GB1202765A - PROCESS FOR THE POLYMERIZATION OF alpha-AMINO ACID-N-CARBOXY ANHYDRIDES - Google Patents
PROCESS FOR THE POLYMERIZATION OF alpha-AMINO ACID-N-CARBOXY ANHYDRIDESInfo
- Publication number
- GB1202765A GB1202765A GB3436468A GB3436468A GB1202765A GB 1202765 A GB1202765 A GB 1202765A GB 3436468 A GB3436468 A GB 3436468A GB 3436468 A GB3436468 A GB 3436468A GB 1202765 A GB1202765 A GB 1202765A
- Authority
- GB
- United Kingdom
- Prior art keywords
- imidazole
- alkyl
- carboxylic
- alpha
- polymerization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polyamides (AREA)
Abstract
1,202,765. Poly-aminoacids. KYOWA HAKKO KOGYO CO. Ltd. 18 July, 1968 [20 July, 1967], No. 34364/68. Heading C3R. Polyaminoacids are prepared by polymerizing an alpha-aminoacid-N-carboxylic anhydride in the presence of imidazole or an aryl-, aralkyl, alkaryl-, alkyl-, halo-alkyl-, halogeno-, hydroxyalkyl-, aminoalkyl-, nitro-, amino-, mercapto-, aldehydo- and/or keto-substituted imidazole, an imidazole carboxylic acid, an imidazole carboxylic amide, an imidazole carboxylic alkyl ester, an imidazoline, imidazolone, imidazolidinone, a benzimidazole or imidazolidine or a mixture thereof. The polymerization may be performed at a temperature in the range - 20‹ to + 120‹ C. in solution or suspension in an inert organic solvent and in the presence of 0À1 mole per cent or more of the imidazole derivative. In examples aminoacids used are L-glutamic acid-gamma-methyl ester, L-alanine, L-leucine and D,L-glutamic acid-gamma-methyl ester. N-ethylimidazole, 2-methylimidazole and ethylene urea (2-imidazolidinone) are specified as imidazole derivatives and dioxan, dichloroethane, dimethyl formamide, ethyl acetate and dimethyl sulphoxide are specified as solvents. The products are precipitated by addition of methanol and may be used to make films and fibres.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4633867 | 1967-07-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1202765A true GB1202765A (en) | 1970-08-19 |
Family
ID=12744333
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3436468A Expired GB1202765A (en) | 1967-07-20 | 1968-07-18 | PROCESS FOR THE POLYMERIZATION OF alpha-AMINO ACID-N-CARBOXY ANHYDRIDES |
Country Status (3)
Country | Link |
---|---|
DE (1) | DE1770908C3 (en) |
FR (1) | FR1603159A (en) |
GB (1) | GB1202765A (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2174097A (en) * | 1985-03-22 | 1986-10-29 | Ceskoslovenska Akademie Ved | Polymeric stabilizer of water-in-oil emulsions |
WO1995004772A1 (en) * | 1993-08-10 | 1995-02-16 | Flamel Technologies | Method for the preparation of polyaminoacids |
US5714138A (en) * | 1991-12-20 | 1998-02-03 | Hoechst Aktiengesellschaft | Polyaspartamide derivatives as adsorbents for bile acids, polyaspartamide derivatives loaded with bile acids and process for their preparation and their use as pharmaceuticals |
WO1999064495A1 (en) * | 1998-06-05 | 1999-12-16 | Ústav Makromolekulární Chemie Akademie Věd České Republiky | FUNCTIONALISED POLYMERS OF α-AMINO ACIDS AND THE METHOD OF PREPARATION THEREOF |
US7659365B2 (en) | 2003-10-03 | 2010-02-09 | Flamel Technologies | Telechelic homopolyamino acids functionalized with hydrophobic groups, and their applications, especially therapeutic applications |
US7678882B2 (en) | 2002-07-30 | 2010-03-16 | Flamel Technologies | Polyamino acids functionalized by at least one hydrophobic group and the therapeutic application thereof |
US7709445B2 (en) | 2001-04-02 | 2010-05-04 | Flamel Technologies | Colloidal suspension of nanoparticles based on an amphiphilic copolymer |
US8084045B2 (en) | 2003-11-21 | 2011-12-27 | Flamel Technologies | Pharmaceutical formulations for the prolonged release of active principle(s) and their applications |
-
1968
- 1968-07-18 FR FR1603159D patent/FR1603159A/fr not_active Expired
- 1968-07-18 GB GB3436468A patent/GB1202765A/en not_active Expired
- 1968-07-19 DE DE19681770908 patent/DE1770908C3/en not_active Expired
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2174097A (en) * | 1985-03-22 | 1986-10-29 | Ceskoslovenska Akademie Ved | Polymeric stabilizer of water-in-oil emulsions |
US5714138A (en) * | 1991-12-20 | 1998-02-03 | Hoechst Aktiengesellschaft | Polyaspartamide derivatives as adsorbents for bile acids, polyaspartamide derivatives loaded with bile acids and process for their preparation and their use as pharmaceuticals |
US6036948A (en) * | 1991-12-20 | 2000-03-14 | Krone; Volker | Polyaspartamide derivatives as adsordents for bile acids, polyaspartamide derivatives loaded with bile acids and process for their preparation and their use as pharmaceuticals |
WO1995004772A1 (en) * | 1993-08-10 | 1995-02-16 | Flamel Technologies | Method for the preparation of polyaminoacids |
FR2708932A1 (en) * | 1993-08-10 | 1995-02-17 | Flamel Tech Sa | Process for the preparation of polyamino acids. |
US5780579A (en) * | 1993-08-10 | 1998-07-14 | Flamel Technologies (Societe Anonyme) | Method for the preparation of polyamino acids |
WO1999064495A1 (en) * | 1998-06-05 | 1999-12-16 | Ústav Makromolekulární Chemie Akademie Věd České Republiky | FUNCTIONALISED POLYMERS OF α-AMINO ACIDS AND THE METHOD OF PREPARATION THEREOF |
US7709445B2 (en) | 2001-04-02 | 2010-05-04 | Flamel Technologies | Colloidal suspension of nanoparticles based on an amphiphilic copolymer |
US7678882B2 (en) | 2002-07-30 | 2010-03-16 | Flamel Technologies | Polyamino acids functionalized by at least one hydrophobic group and the therapeutic application thereof |
US7659365B2 (en) | 2003-10-03 | 2010-02-09 | Flamel Technologies | Telechelic homopolyamino acids functionalized with hydrophobic groups, and their applications, especially therapeutic applications |
US8084045B2 (en) | 2003-11-21 | 2011-12-27 | Flamel Technologies | Pharmaceutical formulations for the prolonged release of active principle(s) and their applications |
Also Published As
Publication number | Publication date |
---|---|
DE1770908B2 (en) | 1973-10-04 |
DE1770908A1 (en) | 1972-01-13 |
DE1770908C3 (en) | 1974-06-06 |
FR1603159A (en) | 1971-03-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |