BR0208109A - Derivados de guanidina bicìclicos e usos terapêuticos destes - Google Patents
Derivados de guanidina bicìclicos e usos terapêuticos destesInfo
- Publication number
- BR0208109A BR0208109A BR0208109-1A BR0208109A BR0208109A BR 0208109 A BR0208109 A BR 0208109A BR 0208109 A BR0208109 A BR 0208109A BR 0208109 A BR0208109 A BR 0208109A
- Authority
- BR
- Brazil
- Prior art keywords
- therapeutic uses
- guanidine derivatives
- bicyclic guanidine
- compounds
- bicyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/06—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Abstract
"DERIVADOS DE GUANIDINA BICìCLICOS E USOS TERAPêUTICOS DESTES". A presente invenção refere-se aos compostos da fórmula geral (I), em que A, X, Y e R1 são definidos na reivindicação 1. Estes compostos podem ser usados no tratamento de patologias associadas com a síndrome da resistência à insulina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0103843A FR2822463B1 (fr) | 2001-03-21 | 2001-03-21 | Derives bicycliques de guanidines et leurs applications en therapeutique |
PCT/EP2002/002094 WO2002076963A1 (en) | 2001-03-21 | 2002-02-27 | Bicyclic guanidine derivatives and therapeutic uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0208109A true BR0208109A (pt) | 2004-03-02 |
Family
ID=8861404
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0208109-1A BR0208109A (pt) | 2001-03-21 | 2002-02-27 | Derivados de guanidina bicìclicos e usos terapêuticos destes |
Country Status (23)
Country | Link |
---|---|
US (1) | US7491733B2 (pt) |
EP (1) | EP1370542B1 (pt) |
JP (1) | JP2004525146A (pt) |
KR (1) | KR20030086312A (pt) |
CN (1) | CN1229362C (pt) |
AR (1) | AR035698A1 (pt) |
AU (1) | AU2002254911B2 (pt) |
BR (1) | BR0208109A (pt) |
CA (1) | CA2441331C (pt) |
CZ (1) | CZ20032765A3 (pt) |
EE (1) | EE200300454A (pt) |
ES (1) | ES2518315T3 (pt) |
FR (1) | FR2822463B1 (pt) |
HK (1) | HK1061562A1 (pt) |
HU (1) | HUP0303612A3 (pt) |
IL (1) | IL158001A0 (pt) |
MX (1) | MXPA03008393A (pt) |
NO (1) | NO20034172L (pt) |
PL (1) | PL362657A1 (pt) |
RU (1) | RU2282622C2 (pt) |
SK (1) | SK12812003A3 (pt) |
WO (1) | WO2002076963A1 (pt) |
ZA (1) | ZA200308145B (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE466013T1 (de) * | 2004-09-03 | 2010-05-15 | Yuhan Corp | Pyrroloä3,2-cüpyridinderivate und verfahren zu deren herstellung |
DE102005034269A1 (de) * | 2005-07-22 | 2007-01-25 | Lanxess Deutschland Gmbh | Halogenfreie, flammwidrige Polyurethanschaumstoffe |
EP2046753A2 (en) | 2006-07-06 | 2009-04-15 | Brystol-Myers Squibb Company | Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors |
EP2624696B1 (en) | 2010-10-06 | 2016-12-21 | Glaxosmithkline LLC | Benzimidazole derivatives as pi3 kinase inhibitors |
RU2711098C1 (ru) * | 2019-04-15 | 2020-01-15 | Федеральное государственное бюджетное научное учреждение "Федеральный Ростовский аграрный научный центр" (ФГБНУ ФРАНЦ) | Производные нитропиридина, обладающие антибактериальной и протистоцидной активностью |
CN113968855A (zh) * | 2020-07-24 | 2022-01-25 | 中国科学院上海药物研究所 | 一种治疗血栓性疾病的化合物 |
CN113967210A (zh) * | 2020-07-24 | 2022-01-25 | 上海交通大学医学院附属瑞金医院 | 一种干扰整合素β3/Src相互作用的化合物的用途 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3428653A (en) * | 1965-06-28 | 1969-02-18 | Sterling Drug Inc | 3-indolylmethylguanidine |
GB1148214A (en) * | 1965-11-26 | 1969-04-10 | Ward Blenkinsop & Co Ltd | Heterocyclic guanidine derivatives |
US3855242A (en) * | 1967-12-15 | 1974-12-17 | Aspro Nicholas Ltd | Benzo{8 b{9 thienyl-alkyl-guanidines |
US3700697A (en) * | 1968-04-22 | 1972-10-24 | Sterling Drug Inc | (2,3-dihydro-2-benzofuranylmethyl) guanidines and their preparation |
DE2739723A1 (de) * | 1977-09-03 | 1979-03-08 | Merck Patent Gmbh | 2-guanidinomethyl-indoline und verfahren zu ihrer herstellung |
CA2011899A1 (en) * | 1989-03-13 | 1990-09-13 | Masaaki Toda | Benzopyran derivatives |
WO1991009023A1 (en) | 1989-12-11 | 1991-06-27 | American Home Products Corporation | N-heteroaralkyl-substituted 1-aryloxy-2-propanolamine and propylamine derivatives possessing class iii antiarrhythmic activity |
AU3443493A (en) | 1992-02-19 | 1993-09-13 | Upjohn Company, The | 3-substituted imidazo(1,5-a)quinoxalines and quinazolines with cns activity |
SE9301912D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | Process for the production of aminoalkylguandines |
KR100196356B1 (ko) | 1993-09-28 | 1999-06-15 | 오스카 아끼히꼬 | 당뇨병 치료제 |
PL318199A1 (en) | 1994-06-29 | 1997-05-26 | Smithkline Beecham Corp | Antagonists of vitronectin receptors |
US5955495A (en) | 1996-05-03 | 1999-09-21 | Hoffmann-La Roche Inc. | Method of treating diseases of the CNS |
US6072075A (en) | 1997-05-22 | 2000-06-06 | The Regents Of The University Of California | Guanidinylation reagents |
-
2001
- 2001-03-21 FR FR0103843A patent/FR2822463B1/fr not_active Expired - Fee Related
-
2002
- 2002-02-27 US US10/472,228 patent/US7491733B2/en not_active Expired - Fee Related
- 2002-02-27 SK SK1281-2003A patent/SK12812003A3/sk not_active Application Discontinuation
- 2002-02-27 CA CA2441331A patent/CA2441331C/en not_active Expired - Fee Related
- 2002-02-27 MX MXPA03008393A patent/MXPA03008393A/es unknown
- 2002-02-27 CN CNB028067940A patent/CN1229362C/zh not_active Expired - Fee Related
- 2002-02-27 RU RU2003130062/04A patent/RU2282622C2/ru not_active IP Right Cessation
- 2002-02-27 ES ES02724186.8T patent/ES2518315T3/es not_active Expired - Lifetime
- 2002-02-27 EP EP02724186.8A patent/EP1370542B1/en not_active Expired - Lifetime
- 2002-02-27 BR BR0208109-1A patent/BR0208109A/pt not_active IP Right Cessation
- 2002-02-27 JP JP2002576223A patent/JP2004525146A/ja active Pending
- 2002-02-27 AU AU2002254911A patent/AU2002254911B2/en not_active Ceased
- 2002-02-27 PL PL02362657A patent/PL362657A1/xx unknown
- 2002-02-27 CZ CZ20032765A patent/CZ20032765A3/cs unknown
- 2002-02-27 EE EEP200300454A patent/EE200300454A/xx unknown
- 2002-02-27 KR KR10-2003-7012151A patent/KR20030086312A/ko not_active Application Discontinuation
- 2002-02-27 WO PCT/EP2002/002094 patent/WO2002076963A1/en active Application Filing
- 2002-02-27 HU HU0303612A patent/HUP0303612A3/hu unknown
- 2002-02-27 IL IL15800102A patent/IL158001A0/xx unknown
- 2002-03-20 AR ARP020100994A patent/AR035698A1/es unknown
-
2003
- 2003-09-19 NO NO20034172A patent/NO20034172L/no not_active Application Discontinuation
- 2003-10-20 ZA ZA200308145A patent/ZA200308145B/en unknown
-
2004
- 2004-06-19 HK HK04104453A patent/HK1061562A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1370542B1 (en) | 2014-08-20 |
HK1061562A1 (en) | 2004-09-24 |
MXPA03008393A (es) | 2004-01-29 |
AU2002254911B2 (en) | 2007-09-06 |
PL362657A1 (en) | 2004-11-02 |
US20040122040A1 (en) | 2004-06-24 |
RU2003130062A (ru) | 2005-04-10 |
CA2441331C (en) | 2010-10-05 |
KR20030086312A (ko) | 2003-11-07 |
US7491733B2 (en) | 2009-02-17 |
JP2004525146A (ja) | 2004-08-19 |
ZA200308145B (en) | 2005-01-20 |
FR2822463A1 (fr) | 2002-09-27 |
RU2282622C2 (ru) | 2006-08-27 |
CA2441331A1 (en) | 2002-10-03 |
EE200300454A (et) | 2003-12-15 |
NO20034172D0 (no) | 2003-09-19 |
CZ20032765A3 (cs) | 2004-01-14 |
EP1370542A1 (en) | 2003-12-17 |
FR2822463B1 (fr) | 2004-07-30 |
IL158001A0 (en) | 2004-03-28 |
HUP0303612A3 (en) | 2005-02-28 |
ES2518315T3 (es) | 2014-11-05 |
HUP0303612A2 (hu) | 2004-03-01 |
CN1498214A (zh) | 2004-05-19 |
WO2002076963A1 (en) | 2002-10-03 |
CN1229362C (zh) | 2005-11-30 |
AR035698A1 (es) | 2004-06-23 |
NO20034172L (no) | 2003-09-19 |
SK12812003A3 (sk) | 2004-02-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0107815A (pt) | Derivados aminados de di-hidro-1,3,5-triazina e suas aplicações em terapêutica | |
SE0001899D0 (sv) | New compounds | |
DE60236541D1 (de) | Inhibitoren von 11-beta-hydroxysteroiddehydrogenase typ 1 | |
BR0207726A (pt) | Sais farmacêuticos | |
BR0208338A (pt) | Derivados de piridina | |
BR0302369A (pt) | Conjunto de elementos para estruturas de montagem | |
BR0208142A (pt) | Combinações compreendendo um agente antidiarréico e epotilona ou derivado de epotilona | |
BR0113643A (pt) | Compostos de guanidinobenzamidas como agonistas de mc4-r e seus usos | |
GT200100183A (es) | Derivados de quinolina y quinazolina. | |
BR0206588A (pt) | Composto, processo para produzir o mesmo, uso do mesmo, composição farmacêutica, e, método para tratar um paciente afligido com uma condição patológica suscetìvel à melhora pelo antagonismo de integrinas alfa4beta1 e/ou alfa4beta7 | |
DE60121988D1 (de) | Kombinationstherapie mit antidiabetischen und antikonvulsiven mitteln | |
BR0209821A (pt) | Compostos, processo para a manufatura desses compostos, composições farmacêuticas que compreendem os mesmos, processo para o tratamento e/ou profilaxia de enfermidades e utilização dos compostos | |
BR0110573A (pt) | Composto, composição farmacêutica que compreende esse composto, processo para a preparação de uma composição farmacêutica, utilização do composto e processo para o tratamento profilático ou terapêutico e para a preparação do composto | |
BR0213539A (pt) | Compostos, processo para a preparação de compostos, composições farmacêuticas que compreendem um composto método para o tratamento e/ou profilaxia de enfermidades que estão associadas com dpp iv e utilização desses compostos | |
BR0318278A (pt) | compostos de éter aminocicloexìlico e usos dos mesmo | |
BR0015992A (pt) | Compostos, utilização dos mesmos, e, associações terapêuticas | |
BR0316227A (pt) | IsÈmeros posicionais de peg ifn alfa 2a | |
BR0208109A (pt) | Derivados de guanidina bicìclicos e usos terapêuticos destes | |
SE0102147D0 (sv) | New methods | |
BR0208131A (pt) | Derivados biguanida | |
BR0211903A (pt) | Isoxazolopiridinonas | |
BR0113408A (pt) | Derivados de aminociclohexano | |
BR0115139A (pt) | Compostos bis-heterocìclicos com atividade antitumor e quimiossensibilizante | |
BR0205944A (pt) | Compostos de ácido ascórbico, métodos de sìntese e suas aplicações | |
ATE284878T1 (de) | Pharmazeutische verbindungen mit serotonin rezeptor aktivität |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A,7A E 8A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2055 DE 25/05/2010. |