BR0208605A - Suspensão coloidal de nanopartìculas à base de copolìmero anfìfilo, para a vetorização de princìpios ativos - Google Patents

Suspensão coloidal de nanopartìculas à base de copolìmero anfìfilo, para a vetorização de princìpios ativos

Info

Publication number
BR0208605A
BR0208605A BR0208605-0A BR0208605A BR0208605A BR 0208605 A BR0208605 A BR 0208605A BR 0208605 A BR0208605 A BR 0208605A BR 0208605 A BR0208605 A BR 0208605A
Authority
BR
Brazil
Prior art keywords
suspension
triblock copolymer
active principles
vectorization
nanoparticles
Prior art date
Application number
BR0208605-0A
Other languages
English (en)
Inventor
Gerard Soula
Nathan Bryson
Original Assignee
Flamel Tech Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flamel Tech Sa filed Critical Flamel Tech Sa
Publication of BR0208605A publication Critical patent/BR0208605A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"SUSPENSãO COLOIDAL DE NANOPARTìCULAS à BASE DE COPOLìMERO ANFìFILO, PARA A VETORIZAçãO DE PRINCìPIOS ATIVOS". A invenção refere-se a uma suspensão aquosa, estável em meio fisiológico, de nanopartículas de vetorização PV de princípios ativos PA (por exemplo, insulina). Essas PV são à base de um copolímero tribloco: polietileno-glicol/poliaminoácido hidrófilo/poliaminoácido hidrófobo. Essas partículas de copolímero tribloco podem se associar a um PA, sem desnaturá-lo, depois ampliar esse PA in vivo, de forma controlada e por uma duração muito longa. Isto assegura, portanto, ao PA uma duração de ação muito prolongada. A invenção visa, igualmente, o sólido pulverulento a partir do qual são oriundas as PV, assim como a preparação desse sólido pulverulento e dessa suspensão de PV à base de copolímero tribloco. A invenção refere-se às especialidades farmacêuticas capazes de serem obtidas a partir dessas partículas de vetorização carregadas de princípio ativo.
BR0208605-0A 2001-04-02 2002-03-26 Suspensão coloidal de nanopartìculas à base de copolìmero anfìfilo, para a vetorização de princìpios ativos BR0208605A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0104512A FR2822834B1 (fr) 2001-04-02 2001-04-02 Suspension colloidale de nanoparticules a base de copolymeres amphiphile pour la vectorisation de principes actifs et leur mode de preparation
PCT/FR2002/001045 WO2002078677A1 (fr) 2001-04-02 2002-03-26 Suspension colloidale de nanoparticules a base d'un copolymere amphiphile

Publications (1)

Publication Number Publication Date
BR0208605A true BR0208605A (pt) 2004-03-09

Family

ID=8861882

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0208605-0A BR0208605A (pt) 2001-04-02 2002-03-26 Suspensão coloidal de nanopartìculas à base de copolìmero anfìfilo, para a vetorização de princìpios ativos

Country Status (11)

Country Link
US (1) US7709445B2 (pt)
EP (1) EP1372618B1 (pt)
JP (1) JP4339595B2 (pt)
KR (1) KR20030088488A (pt)
CN (1) CN100534419C (pt)
BR (1) BR0208605A (pt)
CA (1) CA2442532A1 (pt)
FR (1) FR2822834B1 (pt)
IL (1) IL158090A0 (pt)
MX (1) MXPA03009007A (pt)
WO (1) WO2002078677A1 (pt)

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FR2838964B1 (fr) 2002-04-26 2004-07-09 Flamel Tech Sa Suspension colloidale de particules submicroniques de vectorisation de principes actifs et leur mode de preparation
FR2840614B1 (fr) 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
FR2843117B1 (fr) 2002-07-30 2004-10-15 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques
WO2004060968A1 (fr) 2002-12-04 2004-07-22 Flamel Technologies Polyaminoacides fonctionnalises par au moins un groupement (oligo)aminoacide et leurs applications notamment therapeutiques
FR2855521B1 (fr) 2003-05-28 2005-08-05 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques.
FR2860516B1 (fr) 2003-10-03 2006-01-13 Flamel Tech Sa Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
FR2862536B1 (fr) 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
FR2873040B1 (fr) 2004-07-19 2007-11-30 Flamel Technologies Sa Formulation colloidale d'insuline longue action et sa preparation
FR2881140B1 (fr) 2005-01-27 2007-04-06 Flamel Technologies Sa Copolyhydroxyalkylglutamines fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
FR2891149B1 (fr) 2005-09-26 2007-11-30 Biodex Sarl Composition pharmaceutique a action cicatrisante comprenant un derive de dextrane soluble et un facteur de croissance derive des plaquettes.
JP2009532552A (ja) 2006-04-07 2009-09-10 アドシア 二官能化された多糖類
FR2915748B1 (fr) 2007-05-03 2012-10-19 Flamel Tech Sa Acides polyglutamiques fonctionnalises par des groupes cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques

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CN1503664A (zh) 2004-06-09
JP4339595B2 (ja) 2009-10-07
WO2002078677A1 (fr) 2002-10-10
US20040138095A1 (en) 2004-07-15
EP1372618A1 (fr) 2004-01-02
FR2822834B1 (fr) 2005-02-25
US7709445B2 (en) 2010-05-04
EP1372618B1 (fr) 2012-12-05
CN100534419C (zh) 2009-09-02
KR20030088488A (ko) 2003-11-19
CA2442532A1 (fr) 2002-10-10
FR2822834A1 (fr) 2002-10-04
JP2004525939A (ja) 2004-08-26
IL158090A0 (en) 2004-03-28

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