GB1202765A - PROCESS FOR THE POLYMERIZATION OF alpha-AMINO ACID-N-CARBOXY ANHYDRIDES - Google Patents

PROCESS FOR THE POLYMERIZATION OF alpha-AMINO ACID-N-CARBOXY ANHYDRIDES

Info

Publication number
GB1202765A
GB1202765A GB3436468A GB3436468A GB1202765A GB 1202765 A GB1202765 A GB 1202765A GB 3436468 A GB3436468 A GB 3436468A GB 3436468 A GB3436468 A GB 3436468A GB 1202765 A GB1202765 A GB 1202765A
Authority
GB
United Kingdom
Prior art keywords
imidazole
alkyl
carboxylic
alpha
polymerization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3436468A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of GB1202765A publication Critical patent/GB1202765A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polyamides (AREA)

Abstract

1,202,765. Poly-aminoacids. KYOWA HAKKO KOGYO CO. Ltd. 18 July, 1968 [20 July, 1967], No. 34364/68. Heading C3R. Polyaminoacids are prepared by polymerizing an alpha-aminoacid-N-carboxylic anhydride in the presence of imidazole or an aryl-, aralkyl, alkaryl-, alkyl-, halo-alkyl-, halogeno-, hydroxyalkyl-, aminoalkyl-, nitro-, amino-, mercapto-, aldehydo- and/or keto-substituted imidazole, an imidazole carboxylic acid, an imidazole carboxylic amide, an imidazole carboxylic alkyl ester, an imidazoline, imidazolone, imidazolidinone, a benzimidazole or imidazolidine or a mixture thereof. The polymerization may be performed at a temperature in the range - 20‹ to + 120‹ C. in solution or suspension in an inert organic solvent and in the presence of 0À1 mole per cent or more of the imidazole derivative. In examples aminoacids used are L-glutamic acid-gamma-methyl ester, L-alanine, L-leucine and D,L-glutamic acid-gamma-methyl ester. N-ethylimidazole, 2-methylimidazole and ethylene urea (2-imidazolidinone) are specified as imidazole derivatives and dioxan, dichloroethane, dimethyl formamide, ethyl acetate and dimethyl sulphoxide are specified as solvents. The products are precipitated by addition of methanol and may be used to make films and fibres.
GB3436468A 1967-07-20 1968-07-18 PROCESS FOR THE POLYMERIZATION OF alpha-AMINO ACID-N-CARBOXY ANHYDRIDES Expired GB1202765A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4633867 1967-07-20

Publications (1)

Publication Number Publication Date
GB1202765A true GB1202765A (en) 1970-08-19

Family

ID=12744333

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3436468A Expired GB1202765A (en) 1967-07-20 1968-07-18 PROCESS FOR THE POLYMERIZATION OF alpha-AMINO ACID-N-CARBOXY ANHYDRIDES

Country Status (3)

Country Link
DE (1) DE1770908C3 (en)
FR (1) FR1603159A (en)
GB (1) GB1202765A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2174097A (en) * 1985-03-22 1986-10-29 Ceskoslovenska Akademie Ved Polymeric stabilizer of water-in-oil emulsions
WO1995004772A1 (en) * 1993-08-10 1995-02-16 Flamel Technologies Method for the preparation of polyaminoacids
US5714138A (en) * 1991-12-20 1998-02-03 Hoechst Aktiengesellschaft Polyaspartamide derivatives as adsorbents for bile acids, polyaspartamide derivatives loaded with bile acids and process for their preparation and their use as pharmaceuticals
WO1999064495A1 (en) * 1998-06-05 1999-12-16 Ústav Makromolekulární Chemie Akademie Věd České Republiky FUNCTIONALISED POLYMERS OF α-AMINO ACIDS AND THE METHOD OF PREPARATION THEREOF
US7659365B2 (en) 2003-10-03 2010-02-09 Flamel Technologies Telechelic homopolyamino acids functionalized with hydrophobic groups, and their applications, especially therapeutic applications
US7678882B2 (en) 2002-07-30 2010-03-16 Flamel Technologies Polyamino acids functionalized by at least one hydrophobic group and the therapeutic application thereof
US7709445B2 (en) 2001-04-02 2010-05-04 Flamel Technologies Colloidal suspension of nanoparticles based on an amphiphilic copolymer
US8084045B2 (en) 2003-11-21 2011-12-27 Flamel Technologies Pharmaceutical formulations for the prolonged release of active principle(s) and their applications

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2174097A (en) * 1985-03-22 1986-10-29 Ceskoslovenska Akademie Ved Polymeric stabilizer of water-in-oil emulsions
US5714138A (en) * 1991-12-20 1998-02-03 Hoechst Aktiengesellschaft Polyaspartamide derivatives as adsorbents for bile acids, polyaspartamide derivatives loaded with bile acids and process for their preparation and their use as pharmaceuticals
US6036948A (en) * 1991-12-20 2000-03-14 Krone; Volker Polyaspartamide derivatives as adsordents for bile acids, polyaspartamide derivatives loaded with bile acids and process for their preparation and their use as pharmaceuticals
WO1995004772A1 (en) * 1993-08-10 1995-02-16 Flamel Technologies Method for the preparation of polyaminoacids
FR2708932A1 (en) * 1993-08-10 1995-02-17 Flamel Tech Sa Process for the preparation of polyamino acids.
US5780579A (en) * 1993-08-10 1998-07-14 Flamel Technologies (Societe Anonyme) Method for the preparation of polyamino acids
WO1999064495A1 (en) * 1998-06-05 1999-12-16 Ústav Makromolekulární Chemie Akademie Věd České Republiky FUNCTIONALISED POLYMERS OF α-AMINO ACIDS AND THE METHOD OF PREPARATION THEREOF
US7709445B2 (en) 2001-04-02 2010-05-04 Flamel Technologies Colloidal suspension of nanoparticles based on an amphiphilic copolymer
US7678882B2 (en) 2002-07-30 2010-03-16 Flamel Technologies Polyamino acids functionalized by at least one hydrophobic group and the therapeutic application thereof
US7659365B2 (en) 2003-10-03 2010-02-09 Flamel Technologies Telechelic homopolyamino acids functionalized with hydrophobic groups, and their applications, especially therapeutic applications
US8084045B2 (en) 2003-11-21 2011-12-27 Flamel Technologies Pharmaceutical formulations for the prolonged release of active principle(s) and their applications

Also Published As

Publication number Publication date
DE1770908B2 (en) 1973-10-04
DE1770908C3 (en) 1974-06-06
FR1603159A (en) 1971-03-22
DE1770908A1 (en) 1972-01-13

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee