IL158001A0 - Bicyclic guanidine derivatives and therapeutic uses thereof - Google Patents
Bicyclic guanidine derivatives and therapeutic uses thereofInfo
- Publication number
- IL158001A0 IL158001A0 IL15800102A IL15800102A IL158001A0 IL 158001 A0 IL158001 A0 IL 158001A0 IL 15800102 A IL15800102 A IL 15800102A IL 15800102 A IL15800102 A IL 15800102A IL 158001 A0 IL158001 A0 IL 158001A0
- Authority
- IL
- Israel
- Prior art keywords
- therapeutic uses
- guanidine derivatives
- bicyclic guanidine
- bicyclic
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/06—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0103843A FR2822463B1 (en) | 2001-03-21 | 2001-03-21 | BICYCLIC GUANIDINE DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS |
PCT/EP2002/002094 WO2002076963A1 (en) | 2001-03-21 | 2002-02-27 | Bicyclic guanidine derivatives and therapeutic uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
IL158001A0 true IL158001A0 (en) | 2004-03-28 |
Family
ID=8861404
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15800102A IL158001A0 (en) | 2001-03-21 | 2002-02-27 | Bicyclic guanidine derivatives and therapeutic uses thereof |
Country Status (23)
Country | Link |
---|---|
US (1) | US7491733B2 (en) |
EP (1) | EP1370542B1 (en) |
JP (1) | JP2004525146A (en) |
KR (1) | KR20030086312A (en) |
CN (1) | CN1229362C (en) |
AR (1) | AR035698A1 (en) |
AU (1) | AU2002254911B2 (en) |
BR (1) | BR0208109A (en) |
CA (1) | CA2441331C (en) |
CZ (1) | CZ20032765A3 (en) |
EE (1) | EE200300454A (en) |
ES (1) | ES2518315T3 (en) |
FR (1) | FR2822463B1 (en) |
HK (1) | HK1061562A1 (en) |
HU (1) | HUP0303612A3 (en) |
IL (1) | IL158001A0 (en) |
MX (1) | MXPA03008393A (en) |
NO (1) | NO20034172L (en) |
PL (1) | PL362657A1 (en) |
RU (1) | RU2282622C2 (en) |
SK (1) | SK12812003A3 (en) |
WO (1) | WO2002076963A1 (en) |
ZA (1) | ZA200308145B (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100946220B1 (en) | 2004-09-03 | 2010-03-08 | 주식회사유한양행 | Pyrrolo[3,2-c]pyridine derivatives and processes for the preparation thereof |
DE102005034269A1 (en) * | 2005-07-22 | 2007-01-25 | Lanxess Deutschland Gmbh | Halogen-free, flame-retardant polyurethane foams |
EP2046753A2 (en) | 2006-07-06 | 2009-04-15 | Brystol-Myers Squibb Company | Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors |
EP2624696B1 (en) | 2010-10-06 | 2016-12-21 | Glaxosmithkline LLC | Benzimidazole derivatives as pi3 kinase inhibitors |
RU2711098C1 (en) * | 2019-04-15 | 2020-01-15 | Федеральное государственное бюджетное научное учреждение "Федеральный Ростовский аграрный научный центр" (ФГБНУ ФРАНЦ) | Nitro pyridine derivatives, having antibacterial and anti-protist activity |
CN113968855A (en) * | 2020-07-24 | 2022-01-25 | 中国科学院上海药物研究所 | Compound for treating thrombotic diseases |
CN113967210A (en) * | 2020-07-24 | 2022-01-25 | 上海交通大学医学院附属瑞金医院 | Application of compound interfering integrin beta 3/Src interaction |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3428653A (en) * | 1965-06-28 | 1969-02-18 | Sterling Drug Inc | 3-indolylmethylguanidine |
GB1148214A (en) * | 1965-11-26 | 1969-04-10 | Ward Blenkinsop & Co Ltd | Heterocyclic guanidine derivatives |
US3855242A (en) * | 1967-12-15 | 1974-12-17 | Aspro Nicholas Ltd | Benzo{8 b{9 thienyl-alkyl-guanidines |
US3700697A (en) * | 1968-04-22 | 1972-10-24 | Sterling Drug Inc | (2,3-dihydro-2-benzofuranylmethyl) guanidines and their preparation |
DE2739723A1 (en) | 1977-09-03 | 1979-03-08 | Merck Patent Gmbh | 2-GUANIDINOMETHYL INDOLINE AND METHOD FOR THE PRODUCTION THEREOF |
CA2011899A1 (en) * | 1989-03-13 | 1990-09-13 | Masaaki Toda | Benzopyran derivatives |
AU6977391A (en) | 1989-12-11 | 1991-07-18 | American Home Products Corporation | N-heteroaralkyl-substituted 1-aryloxy-2-propanolamine and propylamine derivatives possessing class iii antiarrhythmic activity |
EP0626966A1 (en) | 1992-02-19 | 1994-12-07 | PHARMACIA & UPJOHN COMPANY | 3-substituted imidazo(1,5-a)quinoxalines and quinazolines with cns activity |
SE9301912D0 (en) | 1993-06-03 | 1993-06-03 | Ab Astra | PROCESS FOR THE PRODUCTION OF AMINOALKYLGUANDINES |
AU674613B2 (en) | 1993-09-28 | 1997-01-02 | Otsuka Pharmaceutical Co., Ltd. | Quinoxaline derivative as antidiabetic agent |
AU702661B2 (en) | 1994-06-29 | 1999-02-25 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
US5955495A (en) | 1996-05-03 | 1999-09-21 | Hoffmann-La Roche Inc. | Method of treating diseases of the CNS |
US6072075A (en) | 1997-05-22 | 2000-06-06 | The Regents Of The University Of California | Guanidinylation reagents |
-
2001
- 2001-03-21 FR FR0103843A patent/FR2822463B1/en not_active Expired - Fee Related
-
2002
- 2002-02-27 CN CNB028067940A patent/CN1229362C/en not_active Expired - Fee Related
- 2002-02-27 WO PCT/EP2002/002094 patent/WO2002076963A1/en active Application Filing
- 2002-02-27 AU AU2002254911A patent/AU2002254911B2/en not_active Ceased
- 2002-02-27 US US10/472,228 patent/US7491733B2/en not_active Expired - Fee Related
- 2002-02-27 BR BR0208109-1A patent/BR0208109A/en not_active IP Right Cessation
- 2002-02-27 KR KR10-2003-7012151A patent/KR20030086312A/en not_active Application Discontinuation
- 2002-02-27 EP EP02724186.8A patent/EP1370542B1/en not_active Expired - Lifetime
- 2002-02-27 ES ES02724186.8T patent/ES2518315T3/en not_active Expired - Lifetime
- 2002-02-27 CA CA2441331A patent/CA2441331C/en not_active Expired - Fee Related
- 2002-02-27 RU RU2003130062/04A patent/RU2282622C2/en not_active IP Right Cessation
- 2002-02-27 PL PL02362657A patent/PL362657A1/en unknown
- 2002-02-27 EE EEP200300454A patent/EE200300454A/en unknown
- 2002-02-27 CZ CZ20032765A patent/CZ20032765A3/en unknown
- 2002-02-27 SK SK1281-2003A patent/SK12812003A3/en not_active Application Discontinuation
- 2002-02-27 HU HU0303612A patent/HUP0303612A3/en unknown
- 2002-02-27 MX MXPA03008393A patent/MXPA03008393A/en unknown
- 2002-02-27 IL IL15800102A patent/IL158001A0/en unknown
- 2002-02-27 JP JP2002576223A patent/JP2004525146A/en active Pending
- 2002-03-20 AR ARP020100994A patent/AR035698A1/en unknown
-
2003
- 2003-09-19 NO NO20034172A patent/NO20034172L/en not_active Application Discontinuation
- 2003-10-20 ZA ZA200308145A patent/ZA200308145B/en unknown
-
2004
- 2004-06-19 HK HK04104453A patent/HK1061562A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MXPA03008393A (en) | 2004-01-29 |
KR20030086312A (en) | 2003-11-07 |
SK12812003A3 (en) | 2004-02-03 |
EE200300454A (en) | 2003-12-15 |
HUP0303612A2 (en) | 2004-03-01 |
ZA200308145B (en) | 2005-01-20 |
ES2518315T3 (en) | 2014-11-05 |
HK1061562A1 (en) | 2004-09-24 |
NO20034172D0 (en) | 2003-09-19 |
EP1370542A1 (en) | 2003-12-17 |
JP2004525146A (en) | 2004-08-19 |
NO20034172L (en) | 2003-09-19 |
RU2282622C2 (en) | 2006-08-27 |
BR0208109A (en) | 2004-03-02 |
PL362657A1 (en) | 2004-11-02 |
FR2822463B1 (en) | 2004-07-30 |
HUP0303612A3 (en) | 2005-02-28 |
CA2441331A1 (en) | 2002-10-03 |
AR035698A1 (en) | 2004-06-23 |
RU2003130062A (en) | 2005-04-10 |
US20040122040A1 (en) | 2004-06-24 |
CN1229362C (en) | 2005-11-30 |
EP1370542B1 (en) | 2014-08-20 |
CZ20032765A3 (en) | 2004-01-14 |
AU2002254911B2 (en) | 2007-09-06 |
CN1498214A (en) | 2004-05-19 |
US7491733B2 (en) | 2009-02-17 |
CA2441331C (en) | 2010-10-05 |
WO2002076963A1 (en) | 2002-10-03 |
FR2822463A1 (en) | 2002-09-27 |
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