 1996-03-27 | コロンビア ラボラトリーズ インコーポレイテッド | 生物接着性組成物およびそれにより治療する方法 |
US4894240A (en) | 1983-12-22 | 1990-01-16 | Elan Corporation Plc | Controlled absorption diltiazem formulation for once-daily administration |
ATE60340T1 (de) | 1984-10-19 | 1991-02-15 | Battelle Memorial Institute | Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten. |
US4661345A (en) | 1985-02-26 | 1987-04-28 | The Rockefeller University | Method for treating pertussis |
EP0198769A3 (en) | 1985-04-12 | 1987-09-02 | Forest Laboratories, Inc. | Floating sustained release therapeutic compositions |
MX9203291A (es) | 1985-06-26 | 1992-08-01 | Liposome Co Inc | Metodo para acoplamiento de liposomas. |
US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
US5102872A (en) | 1985-09-20 | 1992-04-07 | Cetus Corporation | Controlled-release formulations of interleukin-2 |
CH667874A5 (fr) | 1985-12-19 | 1988-11-15 | Battelle Memorial Institute | Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments. |
GB8601100D0 (en) | 1986-01-17 | 1986-02-19 | Cosmas Damian Ltd | Drug delivery system |
US4835293A (en) | 1987-02-24 | 1989-05-30 | E. I. Du Pont De Nemours And Company | Atmospheric pressure process for preparing pure cyclic esters |
GB8723846D0 (en) | 1987-10-10 | 1987-11-11 | Danbiosyst Ltd | Bioadhesive microsphere drug delivery system |
DE3837825A1 (de) | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
US4976968A (en) | 1989-02-24 | 1990-12-11 | Clinical Technologies Associates, Inc. | Anhydrous delivery systems for pharmacological agents |
US5084278A (en) | 1989-06-02 | 1992-01-28 | Nortec Development Associates, Inc. | Taste-masked pharmaceutical compositions |
CA1340681C (en) | 1989-07-07 | 1999-07-27 | Robert Deziel | Antiherpes tetrapeptides having a substituted aspartic acid side chain |
IT1256651B (it) | 1992-12-11 | 1995-12-12 | Giancarlo Santus | Composizione farmaceutica a rilascio controllato in sospensione liquida |
GB2240547A (en) * | 1990-01-31 | 1991-08-07 | Ciba Geigy Ag | New compositions |
US5023349A (en) | 1990-05-08 | 1991-06-11 | E. I. Du Pont De Nemours And Company | Continuous process for rapid conversion of oligomers to cyclic esters |
SE9002684D0 (sv) | 1990-08-17 | 1990-08-17 | Malvac Foundation C O Peter Pe | New peptides and their use |
FI922107A0 (fi) | 1991-05-10 | 1992-05-08 | Faulding F H & Co Ltd | Mikrokapselkomposition och foerfarande. |
US5286497A (en) | 1991-05-20 | 1994-02-15 | Carderm Capital L.P. | Diltiazem formulation |
FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
US5286495A (en) | 1992-05-11 | 1994-02-15 | University Of Florida | Process for microencapsulating cells |
KR940003548U (ko) | 1992-08-14 | 1994-02-21 | 김형술 | 세탁물 건조기 |
US6153193A (en) | 1993-04-28 | 2000-11-28 | Supratek Pharma Inc. | Compositions for targeting biological agents |
PT674506E (pt) | 1992-12-02 | 2001-01-31 | Alkermes Inc | Microsferas contendo hormona de crescimento com libertacao controlada |
FR2702373B1 (fr) | 1993-03-08 | 1996-06-07 | Rhone Merieux | Emulsions vaccinales fluides eau-dans-l'huile contenant une huile métabolisable. |
RU2130464C1 (ru) | 1993-05-20 | 1999-05-20 | Биотек Аустралиа Пти, Лимитед | Антагонист лг-рилизинг-фактора (lhrh), комплекс, способ химической кастрации и/или лечения гонадотропинзависимых расстройств |
DK72793D0 (da) | 1993-06-21 | 1993-06-21 | Novo Nordisk As | Nyt produkt |
FR2708932B1 (fr) | 1993-08-10 | 1995-11-10 | Flamel Tech Sa | Procédé de préparation de polyaminoacides. |
KR0141431B1 (ko) | 1994-05-17 | 1998-07-01 | 김상웅 | 생분해성 하이드로겔 고분자 |
JP3460340B2 (ja) | 1994-09-09 | 2003-10-27 | Jsr株式会社 | ポリ−α−アミノ酸のエマルジョンおよびその製造方法並びにポリ−α−アミノ酸の中空ポリマー粒子 |
KR0167613B1 (ko) * | 1994-12-28 | 1999-01-15 | 한스 루돌프 하우스, 니콜 케르커 | 사이클로스포린-함유 연질캅셀제 조성물 |
JP2690276B2 (ja) | 1995-01-10 | 1997-12-10 | 科学技術振興事業団 | 静電結合型高分子ミセル薬物担体とその薬剤 |
FR2732218B1 (fr) | 1995-03-28 | 1997-08-01 | Flamel Tech Sa | Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s) et leurs procedes de preparation |
US5872210A (en) | 1995-10-05 | 1999-02-16 | The United States Of America As Represented By The Department Of Health And Human Services | Transframe peptide inhibitor of viral protease |
FR2746035B1 (fr) | 1996-03-15 | 1998-06-12 | Microparticules de gel composite susceptibles d'etre utilisees comme vecteur(s) de principe(s) actif(s), l'un de leurs procedes de preparation et leurs applications | |
US6284267B1 (en) | 1996-08-14 | 2001-09-04 | Nutrimed Biotech | Amphiphilic materials and liposome formulations thereof |
US6083484A (en) * | 1996-10-17 | 2000-07-04 | Molecular Biosystems, Inc. | Microparticles stabilized by polynuclear chromium complexes and their use as ultrasound contrast agents |
US5981761A (en) | 1997-03-27 | 1999-11-09 | Solutia Inc. | Crosslinked polyaspartate salts a process for their production |
KR100195291B1 (ko) | 1997-07-12 | 1999-06-15 | 서경배 | 비이온성 비타민 |
US6201072B1 (en) | 1997-10-03 | 2001-03-13 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
US6320017B1 (en) | 1997-12-23 | 2001-11-20 | Inex Pharmaceuticals Corp. | Polyamide oligomers |
CA2320032A1 (en) | 1998-02-10 | 1999-08-12 | University Of Utah Research Foundation | Methods for purifying and assaying a conus .gamma.-carboxylase |
EP0963758A3 (en) | 1998-05-07 | 2000-03-22 | Universiteit Gent | Synthetic polyaminoacid complexes for delivery of nucleic acids to target cells |
DE19822600C2 (de) | 1998-05-20 | 2003-08-21 | Goldschmidt Ag Th | Copolymere, hydrophob modifizierte Polyasparaginsäureester mit erhöhter Molekularmasse |
GB9811059D0 (en) | 1998-05-23 | 1998-07-22 | Univ Strathclyde | Polyamino acid vesicles |
US7030155B2 (en) | 1998-06-05 | 2006-04-18 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US6143314A (en) | 1998-10-28 | 2000-11-07 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
FR2786098B1 (fr) | 1998-11-20 | 2003-05-30 | Flamel Tech Sa | Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s), suspension colloidale les comprenant et leurs procedes de fabrication |
US7060708B2 (en) | 1999-03-10 | 2006-06-13 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
US6309633B1 (en) * | 1999-06-19 | 2001-10-30 | Nobex Corporation | Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same |
FR2801226B1 (fr) | 1999-11-23 | 2002-01-25 | Flamel Tech Sa | Suspension colloidale de particules submicroniques de vectorisation de principes actifs et son mode de preparation |
US7785625B2 (en) | 2000-01-14 | 2010-08-31 | Lg Life Sciences, Limited | Lipophilic-coated microparticle containing a protein drug and formulation comprising same |
FR2814952B1 (fr) | 2000-10-06 | 2004-01-02 | Flamel Tech Sa | Suspension colloidale de particules submicromiques de vectorisation de principes actifs et leur mode de preparation |
US6541014B2 (en) | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
FR2816840B1 (fr) | 2000-11-17 | 2004-04-09 | Flamel Tech Sa | Medicament a base de microcapsules d'anti-hyperclycemiant a liberation prolongee et son procede de preparation |
ATE438382T1 (de) | 2001-02-28 | 2009-08-15 | Intervet Int Bv | Wasser-in-öl-injektionsemulsionen |
AU2002248792B2 (en) | 2001-04-18 | 2006-09-21 | Nostrum Pharmaceuticals Inc. | A novel coating for a sustained release pharmaceutical composition |
US6933269B2 (en) | 2001-08-03 | 2005-08-23 | The Procter & Gamble Company | Polyaspartate derivatives for use in detergent compositions |
WO2003041689A1 (en) | 2001-11-12 | 2003-05-22 | Alkermes Controlled Therapeutics, Inc. | Biocompatible polymer blends and uses thereof |
US7261875B2 (en) | 2001-12-21 | 2007-08-28 | Board Of Regents, The University Of Texas System | Dendritic poly (amino acid) carriers and methods of use |
FR2838964B1 (fr) | 2002-04-26 | 2004-07-09 | Flamel Tech Sa | Suspension colloidale de particules submicroniques de vectorisation de principes actifs et leur mode de preparation |
FR2840614B1 (fr) | 2002-06-07 | 2004-08-27 | Flamel Tech Sa | Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques |
FR2843117B1 (fr) | 2002-07-30 | 2004-10-15 | Flamel Tech Sa | Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques |
WO2004060968A1 (fr) | 2002-12-04 | 2004-07-22 | Flamel Technologies | Polyaminoacides fonctionnalises par au moins un groupement (oligo)aminoacide et leurs applications notamment therapeutiques |
FR2855521B1 (fr) | 2003-05-28 | 2005-08-05 | Flamel Tech Sa | Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques. |
FR2860516B1 (fr) | 2003-10-03 | 2006-01-13 | Flamel Tech Sa | Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques |
FR2862536B1 (fr) | 2003-11-21 | 2007-11-23 | Flamel Tech Sa | Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques |
FR2873040B1 (fr) | 2004-07-19 | 2007-11-30 | Flamel Technologies Sa | Formulation colloidale d'insuline longue action et sa preparation |
FR2881140B1 (fr) | 2005-01-27 | 2007-04-06 | Flamel Technologies Sa | Copolyhydroxyalkylglutamines fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques |
FR2891149B1 (fr) | 2005-09-26 | 2007-11-30 | Biodex Sarl | Composition pharmaceutique a action cicatrisante comprenant un derive de dextrane soluble et un facteur de croissance derive des plaquettes. |
JP2009532552A (ja) | 2006-04-07 | 2009-09-10 | アドシア | 二官能化された多糖類 |
FR2915748B1 (fr) | 2007-05-03 | 2012-10-19 | Flamel Tech Sa | Acides polyglutamiques fonctionnalises par des groupes cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques |
-
2001
- 2001-04-02 FR FR0104512A patent/FR2822834B1/fr not_active Expired - Fee Related
-
2002
- 2002-03-26 CA CA002442532A patent/CA2442532A1/fr not_active Abandoned
- 2002-03-26 CN CNB028086392A patent/CN100534419C/zh not_active Expired - Fee Related
- 2002-03-26 IL IL15809002A patent/IL158090A0/xx unknown
- 2002-03-26 KR KR10-2003-7013007A patent/KR20030088488A/ko not_active Application Discontinuation
- 2002-03-26 US US10/473,821 patent/US7709445B2/en not_active Expired - Fee Related
- 2002-03-26 WO PCT/FR2002/001045 patent/WO2002078677A1/fr active Application Filing
- 2002-03-26 JP JP2002576943A patent/JP4339595B2/ja not_active Expired - Fee Related
- 2002-03-26 EP EP02724379A patent/EP1372618B1/fr not_active Expired - Lifetime
- 2002-03-26 BR BR0208605-0A patent/BR0208605A/pt not_active Application Discontinuation
- 2002-03-26 MX MXPA03009007A patent/MXPA03009007A/es unknown
Also Published As
Publication number | Publication date |
---|---|
MXPA03009007A (es) | 2004-02-17 |
CN1503664A (zh) | 2004-06-09 |
JP4339595B2 (ja) | 2009-10-07 |
WO2002078677A1 (fr) | 2002-10-10 |
US20040138095A1 (en) | 2004-07-15 |
EP1372618A1 (fr) | 2004-01-02 |
FR2822834B1 (fr) | 2005-02-25 |
US7709445B2 (en) | 2010-05-04 |
EP1372618B1 (fr) | 2012-12-05 |
CN100534419C (zh) | 2009-09-02 |
KR20030088488A (ko) | 2003-11-19 |
CA2442532A1 (fr) | 2002-10-10 |
FR2822834A1 (fr) | 2002-10-04 |
JP2004525939A (ja) | 2004-08-26 |
IL158090A0 (en) | 2004-03-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0208605A (pt) | Suspensão coloidal de nanopartìculas à base de copolìmero anfìfilo, para a vetorização de princìpios ativos | |
Wasiak et al. | Dextran nanoparticle synthesis and properties | |
BR0114512A (pt) | Suspensão coloidal, sólido pulverulento, processos de preparação, produtos intermediários de processo, especialidade farmacêutica, nutricional, fitossanitária ou cosmética e uso de uma suspensão coloidal estável | |
NZ532198A (en) | Polymeric micelle composition of an amphiphilic block copolymer and a polylactic acid derivative | |
CA2449244A1 (en) | Negatively charged amphiphilic block copolymer as drug carrier and complex thereof with positively charged drug | |
CA2408716A1 (en) | Stable polymeric micelle-type drug composition and method for the preparation thereof | |
DE60004704D1 (de) | Kolloidale suspension von submikronischen teilchen als vektoren von aktiven prinzipien sowie deren herstellung | |
FR2786098B1 (fr) | Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s), suspension colloidale les comprenant et leurs procedes de fabrication | |
BR0114513A (pt) | Suspensão coloidal, sólida pulverulento, processo de preparação do sólido pulverulento, processo de preparação da suspensão, produtos intermediários do processo e especialidade farmacêutica, nutricional, fitossanitária ou cosmética | |
HK1064295A1 (en) | Medical aerosol formulations | |
WO2005032511A3 (en) | Nanoparticulate therapeutic biologically active agents | |
BR9909189A (pt) | Suspensão de agente ativo peroral | |
ZA200703751B (en) | Ophthalmic oil-in-water type emulsion with stable positive zeta potential | |
HUE039448T2 (hu) | Csontba szállító konjugátumok és alkalmazási módszerük a fehérjék csontba juttatására | |
ATE449806T1 (de) | Mittels wasserabweisender implantate mit anionischer ladung funktionalisierte polyaminosäuren und anwendungen, wie etwa therapeutische anwendungen dafür | |
WO2007141344A3 (fr) | Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques | |
US10947349B2 (en) | Shape-preserving polymeric replication of biological matter | |
MX2009011814A (es) | Formulaciones farmaceuticas autoprecipitantes para la liberacion modificada de un principio activo. | |
WO2005033181A3 (fr) | Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques | |
MXPA04000317A (es) | Un copolimero de bloque amfifilico cargado positivamente como un vehiculo de medicamento y complejo del mismo con un medicamento cargado negativamente. | |
WO2003087757A3 (en) | Particle-bound human immunodeficiency virus envelope clycoproteins and related compositions and methods | |
JP2007197394A (ja) | ジスルフィド架橋したタンパク質ナノ粒子 | |
Jobdeedamrong et al. | Nanocapsules with excellent biocompatibility and stability in protein solutions | |
KR101891715B1 (ko) | 바이러스 감염의 치료용 폴리아미노산 기반의 생체환경 감응형 나노입자 | |
AR054221A1 (es) | Vehiculos de fase unica no acuosos y formulaciones que utilizan tales vehiculos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |