BR0203386A - Proteìna de fusão, ácido nucleico codificador e método para a preparação de uma proteìna de fusão possuindo uma melhorada atividade epo in-vivo - Google Patents

Proteìna de fusão, ácido nucleico codificador e método para a preparação de uma proteìna de fusão possuindo uma melhorada atividade epo in-vivo

Info

Publication number
BR0203386A
BR0203386A BR0203386-0A BR0203386A BR0203386A BR 0203386 A BR0203386 A BR 0203386A BR 0203386 A BR0203386 A BR 0203386A BR 0203386 A BR0203386 A BR 0203386A
Authority
BR
Brazil
Prior art keywords
fusion protein
preparation
nucleic acid
improved
coding nucleic
Prior art date
Application number
BR0203386-0A
Other languages
English (en)
Inventor
Dong-Eok Lee
Myung-Suk Oh
Ki-Wan Kim
Bo-Sup Chung
Ji-Sook Park
Original Assignee
Cheil Jedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cheil Jedang Corp filed Critical Cheil Jedang Corp
Publication of BR0203386A publication Critical patent/BR0203386A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"PROTEìNA DE FUSãO, áCIDO NUCLEICO CODIFICADOR E MéTODO PARA A PREPARAçãO DE UMA PROTEìNA DE FUSãO POSSUINDO UMA MELHORADA ATIVIDADE EPO IN-VIVO". é proporcionada uma proteína de fusão compreendendo, em seu terminal carbóxi de eritropoietina humana (EPO), um mutante possuindo de uma até quatro substituições de aminoácidos no fragmento peptida carbóxi-terminal (CTP) de uma subunidade <225> de gonadotropina coriónica humana (HCG), para aumentar a atividade da meia-vida in-vivo de uma EPO. A meia-vida in-vivo pode ser grandemente prolongada mantendo ao mesmo tempo a atividade intrínseca da EPO, sem aumentar o teor de cadeia de açúcar.
BR0203386-0A 2001-12-03 2002-08-26 Proteìna de fusão, ácido nucleico codificador e método para a preparação de uma proteìna de fusão possuindo uma melhorada atividade epo in-vivo BR0203386A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR10-2001-0075994A KR100467751B1 (ko) 2001-12-03 2001-12-03 생체내 에리스로포이에틴 활성이 증진된 융합단백질

Publications (1)

Publication Number Publication Date
BR0203386A true BR0203386A (pt) 2004-05-25

Family

ID=36123483

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0203386-0A BR0203386A (pt) 2001-12-03 2002-08-26 Proteìna de fusão, ácido nucleico codificador e método para a preparação de uma proteìna de fusão possuindo uma melhorada atividade epo in-vivo

Country Status (17)

Country Link
US (1) US7091326B2 (pt)
EP (1) EP1316561B1 (pt)
JP (1) JP4035400B2 (pt)
KR (1) KR100467751B1 (pt)
CN (1) CN100400548C (pt)
AT (1) ATE352565T1 (pt)
AU (1) AU2002300734B2 (pt)
BR (1) BR0203386A (pt)
CA (1) CA2400908C (pt)
DE (1) DE60217804T2 (pt)
ES (1) ES2280487T3 (pt)
MX (1) MXPA02008454A (pt)
NZ (1) NZ520776A (pt)
RU (1) RU2232192C2 (pt)
TW (1) TWI243827B (pt)
WO (1) WO2003048210A1 (pt)
ZA (1) ZA200206879B (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7345019B1 (en) * 1999-04-13 2008-03-18 The Kenneth S. Warren Institute, Inc. Modulation of excitable tissue function by peripherally administered erythropoietin
US7767643B2 (en) 2000-12-29 2010-08-03 The Kenneth S. Warren Institute, Inc. Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
US20030072737A1 (en) * 2000-12-29 2003-04-17 Michael Brines Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
ZA200603396B (en) * 2003-09-29 2007-11-28 Warren Pharmaceuticals Inc Tissue protective cytokines for the treatment and prevention of sepsis and the formation of adhesions
CN100516225C (zh) * 2004-07-30 2009-07-22 成都地奥制药集团有限公司 人血清蛋白与促红细胞生成素的融合蛋白
NZ565937A (en) * 2005-08-05 2011-09-30 Araim Pharmaceuticals Inc Tissue protective peptides and uses thereof
US7625564B2 (en) 2006-01-27 2009-12-01 Novagen Holding Corporation Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US7553941B2 (en) * 2006-02-03 2009-06-30 Modigene Inc Long-acting polypeptides and methods of producing same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
CN100436482C (zh) * 2006-04-14 2008-11-26 东莞太力生物工程有限公司 长效人促红细胞生成素融合蛋白及其制备和纯化方法
BRPI0814465B1 (pt) 2007-07-26 2021-11-23 Novagen Holding Corporation Proteína de fusão, dímero, método para produzir uma proteína de fusão, linhagem de célula, usos de uma proteína de fusão e de uma composição farmacêutica e composição farmacêutica
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
CN102994547B (zh) * 2011-09-08 2015-05-13 哈药集团技术中心 重组人促红素-ctp融合蛋白生产工艺及应用
CN103182073A (zh) * 2011-12-29 2013-07-03 哈药集团技术中心 一种重组人干扰素α-CTP融合蛋白的药物注射剂
SG11201406671RA (en) 2012-04-19 2014-11-27 Opko Biolog Ltd Long-acting oxyntomodulin variants and methods of producing same
MY172997A (en) * 2012-11-20 2019-12-18 Opko Biologics Ltd Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides
EP2968391A1 (en) 2013-03-13 2016-01-20 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
EP4212546A1 (en) * 2014-12-10 2023-07-19 OPKO Biologics Ltd. Methods of producing long acting ctp-modified polypeptides
IL301728A (en) 2015-06-19 2023-05-01 Opko Biologics Ltd Long-term coagulation factors and methods for their preparation
BR112019000610A2 (pt) 2016-07-11 2019-07-02 Opko Biologics Ltd fator vii de coagulação de longa ação e métodos de produção do mesmo
CN110393801A (zh) * 2018-04-24 2019-11-01 中国科学院上海生命科学研究院 靶向促黄体生成素促进机体造血的应用
CN112175088B (zh) * 2019-07-02 2023-03-28 江苏晟斯生物制药有限公司 改进的fix融合蛋白、缀合物及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225449B1 (en) * 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
EP0461200B1 (en) * 1989-02-21 1997-01-22 Washington University Modified forms of reproductive hormones
US5856298A (en) * 1989-10-13 1999-01-05 Amgen Inc. Erythropoietin isoforms
ES2141229T3 (es) * 1993-04-20 2000-03-16 Univ Washington Productos farmaceuticos de proteinas y peptidos modificados.
IL110669A (en) 1993-08-17 2008-11-26 Kirin Amgen Inc Erythropoietin analogs
CZ299516B6 (cs) 1999-07-02 2008-08-20 F. Hoffmann-La Roche Ag Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
PE20010288A1 (es) * 1999-07-02 2001-03-07 Hoffmann La Roche Derivados de eritropoyetina
JP4944324B2 (ja) 1999-07-13 2012-05-30 ボルダー バイオテクノロジー， インコーポレイテッド 免疫グロブリン融合タンパク質
CA2391080A1 (en) 1999-11-12 2001-05-25 Merck Patent Gesellschaft Mit Beschraenkter Haftung Erythropoietin forms with improved properties
WO2002048194A1 (en) 2000-12-11 2002-06-20 Cheil Jedang Corporation Fusion protein having the enhanced in vivo activity of erythropoietin

Also Published As

Publication number Publication date
KR20030045341A (ko) 2003-06-11
NZ520776A (en) 2004-02-27
DE60217804T2 (de) 2007-09-13
EP1316561B1 (en) 2007-01-24
KR100467751B1 (ko) 2005-01-24
JP2003189853A (ja) 2003-07-08
EP1316561A1 (en) 2003-06-04
WO2003048210A1 (en) 2003-06-12
CA2400908C (en) 2011-04-12
RU2232192C2 (ru) 2004-07-10
ZA200206879B (en) 2003-04-29
CN100400548C (zh) 2008-07-09
US7091326B2 (en) 2006-08-15
JP4035400B2 (ja) 2008-01-23
MXPA02008454A (es) 2005-08-26
DE60217804D1 (de) 2007-03-15
US20030113871A1 (en) 2003-06-19
AU2002300734B2 (en) 2009-01-08
CN1422870A (zh) 2003-06-11
ES2280487T3 (es) 2007-09-16
CA2400908A1 (en) 2003-06-03
ATE352565T1 (de) 2007-02-15
TWI243827B (en) 2005-11-21

Similar Documents

Publication Publication Date Title
BR0203386A (pt) Proteìna de fusão, ácido nucleico codificador e método para a preparação de uma proteìna de fusão possuindo uma melhorada atividade epo in-vivo
ATE320449T1 (de) Fusionsprotein mit verbesserter in vivo erythropoietinwirkung
IL197339A (en) Recombinant chimeric uricase protein, protein-containing linker and preparations containing them
BR0204200A (pt) Conector transversal poliaxial
ATE259161T1 (de) Der gesundheit dienendes riegel-formulierung
BR9709006A (pt) Processo para obter á partir de sumbstrato protéico um hidrolisado enriquecido com ácido glutámico livre e/ou resíduos de ácido glutámico libados por peptídeo produto alimentício e aditivo de racão animal
EE05473B1 (et) Levodopa/karbidopa/entakapooni farmatseutiline preparaat, selle valmistamise meetod ja kasutamine
EP2557160A3 (en) Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives using the same
GB2382580B (en) Fusion protein having enhanced in vivo activity of erythropoietin
DE3850654D1 (de) Immunglobulin-e-kompetitor.
WO2004081043A3 (en) Baff mutants with at least one amino acid substitution and methods of their production
WO2000069901A3 (en) Proteins with insulin-like activity useful in the treatment of diabetes
ATE367826T1 (de) Impfstoffe, die hybride polypeptide mit mindestens zwei verschiedene allergenen enthalten
DK0427863T3 (da) DNA, som koder for protein, som kan kombinere med forstærker for alfa-fetoprotein-gen
EE200000487A (et) Kaspaas-8 proteaasiga interakteeruv proteiin, seda kodeeriv DNA järjestus, selle valmistamis- ja identifitseerimismeetod ning kasutamine ravimi valmistamiseks
AU2003298570A8 (en) Isolated human hepsin/46 proteins, nucleic acid molecules encoding human hepsin/46 proteins, and uses thereof
EP1383871A4 (en) INSULATED HUMAN ENZYMATIC PROTEINS, NUCLEIC ACID MOLECULES ENCODING THESE PROTEINS, AND USES THEREOF
AU5730300A (en) Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto
EP1383908A4 (en) ISOLATED HUMAN ENZYME PROTEINS, HUMAN ENZYME PROTEIN CODING NUCLEIC ACID MOLECULES, AND USES THEREOF
EP1385991A4 (en) HUMAN INSULATED ENZYMATIC PROTEINS, NUCLEIC ACID MOLECULES ENCODING THE SAME AND USES THEREOF
DE69729780D1 (de) Protein mit Ethylendiamine-N,N&#39;-Dibarnsteinsäure: Ethylendiamin Lyase Aktivität und dafür kodierendes Gen
WO2002016435A3 (en) Human 7tm proteins and polynucleotides encoding the same
WO2001072842A3 (en) Human 7-transmembrane proteins and polynucleotides encoding the same
WO2001057086A3 (en) Novel human g protein coupled receptor proteins and polynucleotides encoding the same
AU2003284579A1 (en) PROTEIN FORMING COMPLEX WITH c-Fos PROTEIN, NUCLEIC ACID ENCODING THE SAME AND METHOD OF USING THE SAME

Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: CJ CORPORATION (KR)

Free format text: ALTERADO DE: CHEIL JEDANG CORPORATION

B25D Requested change of name of applicant approved

Owner name: CJ CHEILJEDANG CORPORATION (KR)

Free format text: ALTERADO DE: CJ CORPORATION

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: CJ HEALTHCARE CORPORATION (KR)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL